The cheapest and fastest buses from Lyon to Brussels
Cheapest price
$28
Average price
$66
Fastest journey
9 h 40 m
Average duration
10 h 13 m
Buses per day
15
Distance
569 km
The best way to find a cheap bus ticket from Lyon to Brussels is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Lyon to Brussels will cost around $66 if you buy it on the day, but the cheapest tickets can be found for only $28.
Of the 15 buses that leave Lyon for Brussels on Fri, Mar 06, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Mar 06 the direct buses cover the 569 km distance in an average of 10 h 13 m but if you time it right, some buses will get you there in just 9 h 40 m .
On Fri, Mar 06 the slowest buses will take 10 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
94782 · 1466
50884 · 50321
94742 · 1657
4788 · 50327
58074 · 50337
50805
50884 · 50321
4788 · 50327
51470 · 1613
94742 · 1657Travel Information
Compare train, bus, and flight for Lyon to Brussels
Omio recommends booking the train as it is the most popular option from Lyon to Brussels among Omio's users. If you are prioritising price take the bus with prices starting from $24. For those with little time consider booking a flight which can get you there in 1h 54m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.5kg. The ticket price range depends on the travel mode: a bus costs an average of $24, and a flight costs an average of $120.
Distance: 353 miles (569 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
$51 Average price Cheapest | $134 Average price | $278 Average price |
8h 28m Average total duration 7h 58m Onboard + 30m Additional time* | 6h 8m Average total duration 5h 38m Onboard + 30m Additional time* | 4h 54m Average total duration Fastest 1h 54m Onboard + 3h 0m Additional time* |
0.6 - 1.4kg CO2 emissions | 0.2 - 0.5kg CO2 emissions Lowest | 1.7 - 3.4kg CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Lyon to Brussels Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator BlaBlaCar | Departure Time 12:00AM | Arrival Time 07:50AM | Duration 7h50 | Departure days Sat | Cheapest price $80 |
Operator FlixBus | Departure Time 12:10AM | Arrival Time 12:20PM | Duration 12h10 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $59 |
Operator FlixBus | Departure Time 12:50AM | Arrival Time 12:45PM | Duration 11h55 | Departure days Tue, Wed, Thu, Fri, Sat, Sun | Cheapest price $59 |
Operator BlaBlaCar Bus | Departure Time 01:20AM | Arrival Time 12:00PM | Duration 10h40 | Departure days Tue, Thu | Cheapest price $30 |
Operator BlaBlaCar Bus | Departure Time 01:30AM | Arrival Time 12:00PM | Duration 10h30 | Departure days Mon, Fri, Sat, Sun | Cheapest price $27 |
Operator FlixBus | Departure Time 01:40AM | Arrival Time 01:40PM | Duration 12h00 | Departure days Mon, Thu, Fri | Cheapest price $47 |
Operator FlixBus | Departure Time 01:45AM | Arrival Time 01:40PM | Duration 11h55 | Departure days Sat | Cheapest price $73 |
Operator BlaBlaCar Bus | Departure Time 02:25AM | Arrival Time 01:30PM | Duration 11h05 | Departure days Mon, Tue, Sat, Sun | Cheapest price $27 |
Operator BlaBlaCar Bus | Departure Time 02:30AM | Arrival Time 01:30PM | Duration 11h00 | Departure days Mon, Fri, Sun | Cheapest price $27 |
Operator BlaBlaCar Bus | Departure Time 05:00AM | Arrival Time 03:15PM | Duration 10h15 | Departure days Thu, Fri, Sat, Sun | Cheapest price $28 |
Operator FlixBus | Departure Time 05:25AM | Arrival Time 05:55PM | Duration 12h30 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $47 |
Operator BlaBlaCar Bus | Departure Time 06:15AM | Arrival Time 04:30PM | Duration 10h15 | Departure days Mon, Thu, Fri, Sun | Cheapest price $27 |
Operator BlaBlaCar | Departure Time 07:40AM | Arrival Time 02:40PM | Duration 7h00 | Departure days Mon | Cheapest price $79 |
Operator FlixBus | Departure Time 09:10AM | Arrival Time 12:35AM | Duration 15h25 | Departure days Thu | Cheapest price $81 |
Operator BlaBlaCar | Departure Time 09:30AM | Arrival Time 05:30PM | Duration 8h00 | Departure days Wed | Cheapest price $48 |
Operator BlaBlaCar | Departure Time 10:50AM | Arrival Time 06:20PM | Duration 7h30 | Departure days Sat | Cheapest price $95 |
Operator FlixBus | Departure Time 11:50AM | Arrival Time 11:30PM | Duration 11h40 | Departure days Mon, Fri, Sat, Sun | Cheapest price $56 |
Operator BlaBlaCar Bus | Departure Time 12:00PM | Arrival Time 11:35PM | Duration 11h35 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $27 |
Operator BlaBlaCar | Departure Time 12:50PM | Arrival Time 08:50PM | Duration 8h00 | Departure days Sat | Cheapest price $104 |
Operator BlaBlaCar | Departure Time 02:00PM | Arrival Time 09:30PM | Duration 7h30 | Departure days Sun | Cheapest price $61 |
Operator FlixBus | Departure Time 03:15PM | Arrival Time 03:05AM | Duration 11h50 | Departure days Mon, Tue, Fri, Sat, Sun | Cheapest price $50 |
Operator BlaBlaCar Bus | Departure Time 03:50PM | Arrival Time 02:13AM | Duration 10h23 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $27 |
Operator BlaBlaCar | Departure Time 06:20PM | Arrival Time 02:10AM | Duration 7h50 | Departure days Sun | Cheapest price $61 |
Operator BlaBlaCar | Departure Time 08:20PM | Arrival Time 03:40AM | Duration 7h20 | Departure days Mon | Cheapest price $114 |
Operator BlaBlaCar Bus | Departure Time 08:40PM | Arrival Time 06:20AM | Duration 9h40 | Departure days Mon, Fri | Cheapest price $52 |
Operator BlaBlaCar | Departure Time 09:00PM | Arrival Time 05:30AM | Duration 8h30 | Departure days Thu | Cheapest price $58 |
Operator FlixBus | Departure Time 09:25PM | Arrival Time 08:15AM | Duration 10h50 | Departure days Everyday | Cheapest price $50 |
Operator BlaBlaCar Bus | Departure Time 10:45PM | Arrival Time 08:25AM | Duration 9h40 | Departure days Sat, Sun | Cheapest price $61 |
Operator BlaBlaCar Bus | Departure Time 11:59PM | Arrival Time 12:00PM | Duration 12h01 | Departure days Tue | Cheapest price $37 |
Live departures
Lyon to Brussels bus times
The table below shows live departures for Lyon to Brussels buses for today, Thursday, March 5. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
4788 · 50327 | 5:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 10h15 | 3:30 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 8:10 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 15h25 | 11:35 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
58074 · 50337 | 11:00 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 11h35 | 10:35 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
50470 · 1613 | 2:50 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 10h23 | 1:13 AM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus | 8:25 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 10h50 | 7:15 AM Brussels, Brussels South (Gare du Midi) | 0 transfersDirect | |
FlixBus · FlixBus | 11:10 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 12h10 | 11:20 AM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 11:50 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 11h55 | 11:45 AM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
| Friday, March 6 | |||||
94742 · 1657 | 12:30 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 10h30 | 11:00 AM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 12:40 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 14h10 | 2:50 PM Brussels, Gare Du Midi | 1 transfer | |
FlixBus · FlixBus | 12:40 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 12h00 | 12:40 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
94782 · 1466 | 1:30 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 11h00 | 12:30 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
50884 · 50321 | 4:00 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 10h15 | 2:15 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 4:25 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 12h30 | 4:55 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Lyon to Brussels by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 05
Mar 06
Mar 07
Mar 08
Mar 09
Mar 10
Mar 11
Mar 12
Mar 13
Mar 14
Mar 15
Mar 16
Mar 17
Mar 18
Mar 19
Mar 20
Mar 21
Mar 22
Mar 23
Mar 24
Mar 25
Why should you book Lyon to Brussels buses with Omio?
Why book with Omio vs BlaBlaCar Bus?
- Compare with other providers: On Omio, you can not only buy tickets for BlaBlaCar Bus, but also compare tickets for the likes of FlixBus to find the best option for your trip from Lyon to Brussels.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare BlaBlaCar Bus with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Lyon to Brussels.
Why book with Omio over Checkmybus, Wanderu or Busbud?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Lyon to Brussels.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Lyon to Brussels.
Journey information
Overview: Bus from Lyon to Brussels
Buses from Lyon to Brussels run on average 16 times per day, taking around 7h 58m. Cheap bus tickets for this journey start at $24 (€19) if you book in advance.
There are 3 buses per day. The earliest bus runs at 00:10, the last at 23:55. The fastest bus covers the 353 miles (569 km) distance in 9h 40m.
Distance 353 miles (569 km) |
Average bus duration 7h 58m |
Cheapest ticket price $24 (€19) |
Buses per day 16 |
Direct buses 3 |
Fastest bus 9h 40m |
First bus 00:10 |
Last bus 23:55 |
Bus providers: BlaBlaCar Bus, FlixBus, BlaBlaCar from Lyon to BrusselsYou can travel by bus between Lyon to Brussels with BlaBlaCar Bus, FlixBus, BlaBlaCar for as low as $24 (€19). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
BlaBlaCar Bus
BlaBlaCar
FAQs: Bus from Lyon to Brussels
Find answers to the most common questions about traveling from Lyon to Brussels by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brussels, this guide helps you travel smarter and with confidence.

- BlaBlaCar Bus
- Assistance
- Priority boarding
- Accessible seating options.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Grand Place, a UNESCO World Heritage site known for its opulent guildhalls and vibrant flower market
- Atomium, an iconic structure and museum offering panoramic views of the city
- Manneken Pis, a famous bronze statue symbolizing the irreverent spirit of Brussels
- Royal Palace of Brussels, the official palace of the Belgian king with impressive architecture and gardens
- Magritte Museum, dedicated to the works of surrealist artist René Magritte, featuring an extensive collection of his paintings and drawings.
- Explore the vibrant Marolles district, known for its eclectic mix of antique shops and street art
- Enjoy a leisurely stroll through the picturesque Parc du Cinquantenaire, home to impressive arches and museums
- Sample Belgian chocolates at one of the city's renowned chocolatiers
- Discover the lively atmosphere of the Saint-Géry district, filled with trendy bars and cafes
- Attend a performance at the historic La Monnaie opera house, showcasing world-class productions.
- BlaBlaCar Bus
- You can cancel your ticket up to 30 minutes before departure for a refund in the form of a voucher.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- BlaBlaCar Bus
- One carry-on bag up to 7kg and one checked bag up to 20kg.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- BlaBlaCar Bus
- Additional luggage can be purchased for a fee.
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Lyon to Brussels
- 06:00-23:00
- Free Wi-Fi
- Café de la Gare (in the station)
- Le Bistrot de Lyon (0.5 km)
- Brasserie Georges (0.6 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: C19, C20, 31, 46, 49, 55, 60, S1 Metro: A Tram: T1, T2
- 06:00-23:00
- Free Wi-Fi
- Café de la Gare (in the station)
- Bistro Lyonnais (0.2 km)
- Fast Food Express (0.3 km).
- Available outside the main entrance.
- Elevators, ramps
- Available on the concourse.
- Bus: C21, C22, S1 Metro: A Train: TER
- 06:00-23:00
- Free Wi-Fi
- Cafeteria Midi (in the station)
- Belgian Bites (in the station)
- Fritland Express (0.5 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 27, 49, 50, 78 Metro: 2, 6 Train: IC, S, Thalys, Eurostar
- 06:00-23:59
- Free Wi-Fi
- Cafeteria Noord (in the station)
- Quick Brussels Noord (in the station)
- Le Pain Quotidien (0.5 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 14, 57, 58 Metro: 2, 6 Train: IC, S1, S2
Most popular bus connections from Lyon
More options for your journey from Lyon to Brussels
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