- Recommended
Park Circle Gallery
Contemporary visual arts center with rotating exhibitions, artist talks, and community programs inside Firefly Distillery's campus.
Cheapest price on Sep 20
$185
Average ticket price on Sep 20
$198
Fastest journey on Sep 20
1 d 4 h 45 m
Average journey duration on Sep 20
1 d 11 h 53 m
Buses on Sep 20
2
Distance
1118 km
The best way to find a cheap bus ticket from St. Louis, MO to North Charleston, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to North Charleston, SC will cost around $198 if you buy it on the day, but the cheapest tickets can be found for only $185.
It's difficult to get from St. Louis, MO to North Charleston, SC without transferring at least once.




| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 01:45PM | Arrival Time 06:30PM | Duration 28h45 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $210 |
Operator Flixbus USA | Departure Time 11:30PM | Arrival Time 06:30PM | Duration 43h00 | Departure days Mon, Tue, Wed, Thu, Sun | Cheapest price $185 |
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Discover the best of North Charleston, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect North Charleston, SC trip today.
Contemporary visual arts center with rotating exhibitions, artist talks, and community programs inside Firefly Distillery's campus.
Hands-on children's museum with imaginative exhibits and play spaces that encourage learning through movement and creativity.
Museum in the old North Charleston fire station featuring local firefighting history, restored apparatus, and memorabilia.
Popular neighborhood with a traffic circle, indie shops, murals, and a relaxed local feel ideal for strolling and events.
Large regional park with paved trails, sports facilities, wetlands, and broad open space for walking and outdoor recreation.
Scenic riverfront green space at the former Navy Yard with lawns, public art, and views toward the Cooper River and bridge.
Find answers to the most common questions about traveling from St. Louis, MO to North Charleston, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at North Charleston, SC, this guide helps you travel smarter and with confidence.

Most St. Louis, MO to North Charleston, SC buses use the St. Louis, S 15th St (Civic center) to Charleston, Gaynor Avenue (Greyhound Bus Station) station pair. Use this guide to compare St. Louis, MO and North Charleston, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Ticket office support is available at St. Louis, S 15th St (Civic center).
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
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