Travel Information
Compare bus, train, and flight for Mainz to Prague
Omio recommends booking the train as it is the most popular option from Mainz to Prague among Omio's users. If you are prioritising price take the bus with prices starting from $32. For those with little time consider booking a flight which can get you there in 1h 29m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.4kg. The ticket price range depends on the travel mode: a bus costs an average of $32, and a flight costs an average of $94.
Distance: 272 miles (439 km)
Compare train with
Most popular Train | Bus | Flight | Driving |
|---|---|---|---|
$129 Average price | $47 Average price Cheapest | $215 Average price | $120 Average price (fuel + tolls) |
9h 5m Average total duration 8h 35m Onboard + 30m Additional time* | 7h 35m Average total duration 7h 5m Onboard + 30m Additional time* | 4h 29m Average total duration Fastest 1h 29m Onboard + 3h 0m Additional time* | 5h 50m Average total duration (door-to-door) |
0.1 - 0.4kg CO2 emissions Lowest | 0.4 - 1.1kg CO2 emissions | 1.3 - 2.6kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Mainz to Prague:
A bus is $83 (€67) less than a train for this route with tickets for a train from Mainz to Prague costing on average $129 (€104).
A bus is $168 (€136) less than a flight for this route with tickets for a flight from Mainz to Prague costing on average $215 (€173).
Other travel options to Prague take longer:
Bus takes on average 7h 5m.
Train takes on average 8h 35m.
Travel optionsfrom Mainz to Prague
How to get from Mainz to Prague by train, bus or flight.
Our recommendation
The best way to travel from Mainz to Prague is by taking a bus because it’s the best combination of price and speed.
(Amsterdam -> Prague)10:00 PM6h48Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)4:48 AMPraha, ÚAN Florenc$491One-way0 transfers
Cheapest
(Amsterdam -> Prague)10:00 PM6h48Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)4:48 AMPraha, ÚAN Florenc$491One-way0 transfers
Fastest
DE44118:25 PM1h00Frankfurt am Main Airport9:25 PMPrague Vaclav Havel Airport$1781One-way0 transfers
Other options
S8 · ICE 527 · 3565+
3578:02 AM8h19Mainz Hbf4:21 PMPrague hlavní nádraží$1381One-way3 transfers
ICE 1557 · rj 3838:43 AM8h42Mainz Hbf5:25 PMPrague hlavní nádraží$1411One-way1 transfer
ICE 1557 · RJ 3838:43 AM8h42Mainz Hbf5:25 PMPrague hlavní nádraží$1741One-way1 transfer
FlixBus4:00 PM8h05Mainz, Binger Schlag (Kurzzeitparkplatz)12:05 AMPraha, Na Knížecí$561One-way0 transfers
FlixBus4:00 PM8h25Mainz, Binger Schlag (Kurzzeitparkplatz)12:25 AMPrague, Central Train Station$561One-way0 transfers
EW7722:25 PM1h10Cologne Bonn Airport3:35 PMPrague Vaclav Havel Airport$961One-way0 transfers
QS80372:25 PM1h10Cologne Bonn Airport3:35 PMPrague Vaclav Havel Airport$1571One-way0 transfers
ICE 1651+
DE441112:43 PM8h42Mainz Hbf9:25 PMPrague Vaclav Havel Airport$2011One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Travel from Mainz to Prague
Travel to Prague easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Mainz to Prague.

This is compared to other travel options from Mainz to Prague:
A bus is $83 (€67) less than a train for this route with tickets for a train from Mainz to Prague costing on average $129 (€104).
A bus is $168 (€136) less than a flight for this route with tickets for a flight from Mainz to Prague costing on average $215 (€173).
Other travel options to Prague take longer:
Bus takes on average 7h 5m.
Train takes on average 8h 35m.
- Around 70 flights per day.
- Around 8 trains per day.
- Around 6 buses per day.
However, we recommend checking specific travel dates for your route between Mainz and Prague as scheduled services by bus, train, and flight can vary by season or day of the week.
- Flights mostly depart from Frankfurt am Main Airport and arrive in Prague Vaclav Havel Airport.
- Trains mostly depart from Mainz Hbf and arrive in Prague hlavní nádraží.
- Buses mostly depart from Mainz, Binger Schlag (Kurzzeitparkplatz) and arrive in Praha, ÚAN Florenc.
- Travel with Deutsche Bahn, alex-Länderbahn und Vogtlandbahn-GmbH, České dráhy to go to Prague by train.
- Travel with FlixBus, BlaBlaCar to go to Prague by bus.
- Travel with Air Dolomiti, Lufthansa, Lot Polish Airlines, Eurowings, Condor Flugdienst to go to Prague by flight.
- 3 direct buses per day with FlixBus, BlaBlaCar.
- 9 direct flights per day with Air Dolomiti, Lufthansa, Eurowings, Condor Flugdienst.
Travelling from Mainz to Prague: related information
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