The cheapest and fastest trains from Mainz to Lyon
Cheapest price
$262
Average price
$291
Fastest journey
9 h 2 m
Average duration
9 h 19 m
Trains per day
12
Distance
536 km
The best way to find a cheap train ticket from Mainz to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Mainz to Lyon will cost around $291 if you buy it on the day, but the cheapest tickets can be found for only $262.
It's difficult to get from Mainz to Lyon without transferring at least 2 times.
S6 · ICE 9590+
9580
S5 · ICE 9590+
9580
S6 · ICE 9590+
9580
29247 · ICE 573 · ICE 9590+
9580
S5 · ICE 9590+
5537
S6 · ICE 9590+
12177
S6 · ICE 9590+
5537
29247 · ICE 573 · ICE 9590+
12177
29247 · ICE 573 · ICE 9590+
5537
S5 · ICE 9590+
5537Travel Information
Compare train, bus, and flight for Mainz to Lyon
Omio recommends booking the train as it is the most popular option from Mainz to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from €26. For those with little time consider booking a flight which can get you there in 1h 25m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.5kg. The ticket price range depends on the travel mode: a bus costs an average of €26, and a flight costs an average of €73.
Distance: 333 miles (536 km)
Compare train with
Most popular Train | Flight | Bus |
|---|---|---|
€127 Average price | €165 Average price | €41 Average price Cheapest |
6h 33m Average total duration 6h 3m Onboard + 30m Additional time* | 4h 25m Average total duration Fastest 1h 25m Onboard + 3h 0m Additional time* | 9h 20m Average total duration 8h 50m Onboard + 30m Additional time* |
0.2 - 0.5kg CO2 emissions Lowest | 1.6 - 3.2kg CO2 emissions | 0.5 - 1.3kg CO2 emissions |
![]() Most popular train company | ![]() Most popular airline | ![]() Most popular bus company |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Live departures
Mainz to Lyon train times
The table below shows live departures for Mainz to Lyon trains for tomorrow, Monday, December 29. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
S6 · ICE 9590+ 5537 | On time 6:57 AM Mainz Römisches Theater station | 10h02 | 4:59 PM Lyon Part Dieu | 2 transfers | |
S6 · ICE 9590+ 12177 | On time 6:57 AM Mainz Römisches Theater station | 10h02 | 4:59 PM Lyon Part Dieu | 2 transfers | |
S6 · ICE 9590+ 9580 | On time 6:57 AM Mainz Römisches Theater station | 12h01 | 6:58 PM Lyon Part Dieu | 2 transfers | |
S5 · ICE 9590+ 5537 | On time 7:26 AM Mainz Römisches Theater station | 9h33 | 4:59 PM Lyon Part Dieu | 2 transfers | |
S5 · ICE 9590+ 9580 | On time 7:26 AM Mainz Römisches Theater station | 11h32 | 6:58 PM Lyon Part Dieu | 2 transfers | |
S5 · ICE 9590+ 12177 | On time 7:26 AM Mainz Römisches Theater station | 9h33 | 4:59 PM Lyon Part Dieu | 2 transfers | |
29247 · ICE 573 · ICE 9590+ 9580 | On time 7:30 AM Mainz Römisches Theater station | 11h28 | 6:58 PM Lyon Part Dieu | 3 transfers | |
29247 · ICE 573 · ICE 9590+ 12177 | On time 7:30 AM Mainz Römisches Theater station | 9h29 | 4:59 PM Lyon Part Dieu | 3 transfers | |
29247 · ICE 573 · ICE 9590+ 5537 | On time 7:30 AM Mainz Römisches Theater station | 9h29 | 4:59 PM Lyon Part Dieu | 3 transfers | |
S6 · ICE 9590+ 12177 | On time 7:57 AM Mainz Römisches Theater station | 9h02 | 4:59 PM Lyon Part Dieu | 2 transfers | |
S6 · ICE 9590+ 9580 | On time 7:57 AM Mainz Römisches Theater station | 11h01 | 6:58 PM Lyon Part Dieu | 2 transfers | |
S6 · ICE 9590+ 5537 | On time 7:57 AM Mainz Römisches Theater station | 9h02 | 4:59 PM Lyon Part Dieu | 2 transfers | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Mainz to Lyon by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Dec 29
Dec 30
Dec 31
Jan 01
Jan 02
Jan 03
Jan 04
Why should you book Mainz to Lyon trains with Omio?
TGV as well as TGV INOUI and Süwex offer trains services from Mainz to Lyon. Omio is an official ticket reseller for all your travel options from Mainz to Lyon.
Why book with Omio vs TGV?
- Compare with other providers: On Omio, you can not only buy tickets for TGV, but also compare tickets for the likes of TGV INOUI and Süwex to find the best option for your trip from Mainz to Lyon.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare TGV with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Mainz to Lyon.
Why book with Omio over Trainline and Rail Europe?
- Multiple travel company options: While TGV tickets can be bought on TGV's website or third party sellers, Omio allows you to compare with the likes of TGV INOUI and Süwex to help you choose the right option for your journey from Mainz to Lyon.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Mainz to Lyon.
Journey information
Overview: Train from Mainz to Lyon
Trains from Mainz to Lyon run on average 3 times per day, taking around 6h 3m. Cheap train tickets for this journey start at $93 (€74) but you can travel from only $33 (€26) by bus.
There are 1 trains per day. The earliest train runs at 03:15, the last at 22:25. The fastest train covers the 333 miles (536 km) distance in 5h 17m.
Distance 333 miles (536 km) |
Average train duration 6h 3m |
Cheapest ticket price $93 (€74) |
Trains per day 3 |
Direct trains 1 |
Fastest train 5h 17m |
First train 03:15 |
Last train 22:25 |
Train companies: TGV, TGV INOUI, Süwex from Mainz to Lyon trainsTGV, TGV INOUI, Süwex trains will get you between Mainz and Lyon from $33 (€26). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
TGV
TGV INOUI
Süwex
FAQs: Trains from Mainz to Lyon
Find answers to the most common questions about traveling from Mainz to Lyon by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Mainz to Lyon
- Monday: 06:00 - 21:15
- Tuesday: 06:00 - 21:15
- Wednesday: 06:00 - 21:15
- Thursday: 06:00 - 21:15
- Friday: 06:00 - 21:15
- Saturday: 07:00 - 19:00
- Sunday: 08:00 - 20:00
- Mangal
- Asia Wok
- Bistrorante Midi
- McDonald's
- Advena Europa Hotel
- GuestHouse Mainz
- Terminus
- Hotel Moguntia
- Mon - Wed: 05:00 - 20:45
- Thu - Sat: 05:00 - 21:45
- Sun: 06:45 - 21:45
- Free unlimited WiFi.
- Luggage lockers are available daily from 06:15 to 23:15. They are located near the station's reception desk.
- Alto Café
- Paul
- Paul The Café
- Starbucks
- Exki
- Sushi Shop
- Carrefour
- Complimentary personalized care is available.
- Radisson Blu Hotel Lyon
- Mercure Lyon Center
- ibis Styles Lyon Center
- Mon - Wed: 05:00 - 20:45
- Thu - Sat: 05:00 - 21:45
- Sun: 06:45 - 21:45
- Located in the station's main hall.
- Metro lines: A, B, C, D
- Tram lines: T4, K240, T3, K100
- Bus lines: 2960, C2, C3, C6, C9
- Train lines: TGV, TGV Lyria, TGV INOUI, OUIGO, TER, Intercités, Eurostar, AVE
Most popular train connections from Mainz
More options for your journey from Mainz to Lyon
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