The cheapest and fastest buses from Pisa to Brussels
Cheapest price
$85
Average price
$110
Fastest journey
1 d 1 h 10 m
Average duration
1 d 2 h 25 m
Buses per day
4
Distance
914 km
The best way to find a cheap bus ticket from Pisa to Brussels is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Pisa to Brussels will cost around $110 if you buy it on the day, but the cheapest tickets can be found for only $85.
Of the 4 buses that leave Pisa for Brussels on Fri, Mar 06, 4 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Mar 06 the direct buses cover the 914 km distance in an average of 1 d 2 h 25 m but if you time it right, some buses will get you there in just 1 d 1 h 10 m .
On Fri, Mar 06 the slowest buses will take 1 d 3 h 35 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.








Travel Information
Compare train, bus, and flight for Pisa to Brussels
Omio recommends booking the flight as it is the most popular option from Pisa to Brussels among Omio's users. If you are prioritising price take the bus with prices starting from $74. For those with little time consider booking a flight which can get you there in 2h 30m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.9 - 2.3kg. The ticket price range depends on the travel mode: a bus costs an average of $74, and a train costs an average of $364.
Distance: 567 miles (914 km)
Compare bus with
| Bus | Most popular Flight | Train |
|---|---|---|
$125 Average price Cheapest | $127 Average price | $364 Average price |
21h 28m Average total duration 20h 58m Onboard + 30m Additional time* | 5h 30m Average total duration Fastest 2h 30m Onboard + 3h 0m Additional time* | 21h 8m Average total duration 20h 38m Onboard + 30m Additional time* |
0.9 - 2.3kg CO2 emissions Lowest | 2.7 - 5.5kg CO2 emissions | - CO2 emissions |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Live departures
Pisa to Brussels bus times
The table below shows live departures for Pisa to Brussels buses for today, Thursday, March 5. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 10:45 PM Pisa | 32h30 | 7:15 AM Brussels | 0 transfersDirect | |
| Friday, March 6 | |||||
![]() | 5:25 AM Pisa | 25h50 | 7:15 AM Brussels | 0 transfersDirect | |
![]() | 8:40 AM Pisa | 27h05 | 11:45 AM Brussels | 0 transfersDirect | |
![]() | 3:45 PM Pisa | 25h10 | 4:55 PM Brussels | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Pisa to Brussels by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 06
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Why should you book Pisa to Brussels buses with Omio?
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Pisa to Brussels.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Pisa to Brussels.
Journey information
Overview: Bus from Pisa to Brussels
Buses from Pisa to Brussels run on average 5 times per day, taking around 20h 58m. Cheap bus tickets for this journey start at $74 (€60) but you can travel from only $21 (€17) by flight.
The earliest bus runs at 01:30, the last at 23:45. The fastest bus covers the 567 miles (914 km) distance in 22h 35m.
Distance 567 miles (914 km) |
Average bus duration 20h 58m |
Cheapest ticket price $74 (€60) |
Buses per day 5 |
Fastest bus 22h 35m |
First bus 01:30 |
Last bus 23:45 |
Cheapest month Apr |
Cheapest day Tue |
High season Oct - Dec |
Low season Jan - Mar |
Busiest day Wed |
Least busy day Fri |
Best day to book ahead 42 days |
Bus providers: FlixBus from Pisa to BrusselsYou can travel by bus between Pisa to Brussels with FlixBus for as low as $21 (€17). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
FAQs: Bus from Pisa to Brussels
Find answers to the most common questions about traveling from Pisa to Brussels by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brussels, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Grand Place, a UNESCO World Heritage site known for its opulent guildhalls and vibrant flower market
- Atomium, an iconic structure and museum offering panoramic views of the city
- Manneken Pis, a famous bronze statue symbolizing the irreverent spirit of Brussels
- Royal Palace of Brussels, the official palace of the Belgian king with impressive architecture and gardens
- Magritte Museum, dedicated to the works of surrealist artist René Magritte, featuring an extensive collection of his paintings and drawings.
- Explore the vibrant Marolles district, known for its eclectic mix of antique shops and street art
- Enjoy a leisurely stroll through the picturesque Parc du Cinquantenaire, home to impressive arches and museums
- Sample Belgian chocolates at one of the city's renowned chocolatiers
- Discover the lively atmosphere of the Saint-Géry district, filled with trendy bars and cafes
- Attend a performance at the historic La Monnaie opera house, showcasing world-class productions.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Pisa to Brussels
- 06:00-23:00
- Free Wi-Fi
- Cafeteria Midi (in the station)
- Belgian Bites (in the station)
- Fritland Express (0.5 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 27, 49, 50, 78 Metro: 2, 6 Train: IC, S, Thalys, Eurostar
- 06:00-23:59
- Free Wi-Fi
- Cafeteria Noord (in the station)
- Quick Brussels Noord (in the station)
- Le Pain Quotidien (0.5 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 14, 57, 58 Metro: 2, 6 Train: IC, S1, S2
Most popular bus connections from Pisa
More options for your journey from Pisa to Brussels
Here are some other resources that might have the information you need
