- Must visit
National Museum
Major museum of Czech history and natural sciences in a monumental Neo-Renaissance building overlooking Wenceslas Square.
Cheapest price
€32
Average price
€33
Fastest journey
6 h 48 m
Average duration
7 h 48 m
Buses per day
3
Distance
439 km
The best way to find a cheap bus ticket from Mainz to Prague is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Mainz to Prague will cost around €33 if you buy it on the day, but the cheapest tickets can be found for only €32.
Of the 3 buses that leave Mainz for Prague on Wed, Aug 05, 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Aug 05 the direct buses cover the 439 km distance in an average of 7 h 48 m but if you time it right, some buses will get you there in just 6 h 48 m .
On Wed, Aug 05 the slowest buses will take 8 h 25 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus
FlixBus
(Amsterdam -> Prague)
(Amsterdam -> Prague)
FlixBus
FlixBusOmio recommends booking the train as it is the most popular option from Mainz to Prague among Omio's users. If you are prioritising price take the bus with prices starting from €26. For those with little time consider booking a flight which can get you there in 1h 29m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.4kg. The ticket price range depends on the travel mode: a bus costs an average of €26, and a flight costs an average of €76.
Distance: 272 miles (439 km)
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
€38 Average price Cheapest | €104 Average price | €173 Average price | €96 Average price (fuel + tolls) |
7h 35m Average total duration 7h 5m Onboard + 30m Additional time* | 9h 5m Average total duration 8h 35m Onboard + 30m Additional time* | 4h 29m Average total duration Fastest 1h 29m Onboard + 3h 0m Additional time* | 5h 50m Average total duration (door-to-door) |
0.4 - 1.1kg CO2 emissions | 0.1 - 0.4kg CO2 emissions Lowest | 1.3 - 2.6kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Mainz to Prague:
A bus is €67 less than a train for this route with tickets for a train from Mainz to Prague costing on average €104.
A bus is €136 less than a flight for this route with tickets for a flight from Mainz to Prague costing on average €173.
Other travel options to Prague take longer:
Bus takes on average 7h 5m.
Train takes on average 8h 35m.
Tickets start at around €38 compared to roughly €96 in fuel and tolls — a saving of about €59. The journey takes 7h 5m versus 5h 50m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus, BlaBlaCar.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 04:15AM | Arrival Time 03:00PM | Duration 10h45 | Departure days Thu | Cheapest price €48 |
Operator BlaBlaCar | Departure Time 09:00AM | Arrival Time 02:50PM | Duration 5h50 | Departure days Tue | Cheapest price €38 |
Operator BlaBlaCar | Departure Time 11:40AM | Arrival Time 05:40PM | Duration 6h00 | Departure days Sat | Cheapest price €41 |
Operator FlixBus | Departure Time 02:00PM | Arrival Time 10:05PM | Duration 8h05 | Departure days Thu, Sun | Cheapest price €37 |
Operator BlaBlaCar | Departure Time 02:10PM | Arrival Time 08:00PM | Duration 5h50 | Departure days Tue | Cheapest price €51 |
Operator FlixBus | Departure Time 03:00PM | Arrival Time 11:05PM | Duration 8h05 | Departure days Sun | Cheapest price €37 |
Operator FlixBus | Departure Time 04:20PM | Arrival Time 12:30AM | Duration 8h10 | Departure days Tue, Wed, Fri, Sat | Cheapest price €32 |
Operator FlixBus | Departure Time 06:00PM | Arrival Time 09:30AM | Duration 15h30 | Departure days Thu | Cheapest price €156 |
Operator RegioJet a.s. | Departure Time 10:00PM | Arrival Time 04:48AM | Duration 6h48 | Departure days Tue, Wed, Fri, Sat | Cheapest price €35 |
Operator FlixBus | Departure Time 10:30PM | Arrival Time 09:40AM | Duration 11h10 | Departure days Tue, Fri, Sat | Cheapest price €49 |
Operator BlaBlaCar | Departure Time 11:30PM | Arrival Time 05:40AM | Duration 6h10 | Departure days Sat | Cheapest price €53 |
The table below shows live departures for Mainz to Prague buses for today, Tuesday, August 4. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus | 4:20 PM Mainz, Binger Schlag (Kurzzeitparkplatz) | 8h25 | 12:45 AM Prague, Central Train Station | 0 transfersDirect | |
FlixBus | 4:20 PM Mainz, Binger Schlag (Kurzzeitparkplatz) | 8h10 | 12:30 AM Praha, Na Knížecí | 0 transfersDirect | |
(Amsterdam -> Prague) | 10:00 PM Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) | 6h48 | 4:48 AM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus · FlixBus | 10:30 PM Mainz, Binger Schlag (Kurzzeitparkplatz) | 11h40 | 10:10 AM Praha, ÚAN Florenc | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Mainz to Prague run on average 6 times per day, taking around 7h 5m. Cheap bus tickets for this journey start at €26 if you book in advance.
There are 3 buses per day. The earliest bus runs at 03:50, the last at 23:50. The fastest bus covers the 272 miles (439 km) distance in 6h 45m.
Distance 272 miles (439 km) |
Average bus duration 7h 5m |
Cheapest ticket price €26 |
Buses per day 6 |
Direct buses 3 |
Fastest bus 6h 45m |
First bus 3:50 AM |
Last bus 11:50 PM |
Cheapest Month May |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Sat |
Least Busy Day Mon |
Best time to book 21 days |
Discover the best of Prague — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Prague trip today.
Major museum of Czech history and natural sciences in a monumental Neo-Renaissance building overlooking Wenceslas Square.
Well-curated Jewish history museum across several historic sites. Important for understanding Prague's Jewish heritage and resilience.
Leading Czech art museum with medieval to modern works in a grand historic palace. Essential for fine art and decorative arts lovers.
Historic square at Prague's core, surrounded by Gothic and Baroque landmarks. A must for first-time visitors and classic city views.
Lively boulevard of Czech modern history, lined with shops and major buildings. Worth visiting for atmosphere and historic significance.
Romantic quarter of palaces, lanes, and church domes beneath Prague Castle. Ideal for wandering, photography, and quieter historic charm.
Slow-braised beef in a creamy root-vegetable sauce, usually served with bread dumplings. A classic Czech Sunday dish strongly linked to Bohemian home cooking.
Crisp roasted pork knuckle, often served with mustard, horseradish, and pickles. A hearty pub staple popular with Czech beer culture.
Roast pork with sauerkraut and dumplings. This iconic Czech combination is a cornerstone of traditional pub and family meals.
Traditional Czech restaurant and brewery by Prague Castle, praised for roast meats, dumplings, and polished historic interiors.
Upscale restaurant focused on Czech ingredients and game, with sophisticated service in an Art Nouveau municipal house setting.
Elegant Michelin-starred restaurant known for modern Czech tasting menus in a refined setting near the Vltava.
Moderate for Europe: transit is cheap, casual meals are reasonable, and hotels in the center can raise daily costs in peak season.
Service is often not included. Tip about 5-10% in restaurants, round up for cafes, and round up or add about 10% for taxis if service is good.
Official public transport app
Prague Central Train Station -> Wenceslas Square
Find answers to the most common questions about traveling from Mainz to Prague by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Prague, this guide helps you travel smarter and with confidence.

Most Mainz to Prague buses use the Mainz, Binger Schlag (Kurzzeitparkplatz) to Praha, Hlavní Nádraží station pair, with some services arriving at Praha, ÚAN Florenc. Use this guide to compare Mainz and Prague bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Praha, ÚAN Florenc is 1 km from Prague city centre. Public transport options include:
Praha, ÚAN Florenc has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Florenc (in the station), Bistro Florenc (0.2 km), Restaurace U Rozvařilů (0.5 km).
Free Wi-Fi. ATMs are located inside the station, offering multiple currency options.
Ticket office support is available at Praha, ÚAN Florenc.
Available at Praha, ÚAN Florenc: Parking, Taxis, WC.
Accessibility facilities are available at Praha, ÚAN Florenc: Elevators, ramps.
Praha, Hlavní Nádraží is 1 km from Prague city centre. Public transport options include:
Praha, Hlavní Nádraží has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Czech Bistro (in the station), Fast Food Express (in the station), Bohemian Café (0.2 km).
Free Wi-Fi. ATMs are located near the main entrance and ticketing area.
Ticket office support is available at Praha, Hlavní Nádraží.
Available at Praha, Hlavní Nádraží: Parking, Taxis, WC.
Accessibility facilities are available at Praha, Hlavní Nádraží: Elevators, ramps.
Praha, Na Knížecí is 2 km from Prague city centre. Public transport options include:
Praha, Na Knížecí has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, and WC.
Food options include: Café Na Knížecí (in the station), Bistro Praha (0.2 km), Restaurace U Knížete (0.5 km).
Free Wi-Fi. ATMs are located near the entrance.
Available at Praha, Na Knížecí: Parking, Taxis, WC.
Accessibility facilities are available at Praha, Na Knížecí: Elevators, ramps.
Here are some other resources that might have the information you need