4.9
4.6
Travel Information
Compare bus, train, and flight for Mainz to Prague
Omio recommends booking the train as it is the most popular option from Mainz to Prague among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $51 For those with little time, consider booking a flight, which has an average total journey time of 4h 51m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.1 - 0.4kg. Average ticket prices depend on the travel mode: a bus costs an average of $51, while a flight costs an average of $440.
Distance: 272 miles (439 km)
Compare train with
Most popular Train | Bus | Flight | Driving |
|---|---|---|---|
$151 Average price | $51 Average price Cheapest | $440 Average price | $116 Average price (fuel + tolls) |
8h 10m Average total duration 7h 40m Onboard + 30m Additional time* | 9h 24m Average total duration 8h 54m Onboard + 30m Additional time* | 4h 51m Average total duration Fastest 2h 51m Onboard + 2h 0m Additional time* | 5h 50m Average total duration (door-to-door) |
0.1 - 0.4kg CO2 emissions Lowest | 0.4 - 1.1kg CO2 emissions | 1.3 - 2.6kg CO2 emissions | - CO2 emissions |
 Most popular train company |  Most popular bus company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Compare ways to travel from Mainz to Prague
Compare the available ways to get from Mainz to Prague, with the key details around price, speed, convenience, and direct service.
This is compared to other travel options from Mainz to Prague:
A bus is $100 less than a train for this route with tickets for a train from Mainz to Prague costing on average $151.
A bus is $390 less than a flight for this route with tickets for a flight from Mainz to Prague costing on average $440.
Other travel options to Prague take longer:
Train takes on average 8h 10m.
Bus takes on average 9h 24m.
Tickets start at around $151 compared to roughly $116 in fuel and tolls — a saving of about -$34. The journey takes 7h 40m versus 5h 50m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Travel optionsfrom Mainz to Prague
How to get from Mainz to Prague by train, bus or flight.
Our recommendation
The best way to travel from Mainz to Prague is by taking a bus because it’s the best combination of price and speed.
(Amsterdam -> Prague)10:00 PM6h48Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)4:48 AMPraha, ÚAN Florenc$481One-way0 transfers
Cheapest
- (Amsterdam -> Prague)10:00 PM6h48Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)4:48 AMPraha, ÚAN Florenc$481One-way0 transfers
Fastest
DE44118:25 PM1h00Frankfurt am Main Airport9:25 PMPrague Vaclav Havel Airport$1871One-way0 transfers
Other options
4257 · ICE 621 · 3569 · Bus RE2510:10 AM8h11Mainz Hbf6:21 PMPrague hlavní nádraží$1691One-way4 transfers- S8 · ICE 527 · 3565 · Bus RE258:02 AM8h19Mainz Hbf4:21 PMPrague hlavní nádraží$1691One-way4 transfers
- ICE 25 · 3569 · Bus RE25 · EX 3599:42 AM8h39Mainz Hbf6:21 PMPrague hlavní nádraží$1691One-way3 transfers
- FlixBus4:20 PM8h10Mainz, Binger Schlag (Kurzzeitparkplatz)12:30 AMPraha, Na Knížecí$571One-way0 transfers
- FlixBus4:20 PM8h25Mainz, Binger Schlag (Kurzzeitparkplatz)12:45 AMPrague, Central Train Station$571One-way0 transfers
- FlixBus · FlixBus10:30 PM11h10Mainz, Binger Schlag (Kurzzeitparkplatz)9:40 AMPraha, ÚAN Florenc$731One-way1 transfer
EW7722:25 PM1h10Cologne Bonn Airport3:35 PMPrague Vaclav Havel Airport$1661One-way0 transfers- DE44099:40 AM1h10Frankfurt am Main Airport10:50 AMPrague Vaclav Havel Airport$1731One-way0 transfers
- DE44073:00 PM1h00Frankfurt am Main Airport4:00 PMPrague Vaclav Havel Airport$2021One-way0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Travel from Mainz to Prague
Travel to Prague easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Mainz to Prague.
This is compared to other travel options from Mainz to Prague:
A bus is $100 less than a train for this route with tickets for a train from Mainz to Prague costing on average $151.
A bus is $390 less than a flight for this route with tickets for a flight from Mainz to Prague costing on average $440.
Other travel options to Prague take longer:
Train takes on average 8h 10m.
Bus takes on average 9h 24m.
- Around 58 flights per day.
- Around 7 trains per day.
- Around 3 buses per day.
However, we recommend checking specific travel dates for your route between Mainz and Prague as scheduled services by bus, train, and flight can vary by season or day of the week.
- Flights mostly depart from Frankfurt am Main Airport and arrive in Prague Vaclav Havel Airport.
- Buses mostly depart from Mainz, Binger Schlag (Kurzzeitparkplatz) and arrive in Prague, Central Train Station.
- Trains mostly depart from Mainz Hbf and arrive in Prague hlavní nádraží.
- Travel with FlixBus to go to Prague by bus.
- Travel with alex-Länderbahn und Vogtlandbahn-GmbH, Deutsche Bahn, České dráhy, Leo Express to go to Prague by train.
- Travel with Air Dolomiti, Lufthansa, Condor Flugdienst, Lot Polish Airlines, Eurowings, Lufthansa Cityline, KLM Cityhopper, Brussels Airlines, Qatar Airways, Avion Express Malta, Croatia Airlines, Air Baltic, Helvetic Airways, Egypt Air, British Airways, Edelweiss Air, CitizenPlane, Swiss, Air France, Lufthansa City Airlines, KLM, Austrian Airlines, Smartwings, Turkish Airlines, TAP Portugal to go to Prague by flight.
- 2 direct buses per day with FlixBus.
- 0 direct trains per day with Leo Express.
- 8 direct flights per day with Air Dolomiti, Lufthansa, Condor Flugdienst, Avion Express Malta, Smartwings.
Travelling from Mainz to Prague: related information
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