Pisa to Brussels bus with FlixBus

Sat, Sep 05
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Rede Expressos
Flibco
2,000+ travel companies
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The cheapest and fastest buses from Pisa to Brussels

Showing times, prices and bookable tickets for Sep 05

Cheapest price on Sep 05

$130

Average ticket price on Sep 05

$145

Fastest journey on Sep 05

1 d 1 h 10 m

Average journey duration on Sep 05

1 d 2 h

Buses on Sep 05

4

Distance

914 km

Cheap tickets

The best way to find a cheap bus ticket from Pisa to Brussels is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from Pisa to Brussels will cost around $145 if you buy it on the day, but the cheapest tickets can be found for only $130.

Fast buses

It's difficult to get from Pisa to Brussels without transferring at least 2 times.

  • FlixBusFlixBus · FlixBus · FlixBus
    4:45 PM25h10
    Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
    5:55 PMBrussels, Brussels South (Gare du Midi)
    $1301One-way
    2 transfers
  • FlixBusFlixBus · FlixBus · FlixBus
    9:40 AM27h05
    Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
    12:45 PMBrussels, Brussels South (Gare du Midi)
    $1411One-way
    2 transfers
  • FlixBusFlixBus · FlixBus · FlixBus
    1:50 PM25h55
    Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
    3:45 PMBrussels, Brussels South (Gare du Midi)
    $1451One-way
    2 transfers
  • FlixBusFlixBus · FlixBus · FlixBus
    6:25 AM25h50
    Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
    8:15 AMBrussels, Brussels South (Gare du Midi)
    $1641One-way
    2 transfers

Travel Information

Compare train, bus, and flight for Pisa to Brussels

Omio recommends booking the flight as it is the most popular option from Pisa to Brussels among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $152 For those with little time, consider booking a flight, which has an average total journey time of 5h 48m. If you are seeking to minimise your carbon footprint, the bus is your best option, with estimated CO2 emissions of 0.9 - 2.3kg. Average ticket prices depend on the travel mode: a bus costs an average of $152, while a flight costs an average of $598.

Distance: 567 miles (914 km)

Compare bus with

Bus
Most popular
Flight
Train
Driving

$152

Average price

Cheapest

$598

Average price

$356

Average price

(fuel + tolls)

23h 21m

Average total duration

22h 51m

Onboard

+

30m

Additional time*

5h 48m

Average total duration

Fastest

3h 48m

Onboard

+

2h 0m

Additional time*

12h 39m

Average total duration

(door-to-door)

0.9 - 2.3kg

CO2 emissions

Lowest

2.7 - 5.5kg

CO2 emissions

-

CO2 emissions

-

CO2 emissions

Direct Options

Direct Options

Direct Options

Direct Options

Additional time: Average total travel duration to departure point, security checks and transfers.

The cheapest way to travel from Pisa to Brussels is a bus with an average price of $152 (€123).

This is compared to other travel options from Pisa to Brussels:

A bus is $445 (€360) less than a flight for this route with tickets for a flight from Pisa to Brussels costing on average $598 (€483).

The fastest way to travel from Pisa to Brussels is by flight with an average journey time of 3h 48m.

Other travel options to Brussels take longer:

Bus takes on average 22h 51m.

It's helpful to compare your options as there are 3 ways to travel between Pisa and Brussels including taking a train, bus, and flight.
We recommend using the flight as it is the most popular way to get from Pisa to Brussels among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.

Tickets start at around $152 (€123) compared to roughly $356 (€287) in fuel and tolls — a saving of about $203 (€164). The journey takes 22h 51m versus 12h 39m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.

Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.

Pisa to Brussels Bus Timetables

OperatorDeparture TimeArrival TimeDurationDeparture daysCheapest price
Operator
FlixBus
Departure Time
05:45AM
Arrival Time
08:15AM
Duration
26h30
Departure days
Tue, Wed
Cheapest price
$80
Operator
FlixBus
Departure Time
06:25AM
Arrival Time
08:15AM
Duration
25h50
Departure days
Mon, Thu, Fri, Sat, Sun
Cheapest price
$92
Operator
FlixBus
Departure Time
07:15AM
Arrival Time
12:45PM
Duration
29h30
Departure days
Tue, Wed
Cheapest price
$78
Operator
FlixBus
Departure Time
09:40AM
Arrival Time
01:40PM
Duration
28h00
Departure days
Mon, Thu, Fri, Sat, Sun
Cheapest price
$97
Operator
FlixBus
Departure Time
01:50PM
Arrival Time
03:45PM
Duration
25h55
Departure days
Fri, Sat, Sun
Cheapest price
$134
Operator
FlixBus
Departure Time
04:45PM
Arrival Time
05:55PM
Duration
25h10
Departure days
Mon, Thu, Sat, Sun
Cheapest price
$75
Operator
FlixBus
Departure Time
05:10PM
Arrival Time
01:15AM
Duration
32h05
Departure days
Tue, Wed
Cheapest price
$65

Live departures

Pisa to Brussels bus times

The table below shows live departures for Pisa to Brussels buses for tomorrow, Saturday, September 5. You can also manually refresh the results below to see updated bus journeys.

Last updated at
ProviderDepartsDurationArrivesTransfers
Tickets
FlixBusFlixBus · FlixBus · FlixBus6:25 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
25h50
8:15 AM Brussels, Brussels South (Gare du Midi)2 transfers
FlixBusFlixBus · FlixBus · FlixBus9:40 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
27h05
12:45 PM Brussels, Brussels South (Gare du Midi)2 transfers
FlixBusFlixBus · FlixBus · FlixBus1:50 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
25h55
3:45 PM Brussels, Brussels South (Gare du Midi)2 transfers

This is the last bus of the day.

Find all the dates and times for this journey

Compare prices and tickets Pisa to Brussels by train, bus, or flight

Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Sat
Sep 05
Sun
Sep 06
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Sep 07
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Wed
Sep 09
Thu
Sep 10
Fri
Sep 11
Sat
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Tue
Sep 15
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Sep 16
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Sep 17
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Sep 18

Why should you book Pisa to Brussels buses with Omio?

FlixBus operates all buses services from Pisa to Brussels.
Omio is an official ticket reseller for all your travel options from Pisa to Brussels.

Why book with Omio vs FlixBus?

  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Pisa to Brussels.

Why book with Omio over Wanderu or Trainline?

  • Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Pisa to Brussels.

Journey information

Overview: Bus from Pisa to Brussels

ItalyItaly
BelgiumBelgium
Icon of bus

Buses from Pisa to Brussels run on average 4 times per day, taking around 22h 51m. Cheap bus tickets for this journey start at $74 (€59) but you can travel from only $24 (€19) by flight.

The earliest bus runs at 01:30, the last at 23:45. The fastest bus covers the 567 miles (914 km) distance in 20h 5m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $24 (€19)
Distance
567 miles (914 km)
Average bus duration
22h 51m
Cheapest ticket price
$74 (€59)
Buses per day
4
Fastest bus
20h 5m
First bus
1:30 AM
Last bus
11:45 PM
Cheapest Month
Sep
Cheapest Day
Tue
High Season
Oct - Dec
Low Season
Jan - Mar
Busiest Day
Wed
Least Busy Day
Sun
Best time to book
21 days
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $24 (€19)

Bus providers: FlixBus from Pisa to BrusselsYou can travel by bus between Pisa to Brussels with FlixBus for as low as $24 (€19). When you search for schedules and tickets, Omio will show you the best journey

FlixBus

About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
20h 5m
Cheapest FlixBus Price
$74 (€59)
FlixBus frequency
4 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.

Complete guide to Brussels

Things to do in Brussels

Discover the best of Brussels — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Brussels trip today.

  • Must visit

Royal Museums of Fine Arts of Belgium

Premier fine arts complex with Old Masters, Magritte, and modern collections, essential for understanding Belgian and European art.

  • Must visit

Magritte Museum

Dedicated to surrealist René Magritte, this popular museum presents major works and context for one of Belgium’s most celebrated artists.

  • Must visit

Comics Art Museum

Leading comic art museum in a Horta-designed building, highlighting Tintin, the Smurfs, and Belgium’s influential comics culture.

Euro (€)

Moderate for Western Europe: hotels can be pricey, but dining and transit are manageable for most tourists.

Average meal costs

Budget
€8-15 for fast food or casual takeaway.
Mid-range
€20-35 per person for a standard restaurant meal.
Fine dining
€70+ per person for upscale restaurants.
Coffee
€3-5 for cappuccino or latte.

Tipping culture

Service is usually included. Round up or leave 5-10% for great restaurant service; round up taxi fares; small change is fine in cafes.

FAQs: Bus from Pisa to Brussels

Find answers to the most common questions about traveling from Pisa to Brussels by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brussels, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from Pisa to Brussels can start from as little as $74 (€59) when you book in advance. The average bus ticket price for Pisa to Brussels is $152 (€123) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Pisa to Brussels is 20h 5m to travel the 567 miles (914 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Pisa to Brussels leaves at 1:30 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Pisa to Brussels leaves at 11:45 PM.
There are 4 buses a day from Pisa to Brussels which require at least one change with FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Pisa to Brussels, you can count on FlixBus for the best way to get you to Brussels. You can also check all possible bus companies who offer a service between Pisa and Brussels and compare the amenities they offer before buying a bus ticket.
When departing from Pisa , you have various bus station options to start your journey from including Pisa, Via delle Fiamme Gialle (Park Pietrasantina), Pisa (Pisamover via San Giusto/Aurelia), Pisa, Aeroporto . When arriving in Brussels , you can end your journey in bus stations like Brussels, Brussels South (Gare du Midi), Brussels, Gare Du Midi, Schaerbeek, Bd Roi Albert II (Bruxelles Gare Du Nord), Bruxelles, Gare du Nord .Passengers board the bus most frequently from Pisa, Via delle Fiamme Gialle (Park Pietrasantina), which is located around 0 miles (1 km) away from the city centre, and they get off the bus at Brussels, Brussels South (Gare du Midi), located 2 away from the city centre.
A trip to Brussels from Pisa is worth doing but not as a day trip with a journey time of 20h 5m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Pisa to Brussels is September.
It's helpful to compare your options as there are 3 ways to travel between Pisa and Brussels including taking a train, bus, and flight.
Yes, the following accessibility options are available when taking the bus from Pisa to Brussels:
  • FlixBus
    • Assistance
    • Priority boarding
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Pisa to Brussels for bus company FlixBus.
Some of the most interesting sights to explore in Brussels are:
  • Grand Place, a UNESCO World Heritage site known for its opulent guildhalls and vibrant flower market
  • Atomium, an iconic structure and museum offering panoramic views of the city
  • Manneken Pis, a famous bronze statue symbolizing the irreverent spirit of Brussels
  • Royal Palace of Brussels, the official palace of the Belgian king with impressive architecture and gardens
  • Magritte Museum, dedicated to the works of surrealist artist René Magritte, featuring an extensive collection of his paintings and drawings.
The best things to do in Brussels include:
  • Explore the vibrant Marolles district, known for its eclectic mix of antique shops and street art
  • Enjoy a leisurely stroll through the picturesque Parc du Cinquantenaire, home to impressive arches and museums
  • Sample Belgian chocolates at one of the city's renowned chocolatiers
  • Discover the lively atmosphere of the Saint-Géry district, filled with trendy bars and cafes
  • Attend a performance at the historic La Monnaie opera house, showcasing world-class productions.
Whether you can cancel your bus ticket from Pisa to Brussels depends on the bus companies:
  • FlixBus
    • You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Pisa to Brussels.
Yes, the following luggage options are included when booking a bus ticket from Pisa to Brussels:
  • FlixBus
    • One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Pisa to Brussels:
  • FlixBus
    • Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Pisa to Brussels. The following conditions apply:
  • FlixBus
    • Small pets in carriers allowed
    • guide dogs travel for free.
You can reserve your seat on the bus from Pisa to Brussels with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from Pisa to Brussels with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from Pisa to Brussels with the following bus company: FlixBus.
Since both Pisa and Brussels are in the Schengen Area, a passport is not required for European Union (EU) or Schengen-associated country citizens. A national ID card is sufficient.
We recommend using the flight as it is the most popular way to get from Pisa to Brussels among Omio's users.
Belgium uses the euro (EUR) as its currency. Travelers generally find card payments widely accepted in cities, restaurants, and shops, though carrying some cash is advisable for small purchases or in rural areas.
In Brussels, travelers should be cautious of pickpocketing, especially in crowded areas like Grand Place, public transport, and popular tourist sites. Common scams include distraction techniques and fake petitions. It's advisable to stay vigilant, avoid displaying expensive items, and use official taxi services to ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular bus stations

Popular bus stations from Pisa to Brussels

Most Pisa to Brussels buses use the Pisa, Via delle Fiamme Gialle (Park Pietrasantina) to Brussels, Brussels South (Gare du Midi) station pair, with some services arriving at Brussels, Gare Du Midi. Use this guide to compare Pisa and Brussels bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.

Departure bus stations in Pisa
Arrival bus stations in Brussels

Which Pisa station do buses to Brussels leave from?

Buses from Pisa to Brussels leave from Pisa, Via delle Fiamme Gialle (Park Pietrasantina). The station is 1 miles (2 km) from Pisa city centre at Pisa Pietrasantina Parking, 56123 Pisa PI, Italy.
Pisa, Via delle Fiamme Gialle (Park Pietrasantina)Pisa Pietrasantina Parking, 56123 Pisa PI, ItalyWifiParkingATMTaxisAccessibilityWCShowerTicket OfficeBike ParkingBike Rental
City-centre transport

Getting to Pisa, Via delle Fiamme Gialle (Park Pietrasantina) from Pisa city centre

Pisa, Via delle Fiamme Gialle (Park Pietrasantina) is 1 km from Pisa city centre. Public transport options include:

Bus21, E24, 1+ · 12m · $1 · every ~10 min
1+, 21 · 14m · $1 · every ~9 min
1+ · 24m · $2 · every ~9 min
21 · 30m · $2

Pisa, Via delle Fiamme Gialle (Park Pietrasantina) bus station facilities and services

Pisa, Via delle Fiamme Gialle (Park Pietrasantina) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, Ticket Office, Bike Parking, and Bike Rental.

Wi-Fi and ATMs

Wi-Fi is available at Pisa, Via delle Fiamme Gialle (Park Pietrasantina). ATMs are available at Pisa, Via delle Fiamme Gialle (Park Pietrasantina).

Tickets and information

Ticket office support is available at Pisa, Via delle Fiamme Gialle (Park Pietrasantina).

Parking, taxis and toilets

Available at Pisa, Via delle Fiamme Gialle (Park Pietrasantina): Parking, Taxis, WC.

Bike and car services

Available at Pisa, Via delle Fiamme Gialle (Park Pietrasantina): Bike Parking, Bike Rental.

Accessibility

Accessibility facilities are available at Pisa, Via delle Fiamme Gialle (Park Pietrasantina): The station is accessible for people with reduced mobility.

Pisa (Pisamover via San Giusto/Aurelia)Via S. Giusto, 56121 Pisa PI, ItalyWifiParkingATMTaxisAccessibilityWCShowerTicket Office
City-centre transport

Getting to Pisa (Pisamover via San Giusto/Aurelia) from Pisa city centre

Pisa (Pisamover via San Giusto/Aurelia) is 1 km from Pisa city centre. Public transport options include:

Bus15 · 5m · $1 · every ~3 min
15 · 7m · $1 · every ~3 min
15 · 9m · $1 · every ~3 min

Pisa (Pisamover via San Giusto/Aurelia) bus station facilities and services

Pisa (Pisamover via San Giusto/Aurelia) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.

Wi-Fi and ATMs

Wi-Fi is available at Pisa (Pisamover via San Giusto/Aurelia). ATMs are available at Pisa (Pisamover via San Giusto/Aurelia).

Tickets and information

Ticket office support is available at Pisa (Pisamover via San Giusto/Aurelia).

Parking, taxis and toilets

Available at Pisa (Pisamover via San Giusto/Aurelia): Parking, Taxis, WC.

Accessibility

Accessibility facilities are available at Pisa (Pisamover via San Giusto/Aurelia): Wheelchair accessible with assistance.

Pisa, AeroportoPisa V.Aeroporto 62, 56121 Pisa PI, ItalyWifiParkingATMTaxisAccessibilityWCShowerTicket Office
City-centre transport

Getting to Pisa, Aeroporto from Pisa city centre

Pisa, Aeroporto is 1 km from Pisa city centre. Public transport options include:

Train5m · $7 · every ~16 min
Shuttle5m · $7 · every ~16 min

Pisa, Aeroporto bus station facilities and services

Pisa, Aeroporto has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.

Wi-Fi and ATMs

Wi-Fi is available at Pisa, Aeroporto. ATMs are available at Pisa, Aeroporto.

Tickets and information

Ticket office support is available at Pisa, Aeroporto.

Parking, taxis and toilets

Available at Pisa, Aeroporto: Parking, Taxis, WC.

Accessibility

Accessibility facilities are available at Pisa, Aeroporto: Wheelchair ramps available.

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