- Must visit
Royal Museums of Fine Arts of Belgium
Premier fine arts complex with Old Masters, Magritte, and modern collections, essential for understanding Belgian and European art.
Cheapest price on Sep 05
$130
Average ticket price on Sep 05
$145
Fastest journey on Sep 05
1 d 1 h 10 m
Average journey duration on Sep 05
1 d 2 h
Buses on Sep 05
4
Distance
914 km
The best way to find a cheap bus ticket from Pisa to Brussels is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Pisa to Brussels will cost around $145 if you buy it on the day, but the cheapest tickets can be found for only $130.
It's difficult to get from Pisa to Brussels without transferring at least 2 times.
FlixBus · FlixBus · FlixBus
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FlixBus · FlixBus · FlixBus
FlixBus · FlixBus · FlixBusOmio recommends booking the flight as it is the most popular option from Pisa to Brussels among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $152 For those with little time, consider booking a flight, which has an average total journey time of 5h 48m. If you are seeking to minimise your carbon footprint, the bus is your best option, with estimated CO2 emissions of 0.9 - 2.3kg. Average ticket prices depend on the travel mode: a bus costs an average of $152, while a flight costs an average of $598.
Distance: 567 miles (914 km)
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$152 Average price Cheapest | $598 Average price | $356 Average price (fuel + tolls) | |
23h 21m Average total duration 22h 51m Onboard + 30m Additional time* | 5h 48m Average total duration Fastest 3h 48m Onboard + 2h 0m Additional time* | 12h 39m Average total duration (door-to-door) | |
0.9 - 2.3kg CO2 emissions Lowest | 2.7 - 5.5kg CO2 emissions | - CO2 emissions | - CO2 emissions |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Pisa to Brussels:
A bus is $445 (€360) less than a flight for this route with tickets for a flight from Pisa to Brussels costing on average $598 (€483).
Other travel options to Brussels take longer:
Bus takes on average 22h 51m.
Tickets start at around $152 (€123) compared to roughly $356 (€287) in fuel and tolls — a saving of about $203 (€164). The journey takes 22h 51m versus 12h 39m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 05:45AM | Arrival Time 08:15AM | Duration 26h30 | Departure days Tue, Wed | Cheapest price $80 |
Operator FlixBus | Departure Time 06:25AM | Arrival Time 08:15AM | Duration 25h50 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $92 |
Operator FlixBus | Departure Time 07:15AM | Arrival Time 12:45PM | Duration 29h30 | Departure days Tue, Wed | Cheapest price $78 |
Operator FlixBus | Departure Time 09:40AM | Arrival Time 01:40PM | Duration 28h00 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $97 |
Operator FlixBus | Departure Time 01:50PM | Arrival Time 03:45PM | Duration 25h55 | Departure days Fri, Sat, Sun | Cheapest price $134 |
Operator FlixBus | Departure Time 04:45PM | Arrival Time 05:55PM | Duration 25h10 | Departure days Mon, Thu, Sat, Sun | Cheapest price $75 |
Operator FlixBus | Departure Time 05:10PM | Arrival Time 01:15AM | Duration 32h05 | Departure days Tue, Wed | Cheapest price $65 |
The table below shows live departures for Pisa to Brussels buses for tomorrow, Saturday, September 5. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus · FlixBus | 6:25 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 25h50 | 8:15 AM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 9:40 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 27h05 | 12:45 PM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 1:50 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 25h55 | 3:45 PM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Pisa to Brussels run on average 4 times per day, taking around 22h 51m. Cheap bus tickets for this journey start at $74 (€59) but you can travel from only $24 (€19) by flight.
The earliest bus runs at 01:30, the last at 23:45. The fastest bus covers the 567 miles (914 km) distance in 20h 5m.
Distance 567 miles (914 km) |
Average bus duration 22h 51m |
Cheapest ticket price $74 (€59) |
Buses per day 4 |
Fastest bus 20h 5m |
First bus 1:30 AM |
Last bus 11:45 PM |
Cheapest Month Sep |
Cheapest Day Tue |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Wed |
Least Busy Day Sun |
Best time to book 21 days |
Discover the best of Brussels — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Brussels trip today.
Premier fine arts complex with Old Masters, Magritte, and modern collections, essential for understanding Belgian and European art.
Dedicated to surrealist René Magritte, this popular museum presents major works and context for one of Belgium’s most celebrated artists.
Leading comic art museum in a Horta-designed building, highlighting Tintin, the Smurfs, and Belgium’s influential comics culture.
Grand square at Brussels’ heart, lined with ornate guildhalls and lively events, perfect for first-time visitors and evening atmosphere.
Large urban park with the triumphal arch, museums, and wide lawns, excellent for walking, picnics, and classic city photographs.
Popular hilltop viewpoint and garden terrace with one of the best panoramas over central Brussels, especially at sunset.
Mussels steamed with white wine, celery and onion, often served with fries. A Brussels brasserie classic, especially popular in mussel season.
Double-fried potato fries, traditionally served in paper cones with sauces. They are a point of national pride and central to everyday Belgian street food.
A rich beef and onion stew braised with Belgian dark beer. It is a beloved comfort dish found in traditional Brussels restaurants.
Two-Michelin-star restaurant by chef Karen Torosyan, celebrated for pâté en croûte and inventive fine dining in an intimate setting.
Elegant Belle Époque brasserie serving refined Belgian classics, seafood and game in a grand old-world dining room.
Famous casual stop for Brussels waffles with many toppings. Popular, fast-moving and central for a classic sweet local treat.
Moderate for Western Europe: hotels can be pricey, but dining and transit are manageable for most tourists.
Service is usually included. Round up or leave 5-10% for great restaurant service; round up taxi fares; small change is fine in cafes.
Official public transport app
Brussels South (Gare du Midi) -> Brussels Central Station, Brussels
Find answers to the most common questions about traveling from Pisa to Brussels by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brussels, this guide helps you travel smarter and with confidence.

Most Pisa to Brussels buses use the Pisa, Via delle Fiamme Gialle (Park Pietrasantina) to Brussels, Brussels South (Gare du Midi) station pair, with some services arriving at Brussels, Gare Du Midi. Use this guide to compare Pisa and Brussels bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Pisa, Via delle Fiamme Gialle (Park Pietrasantina) is 1 km from Pisa city centre. Public transport options include:
Pisa, Via delle Fiamme Gialle (Park Pietrasantina) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, Ticket Office, Bike Parking, and Bike Rental.
Wi-Fi is available at Pisa, Via delle Fiamme Gialle (Park Pietrasantina). ATMs are available at Pisa, Via delle Fiamme Gialle (Park Pietrasantina).
Ticket office support is available at Pisa, Via delle Fiamme Gialle (Park Pietrasantina).
Available at Pisa, Via delle Fiamme Gialle (Park Pietrasantina): Parking, Taxis, WC.
Available at Pisa, Via delle Fiamme Gialle (Park Pietrasantina): Bike Parking, Bike Rental.
Accessibility facilities are available at Pisa, Via delle Fiamme Gialle (Park Pietrasantina): The station is accessible for people with reduced mobility.
Pisa (Pisamover via San Giusto/Aurelia) is 1 km from Pisa city centre. Public transport options include:
Pisa (Pisamover via San Giusto/Aurelia) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Pisa (Pisamover via San Giusto/Aurelia). ATMs are available at Pisa (Pisamover via San Giusto/Aurelia).
Ticket office support is available at Pisa (Pisamover via San Giusto/Aurelia).
Available at Pisa (Pisamover via San Giusto/Aurelia): Parking, Taxis, WC.
Accessibility facilities are available at Pisa (Pisamover via San Giusto/Aurelia): Wheelchair accessible with assistance.
Pisa, Aeroporto is 1 km from Pisa city centre. Public transport options include:
Pisa, Aeroporto has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Pisa, Aeroporto. ATMs are available at Pisa, Aeroporto.
Ticket office support is available at Pisa, Aeroporto.
Available at Pisa, Aeroporto: Parking, Taxis, WC.
Accessibility facilities are available at Pisa, Aeroporto: Wheelchair ramps available.
Brussels, Brussels South (Gare du Midi) is 2 km from Brussels city centre. Public transport options include:
Brussels, Brussels South (Gare du Midi) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Midi (in the station), Belgian Bites (in the station), Fritland Express (0.5 km).
Free Wi-Fi. ATMs are located near the main entrance and throughout the station.
Ticket office support is available at Brussels, Brussels South (Gare du Midi).
Available at Brussels, Brussels South (Gare du Midi): Parking, Taxis, WC.
Accessibility facilities are available at Brussels, Brussels South (Gare du Midi): Elevators, ramps.
Brussels, Gare Du Midi is 1 km from Brussels city centre. Public transport options include:
Brussels, Gare Du Midi has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Various dining options are nearby.
Wi-Fi is available at Brussels, Gare Du Midi. ATMs are available at Brussels, Gare Du Midi.
Ticket office support is available at Brussels, Gare Du Midi.
Available at Brussels, Gare Du Midi: Parking, Taxis, WC.
Accessibility facilities are available at Brussels, Gare Du Midi: Station is accessible for individuals with disabilities.
Brussels-Noord is 1 km from Brussels city centre. Public transport options include:
Brussels-Noord has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Noord (in the station), Quick Brussels Noord (in the station), Le Pain Quotidien (0.5 km).
Free Wi-Fi. ATMs are located near the main entrance and in the waiting area.
Ticket office support is available at Brussels-Noord.
Available at Brussels-Noord: Parking, Taxis, WC.
Accessibility facilities are available at Brussels-Noord: Elevators, ramps.
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