- Must visit
Royal Museums of Fine Arts of Belgium
A major complex of art museums covering Flemish masters, Old Masters, and modern art. One of Brussels' essential cultural visits for its scale and national importance.
Cheapest price
$74
Average price
$89
Fastest journey
14 h 50 m
Average duration
15 h 32 m
Buses per day
12
Distance
717 km
The best way to find a cheap bus ticket from Prague to Brussels is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Prague to Brussels will cost around $89 if you buy it on the day, but the cheapest tickets can be found for only $74.
Of the 12 buses that leave Prague for Brussels on Sat, Jun 06, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Jun 06 the direct buses cover the 717 km distance in an average of 15 h 32 m but if you time it right, some buses will get you there in just 14 h 50 m .
On Sat, Jun 06 the slowest buses will take 16 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus
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FlixBus · FlixBus · FlixBus
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FlixBus · FlixBusOmio recommends booking the flight as it is the most popular option from Prague to Brussels among Omio's users. If you are prioritising price take the bus with prices starting from $49. For those with little time consider booking a flight which can get you there in 3h 21m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.6kg. The ticket price range depends on the travel mode: a bus costs an average of $49, and a flight costs an average of $27.
Distance: 445 miles (717 km)
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$85 Average price Cheapest | $157 Average price | $125 Average price | $185 Average price (fuel + tolls) |
15h 24m Average total duration 14h 54m Onboard + 30m Additional time* | 6h 21m Average total duration Fastest 3h 21m Onboard + 3h 0m Additional time* | 12h 20m Average total duration 11h 50m Onboard + 30m Additional time* | 8h 49m Average total duration (door-to-door) |
0.7 - 1.8kg CO2 emissions | 2.2 - 4.3kg CO2 emissions | 0.2 - 0.6kg CO2 emissions Lowest | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Prague to Brussels:
A bus is $40 (€32) less than a train for this route with tickets for a train from Prague to Brussels costing on average $125 (€101).
A bus is $72 (€58) less than a flight for this route with tickets for a flight from Prague to Brussels costing on average $157 (€127).
Other travel options to Brussels take longer:
Train takes on average 11h 50m.
Bus takes on average 14h 54m.
Tickets start at around $85 (€69) compared to roughly $185 (€150) in fuel and tolls — a saving of about $100 (€81). The journey takes 14h 54m versus 8h 49m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 09:10AM | Arrival Time 01:45AM | Duration 16h35 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $60 |
Operator FlixBus | Departure Time 09:55AM | Arrival Time 03:35AM | Duration 17h40 | Departure days Everyday | Cheapest price $58 |
Operator FlixBus | Departure Time 10:35AM | Arrival Time 01:45AM | Duration 15h10 | Departure days Sat | Cheapest price $80 |
Operator FlixBus | Departure Time 10:55AM | Arrival Time 03:35AM | Duration 16h40 | Departure days Everyday | Cheapest price $58 |
Operator FlixBus | Departure Time 11:05AM | Arrival Time 01:45AM | Duration 14h40 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $58 |
Operator FlixBus | Departure Time 12:50PM | Arrival Time 07:20AM | Duration 18h30 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $59 |
Operator FlixBus | Departure Time 02:30PM | Arrival Time 07:20AM | Duration 16h50 | Departure days Mon, Tue, Wed, Thu | Cheapest price $58 |
Operator FlixBus | Departure Time 03:05PM | Arrival Time 07:20AM | Duration 16h15 | Departure days Mon, Tue, Wed, Thu | Cheapest price $58 |
Operator FlixBus | Departure Time 04:15PM | Arrival Time 07:20AM | Duration 15h05 | Departure days Everyday | Cheapest price $56 |
Operator FlixBus | Departure Time 05:45PM | Arrival Time 12:45PM | Duration 19h00 | Departure days Tue, Wed, Thu, Fri, Sat | Cheapest price $64 |
Operator FlixBus | Departure Time 06:00PM | Arrival Time 12:25PM | Duration 18h25 | Departure days Everyday | Cheapest price $61 |
Operator RegioJet a.s. | Departure Time 06:00PM | Arrival Time 06:00AM | Duration 12h00 | Departure days Tue, Fri | Cheapest price $62 |
Operator FlixBus | Departure Time 06:45PM | Arrival Time 01:55PM | Duration 19h10 | Departure days Mon, Tue, Wed, Fri, Sat, Sun | Cheapest price $58 |
Operator BlaBlaCar Bus | Departure Time 07:00PM | Arrival Time 01:30PM | Duration 18h30 | Departure days Thu, Sun | Cheapest price $72 |
Operator FlixBus | Departure Time 07:25PM | Arrival Time 01:55PM | Duration 18h30 | Departure days Sat | Cheapest price $74 |
Operator FlixBus | Departure Time 08:25PM | Arrival Time 01:55PM | Duration 17h30 | Departure days Fri | Cheapest price $105 |
Operator FlixBus | Departure Time 09:50PM | Arrival Time 01:55PM | Duration 16h05 | Departure days Everyday | Cheapest price $58 |
Operator FlixBus | Departure Time 11:05PM | Arrival Time 01:55PM | Duration 14h50 | Departure days Everyday | Cheapest price $56 |
The table below shows live departures for Prague to Brussels buses for today, Friday, June 5. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus · FlixBus | 8:25 PM Praha, Zličín | 17h30 | 1:55 PM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
FlixBus · FlixBus | 9:50 PM Praha, Na Knížecí | 16h05 | 1:55 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus | 11:05 PM Praha, ÚAN Florenc | 14h50 | 1:55 PM Brussels, Brussels South (Gare du Midi) | 0 transfersDirect | |
| Saturday, June 6 | |||||
FlixBus · FlixBus · FlixBus | 9:10 AM Praha, Na Knížecí | 16h35 | 1:45 AM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 9:55 AM Praha, Zličín | 17h30 | 3:25 AM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
FlixBus · FlixBus | 10:35 AM Praha, ÚAN Florenc | 15h10 | 1:45 AM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 10:55 AM Praha, Na Knížecí | 16h30 | 3:25 AM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 12:50 PM Praha, M. Horákové (Hradčanská) | 18h30 | 7:20 AM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus | 4:15 PM Praha, ÚAN Florenc | 15h05 | 7:20 AM Brussels, Brussels South (Gare du Midi) | 0 transfersDirect | |
FlixBus · FlixBus | 5:45 PM Praha, Na Knížecí | 19h00 | 12:45 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 6:00 PM Praha, ÚAN Florenc | 18h25 | 12:25 PM Brussels, Avenue des Magnolias (King Baudouin) | 1 transfer | |
FlixBus · FlixBus · FlixBus | 6:45 PM Prague, Central Train Station | 19h10 | 1:55 PM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 7:25 PM Praha, Zličín | 18h30 | 1:55 PM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Prague to Brussels run on average 15 times per day, taking around 14h 54m. Cheap bus tickets for this journey start at $49 (€40) but you can travel from only $16 (€13) by train.
There are 2 buses per day. The earliest bus runs at 00:10, the last at 23:50. The fastest bus covers the 445 miles (717 km) distance in 12h 0m.
Distance 445 miles (717 km) |
Average bus duration 14h 54m |
Cheapest ticket price $49 (€40) |
Buses per day 15 |
Direct buses 2 |
Fastest bus 12h 0m |
First bus 12:10 AM |
Last bus 11:50 PM |
Cheapest Month Sep |
Cheapest Day Tue |
High Season Oct - Dec |
Low Season Apr - Jun |
Busiest Day Sun |
Least Busy Day Sat |
Best time to book 84 days |
Discover the best of Brussels — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Brussels trip today.
A major complex of art museums covering Flemish masters, Old Masters, and modern art. One of Brussels' essential cultural visits for its scale and national importance.
Dedicated to René Magritte, this museum holds the world's largest collection of his works. It is a standout stop for surrealism lovers and one of Brussels' most famous museums.
A contemporary art museum known for street art, digital culture, and youth-oriented exhibitions. It became especially popular with younger visitors and on social media.
A landscaped cultural hill linking the upper and lower city, known for its formal gardens and classic skyline view. It is one of Brussels' best walking and photography spots.
A beautiful 19th-century covered arcade with elegant glass roofing and historic atmosphere. It is one of the city's most photogenic and fashionable passages.
A grand urban park laid out around monumental buildings and the Cinquantenaire Arch. Ideal for a walk, photos, and combining with nearby museums.
Brussels’ classic pairing of mussels steamed with white wine, celery, and herbs, served with crisp fries. It is one of the city’s most iconic and widely loved meals.
A traditional Belgian beef and onion stew slowly cooked with dark beer, often slightly sweet-sour and served with fries or bread. It is a staple of local brasserie cuisine.
A comforting Brussels side dish of mashed potatoes mixed with seasonal vegetables such as carrots, leeks, or spinach, often served with sausage or meat.
Well-regarded Belgian restaurant serving regional classics, strong beer pairings, and seasonal ingredients in a cozy, old-Brussels dining room.
One of Brussels’ landmark fine-dining restaurants, celebrated for refined Belgian-influenced cuisine, polished service, and an elegant Art Nouveau setting.
Popular traditional restaurant near Sainte-Catherine known for generous Belgian comfort food, beer-based stews, and an unfussy, bustling atmosphere.
Moderate by Western European standards. Beer, waffles, and transit are reasonable; hotels and central dining cost more.
Service is usually included. Tipping is not required, but rounding up or leaving 5-10% for very good restaurant service is appreciated. Round up taxi fares.
Official public transport app
Brussels South (Gare du Midi) -> Brussels Central Station
Find answers to the most common questions about traveling from Prague to Brussels by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brussels, this guide helps you travel smarter and with confidence.

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