- Must visit
National Museum
Prague’s flagship museum on Wenceslas Square, with major natural history, history, and cultural collections in a monumental Neo-Renaissance building.
Cheapest price
$67
Average price
$86
Fastest journey
9 h 55 m
Average duration
10 h 31 m
Buses per day
22
Distance
553 km
The best way to find a cheap bus ticket from Düsseldorf to Prague is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Düsseldorf to Prague will cost around $86 if you buy it on the day, but the cheapest tickets can be found for only $67.
Of the 22 buses that leave Düsseldorf for Prague on Sun, May 31, 8 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, May 31 the direct buses cover the 553 km distance in an average of 10 h 31 m but if you time it right, some buses will get you there in just 9 h 55 m .
On Sun, May 31 the slowest buses will take 11 h 15 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus
FlixBus
FlixBus
FlixBus
FlixBus
(Amsterdam -> Prague)
(Amsterdam -> Prague)
FlixBus
FlixBus · FlixBus
FlixBus · FlixBusOmio recommends booking the train as it is the most popular option from Düsseldorf to Prague among Omio's users. If you are prioritising price take the bus with prices starting from $37. For those with little time consider booking a flight which can get you there in 2h 7m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.5kg. The ticket price range depends on the travel mode: a bus costs an average of $37, and a flight costs an average of $77.
Distance: 343 miles (553 km)
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$58 Average price Cheapest | $94 Average price | $232 Average price | $146 Average price (fuel + tolls) |
10h 36m Average total duration 10h 6m Onboard + 30m Additional time* | 9h 45m Average total duration 9h 15m Onboard + 30m Additional time* | 5h 7m Average total duration Fastest 2h 7m Onboard + 3h 0m Additional time* | 7h 48m Average total duration (door-to-door) |
0.6 - 1.4kg CO2 emissions | 0.2 - 0.5kg CO2 emissions Lowest | 1.7 - 3.3kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Düsseldorf to Prague:
A bus is $35 (€28) less than a train for this route with tickets for a train from Düsseldorf to Prague costing on average $94 (€75).
A bus is $173 (€139) less than a flight for this route with tickets for a flight from Düsseldorf to Prague costing on average $232 (€186).
Other travel options to Prague take longer:
Train takes on average 9h 15m.
Bus takes on average 10h 6m.
Tickets start at around $58 (€47) compared to roughly $146 (€117) in fuel and tolls — a saving of about $87 (€70). The journey takes 10h 6m versus 7h 48m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus, BlaBlaCar, Infobus.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 01:30AM | Arrival Time 01:05PM | Duration 11h35 | Departure days Everyday | Cheapest price $51 |
Operator FlixBus | Departure Time 03:45AM | Arrival Time 05:35PM | Duration 13h50 | Departure days Everyday | Cheapest price $51 |
Operator FlixBus | Departure Time 07:15AM | Arrival Time 07:10PM | Duration 11h55 | Departure days Everyday | Cheapest price $51 |
Operator FlixBus | Departure Time 07:30AM | Arrival Time 07:50PM | Duration 12h20 | Departure days Everyday | Cheapest price $48 |
Operator BlaBlaCar Bus | Departure Time 08:15AM | Arrival Time 09:45AM | Duration 25h30 | Departure days Mon, Fri | Cheapest price $106 |
Operator FlixBus | Departure Time 08:38AM | Arrival Time 10:25PM | Duration 13h47 | Departure days Everyday | Cheapest price $52 |
Operator FlixBus | Departure Time 09:15AM | Arrival Time 09:30PM | Duration 12h15 | Departure days Everyday | Cheapest price $50 |
Operator FlixBus | Departure Time 09:27AM | Arrival Time 12:05AM | Duration 14h38 | Departure days Mon | Cheapest price $63 |
Operator FlixBus | Departure Time 10:15AM | Arrival Time 12:25AM | Duration 14h10 | Departure days Mon, Tue, Wed, Sat | Cheapest price $51 |
Operator FlixBus | Departure Time 02:00PM | Arrival Time 02:50AM | Duration 12h50 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price $51 |
Operator BlaBlaCar | Departure Time 03:20PM | Arrival Time 10:30PM | Duration 7h10 | Departure days Tue | Cheapest price $83 |
Operator FlixBus | Departure Time 04:45PM | Arrival Time 07:00AM | Duration 14h15 | Departure days Mon, Sat | Cheapest price $65 |
Operator FlixBus | Departure Time 06:20PM | Arrival Time 07:30AM | Duration 13h10 | Departure days Everyday | Cheapest price $49 |
Operator RegioJet a.s. | Departure Time 06:50PM | Arrival Time 04:48AM | Duration 9h58 | Departure days Everyday | Cheapest price $37 |
Operator FlixBus | Departure Time 08:10PM | Arrival Time 08:55AM | Duration 12h45 | Departure days Sat, Sun | Cheapest price $78 |
Operator FlixBus | Departure Time 10:35PM | Arrival Time 10:05AM | Duration 11h30 | Departure days Everyday | Cheapest price $49 |
Operator FlixBus | Departure Time 11:30PM | Arrival Time 10:10AM | Duration 10h40 | Departure days Everyday | Cheapest price $49 |
Operator FlixBus | Departure Time 11:59PM | Arrival Time 12:00PM | Duration 12h01 | Departure days Mon, Tue, Wed, Fri, Sat | Cheapest price $49 |
The table below shows live departures for Düsseldorf to Prague buses for today, Saturday, May 30. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 7:15 AM Düsseldorf, ZOB am Hbf | 15h10 | 10:25 PM Praha, Černý Most | 1 transfer | |
FlixBus | 7:15 AM Düsseldorf, ZOB am Hbf | 11h55 | 7:10 PM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus · FlixBus | 7:15 AM Düsseldorf, ZOB am Hbf | 12h45 | 8:00 PM Praha, M. Horákové (Hradčanská) | 1 transfer | |
FlixBus | 7:30 AM Düsseldorf, ZOB am Hbf | 12h05 | 7:35 PM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus | 7:30 AM Düsseldorf, ZOB am Hbf | 11h40 | 7:10 PM Praha, Na Knížecí | 0 transfersDirect | |
FlixTrain+ FlixBus | 8:38 AM Düsseldorf Hbf | 13h47 | 10:25 PM Praha, Černý Most | 1 transfer | |
FlixTrain+ FlixBus · FlixBus | 8:38 AM Düsseldorf Hbf | 15h27 | 12:05 AM Praha, Na Knížecí | 2 transfers | |
FlixBus | 9:15 AM Düsseldorf, ZOB am Hbf | 11h55 | 9:10 PM Praha, Na Knížecí | 0 transfersDirect | |
FlixBus | 9:15 AM Düsseldorf, ZOB am Hbf | 12h15 | 9:30 PM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus · FlixBus | 10:15 AM Düsseldorf, ZOB am Hbf | 14h10 | 12:25 AM Prague, Central Train Station | 1 transfer | |
FlixBus · FlixBus | 2:00 PM Düsseldorf, ZOB am Hbf | 12h50 | 2:50 AM Prague, Central Train Station | 1 transfer | |
FlixBus · FlixBus | 4:45 PM Düsseldorf, ZOB am Hbf | 14h15 | 7:00 AM Prague, Central Train Station | 1 transfer | |
FlixBus · FlixBus | 6:20 PM Düsseldorf, ZOB am Hbf | 13h10 | 7:30 AM Praha, M. Horákové (Hradčanská) | 1 transfer | |
FlixBus · FlixBus · FlixBus | 6:20 PM Düsseldorf, ZOB am Hbf | 14h10 | 8:30 AM Praha, Zličín | 2 transfers | |
(Amsterdam -> Prague) | 6:50 PM Düsseldorf, ZOB am Hbf | 9h58 | 4:48 AM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus · FlixBus · FlixBus | 8:10 PM Düsseldorf, ZOB am Hbf | 12h45 | 8:55 AM Praha, Na Knížecí | 2 transfers | |
FlixBus · FlixBus | 8:10 PM Düsseldorf, ZOB am Hbf | 10h45 | 6:55 AM Praha, ÚAN Florenc | 1 transfer | |
FlixBus · FlixBus | 10:35 PM Düsseldorf, ZOB am Hbf | 12h45 | 11:20 AM Prague, Central Train Station | 1 transfer | |
FlixBus · FlixBus | 10:35 PM Düsseldorf, ZOB am Hbf | 13h10 | 11:45 AM Praha, Na Knížecí | 1 transfer | |
FlixBus | 11:30 PM Düsseldorf, ZOB am Hbf | 10h40 | 10:10 AM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus · FlixBus | 11:30 PM Düsseldorf, ZOB am Hbf | 12h00 | 11:30 AM Prague, Central Train Station | 1 transfer | |
FlixBus · FlixBus | 11:59 PM Düsseldorf, ZOB am Hbf | 12h01 | 12:00 PM Prague, Central Train Station | 1 transfer | |
| Sunday, May 31 | |||||
FlixBus · FlixBus | 1:30 AM Düsseldorf, ZOB am Hbf | 11h35 | 1:05 PM Praha, ÚAN Florenc | 1 transfer | |
FlixBus · FlixBus | 1:30 AM Düsseldorf, ZOB am Hbf | 11h15 | 12:45 PM Praha, Na Knížecí | 1 transfer | |
FlixBus · FlixBus | 3:45 AM Düsseldorf, ZOB am Hbf | 13h50 | 5:35 PM Praha, M. Horákové (Hradčanská) | 1 transfer | |
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Buses from Düsseldorf to Prague run on average 23 times per day, taking around 10h 6m. Cheap bus tickets for this journey start at $37 (€30) if you book in advance.
There are 6 buses per day. The earliest bus runs at 00:10, the last at 23:50. The fastest bus covers the 343 miles (553 km) distance in 9h 55m.
Distance 343 miles (553 km) |
Average bus duration 10h 6m |
Cheapest ticket price $37 (€30) |
Buses per day 23 |
Direct buses 6 |
Fastest bus 9h 55m |
First bus 12:10 AM |
Last bus 11:50 PM |
Cheapest Month Jul |
Cheapest Day Tue |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Thu |
Least Busy Day Mon |
Best time to book 70 days |
Discover the best of Prague — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Prague trip today.
Prague’s flagship museum on Wenceslas Square, with major natural history, history, and cultural collections in a monumental Neo-Renaissance building.
A major museum complex preserving Prague’s Jewish heritage through synagogues, ceremonial objects, archives, and cemetery access.
A leading contemporary art venue in Holešovice known for ambitious exhibitions, design, and the striking Gulliver airship installation.
Prague’s historic central square, surrounded by major landmarks and lively at all hours, making it an essential first stop.
A picturesque district of Baroque streets, embassies, gardens, and hidden corners beneath Prague Castle, ideal for walking and photography.
A broad boulevard-like square central to modern Czech history, shopping, and city life, anchored by the National Museum.
Marinated beef sirloin with creamy root-vegetable sauce, bread dumplings, cranberry sauce, and whipped cream. One of the most classic Czech celebratory dishes.
Roast pork served with bread dumplings and braised cabbage. A cornerstone of traditional Czech home cooking and pub menus.
Czech-style goulash, usually beef, slower-cooked and less soupy than the Hungarian version, commonly served with dumplings. A staple in Prague pubs.
Michelin-starred restaurant offering contemporary Czech fine dining with seasonal ingredients and a sophisticated atmosphere.
Well-known restaurant near Old Town Square offering refined Czech classics in a polished but approachable setting.
Elegant grand cafe and restaurant known for excellent breakfasts, pastries, and upscale Czech and Central European dishes.
Moderate by European standards. Beer, transit, and casual meals are affordable; central hotels cost more.
Around 10% in restaurants for good service, often rounded up. Tip taxis modestly by rounding up. Not expected for counter service, but appreciated.
Official public transport app
Prague Main Railway Station, Prague -> Old Town Square, Prague
Find answers to the most common questions about traveling from Düsseldorf to Prague by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Prague, this guide helps you travel smarter and with confidence.

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