- Must visit
National Museum
Prague’s flagship museum on Wenceslas Square, with major natural history, history, and cultural collections in a monumental Neo-Renaissance building.
Cheapest price
$48
Average price
$141
Fastest journey
8 h 26 m
Average duration
8 h 33 m
Trains per day
26
Distance
553 km
The best way to find a cheap train ticket from Düsseldorf to Prague is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Düsseldorf to Prague will cost around $141 if you buy it on the day, but the cheapest tickets can be found for only $48.
It's difficult to get from Düsseldorf to Prague without transferring at least once.
FlixTrain+
FlixBus
FlixTrain+
FlixBus
ICE 641 · rj 179
FlixTrain+
FlixBus
FlixTrain+
FlixBus
ICE 547 · RJ 177
ICE 543 · rj 175
ICE 549 · ECE 385
ICE 549 · rj 385
ICE 545 · rj 383Omio recommends booking the train as it is the most popular option from Düsseldorf to Prague among Omio's users. If you are prioritising price take the bus with prices starting from $37. For those with little time consider booking a flight which can get you there in 2h 7m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.5kg. The ticket price range depends on the travel mode: a bus costs an average of $37, and a flight costs an average of $76.
Distance: 343 miles (553 km)
Most popular Train | Flight | Bus | Driving |
|---|---|---|---|
$93 Average price | $229 Average price | $58 Average price Cheapest | $144 Average price (fuel + tolls) |
9h 45m Average total duration 9h 15m Onboard + 30m Additional time* | 5h 7m Average total duration Fastest 2h 7m Onboard + 3h 0m Additional time* | 10h 36m Average total duration 10h 6m Onboard + 30m Additional time* | 7h 48m Average total duration (door-to-door) |
0.2 - 0.5kg CO2 emissions Lowest | 1.7 - 3.3kg CO2 emissions | 0.6 - 1.4kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular airline | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Düsseldorf to Prague:
A bus is $35 (€28) less than a train for this route with tickets for a train from Düsseldorf to Prague costing on average $93 (€75).
A bus is $171 (€139) less than a flight for this route with tickets for a flight from Düsseldorf to Prague costing on average $229 (€186).
Other travel options to Prague take longer:
Train takes on average 9h 15m.
Bus takes on average 10h 6m.
Tickets start at around $93 (€75) compared to roughly $144 (€117) in fuel and tolls — a saving of about $51 (€42). The journey takes 9h 15m versus 7h 48m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
The table below shows live departures for Düsseldorf to Prague trains for today, Tuesday, June 9. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
ICE 921 · ICE 827 · 3557+ 353 | Delayed 12:39 AM 2:39 AMDüsseldorf Hbf | 9h42 | 12:21 PM Prague hlavní nádraží | 3 transfers | |
ICE 921 · ICE 827 · R 3557 · EC 353 | Delayed 12:39 AM 2:39 AMDüsseldorf Hbf | 9h42 | 12:21 PM Prague hlavní nádraží | 3 transfers | |
ICE 1543 · rj 175 | On time 6:13 AM Düsseldorf Hbf | 9h02 | 3:15 PM Prague-Holešovice | 1 transfer | |
ICE 543 · rj 175 | On time 6:48 AM Düsseldorf Hbf | 8h27 | 3:15 PM Prague-Holešovice | 1 transfer | |
ICE 543 · RJ 175 | On time 6:48 AM Düsseldorf Hbf | 8h26 | 3:14 PM Prague-Holešovice | 1 transfer | |
ICE 527 · R 3565 · EC 357 | On time 7:22 AM Düsseldorf Hbf | 8h59 | 4:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 527 · 3565+ 357 | On time 7:22 AM Düsseldorf Hbf | 8h59 | 4:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 513 · ICE 1557 · S 31739 · Os 28008 | On time 7:26 AM Düsseldorf Hbf | 9h44 | 5:10 PM Prague hlavní nádraží | 4 transfers | |
FlixTrain+ FlixBus | 8:38 AM Düsseldorf Hbf | 11h02 | 7:40 PM Praha, ÚAN Florenc | 1 transfer | |
FlixTrain+ FlixBus | 8:38 AM Düsseldorf Hbf | 11h22 | 8:00 PM Prague, Central Train Station | 1 transfer | |
ICE 545 · rj 383 | On time 8:48 AM Düsseldorf Hbf | 8h37 | 5:25 PM Prague hlavní nádraží | 1 transfer | |
ICE 621 · 3569+ 359 | On time 9:22 AM Düsseldorf Hbf | 8h59 | 6:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 621 · R 3569 · EC 359 | On time 9:22 AM Düsseldorf Hbf | 8h59 | 6:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 219 · ICE 759 · S1 · 28010 | On time 9:32 AM Düsseldorf Hbf | 9h38 | 7:10 PM Prague hlavní nádraží | 4 transfers | |
ICE 219 · ICE 759 · S 31747 · Os 28010 | On time 9:32 AM Düsseldorf Hbf | 9h38 | 7:10 PM Prague hlavní nádraží | 4 transfers | |
ICE 547 · rj 177 | On time 10:48 AM Düsseldorf Hbf | 8h27 | 7:15 PM Prague-Holešovice | 1 transfer | |
ICE 547 · RJ 177 | On time 10:48 AM Düsseldorf Hbf | 8h26 | 7:14 PM Prague-Holešovice | 1 transfer | |
ICE 625 · 3573+ 361 | On time 11:19 AM Düsseldorf Hbf | 9h02 | 8:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 625 · R 3573 · EC 361 | On time 11:19 AM Düsseldorf Hbf | 9h02 | 8:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 517 · ICE 1651 · S 31755 · Os 28012 | On time 11:26 AM Düsseldorf Hbf | 9h44 | 9:10 PM Prague hlavní nádraží | 4 transfers | |
ICE 1053 · rj 385 | On time 12:06 PM Düsseldorf Hbf | 9h19 | 9:25 PM Prague hlavní nádraží | 1 transfer | |
ICE 549 · rj 385 | On time 12:48 PM Düsseldorf Hbf | 8h37 | 9:25 PM Prague hlavní nádraží | 1 transfer | |
ICE 549 · RJ 393 | On time 12:48 PM Düsseldorf Hbf | 8h37 | 9:25 PM Prague hlavní nádraží | 1 transfer | |
ICE 549 · RJ 385 | On time 12:48 PM Düsseldorf Hbf | 8h37 | 9:25 PM Prague hlavní nádraží | 1 transfer | |
ICE 629 · 3577+ 363 | On time 1:22 PM Düsseldorf Hbf | 9h00 | 10:22 PM Prague hlavní nádraží | 2 transfers | |
ICE 629 · R 3597 · EC 363 | On time 1:22 PM Düsseldorf Hbf | 9h00 | 10:22 PM Prague hlavní nádraží | 2 transfers | |
ICE 641 · rj 179 | On time 2:48 PM Düsseldorf Hbf | 8h43 | 11:31 PM Prague hlavní nádraží | 1 transfer | |
ICE 641 · RJ 179 | On time 2:48 PM Düsseldorf Hbf | 8h43 | 11:31 PM Prague hlavní nádraží | 1 transfer | |
ICE 611 · ICE 1655 · NJ 457 | On time 3:26 PM Düsseldorf Hbf | 9h00 | 12:26 AM Prague hlavní nádraží | 2 transfers | |
ICE 943 · IC 2045 · S1 · 28023 | On time 3:50 PM Düsseldorf Hbf | 14h20 | 6:10 AM Prague hlavní nádraží | 4 transfers | |
ICE 725 · ICE 594 · IC 2045 · S1 | On time 4:22 PM Düsseldorf Hbf | 13h48 | 6:10 AM Prague hlavní nádraží | 5 transfers | |
FlixTrain+ FlixBus | 4:38 PM Düsseldorf Hbf | 11h02 | 3:40 AM Prague, Central Train Station | 1 transfer | |
FlixTrain+ FlixBus | 4:38 PM Düsseldorf Hbf | 10h52 | 3:30 AM Praha, ÚAN Florenc | 1 transfer | |
ICE 947 · RJ 479 | On time 7:50 PM Düsseldorf Hbf | 9h35 | 5:25 AM Prague hlavní nádraží | 1 transfer | |
ICE 823 · ICE 590 · 16501 · S1 | On time 8:09 PM Düsseldorf Hbf | 13h01 | 9:10 AM Prague hlavní nádraží | 5 transfers | |
S 30107 · ICE 541 · rj 173 | On time 3:37 AM Düsseldorf Hbf | 9h48 | 1:25 PM Prague hlavní nádraží | 2 transfers | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Düsseldorf to Prague run on average 14 times per day, taking around 9h 15m. Cheap train tickets for this journey start at $51 (€41) but you can travel from only $37 (€30) by bus.
The earliest train runs at 00:10, the last at 23:54. The fastest train covers the 343 miles (553 km) distance in 8h 27m.
Distance 343 miles (553 km) |
Average train duration 9h 15m |
Cheapest ticket price $51 (€41) |
Trains per day 14 |
Fastest train 8h 27m |
First train 12:10 AM |
Last train 11:54 PM |
Cheapest Month Jul |
Cheapest Day Sat |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Thu |
Least Busy Day Mon |
Best time to book 56 days |
Discover the best of Prague — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Prague trip today.
Prague’s flagship museum on Wenceslas Square, with major natural history, history, and cultural collections in a monumental Neo-Renaissance building.
A major museum complex preserving Prague’s Jewish heritage through synagogues, ceremonial objects, archives, and cemetery access.
A leading contemporary art venue in Holešovice known for ambitious exhibitions, design, and the striking Gulliver airship installation.
Prague’s historic central square, surrounded by major landmarks and lively at all hours, making it an essential first stop.
A picturesque district of Baroque streets, embassies, gardens, and hidden corners beneath Prague Castle, ideal for walking and photography.
A broad boulevard-like square central to modern Czech history, shopping, and city life, anchored by the National Museum.
Marinated beef sirloin with creamy root-vegetable sauce, bread dumplings, cranberry sauce, and whipped cream. One of the most classic Czech celebratory dishes.
Roast pork served with bread dumplings and braised cabbage. A cornerstone of traditional Czech home cooking and pub menus.
Czech-style goulash, usually beef, slower-cooked and less soupy than the Hungarian version, commonly served with dumplings. A staple in Prague pubs.
Michelin-starred restaurant offering contemporary Czech fine dining with seasonal ingredients and a sophisticated atmosphere.
Well-known restaurant near Old Town Square offering refined Czech classics in a polished but approachable setting.
Elegant grand cafe and restaurant known for excellent breakfasts, pastries, and upscale Czech and Central European dishes.
Moderate by European standards. Beer, transit, and casual meals are affordable; central hotels cost more.
Around 10% in restaurants for good service, often rounded up. Tip taxis modestly by rounding up. Not expected for counter service, but appreciated.
Official public transport app
Prague hlavní nádraží -> Old Town Square, Prague
The train connection between Düsseldorf and Prague offers a convenient way to travel between these two cities. Passengers can choose from several providers, including Deutsche Bahn, FlixTrain, and alex-Länderbahn und Vogtlandbahn-GmbH. With comfortable seating and scenic views along the route, this journey is an excellent option for those looking to explore both destinations without the hassle of driving or flying.
The train connection from Düsseldorf to Prague takes approximately 8 hours and 59 minutes, with a total of 6 connections available per day. This route is not direct, requiring at least one transfer during the journey. The average layover time between trains is about 1 hour and 10 minutes.
The first daily train journey from Düsseldorf to Prague departs at 07:18, providing an early start for travelers eager to explore the beautiful city of Prague. The last departure is scheduled for 21:52, allowing those who wish to enjoy a full day in Düsseldorf before heading out in the evening.
The cheapest ticket price for the train connection from Düsseldorf to Prague is €14. The average ticket price typically hovers around €50, making it a budget-friendly option for travelers looking to explore these vibrant cities.
Prague Castle, dating back to the 9th century, is not only one of the largest ancient castles in the world but also a symbol of Czech history and culture. Its stunning architecture showcases various styles from Gothic to Baroque, with highlights including St. Vitus Cathedral and the picturesque Golden Lane that transport you through centuries of royal heritage. As we explore its vast grounds, you'll feel like you've stepped into a fairy tale where every corner tells a story.
The Charles Bridge, completed in 1402 and adorned with 30 statues of saints, has been an iconic connection between Prague's Old Town and Lesser Town for over six centuries. This cobblestone marvel offers breathtaking views along the Vltava River while serving as a vibrant hub for artists and musicians who bring life to this historic thoroughfare. Walking across it feels like traversing time itself—each step echoing tales from medieval merchants to modern-day lovers.
Old Town Square is truly the heart of Prague; it's where history comes alive amidst colorful baroque buildings and bustling cafes that have witnessed countless events since its establishment in the 12th century. The square features remarkable landmarks such as the Astronomical Clock—a masterpiece that draws crowds every hour—and Týn Church with its striking spires dominating skyline views. Here at Old Town Square, you can immerse yourself in local traditions while savoring delicious pastries or simply soaking up an atmosphere rich with stories waiting to be discovered.
Find answers to the most common questions about traveling from Düsseldorf to Prague by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Prague, this guide helps you travel smarter and with confidence.

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