- Must visit
National Museum
Major museum of Czech history and natural sciences in a monumental Neo-Renaissance building overlooking Wenceslas Square.
Cheapest price
€33
Average price
€74
Fastest journey
8 h 15 m
Average duration
8 h 35 m
Trains per day
5
Distance
439 km
The best way to find a cheap train ticket from Mainz to Prague is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Mainz to Prague will cost around €74 if you buy it on the day, but the cheapest tickets can be found for only €33.
It's difficult to get from Mainz to Prague without transferring at least 2 times.
S8 · ICE 527 · 3565+
357
29247 · ICE 1557 · RJ 383
29507 · ICE 2592 · IC 2443 · RJ 383
29247 · ICE 1557 · S1 · 28008
ICE 25 · R 3567 · EC 359
29507 · ICE 2592 · IC 2443 · RJ 383
S8 · ICE 527 · 3565+
357
ICE 25 · R 3567 · EC 359
29247 · ICE 1557 · S1 · 28008
29247 · ICE 1557 · RJ 383Omio recommends booking the train as it is the most popular option from Mainz to Prague among Omio's users. If you are prioritising price take the bus with prices starting from €26. For those with little time consider booking a flight which can get you there in 1h 29m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.4kg. The ticket price range depends on the travel mode: a bus costs an average of €26, and a flight costs an average of €76.
Distance: 272 miles (439 km)
Most popular Train | Bus | Flight | Driving |
|---|---|---|---|
€104 Average price | €38 Average price Cheapest | €173 Average price | €96 Average price (fuel + tolls) |
9h 5m Average total duration 8h 35m Onboard + 30m Additional time* | 7h 35m Average total duration 7h 5m Onboard + 30m Additional time* | 4h 29m Average total duration Fastest 1h 29m Onboard + 3h 0m Additional time* | 5h 50m Average total duration (door-to-door) |
0.1 - 0.4kg CO2 emissions Lowest | 0.4 - 1.1kg CO2 emissions | 1.3 - 2.6kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Mainz to Prague:
A bus is €67 less than a train for this route with tickets for a train from Mainz to Prague costing on average €104.
A bus is €136 less than a flight for this route with tickets for a flight from Mainz to Prague costing on average €173.
Other travel options to Prague take longer:
Bus takes on average 7h 5m.
Train takes on average 8h 35m.
Tickets start at around €104 compared to roughly €96 in fuel and tolls — a saving of about €-7.99. The journey takes 8h 35m versus 5h 50m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
The table below shows live departures for Mainz to Prague trains for tomorrow, Wednesday, August 5. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
S8 · ICE 527 · 3565+ 357 | 8:02 AM Mainz Hbf | 8h19 | 4:21 PM Prague hlavní nádraží | 3 transfers | |
29247 · ICE 1557 · RJ 383 | On time 8:27 AM Mainz Hbf | 8h58 | 5:25 PM Prague hlavní nádraží | 2 transfers | |
29247 · ICE 1557 · S1 · 28008 | 8:27 AM Mainz Hbf | 8h43 | 5:10 PM Prague hlavní nádraží | 4 transfers | |
29507 · ICE 2592 · IC 2443 · RJ 383 | On time 9:10 AM Mainz Hbf | 8h15 | 5:25 PM Prague hlavní nádraží | 3 transfers | |
ICE 25 · R 3567 · EC 359 | On time 9:42 AM Mainz Hbf | 8h39 | 6:21 PM Prague hlavní nádraží | 2 transfers |
Find all the dates and times for this journey
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Mainz to Prague run on average 8 times per day, taking around 8h 35m. Cheap train tickets for this journey start at €35 but you can travel from only €26 by bus.
The earliest train runs at 00:30, the last at 23:50. The fastest train covers the 272 miles (439 km) distance in 8h 4m.
Distance 272 miles (439 km) |
Average train duration 8h 35m |
Cheapest ticket price €35 |
Trains per day 8 |
Fastest train 8h 4m |
First train 12:30 AM |
Last train 11:50 PM |
Cheapest Month Apr |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Sat |
Least Busy Day Mon |
Best time to book 5 days |
Discover the best of Prague — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Prague trip today.
Major museum of Czech history and natural sciences in a monumental Neo-Renaissance building overlooking Wenceslas Square.
Well-curated Jewish history museum across several historic sites. Important for understanding Prague's Jewish heritage and resilience.
Leading Czech art museum with medieval to modern works in a grand historic palace. Essential for fine art and decorative arts lovers.
Historic square at Prague's core, surrounded by Gothic and Baroque landmarks. A must for first-time visitors and classic city views.
Lively boulevard of Czech modern history, lined with shops and major buildings. Worth visiting for atmosphere and historic significance.
Romantic quarter of palaces, lanes, and church domes beneath Prague Castle. Ideal for wandering, photography, and quieter historic charm.
Slow-braised beef in a creamy root-vegetable sauce, usually served with bread dumplings. A classic Czech Sunday dish strongly linked to Bohemian home cooking.
Crisp roasted pork knuckle, often served with mustard, horseradish, and pickles. A hearty pub staple popular with Czech beer culture.
Roast pork with sauerkraut and dumplings. This iconic Czech combination is a cornerstone of traditional pub and family meals.
Traditional Czech restaurant and brewery by Prague Castle, praised for roast meats, dumplings, and polished historic interiors.
Upscale restaurant focused on Czech ingredients and game, with sophisticated service in an Art Nouveau municipal house setting.
Elegant Michelin-starred restaurant known for modern Czech tasting menus in a refined setting near the Vltava.
Moderate for Europe: transit is cheap, casual meals are reasonable, and hotels in the center can raise daily costs in peak season.
Service is often not included. Tip about 5-10% in restaurants, round up for cafes, and round up or add about 10% for taxis if service is good.
Official public transport app
Praha hlavní nádraží -> Václavské náměstí, Prague
Find answers to the most common questions about traveling from Mainz to Prague by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Prague, this guide helps you travel smarter and with confidence.

Most Mainz to Prague trains use the Mainz Hbf to Praha hlavní nádraží station pair, with some services arriving at Praha Masarykovo Nádraží. Use this guide to compare Mainz and Prague train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Mainz Hbf is 2 km from Mainz city centre. Public transport options include:
Mainz Hbf has practical services for this route, including Wifi, Lockers, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lounge, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, and Information Desk.
Food options include: Mangal, Asia Wok, Bistrorante Midi, McDonald's
Wi-Fi is available at Mainz Hbf. ATMs are available at Mainz Hbf.
Ticket office support is available at Mainz Hbf. Information desks are available at Mainz Hbf.
Luggage storage is available at Mainz Hbf. Lost and found is available at the station.
Available at Mainz Hbf: Parking, Taxis, WC.
Available at Mainz Hbf: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Mainz Hbf.
Nearby hotels include Advena Europa Hotel, GuestHouse Mainz, Terminus, Hotel Moguntia.
Mainz Römisches Theater is 1 km from Mainz city centre. Public transport options include:
Mainz Römisches Theater has practical services for this route, including Wifi, Lockers, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lounge, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, and Information Desk.
Food options include: McDonald's, Cafe Extrablatt, Hans im Glück, The Big Easy
Wi-Fi is available at Mainz Römisches Theater. ATMs are available at Mainz Römisches Theater.
Ticket office support is available at Mainz Römisches Theater. Information desks are available at Mainz Römisches Theater.
Luggage storage is available at Mainz Römisches Theater. Lost and found is available at the station.
Available at Mainz Römisches Theater: Parking, Taxis, WC.
Available at Mainz Römisches Theater: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Mainz Römisches Theater.
Nearby hotels include Hyatt Regency Mainz, Favorite Parkhotel, Ibis Hotel Mainz City, Hof Ehrenfels.
Mainz-Laubenheim is 3 km from Mainz city centre. Public transport options include:
Mainz-Laubenheim has practical services for this route, including Wifi, Lockers, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lounge, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, and Information Desk.
Food options include: Zum Laubenheimer Ried - Da Giovanni, Mainzer Hof, Pizza Roma, Bäckerei Werner
Wi-Fi is available at Mainz-Laubenheim. ATMs are available at Mainz-Laubenheim.
Ticket office support is available at Mainz-Laubenheim. Information desks are available at Mainz-Laubenheim.
Luggage storage is available at Mainz-Laubenheim. Lost and found is available at the station.
Available at Mainz-Laubenheim: Parking, Taxis, WC.
Available at Mainz-Laubenheim: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Mainz-Laubenheim.
Nearby hotels include Goldene Ente.
Praha hlavní nádraží is 1 km from Prague city centre. Public transport options include:
Praha hlavní nádraží has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Shower, Lounge, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, Information Desk, and Luggage Carts.
Food options include: Restaurant Fantova Kavárna, Sushi Time
Free. ATMs are available in the train station.
Ticket office support is available at Praha hlavní nádraží. Information desks are located in the main hall.
Luggage storage is available at Praha hlavní nádraží. Lost and found is available at the station.
Available at Praha hlavní nádraží: Parking, Taxis, WC.
Available at Praha hlavní nádraží: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Praha hlavní nádraží: Elevators, ramps.
Nearby hotels include Hotel Esplanade Prague, Falkensteiner Hotel Maria Prag, Hotel City Central.
Praha Masarykovo Nádraží has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, Information Desk, and Luggage Carts.
Food options include: Restaurant Kotleta, Café Imperial
Free. ATMs are available in the train station.
Ticket office support is available at Praha Masarykovo Nádraží. Information desks are located in the main hall.
Luggage storage is available at Praha Masarykovo Nádraží. Lost and found is available at the station.
Available at Praha Masarykovo Nádraží: Parking, Taxis, WC.
Available at Praha Masarykovo Nádraží: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Praha Masarykovo Nádraží: Ramps.
Nearby hotels include Hotel Kings Court, Grand Hotel Bohemia, Hotel Paris Prague.
Praha-Holesovice is 2 km from Prague city centre. Public transport options include:
Praha-Holesovice has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, Information Desk, and Luggage Carts.
Food options include: Restaurant Na Kovárně, Cross Club
Free. ATMs are available in the train station.
Ticket office support is available at Praha-Holesovice. Information desks are located in the main hall.
Luggage storage is available at Praha-Holesovice. Lost and found is available at the station.
Available at Praha-Holesovice: Parking, Taxis, WC.
Available at Praha-Holesovice: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Praha-Holesovice: Ramps, restrooms.
Nearby hotels include Mama Shelter Prague, Plaza Alta Hotel, Hotel Belvedere.
Here are some other resources that might have the information you need