The cheapest and fastest buses from Charleston, SC to Durham, NC
Cheapest price
$144
Average price
$144
Fastest journey
13 h 15 m
Average duration
13 h 15 m
Buses per day
1
Distance
370 km
The best way to find a cheap bus ticket from Charleston, SC to Durham, NC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Charleston, SC to Durham, NC will cost around $144 if you buy it on the day, but the cheapest tickets can be found for only $144.
It's difficult to get from Charleston, SC to Durham, NC without transferring at least 3 times.


Travel Information
Compare bus, train, and flight for Charleston, SC to Durham, NC
Omio recommends booking the bus as it is the most popular option from Charleston, SC to Durham, NC among Omio's users. If you are prioritising price take the bus with prices starting from €48. For those with little time consider booking a flight which can get you there in 4h 58m. The ticket price range depends on the travel mode: a bus costs an average of €48, and a flight costs an average of €133.
Distance: 229 miles (370 km)
Compare bus with
Most popular Bus | Train | Flight |
|---|---|---|
€66 Average price Cheapest | €75 Average price | €226 Average price |
6h 20m Average total duration 5h 50m Onboard + 30m Additional time* | 9h 33m Average total duration 9h 3m Onboard + 30m Additional time* | 7h 58m Average total duration Fastest 4h 58m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
Charleston, SC to Durham, NC bus times
The table below shows live departures for Charleston, SC to Durham, NC buses for today, Wednesday, February 4. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 5:55 PM Charleston, SC | 11h10 | 5:05 AM Durham, NC | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Charleston, SC to Durham, NC by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Charleston, SC to Durham, NC buses with Omio?
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of CARTA to find the best option for your trip from Charleston, SC to Durham, NC.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Charleston, SC to Durham, NC.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Charleston, SC to Durham, NC.
Journey information
Overview: Bus from Charleston, SC to Durham, NC
Buses from Charleston, SC to Durham, NC run on average 2 times per day, taking around 5h 50m. Cheap bus tickets for this journey start at $61 (€48) if you book in advance.
The earliest bus runs at 13:55, the last at 22:10. The fastest bus covers the 229 miles (370 km) distance in 8h 5m.
Distance 229 miles (370 km) |
Average bus duration 5h 50m |
Cheapest ticket price $61 (€48) |
Buses per day 2 |
Fastest bus 8h 5m |
First bus 13:55 |
Last bus 22:10 |
Bus providers: Greyhound, CARTA from Charleston, SC to Durham, NCYou can travel by bus between Charleston, SC to Durham, NC with Greyhound, CARTA for as low as $61 (€48). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
CARTA
FAQs: Bus from Charleston, SC to Durham, NC
Find answers to the most common questions about traveling from Charleston, SC to Durham, NC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Durham, NC, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Charleston, SC to Durham, NC
Most popular bus connections from Charleston, SC
More options for your journey from Charleston, SC to Durham, NC
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