- Must visit
Buffalo AKG Art Museum
Buffalo’s flagship art museum, known for its strong modern and contemporary collection and major architectural expansion. A top choice for art lovers.
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The cheapest and fastest buses from Des Moines, IA to Buffalo, NY
Showing times and prices for Jun 21
Cheapest price
$139
Average price
$139
Fastest journey
21 h 40 m
Average duration
21 h 40 m
Buses per day
1
Distance
1219 km
Cheap tickets
The best way to find a cheap bus ticket from Des Moines, IA to Buffalo, NY is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Des Moines, IA to Buffalo, NY will cost around $139 if you buy it on the day, but the cheapest tickets can be found for only $139.
Fast buses
It's difficult to get from Des Moines, IA to Buffalo, NY without transferring at least 2 times.
· · 9:20 AM21h40Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA8:00 AMBuffalo, NFTA Metro Center$1391One-way2 transfers
- · · 9:20 AM21h40Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA8:00 AMBuffalo, NFTA Metro Center$1391One-way2 transfers
Travel Information
Compare bus and flight for Des Moines, IA to Buffalo, NY
Omio recommends booking the bus as it is the most popular option from Des Moines, IA to Buffalo, NY among Omio's users. If you are prioritising price take the bus with prices starting from $108. For those with little time consider booking a flight which can get you there in 7h 54m. The ticket price range depends on the travel mode: a bus costs an average of $108, and a flight costs an average of $351.
Distance: 757 miles (1219 km)
Compare bus with
Most popular Bus | Flight |
|---|---|
$156 Average price Cheapest | $445 Average price |
32h 40m Average total duration 32h 10m Onboard + 30m Additional time* | 10h 54m Average total duration Fastest 7h 54m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options |
The cheapest way to travel from Des Moines, IA to Buffalo, NY is a bus with an average price of $156 (€128).
This is compared to other travel options from Des Moines, IA to Buffalo, NY:
A bus is $290 (€237) less than a flight for this route with tickets for a flight from Des Moines, IA to Buffalo, NY costing on average $445 (€364).
The fastest way to travel from Des Moines, IA to Buffalo, NY is by flight with an average journey time of 7h 54m.
Other travel options to Buffalo, NY take longer:
Bus takes on average 32h 10m.
It's helpful to compare your options as there are 2 ways to travel between Des Moines, IA and Buffalo, NY including taking a bus and flight.
We recommend using the bus as it is the most popular way to get from Des Moines, IA to Buffalo, NY among Omio's users.
Des Moines, IA to Buffalo, NY Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 09:20AM | Arrival Time 04:45PM | Duration 31h25 | Departure days Mon, Wed, Thu, Fri, Sun | Cheapest price $109 |
Operator Greyhound USA | Departure Time 09:45AM | Arrival Time 10:40PM | Duration 36h55 | Departure days Mon | Cheapest price $233 |
Operator Greyhound | Departure Time 02:20PM | Arrival Time 12:00PM | Duration 21h40 | Departure days Sat | Cheapest price $123 |
Operator FlixBus | Departure Time 02:20PM | Arrival Time 08:45PM | Duration 30h25 | Departure days Tue | Cheapest price $189 |
Operator FlixBus | Departure Time 03:20PM | Arrival Time 09:45PM | Duration 30h25 | Departure days Sat | Cheapest price $159 |
Live departures
Des Moines, IA to Buffalo, NY bus times
The table below shows live departures for Des Moines, IA to Buffalo, NY buses for today, Saturday, June 20. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 2:20 PM Des Moines, IA | 21h40 | 12:00 PM Buffalo, NY | 0 transfersDirect | |
 | 3:20 PM Des Moines, IA | 30h25 | 9:45 PM Buffalo, NY | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Des Moines, IA to Buffalo, NY by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Des Moines, IA to Buffalo, NY buses with Omio?
Greyhound operates all buses services from Des Moines, IA to Buffalo, NY.
Omio is an official ticket reseller for all your travel options from Des Moines, IA to Buffalo, NY.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Des Moines, IA to Buffalo, NY.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Des Moines, IA to Buffalo, NY.
Journey information
Overview: Bus from Des Moines, IA to Buffalo, NY
USAUSA
Buses from Des Moines, IA to Buffalo, NY run on average 1 times per day, taking around 32h 10m. Cheap bus tickets for this journey start at $108 (€88) if you book in advance.
The earliest bus runs at 04:45, the last at 23:55. The fastest bus covers the 757 miles (1219 km) distance in 21h 40m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 757 miles (1219 km) |
Average bus duration 32h 10m |
Cheapest ticket price $108 (€88) |
Buses per day 1 |
Fastest bus 21h 40m |
First bus 4:45 AM |
Last bus 11:55 PM |
Cheapest Month Apr |
Cheapest Day Sun |
High Season Jan - Mar |
Low Season Oct - Dec |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from Des Moines, IA to Buffalo, NYYou can travel by bus between Des Moines, IA to Buffalo, NY with Greyhound for as low as $108 (€88). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
21h 40m
Cheapest Price
$108 (€88)
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Buffalo
Things to do in Buffalo
Discover the best of Buffalo — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Buffalo trip today.
- Must visit
Frank Lloyd Wright’s Martin House
An important architectural museum complex and one of Frank Lloyd Wright’s masterpieces, offering deep insight into Prairie School design.
- Recommended
The Buffalo History Museum
A regional history museum in a landmark 1901 Pan-American Exposition building, with exhibits on Buffalo, Erie County, and Western New York.
- Must visit
Canalside
Buffalo’s revitalized waterfront district, popular for boardwalk walks, harbor views, events, and social-media-friendly public spaces.
- Must visit
Delaware Park
A major Frederick Law Olmsted-designed park with scenic roads, the lake, gardens, and cultural institutions nearby. Ideal for walking and relaxing.
- Recommended
Elmwood Village
One of Buffalo’s best-known neighborhoods for strolling, lined with historic homes, local shops, and a lively but relaxed urban atmosphere.
Buffalo Wings
Crispy chicken wings tossed in a buttery cayenne hot sauce, traditionally served with celery and blue cheese. Buffalo’s signature dish originated here and is the city’s must-try food.
Beef on Weck
Thin-sliced roast beef on a kummelweck roll topped with coarse salt and caraway seeds, usually served with horseradish and au jus. It is a classic Western New York sandwich strongly associated with BU
- Vegetarian
- Gluten-free
Sponge Candy
A regional confection made from airy honeycomb toffee coated in chocolate. Buffalo is especially known for it, and local chocolatiers have made it a beloved traditional sweet.
The Left Bank
A long-running bistro on the West Side with a more refined atmosphere, known for consistently good American and European-inspired dishes. A solid option beyond tavern fare.
Schwabl's
A classic Buffalo restaurant renowned for beef on weck, old-school service, and a traditional dining room atmosphere. One of the best-known places to try this regional specialty.
Gabriel's Gate
A beloved neighborhood tavern in a historic building, known for wings, hearty pub food, and a warm local atmosphere. Popular with both residents and visitors.
United States Dollar
Moderate by U.S. standards. Hotels vary by season, while casual dining, coffee, and local transport are fairly affordable.
Average meal costs
- Budget
- USD 10-18 for fast food or a simple lunch.
- Mid-range
- USD 20-40 per person at a mid-range restaurant.
- Fine dining
- USD 60+ per person at upscale restaurants.
- Coffee
- USD 3-6 for a regular coffee or latte.
Tipping culture
Tip 18-20% at restaurants if service is not included; 15-20% for taxis and rideshares. USD 1-2 per drink at bars, USD 1-2 per bag for hotel porters, and a few dollars daily for housekeeping.
FAQs: Bus from Des Moines, IA to Buffalo, NY
Find answers to the most common questions about traveling from Des Moines, IA to Buffalo, NY by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Buffalo, NY, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Des Moines, IA to Buffalo, NY can start from as little as $108 (€88) when you book in advance. The average bus ticket price for Des Moines, IA to Buffalo, NY is $156 (€128) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Des Moines, IA to Buffalo, NY is 21h 40m to travel the 757 miles (1219 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Des Moines, IA to Buffalo, NY leaves at 4:45 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Des Moines, IA to Buffalo, NY leaves at 11:55 PM.
There are 1 buses a day from Des Moines, IA to Buffalo, NY which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Des Moines, IA to Buffalo, NY, you can count on Greyhound for the best way to get you to Buffalo, NY. You can also check all possible bus companies who offer a service between Des Moines, IA and Buffalo, NY and compare the amenities they offer before buying a bus ticket.
A trip to Buffalo, NY from Des Moines, IA is worth doing but not as a day trip with a journey time of 21h 40m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Des Moines, IA to Buffalo, NY is April.
It's helpful to compare your options as there are 2 ways to travel between Des Moines, IA and Buffalo, NY including taking a bus and flight.
Yes, the following accessibility options are available when taking the bus from Des Moines, IA to Buffalo, NY:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Des Moines, IA to Buffalo, NY for bus company Greyhound.
Whether you can cancel your bus ticket from Des Moines, IA to Buffalo, NY depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Des Moines, IA to Buffalo, NY.
Yes, the following luggage options are included when booking a bus ticket from Des Moines, IA to Buffalo, NY:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Des Moines, IA to Buffalo, NY:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Des Moines, IA to Buffalo, NY.
You can reserve your seat on the bus from Des Moines, IA to Buffalo, NY with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Des Moines, IA to Buffalo, NY with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Des Moines, IA to Buffalo, NY with the following bus company: Greyhound.
Since neither Des Moines, IA nor Buffalo, NY are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Des Moines, IA to Buffalo, NY among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Buffalo, NY, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like downtown and tourist spots. Scams involving overcharging for taxi or rideshare services have been reported, so it's advised to use licensed transportation and confirm fares beforehand. Additionally, travelers should stay aware of their surroundings at night, particularly in less populated neighborhoods, to avoid potential safety risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Des Moines, IA to Buffalo, NY
Des Moines
Buffalo
Buffalo, NFTA Metro Center
information
Cheektowaga, BNIA Drway & BNIA Terminal
information
Most popular bus connections from Des Moines, IA
More options for your journey from Des Moines, IA to Buffalo, NY
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