Travel Information
Compare bus, train, and flight for Mainz to Prague
Omio recommends booking the train as it is the most popular option from Mainz to Prague among Omio's users. If you are prioritising price take the bus with prices starting from $32. For those with little time consider booking a flight which can get you there in 1h 29m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.4kg. The ticket price range depends on the travel mode: a bus costs an average of $32, and a flight costs an average of $99.
Distance: 272 miles (439 km)
Compare train with
Most popular Train | Bus | Flight |
|---|---|---|
$108 Average price | $47 Average price Cheapest | $202 Average price |
9h 5m Average total duration 8h 35m Onboard + 30m Additional time* | 7h 40m Average total duration 7h 10m Onboard + 30m Additional time* | 4h 29m Average total duration Fastest 1h 29m Onboard + 3h 0m Additional time* |
0.1 - 0.4kg CO2 emissions Lowest | 0.4 - 1.1kg CO2 emissions | 1.3 - 2.6kg CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Mainz to Prague
How to get from Mainz to Prague by train, bus or flight.
Our recommendation
The best way to travel from Mainz to Prague is by taking a bus because it’s the best combination of price and speed.
(Amsterdam -> Prague)Cheapest
(Amsterdam -> Prague)Fastest
DE4409Other options
4255 · ICE 527 · 3565+
357
29507 · ICE 692 · IC 2443 · RJ 383
4255 · ICE 1557 · RJ 383
(Amsterdam -> Prague)
FlixBus
FlixBus
DE4407
LH5652
EN8950Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Mainz to Prague
Travel to Prague easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Mainz to Prague.

This is compared to other travel options from Mainz to Prague:
A bus is $6 (€5) less than a train for this route with tickets for a train from Mainz to Prague costing on average $38 (€31).
A bus is $67 (€54) less than a flight for this route with tickets for a flight from Mainz to Prague costing on average $99 (€80).
Other travel options to Prague take longer:
Bus takes on average 6h 45m.
Train takes on average 7h 41m.
- Around 73 flights per day.
- Around 9 trains per day.
- Around 6 buses per day.
However, we recommend checking specific travel dates for your route between Mainz and Prague as scheduled services by bus, train, and flight can vary by season or day of the week.
- Flights mostly depart from Frankfurt am Main Airport and arrive in Prague Vaclav Havel Airport.
- Trains mostly depart from Mainz Hbf and arrive in Prague hlavní nádraží.
- Buses mostly depart from Mainz, Binger Schlag (Kurzzeitparkplatz) and arrive in Praha, ÚAN Florenc.
- Travel with FlixBus, BlaBlaCar to go to Prague by bus.
- Travel with Lufthansa, Air Dolomiti, LOT Polish Airlines, Condor, Eurowings to go to Prague by flight.
- Travel with Deutsche Bahn, Alex, České dráhy to go to Prague by train.
- 3 direct buses per day with FlixBus, BlaBlaCar.
- 9 direct flights per day with Lufthansa, Air Dolomiti, Condor.
Travelling from Mainz to Prague: related information
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