- Must visit
Royal Museums of Fine Arts of Belgium
A major complex of art museums covering Flemish masters, Old Masters, and modern art. One of Brussels' essential cultural visits for its scale and national importance.
Cheapest price
$29
Average price
$52
Fastest journey
10 h 20 m
Average duration
10 h 54 m
Buses per day
12
Distance
569 km
The best way to find a cheap bus ticket from Lyon to Brussels is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Lyon to Brussels will cost around $52 if you buy it on the day, but the cheapest tickets can be found for only $29.
Of the 12 buses that leave Lyon for Brussels on Thu, Jun 04, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, Jun 04 the direct buses cover the 569 km distance in an average of 10 h 54 m but if you time it right, some buses will get you there in just 10 h 20 m .
On Thu, Jun 04 the slowest buses will take 11 h 15 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
83134 · 98080
5130 · 50337
4788 · 1433
94782 · 1466
5808 · 1657
83134 · 98080
FlixBus
94782 · 1466
5808 · 1657
4788 · 1433Omio recommends booking the train as it is the most popular option from Lyon to Brussels among Omio's users. If you are prioritising price take the bus with prices starting from $27. For those with little time consider booking a flight which can get you there in 2h 25m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.5kg. The ticket price range depends on the travel mode: a bus costs an average of $27, and a flight costs an average of $113.
Distance: 353 miles (569 km)
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$59 Average price Cheapest | $163 Average price | $311 Average price | $197 Average price (fuel + tolls) |
8h 29m Average total duration 7h 59m Onboard + 30m Additional time* | 5h 17m Average total duration 4h 47m Onboard + 30m Additional time* | 5h 25m Average total duration Fastest 2h 25m Onboard + 3h 0m Additional time* | 7h 28m Average total duration (door-to-door) |
0.6 - 1.4kg CO2 emissions | 0.2 - 0.5kg CO2 emissions Lowest | 1.7 - 3.4kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Lyon to Brussels:
A bus is $103 (€84) less than a train for this route with tickets for a train from Lyon to Brussels costing on average $163 (€131).
A bus is $252 (€204) less than a flight for this route with tickets for a flight from Lyon to Brussels costing on average $311 (€251).
Other travel options to Brussels take longer:
Train takes on average 4h 47m.
Bus takes on average 7h 59m.
Tickets start at around $59 (€48) compared to roughly $197 (€159) in fuel and tolls — a saving of about $138 (€111). The journey takes 7h 59m versus 7h 28m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by BlaBlaCar Bus, FlixBus, BlaBlaCar.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:10AM | Arrival Time 12:20PM | Duration 12h10 | Departure days Everyday | Cheapest price $48 |
Operator FlixBus | Departure Time 12:50AM | Arrival Time 12:45PM | Duration 11h55 | Departure days Wed, Thu, Fri, Sat, Sun | Cheapest price $72 |
Operator BlaBlaCar Bus | Departure Time 12:55AM | Arrival Time 12:00PM | Duration 11h05 | Departure days Thu | Cheapest price $45 |
Operator BlaBlaCar Bus | Departure Time 01:20AM | Arrival Time 12:00PM | Duration 10h40 | Departure days Tue | Cheapest price $29 |
Operator BlaBlaCar Bus | Departure Time 01:30AM | Arrival Time 12:00PM | Duration 10h30 | Departure days Mon, Fri, Sat, Sun | Cheapest price $29 |
Operator FlixBus | Departure Time 01:40AM | Arrival Time 01:40PM | Duration 12h00 | Departure days Everyday | Cheapest price $49 |
Operator BlaBlaCar Bus | Departure Time 02:30AM | Arrival Time 01:30PM | Duration 11h00 | Departure days Mon, Thu, Fri, Sun | Cheapest price $29 |
Operator FlixBus | Departure Time 02:30AM | Arrival Time 05:55PM | Duration 15h25 | Departure days Tue | Cheapest price $49 |
Operator FlixBus | Departure Time 05:00AM | Arrival Time 03:45PM | Duration 10h45 | Departure days Mon, Tue, Wed, Sat, Sun | Cheapest price $49 |
Operator FlixBus | Departure Time 06:00AM | Arrival Time 05:55PM | Duration 11h55 | Departure days Thu, Fri | Cheapest price $60 |
Operator BlaBlaCar Bus | Departure Time 06:15AM | Arrival Time 05:30PM | Duration 11h15 | Departure days Mon, Thu, Fri, Sun | Cheapest price $29 |
Operator BlaBlaCar | Departure Time 08:30AM | Arrival Time 04:30PM | Duration 8h00 | Departure days Thu | Cheapest price $53 |
Operator BlaBlaCar Bus | Departure Time 08:30AM | Arrival Time 06:50PM | Duration 10h20 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $29 |
Operator FlixBus | Departure Time 09:10AM | Arrival Time 11:30PM | Duration 14h20 | Departure days Thu, Fri, Sat, Sun | Cheapest price $61 |
Operator BlaBlaCar | Departure Time 09:20AM | Arrival Time 05:00PM | Duration 7h40 | Departure days Mon | Cheapest price $57 |
Operator BlaBlaCar | Departure Time 10:00AM | Arrival Time 06:10PM | Duration 8h10 | Departure days Tue | Cheapest price $57 |
Operator BlaBlaCar Bus | Departure Time 10:40AM | Arrival Time 11:35PM | Duration 12h55 | Departure days Thu | Cheapest price $29 |
Operator BlaBlaCar | Departure Time 11:30AM | Arrival Time 07:50PM | Duration 8h20 | Departure days Sun | Cheapest price $66 |
Operator BlaBlaCar Bus | Departure Time 12:00PM | Arrival Time 11:35PM | Duration 11h35 | Departure days Mon, Fri, Sat, Sun | Cheapest price $30 |
Operator BlaBlaCar | Departure Time 12:50PM | Arrival Time 08:30PM | Duration 7h40 | Departure days Sat | Cheapest price $115 |
Operator BlaBlaCar | Departure Time 01:00PM | Arrival Time 09:10PM | Duration 8h10 | Departure days Sun | Cheapest price $80 |
Operator BlaBlaCar Bus | Departure Time 02:00PM | Arrival Time 03:05AM | Duration 13h05 | Departure days Fri, Sat, Sun | Cheapest price $49 |
Operator BlaBlaCar | Departure Time 02:30PM | Arrival Time 10:50PM | Duration 8h20 | Departure days Wed | Cheapest price $82 |
Operator FlixBus | Departure Time 03:15PM | Arrival Time 03:05AM | Duration 11h50 | Departure days Everyday | Cheapest price $53 |
Operator BlaBlaCar | Departure Time 04:50PM | Arrival Time 02:50AM | Duration 10h00 | Departure days Fri | Cheapest price $43 |
Operator BlaBlaCar | Departure Time 06:10PM | Arrival Time 02:10AM | Duration 8h00 | Departure days Wed | Cheapest price $83 |
Operator BlaBlaCar | Departure Time 07:00PM | Arrival Time 02:50AM | Duration 7h50 | Departure days Sun | Cheapest price $80 |
Operator BlaBlaCar Bus | Departure Time 09:10PM | Arrival Time 08:00AM | Duration 10h50 | Departure days Mon, Fri, Sat, Sun | Cheapest price $52 |
Operator FlixBus | Departure Time 09:25PM | Arrival Time 08:15AM | Duration 10h50 | Departure days Everyday | Cheapest price $53 |
The table below shows live departures for Lyon to Brussels buses for today, Wednesday, June 3. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 3:15 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 11h50 | 3:05 AM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus | 9:25 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 10h50 | 8:15 AM Brussels, Brussels South (Gare du Midi) | 0 transfersDirect | |
| Thursday, June 4 | |||||
FlixBus · FlixBus | 12:10 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 12h10 | 12:20 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 12:50 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 11h55 | 12:45 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
5808 · 1657 | 12:55 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 11h05 | 12:00 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 1:40 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 13h55 | 3:35 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
94782 · 1466 | 2:30 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 11h00 | 1:30 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 6:00 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 11h55 | 5:55 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
4788 · 1433 | 6:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 11h15 | 5:30 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
83134 · 98080 | 8:30 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 10h20 | 6:50 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 9:10 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 15h25 | 12:35 AM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Lyon to Brussels run on average 14 times per day, taking around 7h 59m. Cheap bus tickets for this journey start at $27 (€22) if you book in advance.
There are 3 buses per day. The earliest bus runs at 00:10, the last at 23:55. The fastest bus covers the 353 miles (569 km) distance in 9h 30m.
Distance 353 miles (569 km) |
Average bus duration 7h 59m |
Cheapest ticket price $27 (€22) |
Buses per day 14 |
Direct buses 3 |
Fastest bus 9h 30m |
First bus 12:10 AM |
Last bus 11:55 PM |
Cheapest Month Aug |
Cheapest Day Sat |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Wed |
Least Busy Day Sun |
Best time to book 77 days |
Discover the best of Brussels — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Brussels trip today.
A major complex of art museums covering Flemish masters, Old Masters, and modern art. One of Brussels' essential cultural visits for its scale and national importance.
Dedicated to René Magritte, this museum holds the world's largest collection of his works. It is a standout stop for surrealism lovers and one of Brussels' most famous museums.
A contemporary art museum known for street art, digital culture, and youth-oriented exhibitions. It became especially popular with younger visitors and on social media.
A landscaped cultural hill linking the upper and lower city, known for its formal gardens and classic skyline view. It is one of Brussels' best walking and photography spots.
A beautiful 19th-century covered arcade with elegant glass roofing and historic atmosphere. It is one of the city's most photogenic and fashionable passages.
A grand urban park laid out around monumental buildings and the Cinquantenaire Arch. Ideal for a walk, photos, and combining with nearby museums.
Brussels’ classic pairing of mussels steamed with white wine, celery, and herbs, served with crisp fries. It is one of the city’s most iconic and widely loved meals.
A traditional Belgian beef and onion stew slowly cooked with dark beer, often slightly sweet-sour and served with fries or bread. It is a staple of local brasserie cuisine.
A comforting Brussels side dish of mashed potatoes mixed with seasonal vegetables such as carrots, leeks, or spinach, often served with sausage or meat.
Well-regarded Belgian restaurant serving regional classics, strong beer pairings, and seasonal ingredients in a cozy, old-Brussels dining room.
One of Brussels’ landmark fine-dining restaurants, celebrated for refined Belgian-influenced cuisine, polished service, and an elegant Art Nouveau setting.
Popular traditional restaurant near Sainte-Catherine known for generous Belgian comfort food, beer-based stews, and an unfussy, bustling atmosphere.
Moderate by Western European standards. Beer, waffles, and transit are reasonable; hotels and central dining cost more.
Service is usually included. Tipping is not required, but rounding up or leaving 5-10% for very good restaurant service is appreciated. Round up taxi fares.
Official public transport app
Brussels South (Gare du Midi) -> Brussels Central Station
Find answers to the most common questions about traveling from Lyon to Brussels by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brussels, this guide helps you travel smarter and with confidence.

Here are some other resources that might have the information you need