- Must visit
The State Museum of Pennsylvania
Major regional museum with American art, natural history, and science exhibits. It is Harrisburg's best-known museum and a strong all-ages visit.
Cheapest price
€141
Average price
€141
Fastest journey
17 h 15 m
Average duration
17 h 15 m
Buses per day
1
Distance
507 km
The best way to find a cheap bus ticket from Durham, NC to Harrisburg, PA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Durham, NC to Harrisburg, PA will cost around €141 if you buy it on the day, but the cheapest tickets can be found for only €141.
Of the 1 buses that leave Durham, NC for Harrisburg, PA on Wed, Aug 05, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Aug 05 the direct buses cover the 507 km distance in an average of 17 h 15 m but if you time it right, some buses will get you there in just 17 h 15 m .
On Wed, Aug 05 the slowest buses will take 17 h 15 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Buses from Durham, NC to Harrisburg, PA run on average 3 times per day, taking around 17h 35m. Cheap bus tickets for this journey start at €67 if you book in advance.
The earliest bus runs at 03:05, the last at 23:20. The fastest bus covers the 315 miles (507 km) distance in 15h 50m.
Distance 315 miles (507 km) |
Average bus duration 17h 35m |
Cheapest ticket price €67 |
Buses per day 3 |
Fastest bus 15h 50m |
First bus 3:05 AM |
Last bus 11:20 PM |
Cheapest Month Feb |
Cheapest Day Thu |
High Season Jan - Mar |
Low Season Oct - Dec |
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 01:15AM | Arrival Time 05:55PM | Duration 16h40 | Departure days Wed | Cheapest price €136 |
Operator Flixbus USA | Departure Time 03:50AM | Arrival Time 01:55PM | Duration 10h05 | Departure days Mon, Sun | Cheapest price €64 |
Operator Greyhound | Departure Time 01:10PM | Arrival Time 06:25AM | Duration 17h15 | Departure days Wed | Cheapest price €141 |
Operator Greyhound | Departure Time 02:10PM | Arrival Time 07:25AM | Duration 17h15 | Departure days Fri | Cheapest price €158 |
Operator Greyhound | Departure Time 09:05PM | Arrival Time 04:20PM | Duration 19h15 | Departure days Thu, Sat | Cheapest price €67 |
Discover the best of Harrisburg, PA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Harrisburg, PA trip today.
Major regional museum with American art, natural history, and science exhibits. It is Harrisburg's best-known museum and a strong all-ages visit.
National Civil War museum with broad exhibits on soldiers, civilians, and the war's legacy. It is one of the city's most important history stops.
Museum at Fort Hunter highlighting local river history, mansion life, and the Susquehanna landscape. A quieter favorite with a scenic setting.
Riverfront promenade and park system with skyline views, paths, and event spaces. It is one of the most pleasant walks in central Harrisburg.
Car-free island in the Susquehanna with walking paths, recreation, and broad water views. A classic local escape close to downtown.
Victorian neighborhood known for colorful homes, local shops, and a creative atmosphere. It is ideal for strolling and seeing everyday Harrisburg charm.
Pennsylvania Dutch chicken pot pie is a rich stew with square noodles, chicken, and vegetables. It is a regional comfort food common around Harrisburg.
Shoofly pie is a classic Pennsylvania Dutch dessert made with molasses crumb filling. Its deep sweetness makes it a traditional local bakery staple.
Whoopie pie features two soft chocolate cake rounds with creamy filling. It is a beloved Amish and Pennsylvania Dutch treat found across the region.
Long-running local favorite serving creative American dishes and seafood in a comfortable, polished neighborhood setting.
Historic market with many established local vendors for Pennsylvania Dutch baked goods, pretzels, sandwiches, and regional specialties in a lively setting.
Popular casual tavern and brewery pouring local beer with pub fare. It is well known for a relaxed atmosphere and central location.
Moderate for US state capitals; hotels and dining are usually below major East Coast cities, while transit needs and limited cheap tourist areas can raise daily costs.
Tip 18-20% at restaurants, 15-20% for taxis, and $1-2 per drink or café order if service is provided.
Find answers to the most common questions about traveling from Durham, NC to Harrisburg, PA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Harrisburg, PA, this guide helps you travel smarter and with confidence.

Most Durham, NC to Harrisburg, PA buses use the Durham, W Pettigrew St (Greyhound Bus Station) to Harrisburg, Market St (Bus Station) station pair, with some services arriving at Harrisburg, Chestnut Street / South 4th Street. Use this guide to compare Durham, NC and Harrisburg, PA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need