Travel Information
Compare bus, train, and flight for Mainz to Prague
Omio recommends booking the train as it is the most popular option from Mainz to Prague among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $45 For those with little time, consider booking a flight, which has an average total journey time of 3h 29m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.1 - 0.4kg. Average ticket prices depend on the travel mode: a bus costs an average of $45, while a flight costs an average of $168.
Distance: 272 miles (439 km)
Compare train with
Most popular Train | Bus | Flight | Driving |
|---|---|---|---|
$85 Average price | $45 Average price Cheapest | $168 Average price | $120 Average price (fuel + tolls) |
8h 58m Average total duration 8h 28m Onboard + 30m Additional time* | 7h 30m Average total duration 7h 0m Onboard + 30m Additional time* | 3h 29m Average total duration Fastest 1h 29m Onboard + 2h 0m Additional time* | 5h 50m Average total duration (door-to-door) |
0.1 - 0.4kg CO2 emissions Lowest | 0.4 - 1.1kg CO2 emissions | 1.3 - 2.6kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Mainz to Prague:
A bus is $39 (€32) less than a train for this route with tickets for a train from Mainz to Prague costing on average $85 (€68).
A bus is $123 (€99) less than a flight for this route with tickets for a flight from Mainz to Prague costing on average $168 (€136).
Other travel options to Prague take longer:
Bus takes on average 7h 30m.
Train takes on average 8h 58m.
Tickets start at around $85 (€68) compared to roughly $120 (€97) in fuel and tolls — a saving of about $35 (€29). The journey takes 8h 28m versus 5h 50m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Travel optionsfrom Mainz to Prague
How to get from Mainz to Prague by train, bus or flight.
Our recommendation
The best way to travel from Mainz to Prague is by taking a bus because it’s the best combination of price and speed.
3:00 PM8h05Mainz11:05 PMPrague$391One-way0 transfers
Cheapest
3:00 PM8h05Mainz11:05 PMPrague$391One-way0 transfers
Fastest
3:00 PM8h05Mainz11:05 PMPrague$391One-way0 transfers
Other options
3:15 AM10h45Mainz2:00 PMPrague$491One-way0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Travel from Mainz to Prague
Travel to Prague easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Mainz to Prague.

This is compared to other travel options from Mainz to Prague:
A bus is $39 (€32) less than a train for this route with tickets for a train from Mainz to Prague costing on average $85 (€68).
A bus is $123 (€99) less than a flight for this route with tickets for a flight from Mainz to Prague costing on average $168 (€136).
Other travel options to Prague take longer:
Bus takes on average 7h 30m.
Train takes on average 8h 58m.
- Around 69 flights per day.
- Around 8 trains per day.
- Around 5 buses per day.
However, we recommend checking specific travel dates for your route between Mainz and Prague as scheduled services by bus, train, and flight can vary by season or day of the week.
- Flights mostly depart from Frankfurt am Main Airport and arrive in Prague Vaclav Havel Airport.
- Trains mostly depart from Mainz Hbf and arrive in Prague hlavní nádraží.
- Buses mostly depart from Mainz, Binger Schlag (Kurzzeitparkplatz) and arrive in Praha, ÚAN Florenc.
- Travel with FlixBus, BlaBlaCar to go to Prague by bus.
- Travel with alex-Länderbahn und Vogtlandbahn-GmbH, Deutsche Bahn, České dráhy to go to Prague by train.
- Travel with Air Dolomiti, Lufthansa, Lot Polish Airlines, Eurowings, Condor Flugdienst to go to Prague by flight.
- 3 direct buses per day with FlixBus, BlaBlaCar.
- 9 direct flights per day with Air Dolomiti, Lufthansa, Eurowings, Condor Flugdienst.
Travelling from Mainz to Prague: related information
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