- Must visit
Buffalo AKG Art Museum
Major regional art museum with modern, contemporary, and historic works, plus a growing campus and frequent exhibitions.
The best way to find a cheap flight ticket from Des Moines, IA to Buffalo, NY is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Des Moines, IA to Buffalo, NY will cost around $318 if you buy it on the day, but the cheapest tickets can be found for only $140.
It's difficult to get from Des Moines, IA to Buffalo, NY without transferring at least once.
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Flights from Des Moines, IA to Buffalo, NY depart on average 43 times per day, taking around 4h 51m. Cheap flight tickets for this journey start at $140 but you can travel from only $106 by bus.
The earliest flight runs at 05:00, the last at 20:25. The fastest flight covers the 757 miles (1219 km) distance in 3h 15m. September is the cheapest month to fly.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Des Moines, IA to Buffalo, NY.
The table below shows live departures for Des Moines, IA to Buffalo, NY flights for today, Monday, November 2. You can also manually refresh the results below to see updated flight journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
UA4777 · UA731 | 5:30 AM Des Moines International Airport | 16h03 | 10:33 PM Buffalo Niagara International Airport | 1 transfer | |
AA2326 · AA1360 | 6:00 AM Des Moines International Airport | 8h50 | 3:50 PM Buffalo Niagara International Airport | 1 transfer | |
AA1242+ AA5476+ AA3347 | 6:00 AM Des Moines International Airport | 8h45 | 3:45 PM Buffalo Niagara International Airport | 2 transfers | |
AA4694+ AA5476 | 6:00 AM Des Moines International Airport | 4h35 | 11:35 AM Buffalo Niagara International Airport | 1 transfer | |
AA3240+ AA4795+ AA3347 | 6:00 AM Des Moines International Airport | 8h45 | 3:45 PM Buffalo Niagara International Airport | 2 transfers | |
UA5308 · UA1335 | 6:05 AM Des Moines International Airport | 13h31 | 8:36 PM Buffalo Niagara International Airport | 1 transfer | |
UA5308 · UA2226 | 6:05 AM Des Moines International Airport | 9h57 | 5:02 PM Buffalo Niagara International Airport | 1 transfer | |
AA2202+ AA4367 | 7:23 AM Des Moines International Airport | 9h42 | 6:05 PM Buffalo Niagara International Airport | 1 transfer | |
AA2774+ AA4496 · AA4367 | 7:23 AM Des Moines International Airport | 9h03 | 5:26 PM Buffalo Niagara International Airport | 2 transfers | |
AA775+ AA4367+ AA3956 | 7:23 AM Des Moines International Airport | 9h28 | 5:51 PM Buffalo Niagara International Airport | 2 transfers | |
AA3051+ AA4367+ AA3956 | 7:23 AM Des Moines International Airport | 9h28 | 5:51 PM Buffalo Niagara International Airport | 2 transfers | |
AA3024+ AA4367 · AA4496 | 7:23 AM Des Moines International Airport | 9h03 | 5:26 PM Buffalo Niagara International Airport | 2 transfers | |
AA2254+ AA4496 · AA4367 | 7:23 AM Des Moines International Airport | 9h03 | 5:26 PM Buffalo Niagara International Airport | 2 transfers | |
AA2036+ AA4367+ AA5980 | 7:23 AM Des Moines International Airport | 10h13 | 6:36 PM Buffalo Niagara International Airport | 2 transfers | |
UA2668 · UA1335 | 8:00 AM Des Moines International Airport | 11h36 | 8:36 PM Buffalo Niagara International Airport | 1 transfer | |
UA2668 · UA2226 | 8:00 AM Des Moines International Airport | 8h02 | 5:02 PM Buffalo Niagara International Airport | 1 transfer | |
AA1985 · AA1256 | 8:07 AM Des Moines International Airport | 9h01 | 6:08 PM Buffalo Niagara International Airport | 1 transfer | |
UA567 · UA731 | 9:00 AM Des Moines International Airport | 12h33 | 10:33 PM Buffalo Niagara International Airport | 1 transfer | |
AA2774+ AA6284+ AA4496 | 9:25 AM Des Moines International Airport | 7h01 | 5:26 PM Buffalo Niagara International Airport | 2 transfers | |
AA2036+ AA5980+ AA6284 | 9:25 AM Des Moines International Airport | 8h11 | 6:36 PM Buffalo Niagara International Airport | 2 transfers | |
AA2879 · AA1256+ AA6284 | 9:25 AM Des Moines International Airport | 7h43 | 6:08 PM Buffalo Niagara International Airport | 2 transfers | |
AA2202+ AA6284 | 9:25 AM Des Moines International Airport | 7h40 | 6:05 PM Buffalo Niagara International Airport | 1 transfer | |
UA5439 · UA1335 | 9:50 AM Des Moines International Airport | 9h46 | 8:36 PM Buffalo Niagara International Airport | 1 transfer | |
AA1763 · AA1256 | 11:09 AM Des Moines International Airport | 5h59 | 6:08 PM Buffalo Niagara International Airport | 1 transfer | |
AA1763 · AA3294+ AA4743 | 11:09 AM Des Moines International Airport | 9h26 | 9:35 PM Buffalo Niagara International Airport | 2 transfers | |
AA1763 · AA2977+ AA4736 | 11:09 AM Des Moines International Airport | 10h24 | 10:33 PM Buffalo Niagara International Airport | 2 transfers | |
UA5304 · UA1335 | 11:22 AM Des Moines International Airport | 8h14 | 8:36 PM Buffalo Niagara International Airport | 1 transfer | |
AA603+ AA6283+ AA3660 | 1:58 PM Des Moines International Airport | 9h01 | 11:59 PM Buffalo Niagara International Airport | 2 transfers | |
AA1073+ AA6283 | 1:58 PM Des Moines International Airport | 6h39 | 9:37 PM Buffalo Niagara International Airport | 1 transfer | |
AA2222+ AA6283+ AA5911 | 1:58 PM Des Moines International Airport | 7h46 | 10:44 PM Buffalo Niagara International Airport | 2 transfers | |
AA489+ AA3660+ AA6283 | 1:58 PM Des Moines International Airport | 9h01 | 11:59 PM Buffalo Niagara International Airport | 2 transfers | |
AA2828+ AA4736+ AA6283 | 1:58 PM Des Moines International Airport | 7h35 | 10:33 PM Buffalo Niagara International Airport | 2 transfers | |
AA1680 · AA2401 | 3:31 PM Des Moines International Airport | 6h22 | 10:53 PM Buffalo Niagara International Airport | 1 transfer | |
UA1781 · UA731 | 5:09 PM Des Moines International Airport | 28h24 | 10:33 PM Buffalo Niagara International Airport | 1 transfer | |
UA2770 · UA1335 | 6:45 PM Des Moines International Airport | 24h51 | 8:36 PM Buffalo Niagara International Airport | 1 transfer | |
UA2770 · UA4177 | 6:45 PM Des Moines International Airport | 13h57 | 9:42 AM Buffalo Niagara International Airport | 1 transfer | |
UA2770 · UA2226 | 6:45 PM Des Moines International Airport | 21h17 | 5:02 PM Buffalo Niagara International Airport | 1 transfer | |
UA2770 · UA4382 | 6:45 PM Des Moines International Airport | 17h32 | 1:17 PM Buffalo Niagara International Airport | 1 transfer | |
This is the last flight of the day. | |||||
Find all the dates and times for this journey
Flights from Des Moines, IA to Buffalo, NY with United, American Airlines, and psa airlines. Flights with a stop available on this route with United, American Airlines, and psa airlines. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Buffalo, NY — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Buffalo, NY trip today.
Major regional art museum with modern, contemporary, and historic works, plus a growing campus and frequent exhibitions.
Former presidential inaugural site with exhibits on Theodore Roosevelt, the Pan-American Exposition, and Buffalo politics.
Community museum preserving Buffalo’s African American heritage through local history, culture, and rotating exhibitions.
Waterfront district with canal history, public art, seasonal events, skating, and frequent family-friendly activities downtown.
Lively walkable neighborhood known for boutiques, galleries, architecture, and one of Buffalo’s most popular main streets.
Long urban trail and greenway connecting waterfront areas, parks, and neighborhoods for walking, biking, and sightseeing.
Crisp fried chicken wings coated in spicy butter-hot sauce. Created in Buffalo, they are the city’s signature bar food and a must-try local classic.
Thin-sliced roast beef on a kummelweck roll topped with coarse salt and caraway, usually dipped in jus. It is a longtime Western New York sandwich staple.
Slow-cooked bean soup with ham, tomatoes, and vegetables. It is strongly associated with Buffalo’s old taverns and Friday lunch traditions.
Refined fine-dining restaurant known for seasonal New American tasting menus, polished service, and an elegant special-occasion atmosphere.
Traditional German restaurant celebrated for beef on weck, sausages, and old-world charm. A Buffalo dining landmark with a cozy historic feel.
Long-standing wing institution known for crispy, saucy chicken wings in a classic neighborhood bar setting with a devoted local following.
Moderate for U.S. city travel; hotels are often cheaper than NYC, while dining and local transit stay fairly manageable for visitors.
Tip 18-20% at restaurants, more for great service. Taxis usually 10-15%. For cafes, round up or add $1 per drink.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Buffalo, NY.
Find answers to the most common questions about traveling from Des Moines, IA to Buffalo, NY by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Buffalo, NY, this guide helps you travel smarter and with confidence.

Most Des Moines, IA to Buffalo, NY flights use the Des Moines International Airport to Buffalo Niagara International Airport airport pair. Use this guide to compare Des Moines, IA and Buffalo, NY airports on this route, check city-centre transport, alongside checking practicalities like airport facilities and services.
Des Moines International Airport is 6 km from Des Moines city centre. Public transport options include:
Des Moines International Airport has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Several dining options available in the terminal.
Free Wi-Fi available throughout the airport. ATMs are aTMs located near baggage claim and ticketing areas.
Ticket office support is available at Des Moines International Airport.
Available at Des Moines International Airport: Parking, Taxis, WC.
Accessibility facilities are available at Des Moines International Airport: Facilities include ramps and accessible bathrooms.
Buffalo Niagara International Airport is 2 km from Buffalo city centre. Public transport options include:
Buffalo Niagara International Airport has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lounge, Lost and Found Office, and Car Rental.
Food options include: Restaurants available; Main terminal, fast food and sit-down options like Anchor Bar and Tim Hortons
Free Wi-Fi available throughout the airport. ATMs are located throughout the terminal.
Lost and found is available at the station.
Available at Buffalo Niagara International Airport: Parking, Taxis, WC.
Available at Buffalo Niagara International Airport: Car Rental.
Accessibility facilities are available at Buffalo Niagara International Airport: Elevators, ramps, assistance.
Nearby hotels include Hotels nearby, Courtyard by Marriott Buffalo Airport within walking distance..
See which airports are used for flights between Des Moines, IA and Buffalo, NY, including airport details.