Mainz to Lyon train with TGV

Fri, Dec 26
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TGV
TGV INOUI
Süwex
Regionale
Deutsche Bahn
1,000+ travel companies
TGV
TGV INOUI
Süwex
Regionale
Deutsche Bahn
1,000+ travel companies
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The cheapest and fastest trains from Mainz to Lyon

Showing times and prices for Dec 29

Cheapest price

$262

Average price

$291

Fastest journey

9 h 2 m

Average duration

9 h 19 m

Trains per day

12

Distance

536 km

Cheap tickets

The best way to find a cheap train ticket from Mainz to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from Mainz to Lyon will cost around $291 if you buy it on the day, but the cheapest tickets can be found for only $262.

Fast trains

It's difficult to get from Mainz to Lyon without transferring at least 2 times.

Deutsche BahnS6 · ICE 9590+TGV INOUI9580
07:57AM12h01
Mainz Römisches Theater station
07:58PMLyon Part Dieu
$2621One-way
2 transfers
Deutsche BahnS5 · ICE 9590+TGV INOUI9580
08:26AM11h32
Mainz Römisches Theater station
07:58PMLyon Part Dieu
$2621One-way
2 transfers
Deutsche BahnS6 · ICE 9590+TGV INOUI9580
08:57AM11h01
Mainz Römisches Theater station
07:58PMLyon Part Dieu
$2621One-way
2 transfers
Deutsche Bahn29247 · ICE 573 · ICE 9590+TGV INOUI9580
08:30AM11h28
Mainz Römisches Theater station
07:58PMLyon Part Dieu
$2751One-way
3 transfers
Deutsche BahnS5 · ICE 9590+TGV INOUI5537
08:26AM9h33
Mainz Römisches Theater station
05:59PMLyon Part Dieu
$3001One-way
2 transfers

Travel Information

Compare train, bus, and flight for Mainz to Lyon

Omio recommends booking the train as it is the most popular option from Mainz to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from €26. For those with little time consider booking a flight which can get you there in 1h 25m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.5kg. The ticket price range depends on the travel mode: a bus costs an average of €26, and a flight costs an average of €73.

Distance: 333 miles (536 km)

Compare train with

Most popular
Train
Flight
Bus

€127

Average price

€165

Average price

€41

Average price

Cheapest

6h 33m

Average total duration

6h 3m

Onboard

+

30m

Additional time*

4h 25m

Average total duration

Fastest

1h 25m

Onboard

+

3h 0m

Additional time*

9h 20m

Average total duration

8h 50m

Onboard

+

30m

Additional time*

0.2 - 0.5kg

CO2 emissions

Lowest

1.6 - 3.2kg

CO2 emissions

0.5 - 1.3kg

CO2 emissions

TGV

Most popular train company

Lufthansa

Most popular airline

FlixBus

Most popular bus company

Direct Options

Direct Options

Direct Options

Additional time: Average total travel duration to departure point, security checks and transfers.

Live departures

Mainz to Lyon train times

The table below shows live departures for Mainz to Lyon trains for tomorrow, Monday, December 29. You can also manually refresh the results below to see updated train journeys.

Last updated at 3:43 PM
ProviderDepartsDurationArrivesTransfers
Tickets
deutsche_bahnS6 · ICE 9590+sncf-tgv-inoui5537
On time
6:57 AM Mainz Römisches Theater station
10h02
4:59 PM Lyon Part Dieu
2 transfers
deutsche_bahnS6 · ICE 9590+sncf-tgv-inoui12177
On time
6:57 AM Mainz Römisches Theater station
10h02
4:59 PM Lyon Part Dieu
2 transfers
deutsche_bahnS6 · ICE 9590+sncf-tgv-inoui9580
On time
6:57 AM Mainz Römisches Theater station
12h01
6:58 PM Lyon Part Dieu
2 transfers
deutsche_bahnS5 · ICE 9590+sncf-tgv-inoui5537
On time
7:26 AM Mainz Römisches Theater station
9h33
4:59 PM Lyon Part Dieu
2 transfers
deutsche_bahnS5 · ICE 9590+sncf-tgv-inoui9580
On time
7:26 AM Mainz Römisches Theater station
11h32
6:58 PM Lyon Part Dieu
2 transfers
deutsche_bahnS5 · ICE 9590+sncf-tgv-inoui12177
On time
7:26 AM Mainz Römisches Theater station
9h33
4:59 PM Lyon Part Dieu
2 transfers
deutsche_bahn29247 · ICE 573 · ICE 9590+sncf-tgv-inoui9580
On time
7:30 AM Mainz Römisches Theater station
11h28
6:58 PM Lyon Part Dieu
3 transfers
deutsche_bahn29247 · ICE 573 · ICE 9590+sncf-tgv-inoui12177
On time
7:30 AM Mainz Römisches Theater station
9h29
4:59 PM Lyon Part Dieu
3 transfers
deutsche_bahn29247 · ICE 573 · ICE 9590+sncf-tgv-inoui5537
On time
7:30 AM Mainz Römisches Theater station
9h29
4:59 PM Lyon Part Dieu
3 transfers
deutsche_bahnS6 · ICE 9590+sncf-tgv-inoui12177
On time
7:57 AM Mainz Römisches Theater station
9h02
4:59 PM Lyon Part Dieu
2 transfers
deutsche_bahnS6 · ICE 9590+sncf-tgv-inoui9580
On time
7:57 AM Mainz Römisches Theater station
11h01
6:58 PM Lyon Part Dieu
2 transfers
deutsche_bahnS6 · ICE 9590+sncf-tgv-inoui5537
On time
7:57 AM Mainz Römisches Theater station
9h02
4:59 PM Lyon Part Dieu
2 transfers

This is the last train of the day.

Find all the dates and times for this journey

Compare prices and tickets Mainz to Lyon by train, bus, or flight

Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Mon
Dec 29
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Jan 01
Fri
Jan 02
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Jan 04

Why should you book Mainz to Lyon trains with Omio?

TGV as well as TGV INOUI and Süwex offer trains services from Mainz to Lyon. Omio is an official ticket reseller for all your travel options from Mainz to Lyon.

Why book with Omio vs TGV?

  • Compare with other providers: On Omio, you can not only buy tickets for TGV, but also compare tickets for the likes of TGV INOUI and Süwex to find the best option for your trip from Mainz to Lyon.
  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare TGV with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Mainz to Lyon.

Why book with Omio over Trainline and Rail Europe?

Multiple modes of transport
  • Multiple travel company options: While TGV tickets can be bought on TGV's website or third party sellers, Omio allows you to compare with the likes of TGV INOUI and Süwex to help you choose the right option for your journey from Mainz to Lyon.
  • Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Mainz to Lyon.

Journey information

Overview: Train from Mainz to Lyon

GermanyGermany
FranceFrance
Icon of train

Trains from Mainz to Lyon run on average 3 times per day, taking around 6h 3m. Cheap train tickets for this journey start at $93 (€74) but you can travel from only $33 (€26) by bus.

There are 1 trains per day. The earliest train runs at 03:15, the last at 22:25. The fastest train covers the 333 miles (536 km) distance in 5h 17m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $33 (€26)
Distance
333 miles (536 km)
Average train duration
6h 3m
Cheapest ticket price
$93 (€74)
Trains per day
3
Direct trains
1
Fastest train
5h 17m
First train
03:15
Last train
22:25
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $33 (€26)

Train companies: TGV, TGV INOUI, Süwex from Mainz to Lyon trainsTGV, TGV INOUI, Süwex trains will get you between Mainz and Lyon from $33 (€26). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.

TGV

About
TGV is a high-speed train company based in France. It operates a fleet of modern trains that can reach speeds of up to 320 km/h. The TGV offers a variety of train types, including the TGV Duplex, TGV Lyria, TGV InOui, and TGV OuiGo. Each train type provides different amenities, such as Wi-Fi, power outlets, and comfortable seating. Ticket options include Standard, Flexi, and Prem’s. Onboard facilities feature a bar, restaurant, and luggage storage. Popular TGV routes include Paris to Lyon, Paris to Marseille, and Paris to Lille.
Luggage & cancellation policy
TGV frequency
1 a day
Luggage included
2 pieces of hand luggage and 1 suitcase included in ticket price
Luggage storage
Dedicated luggage areas at end of carriages and overhead racks
Cancellation Policy
According to fare conditions and ticket type
Refund
Full refund provided for canceled trains
Amenities on board the train
Wifi
Food sold onboard
Restaurant car with full meals and bar service, at-seat dining in first class
Seat reservation
Included in first class, optional fee in second class
Toilets
USB plugs
Accessibility
Wheelchair spaces, accessible toilets, and assistance service available
Pets
Small pets in carriers travel free, larger dogs require paid ticket, guide dogs travel free
Quiet zone

TGV INOUI

About
SNCF's TGV INOUI is a premium high-speed train service operating across France and to other European cities. Launched in 2017, it aims to provide an enhanced travel experience with greater comfort, connectivity, and services compared to traditional TGV services. TGV INOUI trains offer features like adjustable seats, electrical outlets, fold-down tables, and dedicated luggage spaces. Passengers can enjoy onboard Wi-Fi and access to the TGV INOUI portal for entertainment and journey information. The service also includes a "Bistro TGV INOUI" for dining, with options for online ordering. SNCF is also introducing a new generation of TGV INOUI trains from 2026, which will be more modular, energy-efficient, and 97% recyclable.
Luggage & cancellation policy
Average Duration
5h 17m
Cheapest Price
$97 (€77)
TGV INOUI frequency
1 a day
Luggage included
1 hand luggage + 2 pieces of luggage free of charge
Luggage storage
Overhead racks, end of carriages, between seats
Cancellation Policy
Refund conditions depend on ticket type
Refund
Full refund if train canceled
Amenities on board the train
Wifi
Food sold onboard
Restaurant car (not all trains), at-seat service in 1st class, snack bar/cafe
Seat reservation
Second class: Optional, additional fee. First class: Included in ticket price
Toilets
USB plugs
Accessibility
Wheelchair spaces, accessible toilets, boarding assistance available
Pets
Small pets in carriers: Free. Large dogs: Paid ticket required. Guide dogs: Free
Quiet zone

Süwex

Luggage & cancellation policy
Average Duration
6h 39m
Cheapest Price
$124 (€99)
Süwex frequency
1 a day

FAQs: Trains from Mainz to Lyon

Find answers to the most common questions about traveling from Mainz to Lyon by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

FAQs
Yes, there is a high-speed train from Mainz to Lyon.
For a fulfilling experience in Lyon, spending 2 to 3 days is ideal. This allows you to explore key attractions such as Vieux Lyon, Basilica of Notre-Dame de Fourvière, and the Musée des Confluences, while also enjoying the city's renowned gastronomy and vibrant cultural scene.
The distance by train from Mainz to Lyon is 333 miles (536 km).
In Lyon, you can explore Les Halles de Lyon Paul Bocuse, an indoor market offering gourmet food, take a river cruise on the Rhône and Saône, and discover the secret passageways of the traboules in Vieux Lyon. Attend a performance at the Opéra de Lyon or visit the Institut Lumière for cinema history. Don't miss the Basilica of Notre-Dame de Fourvière for panoramic views, Vieux Lyon for its Renaissance architecture, Parc de la Tête d'Or with its zoo and botanical garden, the Musée des Confluences, or the bustling Place Bellecour.
Yes, you can take the train from Mainz to Lyon.
The first train from Mainz to Lyon leaves at 3:15 AM.
A day trip from Mainz to Lyon is not feasible as the journey takes 5h 17m. Trains operate 3 times per day. The distance is 333 miles (536 km).
Yes, there is a direct train from Mainz to Lyon. This service operates 1 times per day, provided by TGV INOUI.
The last train from Mainz to Lyon leaves at 10:25 PM.
The train journey from Mainz to Lyon offers scenic views, particularly as it passes through the Rhine Valley with its charming vineyards and historic castles, and continues through the picturesque landscapes of eastern France.
Train ticket prices from Mainz to Lyon can vary. The cheapest ticket starts at $93 (€74), while the average price is around $159 (€127).
The cheapest way to get from Mainz to Lyon is by bus, with a cost of around $33 (€26).
The train from Mainz to Lyon takes 5h 17m and runs 3 per day.
The train station in Mainz that goes to Lyon is Frankfurt (Main) Hbf, which connects to Lyon Part Dieu.
Unfortunately, there is no night train available from Mainz to Lyon.

popular train stations

Popular train stations from Mainz to Lyon

Mainz
Lyon
The major train station for departures in Mainz is Mainz Hbf. Find all the information you need to know about services, amenities and connections at Mainz Hbf for your trip from Mainz to Lyon.
Amenities at train station
WifiWifi
LockersLockers
ShoppingShopping
ParkingParking
DiningDining
ATMATM
TaxisTaxis
AccessibilityAccessibility
WCWC
HotelHotel
LoungeLounge
Lost and Found OfficeLost and Found Office
Ticket OfficeTicket Office
Bike ParkingBike Parking
Bike RentalBike Rental
Car RentalCar Rental
Information DeskInformation Desk
information
ticketOfficeHours
Ticket Office Hours
  • Monday: 06:00 - 21:15
  • Tuesday: 06:00 - 21:15
  • Wednesday: 06:00 - 21:15
  • Thursday: 06:00 - 21:15
  • Friday: 06:00 - 21:15
  • Saturday: 07:00 - 19:00
  • Sunday: 08:00 - 20:00
ticketOfficeHours
Distance to city center
2 km
Dining
Dining
  • Mangal
  • Asia Wok
  • Bistrorante Midi
  • McDonald's
Hotel
Hotel
  • Advena Europa Hotel
  • GuestHouse Mainz
  • Terminus
  • Hotel Moguntia

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