- Must visit
Buffalo AKG Art Museum
Major regional art museum with modern, contemporary, and historic works, plus a growing campus and frequent exhibitions.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
The cheapest and fastest buses from Des Moines, IA to Buffalo, NY
Showing times, prices and bookable tickets for Sep 19
Cheapest price on Sep 19
$144
Average ticket price on Sep 19
$145
Fastest journey on Sep 19
21 h 40 m
Average journey duration on Sep 19
1 d 2 h 21 m
Buses on Sep 19
2
Distance
1219 km
Cheap tickets
The best way to find a cheap bus ticket from Des Moines, IA to Buffalo, NY is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Des Moines, IA to Buffalo, NY will cost around $145 if you buy it on the day, but the cheapest tickets can be found for only $144.
Fast buses
It's difficult to get from Des Moines, IA to Buffalo, NY without transferring at least 2 times.
· · 9:20 AM21h40Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA8:00 AMBuffalo, NFTA Metro Center$1441One-way2 transfers- +
FlixBus+ · 11:59 PM31h01Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA8:00 AMBuffalo, NFTA Metro Center$1471One-way3 transfers
- · · 9:20 AM21h40Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA8:00 AMBuffalo, NFTA Metro Center$1441One-way2 transfers
- +FlixBus+ · 11:59 PM31h01Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA8:00 AMBuffalo, NFTA Metro Center$1471One-way3 transfers
Des Moines, IA to Buffalo, NY Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 09:20AM | Arrival Time 08:00AM | Duration 21h40 | Departure days Everyday | Cheapest price $109 |
Operator FlixBus | Departure Time 11:59PM | Arrival Time 08:00AM | Duration 31h01 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $138 |
Live departures
Des Moines, IA to Buffalo, NY bus times
The table below shows live departures for Des Moines, IA to Buffalo, NY buses for today, Friday, September 18. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| · · | 9:20 AM Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA | 21h40 | 8:00 AM Buffalo, NFTA Metro Center | 2 transfers | |
| +FlixBus+ · | 11:59 PM Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA | 31h01 | 8:00 AM Buffalo, NFTA Metro Center | 3 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Des Moines, IA to Buffalo, NY by bus
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Sat
Sep 19
Sep 19
Sun
Sep 20
Sep 20
Mon
Sep 21
Sep 21
Tue
Sep 22
Sep 22
Wed
Sep 23
Sep 23
Thu
Sep 24
Sep 24
Fri
Sep 25
Sep 25
Why should you book Des Moines, IA to Buffalo, NY buses with Omio?
Greyhound operates all buses services from Des Moines, IA to Buffalo, NY.
Omio is an official ticket reseller for all your travel options from Des Moines, IA to Buffalo, NY.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Journey information
Overview: Bus from Des Moines, IA to Buffalo, NY
USAUSA
Buses from Des Moines, IA to Buffalo, NY run on average 1 times per day, taking around 18h 54m. Cheap bus tickets for this journey start at $110 if you book in advance.
The earliest bus runs at 04:45, the last at 23:55. The fastest bus covers the 757 miles (1219 km) distance in 17h 45m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 757 miles (1219 km) |
Average bus duration 18h 54m |
Cheapest ticket price $110 |
Buses per day 1 |
Fastest bus 17h 45m |
First bus 4:45 AM |
Last bus 11:55 PM |
Cheapest Month Jun |
Cheapest Day Mon |
High Season Jul - Sep |
Low Season Oct - Dec |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound, FlixBus from Des Moines, IA to Buffalo, NYYou can travel by bus between Des Moines, IA to Buffalo, NY with Greyhound, FlixBus for as low as $110. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
24h 15m
Cheapest FlixBus Price
$150
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
17h 45m
Cheapest Greyhound Price
$109
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Buffalo, NY
Things to do in Buffalo, NY
Discover the best of Buffalo, NY — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Buffalo, NY trip today.
- Recommended
Theodore Roosevelt Inaugural National Historic Site
Former presidential inaugural site with exhibits on Theodore Roosevelt, the Pan-American Exposition, and Buffalo politics.
- Recommended
Michigan Street African American Heritage Corridor
Community museum preserving Buffalo’s African American heritage through local history, culture, and rotating exhibitions.
- Must visit
Canalside
Waterfront district with canal history, public art, seasonal events, skating, and frequent family-friendly activities downtown.
- Must visit
Elmwood Village
Lively walkable neighborhood known for boutiques, galleries, architecture, and one of Buffalo’s most popular main streets.
- Must visit
Outer Harbor
Long urban trail and greenway connecting waterfront areas, parks, and neighborhoods for walking, biking, and sightseeing.
Buffalo Wings
Crisp fried chicken wings coated in spicy butter-hot sauce. Created in Buffalo, they are the city’s signature bar food and a must-try local classic.
Beef On Weck
Thin-sliced roast beef on a kummelweck roll topped with coarse salt and caraway, usually dipped in jus. It is a longtime Western New York sandwich staple.
- Gluten-free
Buffalo-Style Bean Soup
Slow-cooked bean soup with ham, tomatoes, and vegetables. It is strongly associated with Buffalo’s old taverns and Friday lunch traditions.
Oliver's Restaurant
Refined fine-dining restaurant known for seasonal New American tasting menus, polished service, and an elegant special-occasion atmosphere.
Schwabl's
Traditional German restaurant celebrated for beef on weck, sausages, and old-world charm. A Buffalo dining landmark with a cozy historic feel.
Duff's Famous Wings
Long-standing wing institution known for crispy, saucy chicken wings in a classic neighborhood bar setting with a devoted local following.
United States dollar ($)
Moderate for U.S. city travel; hotels are often cheaper than NYC, while dining and local transit stay fairly manageable for visitors.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $20-40 per person for a mid-range restaurant meal.
- Fine dining
- $60+ per person for upscale dining.
- Coffee
- $3-6 for a coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, more for great service. Taxis usually 10-15%. For cafes, round up or add $1 per drink.
FAQs: Bus from Des Moines, IA to Buffalo, NY
Find answers to the most common questions about traveling from Des Moines, IA to Buffalo, NY by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Buffalo, NY, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Des Moines, IA to Buffalo, NY can start from as little as $110 when you book in advance. The average bus ticket price for Des Moines, IA to Buffalo, NY is $122 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Des Moines, IA to Buffalo, NY is 17h 45m to travel the 757 miles (1219 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Des Moines, IA to Buffalo, NY leaves at 4:45 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Des Moines, IA to Buffalo, NY leaves at 11:55 PM.
There are 1 buses a day from Des Moines, IA to Buffalo, NY which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Des Moines, IA to Buffalo, NY, you can count on Greyhound for the best way to get you to Buffalo, NY. You can also check all possible bus companies who offer a service between Des Moines, IA and Buffalo, NY and compare the amenities they offer before buying a bus ticket.
When departing from Des Moines, IA , you have various bus station options to start your journey from including Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA . When arriving in Buffalo, NY , you can end your journey in bus stations like Buffalo, NFTA Metro Center, Cheektowaga, BNIA Drway & BNIA Terminal .Passengers board the bus most frequently from Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA, which is located around 1 miles (3 km) away from the city centre, and they get off the bus at Buffalo, NFTA Metro Center, located 0 away from the city centre.
A trip to Buffalo, NY from Des Moines, IA is worth doing but not as a day trip with a journey time of 17h 45m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Des Moines, IA to Buffalo, NY is June.
Yes, you can take a bus between Des Moines, IA and Buffalo, NY.
Yes, the following accessibility options are available when taking the bus from Des Moines, IA to Buffalo, NY:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Des Moines, IA to Buffalo, NY for bus company Greyhound.
Whether you can cancel your bus ticket from Des Moines, IA to Buffalo, NY depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Des Moines, IA to Buffalo, NY.
Yes, the following luggage options are included when booking a bus ticket from Des Moines, IA to Buffalo, NY:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Des Moines, IA to Buffalo, NY:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Des Moines, IA to Buffalo, NY.
You can reserve your seat on the bus from Des Moines, IA to Buffalo, NY with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Des Moines, IA to Buffalo, NY with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Des Moines, IA to Buffalo, NY with the following bus company: Greyhound.
Since neither Des Moines, IA nor Buffalo, NY are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Des Moines, IA to Buffalo, NY among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Buffalo, NY, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like downtown and tourist spots. Scams involving overcharging for taxi or rideshare services have been reported, so it's advised to use licensed transportation and confirm fares beforehand. Additionally, travelers should stay aware of their surroundings at night, particularly in less populated neighborhoods, to avoid potential safety risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Des Moines, IA to Buffalo, NY
Most Des Moines, IA to Buffalo, NY buses use the Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) to Buffalo, NFTA Metro Center station pair, with some services arriving at Cheektowaga, BNIA Drway & BNIA Terminal. Use this guide to compare Des Moines, IA and Buffalo, NY bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Des Moines
Arrival bus stations in Buffalo
Which Des Moines, IA station do buses to Buffalo, NY leave from?
Buses from Des Moines, IA to Buffalo, NY leave from Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.). The station is 1 miles (3 km) from Des Moines, IA city centre at 1625 E Euclid Ave, Des Moines, IA 50313, USA.
Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.)1625 E Euclid Ave, Des Moines, IA 50313, USA
City-centre transport
Getting to Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) from Des Moines city centre
Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) is 3 km from Des Moines city centre. Public transport options include:
TRUE
Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) bus station facilities and services
Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.). ATMs are available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.).
Tickets and information
Ticket office support is available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.).
Parking, taxis and toilets
Available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.): Wheelchair accessible buses available.
Which Buffalo, NY station do buses from Des Moines, IA arrive at?
Buses from Des Moines, IA to Buffalo, NY most often arrive at Buffalo, NFTA Metro Center. Some services arrive at Cheektowaga, BNIA Drway & BNIA Terminal, so check your ticket before travel to confirm your Buffalo, NY arrival station.
Buffalo, NFTA Metro CenterBuffalo, NY, USA
City-centre transport
Getting to Buffalo, NFTA Metro Center from Buffalo city centre
TRUE
Buffalo, NFTA Metro Center bus station facilities and services
Buffalo, NFTA Metro Center has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Free WiFi is available in the station. ATMs are aTM services are available near the entrance.
Tickets and information
Ticket office support is available at Buffalo, NFTA Metro Center.
Parking, taxis and toilets
Available at Buffalo, NFTA Metro Center: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Buffalo, NFTA Metro Center: Accessible for passengers with reduced mobility.
Cheektowaga, BNIA Drway & BNIA Terminal
City-centre transport
Getting to Cheektowaga, BNIA Drway & BNIA Terminal from Buffalo city centre
BusAdt N809 · 10m · $7
24, 78 · 31m · $2 · every ~4 min
24, 78 · 46m · $2 · every ~4 min
Most popular bus connections from Des Moines, IA
More options for your journey from Des Moines, IA to Buffalo, NY
Here are some other resources that might have the information you need
Most popular buses to and from Buffalo, NY and Des Moines, IA
Most popular bus connections to Buffalo, NY
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
