- Recommended
Park Circle Gallery
Contemporary visual arts center with rotating exhibitions, artist talks, and community programs inside Firefly Distillery's campus.
The best way to find a cheap bus ticket from St. Louis, MO to North Charleston, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to North Charleston, SC will cost around $193 if you buy it on the day, but the cheapest tickets can be found for only $181.
It's difficult to get from St. Louis, MO to North Charleston, SC without transferring at least once.

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Take a bus from St. Louis, MO to North Charleston, SC and enjoy the approximately 694 miles (1118 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 08:10, the last at 15:15.
Distance 694 miles (1118 km) |
First bus 8:10 AM |
Last bus 3:15 PM |
Cheapest Month May |
Cheapest Day Wed |
High Season Apr - Jun |
Low Season Jan - Mar |
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from St. Louis, MO to North Charleston, SC.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 01:45PM | Arrival Time 06:30PM | Duration 28h45 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $206 |
Operator Flixbus USA | Departure Time 11:30PM | Arrival Time 06:30PM | Duration 43h00 | Departure days Mon, Tue, Wed, Thu, Sun | Cheapest price $181 |
The table below shows live departures for St. Louis, MO to North Charleston, SC buses for today, Tuesday, November 3. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 1:45 PM St. Louis, MO | 28h45 | 6:30 PM North Charleston, SC | 2 transfers | |
![]() | 11:30 PM St. Louis, MO | 43h00 | 6:30 PM North Charleston, SC | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of North Charleston, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect North Charleston, SC trip today.
Contemporary visual arts center with rotating exhibitions, artist talks, and community programs inside Firefly Distillery's campus.
Hands-on children's museum with imaginative exhibits and play spaces that encourage learning through movement and creativity.
Museum in the old North Charleston fire station featuring local firefighting history, restored apparatus, and memorabilia.
Popular neighborhood with a traffic circle, indie shops, murals, and a relaxed local feel ideal for strolling and events.
Large regional park with paved trails, sports facilities, wetlands, and broad open space for walking and outdoor recreation.
Scenic riverfront green space at the former Navy Yard with lawns, public art, and views toward the Cooper River and bridge.
Lowcountry shrimp and grits pairs local shrimp with creamy grits, often with gravy or bacon. It is a signature coastal South Carolina comfort dish.
She-crab soup is a rich Charleston classic made with crab meat, crab roe, cream, and sherry. It is a traditional Lowcountry seafood specialty.
Hoppin' John combines rice, field peas, pork, and seasonings. It is a longstanding Carolina dish tied to Lowcountry and New Year traditions.
Casual barbecue spot known for smoked meats and hearty Southern sides in a lively, no-frills setting.
Popular brewery and restaurant serving house beers, wood-fired pizza, and pub fare in an energetic industrial space.
Polished oyster bar and seafood restaurant specializing in fresh shellfish and Lowcountry flavors in a stylish setting.
Moderate for U.S. city travel. Hotels and dining are lower than major hubs, but car use and limited transit can raise total visitor costs.
Tip 18-20% at restaurants, more for excellent service. Taxis usually 10-15%. Cafes often have tip jars or screen prompts; $1-2 is common.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in North Charleston, SC.
Find answers to the most common questions about traveling from St. Louis, MO to North Charleston, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at North Charleston, SC, this guide helps you travel smarter and with confidence.

Most St. Louis, MO to North Charleston, SC buses use the St. Louis, S 15th St (Civic center) to station pair. Use this guide to compare St. Louis, MO and North Charleston, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Ticket office support is available at St. Louis, S 15th St (Civic center).
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
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