Harrisburg, PA to Charleston, SC bus with Greyhound

Fri, Mar 20
+ Add return
Greyhound
FlixBus
Alsa
Costa Verde
BlaBlaCar Bus
2,000+ travel companies
Greyhound
FlixBus
Alsa
Costa Verde
BlaBlaCar Bus
2,000+ travel companies
QR-Code
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
rate4.9
42K ratings
Google Play
rate4.6
136K reviews

The cheapest and fastest buses from Harrisburg, PA to Charleston, SC

Showing times and prices for Mar 22

Cheapest price

$179

Average price

$179

Fastest journey

1 d 3 h 40 m

Average duration

1 d 3 h 40 m

Buses per day

1

Distance

877 km

Cheap tickets

The best way to find a cheap bus ticket from Harrisburg, PA to Charleston, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from Harrisburg, PA to Charleston, SC will cost around $179 if you buy it on the day, but the cheapest tickets can be found for only $179.

Fast buses

Of the 1 buses that leave Harrisburg, PA for Charleston, SC on Sun, Mar 22, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.

On Sun, Mar 22 the direct buses cover the 877 km distance in an average of 1 d 3 h 40 m but if you time it right, some buses will get you there in just 1 d 3 h 40 m .

On Sun, Mar 22 the slowest buses will take 1 d 3 h 40 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

Greyhound
07:50PM27h40
Harrisburg, PA
11:30PMCharleston, SC
$1791One-way
0 transfers

Travel Information

Compare bus, train, and flight for Harrisburg, PA to Charleston, SC

Omio recommends booking the train as it is the most popular option from Harrisburg, PA to Charleston, SC among Omio's users. If you are prioritising price take the train with prices starting from $152. For those with little time consider booking a flight which can get you there in 5h 52m. The ticket price range depends on the travel mode: a train costs an average of $152, and a flight costs an average of $143.

Distance: 544 miles (877 km)

Compare bus with

Bus
Most popular
Train
Flight

$228

Average price

$227

Average price

Cheapest

$399

Average price

22h 35m

Average total duration

22h 5m

Onboard

+

30m

Additional time*

14h 21m

Average total duration

13h 51m

Onboard

+

30m

Additional time*

8h 52m

Average total duration

Fastest

5h 52m

Onboard

+

3h 0m

Additional time*

Direct Options

Direct Options

Direct Options

Live departures

Harrisburg, PA to Charleston, SC bus times

The table below shows live departures for Harrisburg, PA to Charleston, SC buses for today, Saturday, March 21. You can also manually refresh the results below to see updated bus journeys.

Last updated at 10:29 AM
ProviderDepartsDurationArrivesTransfers
Tickets
greyhound7:50 PM Harrisburg, PA
27h40
11:30 PM Charleston, SC0 transfersDirect

This is the last bus of the day.

Find all the dates and times for this journey

Compare prices and tickets Harrisburg, PA to Charleston, SC by bus, train, or flight

Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Sun
Mar 22
Mon
Mar 23
Tue
Mar 24
Wed
Mar 25
Thu
Mar 26
Fri
Mar 27
Sat
Mar 28

Why should you book Harrisburg, PA to Charleston, SC buses with Omio?

Greyhound operates all buses services from Harrisburg, PA to Charleston, SC.
Omio is an official ticket reseller for all your travel options from Harrisburg, PA to Charleston, SC.

Why book with Omio vs Greyhound?

  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Harrisburg, PA to Charleston, SC.

Why book with Omio over Wanderu?

  • Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Harrisburg, PA to Charleston, SC.

Journey information

Overview: Bus from Harrisburg, PA to Charleston, SC

USAUSA
USAUSA
Icon of bus

Buses from Harrisburg, PA to Charleston, SC run on average 3 times per day, taking around 22h 5m. Cheap bus tickets for this journey start at $112 (€91) if you book in advance.

The earliest bus runs at 07:45, the last at 23:20. The fastest bus covers the 544 miles (877 km) distance in 27h 40m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
544 miles (877 km)
Average bus duration
22h 5m
Cheapest ticket price
$112 (€91)
Buses per day
3
Fastest bus
27h 40m
First bus
07:45
Last bus
23:20
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: Greyhound from Harrisburg, PA to Charleston, SCYou can travel by bus between Harrisburg, PA to Charleston, SC with Greyhound for as low as $112 (€91). When you search for schedules and tickets, Omio will show you the best journey

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
27h 40m
Cheapest Price
$112 (€91)
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.

FAQs: Bus from Harrisburg, PA to Charleston, SC

Find answers to the most common questions about traveling from Harrisburg, PA to Charleston, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Charleston, SC, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from Harrisburg, PA to Charleston, SC can start from as little as $112 (€91) when you book in advance. The average bus ticket price for Harrisburg, PA to Charleston, SC is $228 (€185) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Harrisburg, PA to Charleston, SC is 27h 40m to travel the 544 miles (877 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Harrisburg, PA to Charleston, SC leaves at 7:45 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Harrisburg, PA to Charleston, SC leaves at 11:20 PM.
There are 3 buses a day from Harrisburg, PA to Charleston, SC which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Harrisburg, PA to Charleston, SC, you can count on Greyhound for the best way to get you to Charleston, SC. You can also check all possible bus companies who offer a service between Harrisburg, PA and Charleston, SC and compare the amenities they offer before buying a bus ticket.
A trip to Charleston, SC from Harrisburg, PA is worth doing but not as a day trip with a journey time of 27h 40m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Harrisburg, PA to Charleston, SC is October.
It's helpful to compare your options as there are 3 ways to travel between Harrisburg, PA and Charleston, SC including taking a bus, train, and flight.
Yes, the following accessibility options are available when taking the bus from Harrisburg, PA to Charleston, SC:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Harrisburg, PA to Charleston, SC for bus company Greyhound.
Whether you can cancel your bus ticket from Harrisburg, PA to Charleston, SC depends on the bus companies:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Harrisburg, PA to Charleston, SC.
Yes, the following luggage options are included when booking a bus ticket from Harrisburg, PA to Charleston, SC:
  • Greyhound
    • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Harrisburg, PA to Charleston, SC:
  • Greyhound
    • $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Harrisburg, PA to Charleston, SC.
You can reserve your seat on the bus from Harrisburg, PA to Charleston, SC with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Harrisburg, PA to Charleston, SC with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Harrisburg, PA to Charleston, SC with the following bus company: Greyhound.

popular bus stations

Popular bus stations from Harrisburg, PA to Charleston, SC

Harrisburg
Charleston
The major bus station for departures in Harrisburg is Harrisburg, Market St (Bus Station). Find all the information you need to know about services, amenities and connections at Harrisburg, Market St (Bus Station) for your trip from Harrisburg to Charleston.
Harrisburg, Market St (Bus Station)
information
Harrisburg, Chestnut Street / South 4th Street
information

More options for your journey from Harrisburg, PA to Charleston, SC

Here are some other resources that might have the information you need

Most popular buses to and from Charleston, SC and Harrisburg, PA

HomeBusesBuses in USAHarrisburg, PA to Charleston, SC bus

The Omio App Makes Travel Planning Easy

We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.

ios-badge
android-badge
Hand With Phone