- Must visit
Museo Nacional del Prado
Spain’s premier fine art museum, famed for masterpieces by Velázquez, Goya, El Greco, Rubens, and Bosch. A top priority for first-time visitors and art lovers.
Cheapest price
$178
Average price
$245
Fastest journey
1 d 4 h 5 m
Average duration
1 d 11 h 19 m
Buses per day
7
Distance
1219 km
The best way to find a cheap bus ticket from Pisa to Madrid is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Pisa to Madrid will cost around $245 if you buy it on the day, but the cheapest tickets can be found for only $178.
It's difficult to get from Pisa to Madrid without transferring at least once.
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FlixBus · FlixBus · FlixBusOmio recommends booking the flight as it is the most popular option from Pisa to Madrid among Omio's users. If you are prioritising price take the bus with prices starting from $68. For those with little time consider booking a flight which can get you there in 3h 38m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 1.2 - 3.0kg. The ticket price range depends on the travel mode: a bus costs an average of $68, and a train costs an average of $256.
Distance: 757 miles (1219 km)
| Bus | Most popular Flight | Train |
|---|---|---|
$142 Average price Cheapest | $235 Average price | $256 Average price |
23h 19m Average total duration 22h 49m Onboard + 30m Additional time* | 6h 38m Average total duration Fastest 3h 38m Onboard + 3h 0m Additional time* | 45h 53m Average total duration 45h 23m Onboard + 30m Additional time* |
1.2 - 3.0kg CO2 emissions Lowest | 3.7 - 7.3kg CO2 emissions | - CO2 emissions |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Pisa to Madrid:
A bus is $93 (€77) less than a flight for this route with tickets for a flight from Pisa to Madrid costing on average $235 (€194).
A bus is $114 (€94) less than a train for this route with tickets for a train from Pisa to Madrid costing on average $256 (€211).
Other travel options to Madrid take longer:
Bus takes on average 22h 49m.
Train takes on average 45h 23m.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 05:45AM | Arrival Time 02:55PM | Duration 33h10 | Departure days Tue, Wed | Cheapest price $169 |
Operator FlixBus | Departure Time 06:25AM | Arrival Time 02:55PM | Duration 32h30 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $162 |
Operator FlixBus | Departure Time 09:40AM | Arrival Time 07:25AM | Duration 45h45 | Departure days Tue, Wed | Cheapest price $245 |
Operator FlixBus | Departure Time 01:50PM | Arrival Time 07:25AM | Duration 41h35 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $252 |
Operator FlixBus | Departure Time 10:00PM | Arrival Time 02:55PM | Duration 40h55 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $178 |
Operator FlixBus | Departure Time 11:30PM | Arrival Time 03:35PM | Duration 40h05 | Departure days Tue, Wed, Thu, Fri, Sat | Cheapest price $174 |
The table below shows live departures for Pisa to Madrid buses for today, Wednesday, July 1. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus · FlixBus | 11:30 PM Pisa (Pisamover via San Giusto/Aurelia) | 40h05 | 3:35 PM Madrid, Estación Sur de Autobuses | 2 transfers | |
FlixBus · FlixBus · FlixBus | 11:30 PM Pisa (Pisamover via San Giusto/Aurelia) | 39h25 | 2:55 PM Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) | 2 transfers | |
| Thursday, July 2 | |||||
FlixBus · FlixBus · FlixBus | 6:25 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 32h30 | 2:55 PM Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) | 2 transfers | |
FlixBus · FlixBus | 6:25 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 28h05 | 10:30 AM Madrid, Estación Sur de Autobuses | 1 transfer | |
FlixBus · FlixBus · FlixBus | 1:50 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 41h35 | 7:25 AM Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 10:00 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 40h55 | 2:55 PM Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 10:00 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 36h30 | 10:30 AM Madrid, Estación Sur de Autobuses | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Pisa to Madrid run on average 5 times per day, taking around 22h 49m. Cheap bus tickets for this journey start at $68 (€56) but you can travel from only $30 (€25) by flight.
The earliest bus runs at 00:25, the last at 23:50. The fastest bus covers the 757 miles (1219 km) distance in 28h 5m.
Distance 757 miles (1219 km) |
Average bus duration 22h 49m |
Cheapest ticket price $68 (€56) |
Buses per day 5 |
Fastest bus 28h 5m |
First bus 12:25 AM |
Last bus 11:50 PM |
Cheapest Month Oct |
Cheapest Day Wed |
High Season Oct - Dec |
Low Season Apr - Jun |
Busiest Day Wed |
Least Busy Day Fri |
Best time to book 63 days |
Discover the best of Madrid — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Madrid trip today.
Spain’s premier fine art museum, famed for masterpieces by Velázquez, Goya, El Greco, Rubens, and Bosch. A top priority for first-time visitors and art lovers.
Madrid’s leading modern art museum, best known for Picasso’s Guernica alongside major works by Dalí and Miró. Essential for 20th-century art.
A major collection spanning medieval to modern art, completing Madrid’s Golden Triangle of Art. Strong for European painting and accessible curation.
Madrid’s historic main square, surrounded by arcaded buildings and linked to the city’s Habsburg past. A classic stop for architecture and atmosphere.
Madrid’s central square and symbolic heart, home to the Kilometer Zero marker and the famous Bear and Strawberry Tree statue.
Madrid’s iconic boulevard lined with historic architecture, shops, and theaters. It is one of the city’s busiest and most recognizable streets.
Madrid’s signature chickpea stew, traditionally served in stages with broth, vegetables, chickpeas, and assorted meats. It is one of the city’s most emblematic comfort dishes.
A classic Madrid sandwich of fried squid rings in crusty bread, especially associated with bars around Plaza Mayor. It is one of the city’s most iconic quick bites.
A rich traditional stew made with tripe, chorizo, and morcilla in a paprika-forward sauce. It is a historic Madrid tavern specialty.
Classic casual bar famed for fried cod and old-school tapas, popular for a quick authentic stop in central Madrid.
Celebrated traditional restaurant known for huevos rotos and classic Spanish cooking in a refined but lively setting.
Historic tavern especially known for cocido madrileño cooked in individual clay pots, with a classic old-Madrid feel.
Moderate for Western Europe: museums and transit are fair, while central hotels and fine dining cost more.
Service is usually included. Round up or leave 5-10% for great restaurant service; small change in cafes, bars, and taxis is appreciated, not required.
Official public transport app
Madrid, Estación Sur de Autobuses -> Sol, Madrid
Find answers to the most common questions about traveling from Pisa to Madrid by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Madrid, this guide helps you travel smarter and with confidence.

Most Pisa to Madrid buses use the Pisa, Via delle Fiamme Gialle (Park Pietrasantina) to Madrid, Estación Sur de Autobuses station pair, with some services arriving at Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid). Use this guide to compare Pisa and Madrid bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Madrid, Estación Sur de Autobuses is 3 km from Madrid city centre. Public transport options include:
Madrid, Estación Sur de Autobuses has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafetería de la estación (in the station), Restaurante El Brillante (0.5 km), La Taberna de Domínguez (0.7 km).
Free Wi-Fi. ATMs are located near the main entrance and in the waiting area.
Ticket office support is available at Madrid, Estación Sur de Autobuses.
Available at Madrid, Estación Sur de Autobuses: Parking, Taxis, WC.
Accessibility facilities are available at Madrid, Estación Sur de Autobuses: Elevators, ramps.
Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) is 12 km from Madrid city centre. Public transport options include:
Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) has practical services for this route, including Dining, ATM, Accessibility, WC, Shower, and Ticket Office.
Food options include: Rodilla, Mahoudrid
ATMs are aTMs located throughout T4, major cards accepted .
Ticket office support is available at Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid).
Available at Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid): WC.
Accessibility facilities are available at Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid): Step-free access, elevators, accessible toilets.
Here are some other resources that might have the information you need