- Must visit
Nasher Museum of Art
Major art museum at Duke with global collections, rotating exhibitions, and strong programs in modern and classical art.
The best way to find a cheap bus ticket from Charleston, SC to Durham, NC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Charleston, SC to Durham, NC will cost around $79 if you buy it on the day, but the cheapest tickets can be found for only $79.
On Wed, Nov 04, we found 1 buses from Charleston, SC to Durham, NC, including 1 direct services.
On Wed, Nov 04 the direct buses cover the 370 km distance in an average of 10 h 45 m but if you time it right, some buses will get you there in just 10 h 45 m .
On Wed, Nov 04 the slowest buses will take 10 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Charleston, SC to Durham, NC run on average 2 times per day, taking around 8h 19m. Cheap bus tickets for this journey start at $47 if you book in advance.
The earliest bus runs at 11:15, the last at 22:10. The fastest bus covers the 229 miles (370 km) distance in 7h 0m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Charleston, SC to Durham, NC.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator CARTA | Departure Time 10:05AM | Arrival Time 10:00PM | Duration 11h55 | Departure days Thu, Fri | Cheapest price $0 |
Operator Greyhound | Departure Time 10:40AM | Arrival Time 10:00PM | Duration 11h20 | Departure days Sat, Sun | Cheapest price $65 |
Operator FlixBus | Departure Time 02:15PM | Arrival Time 03:45AM | Duration 13h30 | Departure days Sat, Sun | Cheapest price $66 |
Operator Greyhound | Departure Time 03:15PM | Arrival Time 02:00AM | Duration 10h45 | Departure days Tue, Wed | Cheapest price $64 |
Operator Greyhound | Departure Time 04:15PM | Arrival Time 03:00AM | Duration 10h45 | Departure days Mon | Cheapest price $86 |
The table below shows live departures for Charleston, SC to Durham, NC buses for today, Tuesday, November 3. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 3:15 PM Charleston, SC | 10h45 | 2:00 AM Durham, NC | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Buses from Charleston, SC to Durham, NC with Greyhound. Overnight buses available on this route with Greyhound. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Durham, NC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Durham, NC trip today.
Major art museum at Duke with global collections, rotating exhibitions, and strong programs in modern and classical art.
Hands-on science museum with aerospace, physics, wildlife, and family exhibits in downtown Durham.
Historic site and museum exploring Washington Duke, tobacco farming, and Durham's industrial origins.
Beloved public garden with terraces, woodland paths, and seasonal blooms, ideal for a scenic walk near Duke.
Lively downtown district for walking among warehouses, public art, music venues, and restored tobacco-era spaces.
Scenic riverside greenway for walking and cycling, connecting downtown with quiet stretches of restored nature.
Eastern North Carolina chopped pork barbecue with a tangy vinegar-pepper sauce. A defining regional staple widely loved across Durham and the Triangle.
Slow-cooked pork shoulder or whole hog, often served on a plate with slaw and hush puppies. It reflects the area’s deep barbecue tradition.
Fried cornmeal batter balls served with barbecue or seafood. They are a classic Southern side found on many Durham menus.
Refined restaurant showcasing seasonal North Carolina ingredients with polished service. Known for elevated Southern cooking and a stylish setting.
Beloved local bakery and café serving excellent pastries, breads, and coffee. A dependable stop for breakfast, lunch, or a quick snack.
Popular casual spot for inventive biscuit sandwiches, shrimp and grits, and Southern brunch favorites in a lively downtown atmosphere.
Moderate for a US college city; hotels and dining are mid-priced, transit is limited, but many casual meals and coffee shops are affordable.
Tip 18-20% at restaurants, 15-20% for taxis, and $1-2 per drink or café order if service is provided.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Durham, NC.
Find answers to the most common questions about traveling from Charleston, SC to Durham, NC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Durham, NC, this guide helps you travel smarter and with confidence.

Most Charleston, SC to Durham, NC buses use the Charleston, Gaynor Avenue (Greyhound Bus Station) to Durham, W Pettigrew St (Greyhound Bus Station) station pair. Use this guide to compare Charleston, SC and Durham, NC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Charleston, Gaynor Avenue (Greyhound Bus Station) is 12 km from Charleston city centre. Public transport options include:
Charleston, Gaynor Avenue (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free Wi-Fi available. ATMs are available at Charleston, Gaynor Avenue (Greyhound Bus Station).
Ticket office support is available at Charleston, Gaynor Avenue (Greyhound Bus Station).
Available at Charleston, Gaynor Avenue (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Charleston, Gaynor Avenue (Greyhound Bus Station): Wheelchair accessible.