- Must visit
National Museum
Prague’s principal museum on Wenceslas Square, known for its grand Neo-Renaissance building and broad natural history, history, and culture collections.
Cheapest price
$55
Average price
$139
Fastest journey
8 h 27 m
Average duration
8 h 33 m
Trains per day
48
Distance
553 km
The best way to find a cheap train ticket from Düsseldorf to Prague is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Düsseldorf to Prague will cost around $139 if you buy it on the day, but the cheapest tickets can be found for only $55.
It's difficult to get from Düsseldorf to Prague without transferring at least once.
ICE 1541 · RJX 251
ICE 1541 · RJ 387
26846 · ICE 827 · 3557+
353
FlixTrain+
FlixBus
FlixTrain+
FlixBus
ICE 543 · rj 175
ICE 543 · RJ 175
ICE 541 · RJ 173
ICE 549 · rj 385
ICE 549 · RJ 385Omio recommends booking the train as it is the most popular option from Düsseldorf to Prague among Omio's users. If you are prioritising price take the bus with prices starting from $36. For those with little time consider booking a flight which can get you there in 2h 7m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.5kg. The ticket price range depends on the travel mode: a bus costs an average of $36, and a flight costs an average of $75.
Distance: 343 miles (553 km)
Most popular Train | Flight | Bus | Driving |
|---|---|---|---|
$92 Average price | $227 Average price | $57 Average price Cheapest | $143 Average price (fuel + tolls) |
9h 45m Average total duration 9h 15m Onboard + 30m Additional time* | 5h 7m Average total duration Fastest 2h 7m Onboard + 3h 0m Additional time* | 10h 36m Average total duration 10h 6m Onboard + 30m Additional time* | 7h 48m Average total duration (door-to-door) |
0.2 - 0.5kg CO2 emissions Lowest | 1.7 - 3.3kg CO2 emissions | 0.6 - 1.4kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular airline | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Düsseldorf to Prague:
A bus is $35 (€28) less than a train for this route with tickets for a train from Düsseldorf to Prague costing on average $92 (€75).
A bus is $170 (€139) less than a flight for this route with tickets for a flight from Düsseldorf to Prague costing on average $227 (€186).
Other travel options to Prague take longer:
Train takes on average 9h 15m.
Bus takes on average 10h 6m.
Tickets start at around $92 (€75) compared to roughly $143 (€117) in fuel and tolls — a saving of about $51 (€42). The journey takes 9h 15m versus 7h 48m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
The table below shows live departures for Düsseldorf to Prague trains for today, Friday, June 19. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
ICE 543 · RJ 175 | Delayed 6:48 AM Düsseldorf Hbf | 8h27 | 1:23 PM 1:23 PMPrague-Holešovice | 1 transfer | |
ICE 543 · rj 175 | On time 6:48 AM Düsseldorf Hbf | 8h27 | 3:15 PM Prague-Holešovice | 1 transfer | |
ICE 527 · R 3565 · EC 357 | On time 7:22 AM Düsseldorf Hbf | 8h59 | 4:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 527 · 3565+ 357 | On time 7:22 AM Düsseldorf Hbf | 8h59 | 4:21 PM Prague hlavní nádraží | 2 transfers | |
FlixTrain+ FlixBus | 8:38 AM Düsseldorf Hbf | 11h02 | 7:40 PM Praha, ÚAN Florenc | 1 transfer | |
FlixTrain+ FlixBus | 8:38 AM Düsseldorf Hbf | 11h22 | 8:00 PM Prague, Central Train Station | 1 transfer | |
ICE 545 · RJ 383 | Delayed 8:48 AM Düsseldorf Hbf | 8h37 | 3:30 PM 3:30 PMPrague hlavní nádraží | 1 transfer | |
ICE 545 · rj 383 | On time 8:48 AM Düsseldorf Hbf | 8h37 | 5:25 PM Prague hlavní nádraží | 1 transfer | |
ICE 621 · R 3569 · EC 359 | On time 9:22 AM Düsseldorf Hbf | 8h59 | 6:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 621 · 3569+ 359 | On time 9:22 AM Düsseldorf Hbf | 8h59 | 6:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 547 · RJ 177 | Delayed 10:48 AM Düsseldorf Hbf | 8h27 | 5:23 PM 5:23 PMPrague-Holešovice | 1 transfer | |
ICE 547 · rj 177 | On time 10:48 AM Düsseldorf Hbf | 8h27 | 7:15 PM Prague-Holešovice | 1 transfer | |
ICE 625 · 3499+ 361 | On time 11:19 AM Düsseldorf Hbf | 9h02 | 8:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 625 · R 3499 · EC 361 | On time 11:19 AM Düsseldorf Hbf | 9h02 | 8:21 PM Prague hlavní nádraží | 2 transfers | |
FlixTrain+ FlixBus | 12:38 PM Düsseldorf Hbf | 10h57 | 11:35 PM Praha, ÚAN Florenc | 1 transfer | |
FlixTrain+ FlixBus | 12:38 PM Düsseldorf Hbf | 11h17 | 11:55 PM Prague, Central Train Station | 1 transfer | |
ICE 549 · RJ 385 | Delayed 12:48 PM Düsseldorf Hbf | 8h37 | 7:36 PM 7:36 PMPrague hlavní nádraží | 1 transfer | |
ICE 549 · rj 385 | On time 12:48 PM Düsseldorf Hbf | 8h37 | 9:25 PM Prague hlavní nádraží | 1 transfer | |
ICE 629 · R 3577 · EC 363 | On time 1:22 PM Düsseldorf Hbf | 9h02 | 10:24 PM Prague hlavní nádraží | 2 transfers | |
ICE 629 · 3577+ 363 | On time 1:22 PM Düsseldorf Hbf | 9h00 | 10:22 PM Prague hlavní nádraží | 2 transfers | |
ICE 941 · RJ 179 | On time 1:50 PM Düsseldorf Hbf | 9h41 | 11:31 PM Prague hlavní nádraží | 1 transfer | |
ICE 941 · rj 179 | On time 1:50 PM Düsseldorf Hbf | 9h41 | 11:31 PM Prague hlavní nádraží | 1 transfer | |
ICE 721 · ICE 834 · IC 2047 · RJ 179 | On time 2:22 PM Düsseldorf Hbf | 9h09 | 11:31 PM Prague hlavní nádraží | 3 transfers | |
ICE 721 · ICE 834 · IC 2047 · rj 179 | On time 2:22 PM Düsseldorf Hbf | 9h09 | 11:31 PM Prague hlavní nádraží | 3 transfers | |
ICE 947 · RJ 479 | On time 7:50 PM Düsseldorf Hbf | 9h35 | 5:25 AM Prague hlavní nádraží | 1 transfer | |
ICE 947 · rj 479 | On time 7:50 PM Düsseldorf Hbf | 9h35 | 5:25 AM Prague hlavní nádraží | 1 transfer | |
ICE 617 · EC 459 | On time 9:27 PM Düsseldorf Hbf | 11h58 | 9:25 AM Prague hlavní nádraží | 1 transfer | |
ICE 617 · EC 459 | On time 9:27 PM Düsseldorf Hbf | 11h58 | 9:25 AM Prague hlavní nádraží | 1 transfer | |
| Saturday, June 20 | |||||
RE 26846 · ICE 827 · R 3557 · EC 353 | 2:43 AM Düsseldorf Hbf | 9h38 | 12:21 PM Prague hlavní nádraží | 3 transfers | |
26846 · ICE 827 · 3557+ 353 | 2:44 AM Düsseldorf Hbf | 9h37 | 12:21 PM Prague hlavní nádraží | 3 transfers | |
RE 26848 · ICE 521 · ICE 934 · IC 2447 | 3:40 AM Düsseldorf Hbf | 9h45 | 1:25 PM Prague hlavní nádraží | 4 transfers | |
RE 26800 · ICE 523 · R 3561 · EC 355 | 4:40 AM Düsseldorf Hbf | 9h41 | 2:21 PM Prague hlavní nádraží | 3 transfers | |
ICE 541 · RJ 173 | On time 4:49 AM Düsseldorf Hbf | 8h36 | 1:25 PM Prague hlavní nádraží | 1 transfer | |
ICE 843 · rj 175 | On time 5:50 AM Düsseldorf Hbf | 9h25 | 3:15 PM Prague-Holešovice | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Düsseldorf to Prague run on average 14 times per day, taking around 9h 15m. Cheap train tickets for this journey start at $50 (€41) but you can travel from only $36 (€30) by bus.
The earliest train runs at 00:10, the last at 23:54. The fastest train covers the 343 miles (553 km) distance in 8h 27m.
Distance 343 miles (553 km) |
Average train duration 9h 15m |
Cheapest ticket price $50 (€41) |
Trains per day 14 |
Fastest train 8h 27m |
First train 12:10 AM |
Last train 11:54 PM |
Cheapest Month Jul |
Cheapest Day Sat |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Thu |
Least Busy Day Mon |
Best time to book 56 days |
Discover the best of Prague — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Prague trip today.
Prague’s principal museum on Wenceslas Square, known for its grand Neo-Renaissance building and broad natural history, history, and culture collections.
A significant museum complex preserving Jewish history and heritage through synagogues, ceremonial objects, and exhibitions in Josefov.
A highly regarded design museum with glass, ceramics, fashion, graphics, and decorative arts in a historic building near the Old Town.
Prague’s ceremonial heart, surrounded by historic facades, churches, and major landmarks; essential for first-time visitors.
A picturesque historic district below Prague Castle with baroque streets, embassies, gardens, and a romantic atmosphere.
A major boulevard-like square central to modern Czech history, shopping, and public life, anchored by the National Museum.
Marinated beef sirloin with creamy root-vegetable sauce, bread dumplings, cranberry, and whipped cream. It is one of the best-known classic Czech festive dishes.
Roast pork served with dumplings and braised cabbage. This is a cornerstone of traditional Czech home-style cooking and pub menus.
Czech-style goulash is usually a rich beef stew with onions, paprika, and bread dumplings. It is a hearty staple often eaten in historic Prague pubs.
Established traditional restaurant known for duck, old-Bohemian recipes, and elegant historic interiors. A strong choice for a refined Czech meal.
Well-known Old Town restaurant offering polished Czech classics and seasonal dishes in a stylish but approachable atmosphere.
A famous modern Czech beer hall serving classic dishes, fresh Pilsner, and dependable traditional cooking in a lively central setting.
Moderate by European standards. Beer, transit, and casual meals are good value; central hotels cost more.
About 10% in restaurants for good service, often rounded up. Tip taxis modestly by rounding up. No tip needed for counter service, though small change is appreciated.
Official public transport app
Prague hlavní nádraží -> Old Town Square, Prague
The train connection between Düsseldorf and Prague offers a convenient way to travel between these two cities. Passengers can choose from several providers, including Deutsche Bahn, FlixTrain, and alex-Länderbahn und Vogtlandbahn-GmbH. With comfortable seating and scenic views along the route, this journey is an excellent option for those looking to explore both destinations without the hassle of driving or flying.
The train connection from Düsseldorf to Prague takes approximately 8 hours and 59 minutes, with a total of 6 connections available per day. This route is not direct, requiring at least one transfer during the journey. The average layover time between trains is about 1 hour and 10 minutes.
The first daily train journey from Düsseldorf to Prague departs at 07:18, providing an early start for travelers eager to explore the beautiful city of Prague. The last departure is scheduled for 21:52, allowing those who wish to enjoy a full day in Düsseldorf before heading out in the evening.
The cheapest ticket price for the train connection from Düsseldorf to Prague is €14. The average ticket price typically hovers around €50, making it a budget-friendly option for travelers looking to explore these vibrant cities.
Prague Castle, dating back to the 9th century, is not only one of the largest ancient castles in the world but also a symbol of Czech history and culture. Its stunning architecture showcases various styles from Gothic to Baroque, with highlights including St. Vitus Cathedral and the picturesque Golden Lane that transport you through centuries of royal heritage. As we explore its vast grounds, you'll feel like you've stepped into a fairy tale where every corner tells a story.
The Charles Bridge, completed in 1402 and adorned with 30 statues of saints, has been an iconic connection between Prague's Old Town and Lesser Town for over six centuries. This cobblestone marvel offers breathtaking views along the Vltava River while serving as a vibrant hub for artists and musicians who bring life to this historic thoroughfare. Walking across it feels like traversing time itself—each step echoing tales from medieval merchants to modern-day lovers.
Old Town Square is truly the heart of Prague; it's where history comes alive amidst colorful baroque buildings and bustling cafes that have witnessed countless events since its establishment in the 12th century. The square features remarkable landmarks such as the Astronomical Clock—a masterpiece that draws crowds every hour—and Týn Church with its striking spires dominating skyline views. Here at Old Town Square, you can immerse yourself in local traditions while savoring delicious pastries or simply soaking up an atmosphere rich with stories waiting to be discovered.
Find answers to the most common questions about traveling from Düsseldorf to Prague by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Prague, this guide helps you travel smarter and with confidence.

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