The cheapest and fastest buses from Des Moines, IA to Buffalo, NY
Cheapest price
$181
Average price
$181
Fastest journey
1 d 5 h 45 m
Average duration
1 d 5 h 45 m
Buses per day
1
Distance
1219 km
The best way to find a cheap bus ticket from Des Moines, IA to Buffalo, NY is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Des Moines, IA to Buffalo, NY will cost around $181 if you buy it on the day, but the cheapest tickets can be found for only $181.
Of the 1 buses that leave Des Moines, IA for Buffalo, NY on Sun, Mar 22, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Mar 22 the direct buses cover the 1219 km distance in an average of 1 d 5 h 45 m but if you time it right, some buses will get you there in just 1 d 5 h 45 m .
On Sun, Mar 22 the slowest buses will take 1 d 5 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare bus and flight for Des Moines, IA to Buffalo, NY
Omio recommends booking the bus as it is the most popular option from Des Moines, IA to Buffalo, NY among Omio's users. If you are prioritising price take the bus with prices starting from $139. For those with little time consider booking a flight which can get you there in 4h 18m. The ticket price range depends on the travel mode: a bus costs an average of $139, and a flight costs an average of $361.
Distance: 757 miles (1219 km)
Compare bus with
Most popular Bus | Flight |
|---|---|
$150 Average price Cheapest | $366 Average price |
32h 40m Average total duration 32h 10m Onboard + 30m Additional time* | 7h 18m Average total duration Fastest 4h 18m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options |
Live departures
Des Moines, IA to Buffalo, NY bus times
The table below shows live departures for Des Moines, IA to Buffalo, NY buses for tomorrow, Saturday, March 21. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 3:30 PM Des Moines, IA | 29h45 | 9:15 PM Buffalo, NY | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Des Moines, IA to Buffalo, NY by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 22
Mar 23
Mar 24
Mar 25
Mar 26
Mar 27
Mar 28
Why should you book Des Moines, IA to Buffalo, NY buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Des Moines, IA to Buffalo, NY.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Des Moines, IA to Buffalo, NY.
Journey information
Overview: Bus from Des Moines, IA to Buffalo, NY
Buses from Des Moines, IA to Buffalo, NY run on average 1 times per day, taking around 32h 10m. Cheap bus tickets for this journey start at $139 (€113) if you book in advance.
The earliest bus runs at 04:45, the last at 23:55. The fastest bus covers the 757 miles (1219 km) distance in 29h 50m.
Distance 757 miles (1219 km) |
Average bus duration 32h 10m |
Cheapest ticket price $139 (€113) |
Buses per day 1 |
Fastest bus 29h 50m |
First bus 04:45 |
Last bus 23:55 |
Bus providers: Greyhound from Des Moines, IA to Buffalo, NYYou can travel by bus between Des Moines, IA to Buffalo, NY with Greyhound for as low as $139 (€113). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Des Moines, IA to Buffalo, NY
Find answers to the most common questions about traveling from Des Moines, IA to Buffalo, NY by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Buffalo, NY, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Des Moines, IA to Buffalo, NY
Most popular bus connections from Des Moines, IA
More options for your journey from Des Moines, IA to Buffalo, NY
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