The cheapest and fastest trains from Mainz to Lyon
Cheapest price
$244
Average price
$275
Fastest journey
9 h 2 m
Average duration
9 h 26 m
Trains per day
9
Distance
536 km
The best way to find a cheap train ticket from Mainz to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Mainz to Lyon will cost around $275 if you buy it on the day, but the cheapest tickets can be found for only $244.
It's difficult to get from Mainz to Lyon without transferring at least 2 times.
S5 · ICE 9590+
553708:26AM9h33Mainz Römisches Theater station05:59PMLyon Part Dieu$2441One-way2 transfers
S6 · ICE 9590+
553707:57AM10h02Mainz Römisches Theater station05:59PMLyon Part Dieu$2441One-way2 transfers
S6 · ICE 9590+
1217707:57AM10h02Mainz Römisches Theater station05:59PMLyon Part Dieu$2441One-way2 transfers
S6 · ICE 9590+
1217708:57AM9h02Mainz Römisches Theater station05:59PMLyon Part Dieu$2441One-way2 transfers
S5 · ICE 9590+
1217708:26AM9h33Mainz Römisches Theater station05:59PMLyon Part Dieu$2441One-way2 transfers
S6 · ICE 9590+
1217708:57AM9h02Mainz Römisches Theater station05:59PMLyon Part Dieu$2441One-way2 transfers
S6 · ICE 9590+
553708:57AM9h02Mainz Römisches Theater station05:59PMLyon Part Dieu$2441One-way2 transfers
S5 · ICE 9590+
553708:26AM9h33Mainz Römisches Theater station05:59PMLyon Part Dieu$2441One-way2 transfers
S5 · ICE 9590+
1217708:26AM9h33Mainz Römisches Theater station05:59PMLyon Part Dieu$2441One-way2 transfers
S6 · ICE 9590+
553707:57AM10h02Mainz Römisches Theater station05:59PMLyon Part Dieu$2441One-way2 transfers
Travel Information
Compare train, bus, and flight for Mainz to Lyon
Omio recommends booking the train as it is the most popular option from Mainz to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $42. For those with little time consider booking a flight which can get you there in 1h 34m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.5kg. The ticket price range depends on the travel mode: a bus costs an average of $42, and a flight costs an average of $134.
Distance: 333 miles (536 km)
Compare train with
Most popular Train | Flight | Bus |
|---|---|---|
$120 Average price | $281 Average price | $67 Average price Cheapest |
6h 32m Average total duration 6h 2m Onboard + 30m Additional time* | 4h 34m Average total duration Fastest 1h 34m Onboard + 3h 0m Additional time* | 10h 40m Average total duration 10h 10m Onboard + 30m Additional time* |
0.2 - 0.5kg CO2 emissions Lowest | 1.6 - 3.2kg CO2 emissions | 0.5 - 1.3kg CO2 emissions |
![]() Most popular train company | ![]() Most popular airline | ![]() Most popular bus company |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Live departures
Mainz to Lyon train times
The table below shows live departures for Mainz to Lyon trains for tomorrow, Sunday, March 29. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
S6 · ICE 9590+ 5537 | On time 5:57 AM Mainz Römisches Theater station | 10h02 | 3:59 PM Lyon Part Dieu | 2 transfers | |
S6 · ICE 9590+ 12177 | On time 5:57 AM Mainz Römisches Theater station | 10h02 | 3:59 PM Lyon Part Dieu | 2 transfers | |
S6 · ICE 9590+ 9580 | On time 5:57 AM Mainz Römisches Theater station | 12h01 | 5:58 PM Lyon Part Dieu | 2 transfers | |
S5 · ICE 9590+ 5537 | On time 6:26 AM Mainz Römisches Theater station | 9h33 | 3:59 PM Lyon Part Dieu | 2 transfers | |
S5 · ICE 9590+ 9580 | On time 6:26 AM Mainz Römisches Theater station | 11h32 | 5:58 PM Lyon Part Dieu | 2 transfers | |
S5 · ICE 9590+ 12177 | On time 6:26 AM Mainz Römisches Theater station | 9h33 | 3:59 PM Lyon Part Dieu | 2 transfers | |
S6 · ICE 9590+ 12177 | On time 6:57 AM Mainz Römisches Theater station | 9h02 | 3:59 PM Lyon Part Dieu | 2 transfers | |
S6 · ICE 9590+ 9580 | On time 6:57 AM Mainz Römisches Theater station | 11h01 | 5:58 PM Lyon Part Dieu | 2 transfers | |
S6 · ICE 9590+ 5537 | On time 6:57 AM Mainz Römisches Theater station | 9h02 | 3:59 PM Lyon Part Dieu | 2 transfers | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Mainz to Lyon by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 30
Mar 31
Apr 01
Apr 02
Apr 03
Apr 04
Apr 05
Journey information
Overview: Train from Mainz to Lyon
Trains from Mainz to Lyon run on average 3 times per day, taking around 6h 2m. Cheap train tickets for this journey start at $120 (€98) but you can travel from only $42 (€34) by bus.
There are 1 trains per day. The earliest train runs at 00:04, the last at 16:04. The fastest train covers the 333 miles (536 km) distance in 6h 39m.
Distance 333 miles (536 km) |
Average train duration 6h 2m |
Cheapest ticket price $120 (€98) |
Trains per day 3 |
Direct trains 1 |
Fastest train 6h 39m |
First train 00:04 |
Last train 16:04 |
Train companies: TGV, TGV INOUI, Süwex from Mainz to Lyon trainsTGV, TGV INOUI, Süwex trains will get you between Mainz and Lyon from $42 (€34). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
TGV
TGV INOUI
Süwex
FAQs: Trains from Mainz to Lyon
Find answers to the most common questions about traveling from Mainz to Lyon by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Mainz to Lyon
- Monday: 06:00 - 21:15
- Tuesday: 06:00 - 21:15
- Wednesday: 06:00 - 21:15
- Thursday: 06:00 - 21:15
- Friday: 06:00 - 21:15
- Saturday: 07:00 - 19:00
- Sunday: 08:00 - 20:00
- Mangal
- Asia Wok
- Bistrorante Midi
- McDonald's
- Advena Europa Hotel
- GuestHouse Mainz
- Terminus
- Hotel Moguntia
- Asia Snack Fu Loi
- Artos
- Pizzaria Da Raffaele
- Hikari Sushi Bar
- Mon - Wed: 05:00 - 20:45
- Thu - Sat: 05:00 - 21:45
- Sun: 06:45 - 21:45
- Free unlimited WiFi.
- Luggage lockers are available daily from 06:15 to 23:15. They are located near the station's reception desk.
- Alto Café
- Paul
- Paul The Café
- Starbucks
- Exki
- Sushi Shop
- Carrefour
- Complimentary personalized care is available.
- Radisson Blu Hotel Lyon
- Mercure Lyon Center
- ibis Styles Lyon Center
- Mon - Wed: 05:00 - 20:45
- Thu - Sat: 05:00 - 21:45
- Sun: 06:45 - 21:45
- Located in the station's main hall.
- Metro lines: A, B, C, D
- Tram lines: T4, K240, T3, K100
- Bus lines: 2960, C2, C3, C6, C9
- Train lines: TGV, TGV Lyria, TGV INOUI, OUIGO, TER, Intercités, Eurostar, AVE
Most popular train connections from Mainz
More options for your journey from Mainz to Lyon
Here are some other resources that might have the information you need



