Travel Information
Compare train, bus, and flight for Pisa to Brussels
Omio recommends booking the flight as it is the most popular option from Pisa to Brussels among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $134 For those with little time, consider booking a flight, which has an average total journey time of 5h 51m. If you are seeking to minimise your carbon footprint, the bus is your best option, with estimated CO2 emissions of 0.9 - 2.3kg. Average ticket prices depend on the travel mode: a bus costs an average of $134, while a flight costs an average of $541.
Distance: 567 miles (914 km)
Compare flight with
Most popular Flight | Bus | Driving |
|---|---|---|
$541 Average price | $134 Average price Cheapest | $343 Average price (fuel + tolls) |
5h 51m Average total duration Fastest 3h 51m Onboard + 2h 0m Additional time* | 23h 28m Average total duration 22h 58m Onboard + 30m Additional time* | 12h 39m Average total duration (door-to-door) |
2.7 - 5.5kg CO2 emissions | 0.9 - 2.3kg CO2 emissions Lowest | - CO2 emissions |
![]() Most popular airline | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Compare ways to travel from Pisa to Brussels
Compare the available ways to get from Pisa to Brussels, with the key details around price, speed, convenience, and direct service.
This is compared to other travel options from Pisa to Brussels:
A bus is $408 less than a flight for this route with tickets for a flight from Pisa to Brussels costing on average $541.
Other travel options to Brussels take longer:
Bus takes on average 23h 28m.
You'll arrive about 8h 48m sooner (3h 51m by flight vs 12h 39m by car). Tickets start at around $541 compared to roughly $343 in fuel and tolls — a bit more, but you get time back and avoid a long drive.
Driving makes more sense if you're travelling as a group, want flexibility on timing, or plan to stop en route.
Travel optionsfrom Pisa to Brussels
How to get from Pisa to Brussels by train, bus or flight.
Our recommendation
The best way to travel from Pisa to Brussels is by taking a bus because it’s the best combination of price and speed.
FlixBus · FlixBus · FlixBus7:15 AM 29h30 Pisa, Via delle Fiamme Gialle (Park Pietrasantina) 12:45 PM Brussels, Brussels South (Gare du Midi) $109 1 One-way 2 transfers
Cheapest
FlixBus · FlixBus · FlixBus7:15 AM 29h30 Pisa, Via delle Fiamme Gialle (Park Pietrasantina) 12:45 PM Brussels, Brussels South (Gare du Midi) $109 1 One-way 2 transfers
Fastest
FR 37468:05 AM 1h45 Pisa International Airport 9:50 AM Brussels South Charleroi Airport $182 1 One-way 0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Pisa to Brussels
Travel to Brussels easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Pisa to Brussels.

This is compared to other travel options from Pisa to Brussels:
A bus is $408 less than a flight for this route with tickets for a flight from Pisa to Brussels costing on average $541.
Other travel options to Brussels take longer:
Bus takes on average 23h 28m.
- Around 16 flights per day.
- Around 4 buses per day.
However, we recommend checking specific travel dates for your route between Pisa and Brussels as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Pisa International Airport and arrive in Brussels Airport.
- Buses mostly depart from Pisa, Via delle Fiamme Gialle (Park Pietrasantina) and arrive in Brussels, Brussels South (Gare du Midi).
- Travel with British Airways, Transavia France, Air Dolomiti, Lufthansa, Brussels Airlines, Malta Air, Austrian Airlines, Ryanair, Air Baltic, Lufthansa City Airlines, TAP Portugal, Wideroe to go to Brussels by flight.
- Travel with FlixBus to go to Brussels by bus.
- 2 direct flights per day with Malta Air, Ryanair.
Travelling from Pisa to Brussels: related information
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