- Must visit
Musée des Confluences
A striking science and anthropology museum at the meeting of the Rhône and Saône, known for bold architecture and major permanent exhibitions.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
Travel Information
Compare train, bus, and flight for Mainz to Lyon
Omio recommends booking the flight as it is the most popular option from Mainz to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $41. For those with little time consider booking a flight which can get you there in 1h 18m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.5 - 1.3kg. The ticket price range depends on the travel mode: a bus costs an average of $41, and a flight costs an average of $167.
Distance: 333 miles (536 km)
Compare flight with
Most popular Flight | Bus | Driving |
|---|---|---|
$328 Average price | $65 Average price Cheapest | $184 Average price (fuel + tolls) |
4h 18m Average total duration Fastest 1h 18m Onboard + 3h 0m Additional time* | 10h 40m Average total duration 10h 10m Onboard + 30m Additional time* | 6h 50m Average total duration (door-to-door) |
1.6 - 3.2kg CO2 emissions | 0.5 - 1.3kg CO2 emissions Lowest | - CO2 emissions |
 Most popular airline |  Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
The cheapest way to travel from Mainz to Lyon is a bus with an average price of $65 (€52).
This is compared to other travel options from Mainz to Lyon:
A bus is $263 (€211) less than a flight for this route with tickets for a flight from Mainz to Lyon costing on average $328 (€264).
The fastest way to travel from Mainz to Lyon is by flight with an average journey time of 1h 18m.
Other travel options to Lyon take longer:
Train takes on average 6h 2m.
Bus takes on average 10h 10m.
It's helpful to compare your options as there are 3 ways to travel between Mainz and Lyon including taking a train, bus, and flight.
We recommend using the train as it is the most popular way to get from Mainz to Lyon among Omio's users.
Live departures
Mainz to Lyon train times
The table below shows live departures for Mainz to Lyon trains for today, Friday, May 15. You can also manually refresh the results below to see updated train journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
 | 11:14 AM Mainz | 8h44 | 7:58 PM Lyon | 3 transfers | |
| 7:14 PM Mainz | 24h44 | 7:58 PM Lyon | 3 transfers | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Mainz to Lyon by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Sat
May 16
May 16
Sun
May 17
May 17
Mon
May 18
May 18
Tue
May 19
May 19
Wed
May 20
May 20
Thu
May 21
May 21
Fri
May 22
May 22
Journey information
Overview: Train from Mainz to Lyon
Germany
France
Take a train from Mainz to Lyon and enjoy the approximately 333 miles (536 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
There are 1 trains per day. The earliest train runs at 00:04, the last at 16:04. The fastest train covers the 333 miles (536 km) distance in 8h 44m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $41 (€33)
Distance 333 miles (536 km) |
Average train duration 6h 2m |
Trains per day 3 |
Direct trains 1 |
Fastest train 8h 44m |
First train 12:04 AM |
Last train 4:04 PM |
Cheapest Month May |
Cheapest Day Tue |
High Season Apr - Jun |
Low Season Jan - Mar |
Best time to book 7 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $41 (€33)
Train companies: TGV, SNCF | TGV INOUI, vlexx from Mainz to Lyon trainsTGV, SNCF | TGV INOUI, vlexx trains will get you between Mainz and Lyon from $41 (€33). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
TGV
About
TGV is a high-speed train company based in France. It operates a fleet of modern trains that can reach speeds of up to 320 km/h. The TGV offers a variety of train types, including the TGV Duplex, TGV Lyria, TGV InOui, and TGV OuiGo. Each train type provides different amenities, such as Wi-Fi, power outlets, and comfortable seating. Ticket options include Standard, Flexi, and Prem’s. Onboard facilities feature a bar, restaurant, and luggage storage. Popular TGV routes include Paris to Lyon, Paris to Marseille, and Paris to Lille.
Luggage & cancellation policy
TGV frequency
1 a day
Luggage included
2 pieces of hand luggage and 1 suitcase included in ticket price
Luggage storage
Dedicated luggage areas at end of carriages and overhead racks
Cancellation Policy
According to fare conditions and ticket type
Refund
Full refund provided for canceled trains
Amenities on board the train
Wifi
Food sold onboard
Restaurant car with full meals and bar service, at-seat dining in first class
Seat reservation
Included in first class, optional fee in second class
Toilets
USB plugs
Accessibility
Wheelchair spaces, accessible toilets, and assistance service available
Pets
Small pets in carriers travel free, larger dogs require paid ticket, guide dogs travel free
Quiet zone
SNCF | TGV INOUI
About
SNCF's TGV INOUI is a premium high-speed train service operating across France and to other European cities. Launched in 2017, it aims to provide an enhanced travel experience with greater comfort, connectivity, and services compared to traditional TGV services. TGV INOUI trains offer features like adjustable seats, electrical outlets, fold-down tables, and dedicated luggage spaces. Passengers can enjoy onboard Wi-Fi and access to the TGV INOUI portal for entertainment and journey information. The service also includes a "Bistro TGV INOUI" for dining, with options for online ordering. SNCF is also introducing a new generation of TGV INOUI trains from 2026, which will be more modular, energy-efficient, and 97% recyclable.
Luggage & cancellation policy
Average Duration
5h 17m
Cheapest Price
$96 (€77)
SNCF | TGV INOUI frequency
2 a day
Luggage included
1 hand luggage + 2 pieces of luggage free of charge
Luggage storage
Overhead racks, end of carriages, between seats
Cancellation Policy
Refund conditions depend on ticket type
Refund
Full refund if train canceled
Amenities on board the train
Wifi
Food sold onboard
Restaurant car (not all trains), at-seat service in 1st class, snack bar/cafe
Seat reservation
Second class: Optional, additional fee. First class: Included in ticket price
Toilets
USB plugs
Accessibility
Wheelchair spaces, accessible toilets, boarding assistance available
Pets
Small pets in carriers: Free. Large dogs: Paid ticket required. Guide dogs: Free
Quiet zone
vlexx
Luggage & cancellation policy
Average Duration
8h 44m
vlexx frequency
1 a day
Complete guide to Lyon
Things to do in Lyon
Discover the best of Lyon — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Lyon trip today.
- Must visit
Museum of Fine Arts of Lyon
One of France’s leading fine arts museums, housed in a former abbey with strong collections from antiquity to modern art.
- Recommended
Lugdunum Museum and Roman Theatres
Archaeological museum on Fourvière Hill with Roman mosaics, inscriptions, and access to the adjacent ancient theatres.
- Must visit
Place Bellecour
One of Europe’s largest open squares, a central meeting point and starting place for exploring Lyon.
- Must visit
Parc de la Tête d'Or
Lyon’s flagship urban park with a lake, botanical gardens, rose garden, and broad walking paths.
- Must visit
La Presqu'île
The central peninsula between the Rhône and Saône, packed with shopping streets, squares, and grand architecture.
Quenelles De Brochet
Light dumplings traditionally made with pike and served with a rich Nantua crayfish sauce, a classic of Lyonnais cooking.
Salade Lyonnaise
A warm salad with frisée, lardons, croutons, and a poached egg, widely associated with Lyon's bouchon tradition.
- Gluten-free
Andouillette
A robust sausage made from pork tripe, famous in Lyon for its strong flavor and served in many traditional bouchons.
La Mère Brazier
Historic fine-dining institution in Lyon, renowned for haute cuisine rooted in the legacy of Eugénie Brazier.
Le Bouchon Des Filles
Popular modern bouchon offering refined Lyonnais classics in a warm, intimate setting.
Café Des Fédérations
Classic bouchon known for traditional Lyonnais dishes, hearty set menus, and a lively, old-school atmosphere.
Euro
Moderate by French standards: bakeries and bouchons are reasonable, while hotels and fine dining cost more.
Average meal costs
- Budget
- EUR 10-15 for a sandwich, kebab, or lunch deal.
- Mid-range
- EUR 20-35 per person at a casual restaurant.
- Fine dining
- EUR 70+ per person at upscale restaurants.
- Coffee
- EUR 2.50-4 for an espresso or cappuccino.
Tipping culture
Service is included in restaurant bills. Leaving 5-10% for great service is appreciated but not required. Round up for taxis; small change for cafés is optional.
TCL: Itinéraires, Tickets
Get the appOfficial public transport app
Prices
- Single ticket
- 2.10 EUR
- Day pass
- 7.00 EUR
To the city center
Lyon Part-Dieu -> Bellecour, Lyon
- Distance
- 3 km
- Travel time
- 10 min
- You can buy tickets in the official TCL app, at ticket machines, or with contactless bank card on metro, tram, and bus validators.
- A single TCL ticket allows transfers within 1 hour, but it is not valid for return trips on the same line.
FAQs: Trains from Mainz to Lyon
Find answers to the most common questions about traveling from Mainz to Lyon by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.
The train from Mainz to Lyon takes 8h 44m and runs 3 per day.
The first train from Mainz to Lyon leaves at 12:04 AM.
The distance by train from Mainz to Lyon is 333 miles (536 km).
The last train from Mainz to Lyon leaves at 4:04 PM.
Yes, there is a high-speed train from Mainz to Lyon.
Yes, there is a direct train from Mainz to Lyon. This service operates 1 times per day, provided by SNCF | TGV INOUI.
Unfortunately, there is no night train available from Mainz to Lyon.
The train station in Mainz that goes to Lyon is Frankfurt (Main) Hbf, which connects to Lyon Part Dieu.
The cheapest way to get from Mainz to Lyon is by bus, with a cost of around $41 (€33).
The train journey from Mainz to Lyon offers scenic views, particularly as it passes through the Rhine Valley with its charming vineyards and historic castles, and continues through the picturesque landscapes of eastern France.
A day trip from Mainz to Lyon is not feasible as the journey takes 8h 44m. Trains operate 3 times per day. The distance is 333 miles (536 km).
In Lyon, you can explore Les Halles de Lyon Paul Bocuse, an indoor market offering gourmet food, take a river cruise on the Rhône and Saône, and discover the secret passageways of the traboules in Vieux Lyon. Attend a performance at the Opéra de Lyon or visit the Institut Lumière for cinema history. Don't miss the Basilica of Notre-Dame de Fourvière for panoramic views, Vieux Lyon for its Renaissance architecture, Parc de la Tête d'Or with its zoo and botanical garden, the Musée des Confluences, or the bustling Place Bellecour.
For a fulfilling experience in Lyon, spending 2 to 3 days is ideal. This allows you to explore key attractions such as Vieux Lyon, Basilica of Notre-Dame de Fourvière, and the Musée des Confluences, while also enjoying the city's renowned gastronomy and vibrant cultural scene.
Yes, you can take the train from Mainz to Lyon.
Since both Mainz and Lyon are in the Schengen Area, a passport is not required for European Union (EU) or Schengen-associated country citizens. A national ID card is sufficient.
Popular day trips by train from Lyon include Annecy, Saint-Étienne, Avignon, Grenoble, Perouges.
We recommend using the train as it is the most popular way to get from Mainz to Lyon among Omio's users.
Items not allowed on trains typically include hazardous materials such as explosives, flammable liquids, corrosive substances, and illegal drugs. Additionally, large or bulky items that may obstruct aisles or emergency exits, as well as pets without proper carriers, may be restricted. Specific prohibited items can vary by train operator and region, so please check the rules for your particular journey.
France uses the euro (EUR) as its currency. Travelers generally find it convenient to use cards for most transactions, especially in cities and larger establishments, but carrying some cash is advisable for small vendors, markets, and rural areas where card acceptance may be limited.
In Lyon, travelers should be cautious of pickpocketing, especially in crowded areas like public transport, popular tourist spots, and markets. Common scams include distraction techniques and fake charity collectors. It's advisable to keep valuables secure and be wary of overly friendly strangers offering unsolicited help. Avoid unlicensed taxi services to prevent overcharging. Staying alert in busy zones ensures a safer visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular train stations
Popular train stations from Mainz to Lyon
Mainz
Lyon
The major train station for departures in Mainz is Mainz Hbf. Find all the information you need to know about services, amenities and connections at Mainz Hbf for your trip from Mainz to Lyon.
Amenities at train station
Wifi
Lockers
Shopping
Parking
Dining
ATM
Taxis
Accessibility
WC
Hotel
Lounge
Lost and Found Office
Ticket Office
Bike Parking
Bike Rental
Car Rental
Information Deskinformation
Ticket Office Hours
- Monday: 06:00 - 21:15
- Tuesday: 06:00 - 21:15
- Wednesday: 06:00 - 21:15
- Thursday: 06:00 - 21:15
- Friday: 06:00 - 21:15
- Saturday: 07:00 - 19:00
- Sunday: 08:00 - 20:00
Distance to city center
2 kmDining
- Mangal
- Asia Wok
- Bistrorante Midi
- McDonald's
Hotel
- Advena Europa Hotel
- GuestHouse Mainz
- Terminus
- Hotel Moguntia
Mainz-Marienborn
Amenities at train station
WifiLockersShoppingParkingDiningATMTaxisAccessibilityWCLoungeLost and Found OfficeTicket OfficeBike ParkingBike RentalCar RentalInformation Deskinformation
Distance to city center
4 kmDining
- Asia Snack Fu Loi
- Artos
- Pizzaria Da Raffaele
- Hikari Sushi Bar
The major train station for arrivals in Lyon is Lyon Part Dieu. Find all the information you need to know about services, amenities and connections at Lyon Part Dieu for your journey to Lyon from Mainz.
Amenities at train station
WifiLockersParkingDiningATMTaxisAccessibilityWCHotelTicket OfficeBike ParkingBike RentalCar RentalInformation Deskinformation
Ticket Office Hours
- Mon - Wed: 05:00 - 20:45
- Thu - Sat: 05:00 - 21:45
- Sun: 06:45 - 21:45
Distance to city center
1 kmWifi
- Free unlimited WiFi.
Lockers
- Luggage lockers are available daily from 06:15 to 23:15. They are located near the station's reception desk.
Dining
- Alto Café
- Paul
- Paul The Café
- Starbucks
- Exki
- Sushi Shop
- Carrefour
Accessibility
- Complimentary personalized care is available.
Hotel
- Radisson Blu Hotel Lyon
- Mercure Lyon Center
- ibis Styles Lyon Center
Ticket Office
- Mon - Wed: 05:00 - 20:45
- Thu - Sat: 05:00 - 21:45
- Sun: 06:45 - 21:45
Information Desk
- Located in the station's main hall.
Public transit options for Lyon Part Dieu
- Metro lines: A, B, C, D
- Tram lines: T4, K240, T3, K100
- Bus lines: 2960, C2, C3, C6, C9
- Train lines: TGV, TGV Lyria, TGV INOUI, OUIGO, TER, Intercités, Eurostar, AVE
Most popular train connections from Mainz
More options for your journey from Mainz to Lyon
Here are some other resources that might have the information you need
Most popular trains to and from Lyon and Mainz
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
