- Must visit
Royal Museums of Fine Arts of Belgium
A major complex of art museums covering Flemish masters, Old Masters, and modern art. One of Brussels' essential cultural visits for its scale and national importance.
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The cheapest and fastest buses from Pisa to Brussels
Showing times and prices for Jun 06
Cheapest price
$129
Average price
$146
Fastest journey
1 d 1 h 50 m
Average duration
1 d 2 h 25 m
Buses per day
4
Distance
914 km
Cheap tickets
The best way to find a cheap bus ticket from Pisa to Brussels is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Pisa to Brussels will cost around $146 if you buy it on the day, but the cheapest tickets can be found for only $129.
Fast buses
It's difficult to get from Pisa to Brussels without transferring at least 2 times.
FlixBus · FlixBus · FlixBus9:40 AM27h05Pisa, Via delle Fiamme Gialle (Park Pietrasantina)12:45 PMBrussels, Brussels South (Gare du Midi)$1291One-way2 transfers- FlixBus · FlixBus · FlixBus6:25 AM25h50Pisa, Via delle Fiamme Gialle (Park Pietrasantina)8:15 AMBrussels, Brussels South (Gare du Midi)$1411One-way2 transfers
- FlixBus · FlixBus · FlixBus1:50 PM25h55Pisa, Via delle Fiamme Gialle (Park Pietrasantina)3:45 PMBrussels, Brussels South (Gare du Midi)$1551One-way2 transfers
- FlixBus · FlixBus · FlixBus4:45 PM26h50Pisa, Via delle Fiamme Gialle (Park Pietrasantina)7:35 PMBrussels, Brussels South (Gare du Midi)$1581One-way2 transfers
- FlixBus · FlixBus · FlixBus6:25 AM25h50Pisa, Via delle Fiamme Gialle (Park Pietrasantina)8:15 AMBrussels, Brussels South (Gare du Midi)$1411One-way2 transfers
- FlixBus · FlixBus · FlixBus1:50 PM25h55Pisa, Via delle Fiamme Gialle (Park Pietrasantina)3:45 PMBrussels, Brussels South (Gare du Midi)$1551One-way2 transfers
- FlixBus · FlixBus · FlixBus4:45 PM26h50Pisa, Via delle Fiamme Gialle (Park Pietrasantina)7:35 PMBrussels, Brussels South (Gare du Midi)$1581One-way2 transfers
- FlixBus · FlixBus · FlixBus9:40 AM27h05Pisa, Via delle Fiamme Gialle (Park Pietrasantina)12:45 PMBrussels, Brussels South (Gare du Midi)$1291One-way2 transfers
Travel Information
Compare train, bus, and flight for Pisa to Brussels
Omio recommends booking the flight as it is the most popular option from Pisa to Brussels among Omio's users. If you are prioritising price take the flight with prices starting from $23. For those with little time consider booking a flight which can get you there in 2h 31m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.9 - 2.3kg. The ticket price range depends on the travel mode: a flight costs an average of $23, and a train costs an average of $282.
Distance: 567 miles (914 km)
Compare bus with
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$136 Average price | $135 Average price Cheapest | $375 Average price | $352 Average price (fuel + tolls) |
21h 28m Average total duration 20h 58m Onboard + 30m Additional time* | 5h 31m Average total duration Fastest 2h 31m Onboard + 3h 0m Additional time* | 19h 50m Average total duration 19h 20m Onboard + 30m Additional time* | 12h 39m Average total duration (door-to-door) |
0.9 - 2.3kg CO2 emissions Lowest | 2.7 - 5.5kg CO2 emissions | - CO2 emissions | - CO2 emissions |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
The cheapest way to travel from Pisa to Brussels is a flight with an average price of $135 (€109).
This is compared to other travel options from Pisa to Brussels:
A flight is $2 (€2) less than a bus for this route with tickets for a bus from Pisa to Brussels costing on average $136 (€110).
A flight is $240 (€194) less than a train for this route with tickets for a train from Pisa to Brussels costing on average $375 (€303).
The fastest way to travel from Pisa to Brussels is by flight with an average journey time of 2h 31m.
Other travel options to Brussels take longer:
Train takes on average 19h 20m.
Bus takes on average 20h 58m.
It's helpful to compare your options as there are 3 ways to travel between Pisa and Brussels including taking a train, bus, and flight.
We recommend using the flight as it is the most popular way to get from Pisa to Brussels among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Pisa to Brussels Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 05:45AM | Arrival Time 08:15AM | Duration 26h30 | Departure days Tue | Cheapest price $86 |
Operator FlixBus | Departure Time 06:25AM | Arrival Time 08:15AM | Duration 25h50 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $101 |
Operator FlixBus | Departure Time 07:15AM | Arrival Time 12:45PM | Duration 29h30 | Departure days Tue, Wed | Cheapest price $91 |
Operator FlixBus | Departure Time 09:40AM | Arrival Time 12:45PM | Duration 27h05 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $109 |
Operator FlixBus | Departure Time 01:50PM | Arrival Time 03:45PM | Duration 25h55 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $90 |
Operator FlixBus | Departure Time 04:45PM | Arrival Time 07:35PM | Duration 26h50 | Departure days Thu, Sat, Sun | Cheapest price $106 |
Operator FlixBus | Departure Time 11:30PM | Arrival Time 08:15AM | Duration 32h45 | Departure days Tue, Wed | Cheapest price $79 |
Live departures
Pisa to Brussels bus times
The table below shows live departures for Pisa to Brussels buses for today, Friday, June 5. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| FlixBus · FlixBus · FlixBus | 9:40 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 27h05 | 12:45 PM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
| FlixBus · FlixBus · FlixBus | 1:50 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 25h55 | 3:45 PM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
| Saturday, June 6 | |||||
| FlixBus · FlixBus · FlixBus | 6:25 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 25h50 | 8:15 AM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Pisa to Brussels by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Pisa to Brussels buses with Omio?
FlixBus operates all buses services from Pisa to Brussels.
Omio is an official ticket reseller for all your travel options from Pisa to Brussels.
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Pisa to Brussels.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Pisa to Brussels.
Journey information
Overview: Bus from Pisa to Brussels
Italy
Belgium
Buses from Pisa to Brussels run on average 4 times per day, taking around 20h 58m. Cheap bus tickets for this journey start at $80 (€65) but you can travel from only $23 (€19) by flight.
The earliest bus runs at 01:30, the last at 23:45. The fastest bus covers the 567 miles (914 km) distance in 25h 10m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $23 (€19)
Distance 567 miles (914 km) |
Average bus duration 20h 58m |
Cheapest ticket price $80 (€65) |
Buses per day 4 |
Fastest bus 25h 10m |
First bus 1:30 AM |
Last bus 11:45 PM |
Cheapest Month Jul |
Cheapest Day Tue |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Wed |
Least Busy Day Fri |
Best time to book 42 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $23 (€19)
Bus providers: FlixBus from Pisa to BrusselsYou can travel by bus between Pisa to Brussels with FlixBus for as low as $23 (€19). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
25h 10m
Cheapest Price
$80 (€65)
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Complete guide to Brussels
Things to do in Brussels
Discover the best of Brussels — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Brussels trip today.
- Must visit
Magritte Museum
Dedicated to René Magritte, this museum holds the world's largest collection of his works. It is a standout stop for surrealism lovers and one of Brussels' most famous museums.
- Recommended
MIMA
A contemporary art museum known for street art, digital culture, and youth-oriented exhibitions. It became especially popular with younger visitors and on social media.
- Must visit
Mont des Arts
A landscaped cultural hill linking the upper and lower city, known for its formal gardens and classic skyline view. It is one of Brussels' best walking and photography spots.
- Must visit
Galeries Royales Saint-Hubert
A beautiful 19th-century covered arcade with elegant glass roofing and historic atmosphere. It is one of the city's most photogenic and fashionable passages.
- Recommended
Parc du Cinquantenaire
A grand urban park laid out around monumental buildings and the Cinquantenaire Arch. Ideal for a walk, photos, and combining with nearby museums.
- Gluten-free
Moules-Frites
Brussels’ classic pairing of mussels steamed with white wine, celery, and herbs, served with crisp fries. It is one of the city’s most iconic and widely loved meals.
Carbonnade Flamande
A traditional Belgian beef and onion stew slowly cooked with dark beer, often slightly sweet-sour and served with fries or bread. It is a staple of local brasserie cuisine.
- Vegetarian
- Gluten-free
Stoemp
A comforting Brussels side dish of mashed potatoes mixed with seasonal vegetables such as carrots, leeks, or spinach, often served with sausage or meat.
Nüetnigenough
Well-regarded Belgian restaurant serving regional classics, strong beer pairings, and seasonal ingredients in a cozy, old-Brussels dining room.
Comme Chez Soi
One of Brussels’ landmark fine-dining restaurants, celebrated for refined Belgian-influenced cuisine, polished service, and an elegant Art Nouveau setting.
Fin de Siècle
Popular traditional restaurant near Sainte-Catherine known for generous Belgian comfort food, beer-based stews, and an unfussy, bustling atmosphere.
Euro
Moderate by Western European standards. Beer, waffles, and transit are reasonable; hotels and central dining cost more.
Average meal costs
- Budget
- EUR 10-18 for fries, sandwiches, or casual spots.
- Mid-range
- EUR 25-40 per person for a standard restaurant meal.
- Fine dining
- EUR 80+ per person at upscale restaurants.
- Coffee
- EUR 3-5 for a cappuccino or similar coffee.
Tipping culture
Service is usually included. Tipping is not required, but rounding up or leaving 5-10% for very good restaurant service is appreciated. Round up taxi fares.
STIB-MIVB
Get the appOfficial public transport app
Prices
- Single ticket
- EUR 2.60
- Day pass
- EUR 8.00
To the city center
Brussels South (Gare du Midi) -> Brussels Central Station
- Distance
- 2 km
- Travel time
- 5 min
- Tap a contactless bank card or mobile wallet directly at metro, tram, and bus validators for the standard fare. Paper and digital tickets are also available in the STIB-MIVB app and at GO machines.
- If you need to reach the historic center, Brussels Central Station is the most practical stop for Grand-Place and nearby sights. Validate every ticket before boarding or entering the metro.
FAQs: Bus from Pisa to Brussels
Find answers to the most common questions about traveling from Pisa to Brussels by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brussels, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Pisa to Brussels can start from as little as $80 (€65) when you book in advance. The average bus ticket price for Pisa to Brussels is $136 (€110) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Pisa to Brussels is 25h 10m to travel the 567 miles (914 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Pisa to Brussels leaves at 1:30 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Pisa to Brussels leaves at 11:45 PM.
There are 4 buses a day from Pisa to Brussels which require at least one change with FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Pisa to Brussels, you can count on FlixBus for the best way to get you to Brussels. You can also check all possible bus companies who offer a service between Pisa and Brussels and compare the amenities they offer before buying a bus ticket.
When departing from Pisa , you have various bus station options to start your journey from including Pisa, Via delle Fiamme Gialle (Park Pietrasantina), Pisa, Aeroporto Parcheggio Aurelia, Lucca, Viale Regina Margherita / Via Montanara . When arriving in Brussels , you can end your journey in bus stations like Brussels, Brussels South (Gare du Midi), Brussels, Gare Du Midi, Schaerbeek, Bd Roi Albert II (Bruxelles Gare Du Nord), Bruxelles, Gare du Nord .Passengers board the bus most frequently from Pisa, Via delle Fiamme Gialle (Park Pietrasantina), which is located around 0 away from the city centre, and they get off the bus at Brussels, Brussels South (Gare du Midi), located 2 away from the city centre.
A trip to Brussels from Pisa is worth doing but not as a day trip with a journey time of 25h 10m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Pisa to Brussels is July.
It's helpful to compare your options as there are 3 ways to travel between Pisa and Brussels including taking a train, bus, and flight.
Yes, the following accessibility options are available when taking the bus from Pisa to Brussels:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Pisa to Brussels for bus company FlixBus.
Some of the most interesting sights to explore in Brussels are:
- Grand Place, a UNESCO World Heritage site known for its opulent guildhalls and vibrant flower market
- Atomium, an iconic structure and museum offering panoramic views of the city
- Manneken Pis, a famous bronze statue symbolizing the irreverent spirit of Brussels
- Royal Palace of Brussels, the official palace of the Belgian king with impressive architecture and gardens
- Magritte Museum, dedicated to the works of surrealist artist René Magritte, featuring an extensive collection of his paintings and drawings.
The best things to do in Brussels include:
- Explore the vibrant Marolles district, known for its eclectic mix of antique shops and street art
- Enjoy a leisurely stroll through the picturesque Parc du Cinquantenaire, home to impressive arches and museums
- Sample Belgian chocolates at one of the city's renowned chocolatiers
- Discover the lively atmosphere of the Saint-Géry district, filled with trendy bars and cafes
- Attend a performance at the historic La Monnaie opera house, showcasing world-class productions.
Whether you can cancel your bus ticket from Pisa to Brussels depends on the bus companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Pisa to Brussels.
Yes, the following luggage options are included when booking a bus ticket from Pisa to Brussels:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Pisa to Brussels:
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Pisa to Brussels. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Pisa to Brussels with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from Pisa to Brussels with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from Pisa to Brussels with the following bus company: FlixBus.
Since both Pisa and Brussels are in the Schengen Area, a passport is not required for European Union (EU) or Schengen-associated country citizens. A national ID card is sufficient.
We recommend using the flight as it is the most popular way to get from Pisa to Brussels among Omio's users.
Belgium uses the euro (EUR) as its currency. Travelers generally find card payments widely accepted in cities, restaurants, and shops, though carrying some cash is advisable for small purchases or in rural areas.
In Brussels, travelers should be cautious of pickpocketing, especially in crowded areas like Grand Place, public transport, and popular tourist sites. Common scams include distraction techniques and fake petitions. It's advisable to stay vigilant, avoid displaying expensive items, and use official taxi services to ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Pisa to Brussels
Pisa
Brussels
The major bus station for departures in Pisa is Pisa, Via delle Fiamme Gialle (Park Pietrasantina). Find all the information you need to know about services, amenities and connections at Pisa, Via delle Fiamme Gialle (Park Pietrasantina) for your trip from Pisa to Brussels.
Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
information
Pisa, Aeroporto Parcheggio Aurelia
information
The major bus station for arrivals in Brussels is Brussels, Brussels South (Gare du Midi). Find all the information you need to know about services, amenities and connections at Brussels, Brussels South (Gare du Midi) for your trip to Brussels from Pisa.
Amenities at bus station
Wifi
Parking
Dining
ATM
Taxis
Accessibility
WC
Ticket Officeinformation
Ticket Office Hours
- 06:00-23:00
Distance to city center
2 km
Car connection
Avenue FonsnyWifi
- Free Wi-Fi
Dining
- Cafeteria Midi (in the station)
- Belgian Bites (in the station)
- Fritland Express (0.5 km).
Taxis
- Available outside the main entrance.
Accessibility
- Elevators, ramps
WC
- Available in the station.
Public transit options for Brussels, Brussels South (Gare du Midi)
- Bus: 27, 49, 50, 78 Metro: 2, 6 Train: IC, S, Thalys, Eurostar
Brussels, Gare Du Midi
information
Amenities at bus station
WifiParkingDiningATMTaxisAccessibilityWCTicket Officeinformation
Ticket Office Hours
- 06:00-23:59
Distance to city center
1 kmCar connection
Rue du ProgrèsWifi
- Free Wi-Fi
Dining
- Cafeteria Noord (in the station)
- Quick Brussels Noord (in the station)
- Le Pain Quotidien (0.5 km).
Taxis
- Available outside the main entrance.
Accessibility
- Elevators, ramps
WC
- Available in the station.
Public transit options for Brussels-Noord
- Bus: 14, 57, 58 Metro: 2, 6 Train: IC, S1, S2
Most popular bus connections from Pisa
More options for your journey from Pisa to Brussels
Here are some other resources that might have the information you need
Most popular buses to and from Brussels and Pisa
Most popular bus connections to Brussels
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