Travel Information
Compare train, bus, and flight for Pisa to Brussels
Omio recommends booking the flight as it is the most popular option from Pisa to Brussels among Omio's users. If you are prioritising price, take the flight, with an average ticket price of €66 For those with little time, consider booking a flight, which has an average total journey time of 4h 31m. If you are seeking to minimise your carbon footprint, the bus is your best option, with estimated CO2 emissions of 0.9 - 2.3kg. Average ticket prices depend on the travel mode: a flight costs an average of €66, while a train costs an average of €303.
Distance: 567 miles (914 km)
Compare flight with
Most popular Flight | Bus | Train | Driving |
|---|---|---|---|
€66 Average price Cheapest | €106 Average price | €303 Average price | €287 Average price (fuel + tolls) |
4h 31m Average total duration Fastest 2h 31m Onboard + 2h 0m Additional time* | 21h 49m Average total duration 21h 19m Onboard + 30m Additional time* | 19h 50m Average total duration 19h 20m Onboard + 30m Additional time* | 12h 39m Average total duration (door-to-door) |
2.7 - 5.5kg CO2 emissions | 0.9 - 2.3kg CO2 emissions Lowest | - CO2 emissions | - CO2 emissions |
![]() Most popular airline | ![]() Most popular bus company | Your own car or car rental | |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Pisa to Brussels:
A flight is €40 less than a bus for this route with tickets for a bus from Pisa to Brussels costing on average €106.
A flight is €237 less than a train for this route with tickets for a train from Pisa to Brussels costing on average €303.
Other travel options to Brussels take longer:
Train takes on average 19h 50m.
Bus takes on average 21h 49m.
You'll arrive about 10h 8m sooner (2h 31m by flight vs 12h 39m by car) and save roughly €221 compared to fuel and tolls (€66 vs €287). You also avoid a long drive, giving you more time to relax or get on with your plans.
Driving is still worth considering if you want to stop along the way, are travelling with bulky luggage, or need a car at your destination.
Travel optionsfrom Pisa to Brussels
How to get from Pisa to Brussels by train, bus or flight.
Our recommendation
The best way to travel from Pisa to Brussels is by taking a bus because it’s the best combination of price and speed.
FlixBus · FlixBus · FlixBus4:45 PM25h10Pisa, Via delle Fiamme Gialle (Park Pietrasantina)5:55 PMBrussels, Brussels South (Gare du Midi)€1361One-way2 transfers
Cheapest
FlixBus · FlixBus · FlixBus4:45 PM25h10Pisa, Via delle Fiamme Gialle (Park Pietrasantina)5:55 PMBrussels, Brussels South (Gare du Midi)€1361One-way2 transfers
Fastest
LH7403+
LH55906:30 PM4h05Pisa International Airport10:35 PMBrussels Airport€4231One-way1 transfer
Other options
FlixBus · FlixBus · FlixBus6:25 AM25h50Pisa, Via delle Fiamme Gialle (Park Pietrasantina)8:15 AMBrussels, Brussels South (Gare du Midi)€1561One-way2 transfers
FlixBus · FlixBus · FlixBus1:50 PM25h55Pisa, Via delle Fiamme Gialle (Park Pietrasantina)3:45 PMBrussels, Brussels South (Gare du Midi)€1591One-way2 transfers
FlixBus · FlixBus · FlixBus9:40 AM28h00Pisa, Via delle Fiamme Gialle (Park Pietrasantina)1:40 PMBrussels, Brussels South (Gare du Midi)€2541One-way2 transfers
LH7401+
LH557610:45 AM6h45Pisa International Airport5:30 PMBrussels Airport€2561One-way1 transfer
LH7403+
LH55886:30 PM15h00Pisa International Airport9:30 AMBrussels Airport€2881One-way1 transfer
LH7403+
LH55726:30 PM17h20Pisa International Airport11:50 AMBrussels Airport€3281One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Travel from Pisa to Brussels
Travel to Brussels easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Pisa to Brussels.

This is compared to other travel options from Pisa to Brussels:
A flight is €40 less than a bus for this route with tickets for a bus from Pisa to Brussels costing on average €106.
A flight is €237 less than a train for this route with tickets for a train from Pisa to Brussels costing on average €303.
Other travel options to Brussels take longer:
Train takes on average 19h 50m.
Bus takes on average 21h 49m.
- Around 7 flights per day.
- Around 4 buses per day.
- Around 2 trains per day.
However, we recommend checking specific travel dates for your route between Pisa and Brussels as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Pisa International Airport and arrive in Brussels Airport.
- Buses mostly depart from Pisa, Via delle Fiamme Gialle (Park Pietrasantina) and arrive in Brussels, Brussels South (Gare du Midi).
- Travel with Malta Air, Ryanair, Vueling, Air Dolomiti to go to Brussels by flight.
- Travel with Regionale to go to Brussels by train.
- Travel with FlixBus to go to Brussels by bus.
- 2 direct flights per day with Malta Air, Ryanair.
Travelling from Pisa to Brussels: related information
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