- Must visit
Royal Museums of Fine Arts of Belgium
Premier fine arts complex with Old Masters, Magritte, and modern collections, essential for understanding Belgian and European art.
Cheapest price
$121
Average price
$128
Fastest journey
1 d 2 h 30 m
Average duration
1 d 5 h 36 m
Buses per day
4
Distance
914 km
The best way to find a cheap bus ticket from Pisa to Brussels is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Pisa to Brussels will cost around $128 if you buy it on the day, but the cheapest tickets can be found for only $121.
It's difficult to get from Pisa to Brussels without transferring at least 2 times.
FlixBus · FlixBus · FlixBus
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FlixBus · FlixBus · FlixBus
FlixBus · FlixBus · FlixBusOmio recommends booking the flight as it is the most popular option from Pisa to Brussels among Omio's users. If you are prioritising price take the flight with prices starting from $23. For those with little time consider booking a flight which can get you there in 2h 31m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.9 - 2.3kg. The ticket price range depends on the travel mode: a flight costs an average of $23, and a train costs an average of $277.
Distance: 567 miles (914 km)
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$134 Average price | $132 Average price Cheapest | $368 Average price | $346 Average price (fuel + tolls) |
21h 28m Average total duration 20h 58m Onboard + 30m Additional time* | 5h 31m Average total duration Fastest 2h 31m Onboard + 3h 0m Additional time* | 19h 50m Average total duration 19h 20m Onboard + 30m Additional time* | 12h 39m Average total duration (door-to-door) |
0.9 - 2.3kg CO2 emissions Lowest | 2.7 - 5.5kg CO2 emissions | - CO2 emissions | - CO2 emissions |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Pisa to Brussels:
A flight is $2 (€2) less than a bus for this route with tickets for a bus from Pisa to Brussels costing on average $134 (€110).
A flight is $236 (€194) less than a train for this route with tickets for a train from Pisa to Brussels costing on average $368 (€303).
Other travel options to Brussels take longer:
Train takes on average 19h 20m.
Bus takes on average 20h 58m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 05:45AM | Arrival Time 08:15AM | Duration 26h30 | Departure days Tue, Wed | Cheapest price $123 |
Operator FlixBus | Departure Time 06:25AM | Arrival Time 08:15AM | Duration 25h50 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $124 |
Operator FlixBus | Departure Time 09:40AM | Arrival Time 12:45PM | Duration 27h05 | Departure days Everyday | Cheapest price $114 |
Operator FlixBus | Departure Time 01:50PM | Arrival Time 03:45PM | Duration 25h55 | Departure days Mon, Fri, Sat, Sun | Cheapest price $145 |
Operator FlixBus | Departure Time 04:45PM | Arrival Time 05:55PM | Duration 25h10 | Departure days Mon, Thu, Sat, Sun | Cheapest price $123 |
Operator FlixBus | Departure Time 05:10PM | Arrival Time 01:15AM | Duration 32h05 | Departure days Tue, Wed | Cheapest price $128 |
Operator FlixBus | Departure Time 11:30PM | Arrival Time 08:15AM | Duration 32h45 | Departure days Tue, Wed | Cheapest price $121 |
The table below shows live departures for Pisa to Brussels buses for today, Tuesday, July 21. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus · FlixBus | 5:10 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 32h05 | 1:15 AM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 11:30 PM Pisa (Pisamover via San Giusto/Aurelia) | 32h45 | 8:15 AM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
| Wednesday, July 22 | |||||
FlixBus · FlixBus · FlixBus | 5:45 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 26h30 | 8:15 AM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 9:40 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 27h05 | 12:45 PM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Pisa to Brussels run on average 4 times per day, taking around 20h 58m. Cheap bus tickets for this journey start at $79 (€65) but you can travel from only $23 (€19) by flight.
The earliest bus runs at 01:30, the last at 23:45. The fastest bus covers the 567 miles (914 km) distance in 25h 10m.
Distance 567 miles (914 km) |
Average bus duration 20h 58m |
Cheapest ticket price $79 (€65) |
Buses per day 4 |
Fastest bus 25h 10m |
First bus 1:30 AM |
Last bus 11:45 PM |
Cheapest Month Jul |
Cheapest Day Tue |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Wed |
Least Busy Day Fri |
Best time to book 42 days |
Discover the best of Brussels — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Brussels trip today.
Premier fine arts complex with Old Masters, Magritte, and modern collections, essential for understanding Belgian and European art.
Dedicated to surrealist René Magritte, this popular museum presents major works and context for one of Belgium’s most celebrated artists.
Leading comic art museum in a Horta-designed building, highlighting Tintin, the Smurfs, and Belgium’s influential comics culture.
Grand square at Brussels’ heart, lined with ornate guildhalls and lively events, perfect for first-time visitors and evening atmosphere.
Large urban park with the triumphal arch, museums, and wide lawns, excellent for walking, picnics, and classic city photographs.
Popular hilltop viewpoint and garden terrace with one of the best panoramas over central Brussels, especially at sunset.
Mussels steamed with white wine, celery and onion, often served with fries. A Brussels brasserie classic, especially popular in mussel season.
Double-fried potato fries, traditionally served in paper cones with sauces. They are a point of national pride and central to everyday Belgian street food.
A rich beef and onion stew braised with Belgian dark beer. It is a beloved comfort dish found in traditional Brussels restaurants.
Two-Michelin-star restaurant by chef Karen Torosyan, celebrated for pâté en croûte and inventive fine dining in an intimate setting.
Elegant Belle Époque brasserie serving refined Belgian classics, seafood and game in a grand old-world dining room.
Famous casual stop for Brussels waffles with many toppings. Popular, fast-moving and central for a classic sweet local treat.
Moderate for Western Europe: hotels can be pricey, but dining and transit are manageable for most tourists.
Service is usually included. Round up or leave 5-10% for great restaurant service; round up taxi fares; small change is fine in cafes.
Official public transport app
Brussels South (Gare du Midi) -> Brussels Central Station, Brussels
Find answers to the most common questions about traveling from Pisa to Brussels by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brussels, this guide helps you travel smarter and with confidence.

Most Pisa to Brussels buses use the Pisa, Via delle Fiamme Gialle (Park Pietrasantina) to Brussels, Brussels South (Gare du Midi) station pair, with some services arriving at Brussels, Gare Du Midi. Use this guide to compare Pisa and Brussels bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Brussels, Brussels South (Gare du Midi) is 2 km from Brussels city centre. Public transport options include:
Brussels, Brussels South (Gare du Midi) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Midi (in the station), Belgian Bites (in the station), Fritland Express (0.5 km).
Free Wi-Fi. ATMs are located near the main entrance and throughout the station.
Ticket office support is available at Brussels, Brussels South (Gare du Midi).
Available at Brussels, Brussels South (Gare du Midi): Parking, Taxis, WC.
Accessibility facilities are available at Brussels, Brussels South (Gare du Midi): Elevators, ramps.
Brussels-Noord is 1 km from Brussels city centre. Public transport options include:
Brussels-Noord has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Noord (in the station), Quick Brussels Noord (in the station), Le Pain Quotidien (0.5 km).
Free Wi-Fi. ATMs are located near the main entrance and in the waiting area.
Ticket office support is available at Brussels-Noord.
Available at Brussels-Noord: Parking, Taxis, WC.
Accessibility facilities are available at Brussels-Noord: Elevators, ramps.
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