- Must visit
Museo Nacional del Prado
Spain’s premier art museum, famous for masterpieces by Velázquez, Goya, El Greco, Rubens, and Bosch. A core stop on Madrid’s Golden Triangle of Art.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
The cheapest and fastest buses from Pisa to Madrid
Showing times and prices for May 18
Cheapest price
$137
Average price
$170
Fastest journey
1 d 4 h 5 m
Average duration
1 d 10 h 59 m
Buses per day
6
Distance
1219 km
Cheap tickets
The best way to find a cheap bus ticket from Pisa to Madrid is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Pisa to Madrid will cost around $170 if you buy it on the day, but the cheapest tickets can be found for only $137.
Fast buses
It's difficult to get from Pisa to Madrid without transferring at least once.
FlixBus · FlixBus · FlixBus4:45 PM39h10Pisa, Via delle Fiamme Gialle (Park Pietrasantina)7:55 AMMadrid, Estación Sur de Autobuses$1371One-way2 transfers- FlixBus · FlixBus · FlixBus10:00 PM40h55Pisa, Via delle Fiamme Gialle (Park Pietrasantina)2:55 PMMadrid, Terminal de autobuses T4 (Aeropuerto de Madrid)$1511One-way2 transfers
- FlixBus · FlixBus6:25 AM28h05Pisa, Via delle Fiamme Gialle (Park Pietrasantina)10:30 AMMadrid, Estación Sur de Autobuses$1651One-way1 transfer
- FlixBus · FlixBus · FlixBus6:25 AM32h30Pisa, Via delle Fiamme Gialle (Park Pietrasantina)2:55 PMMadrid, Terminal de autobuses T4 (Aeropuerto de Madrid)$1741One-way2 transfers
- FlixBus · FlixBus · FlixBus10:00 PM36h30Pisa, Via delle Fiamme Gialle (Park Pietrasantina)10:30 AMMadrid, Estación Sur de Autobuses$1951One-way2 transfers
- FlixBus · FlixBus6:25 AM28h05Pisa, Via delle Fiamme Gialle (Park Pietrasantina)10:30 AMMadrid, Estación Sur de Autobuses$1651One-way1 transfer
- FlixBus · FlixBus · FlixBus6:25 AM32h30Pisa, Via delle Fiamme Gialle (Park Pietrasantina)2:55 PMMadrid, Terminal de autobuses T4 (Aeropuerto de Madrid)$1741One-way2 transfers
- FlixBus · FlixBus · FlixBus10:00 PM36h30Pisa, Via delle Fiamme Gialle (Park Pietrasantina)10:30 AMMadrid, Estación Sur de Autobuses$1951One-way2 transfers
- FlixBus · FlixBus · FlixBus4:45 PM38h40Pisa, Via delle Fiamme Gialle (Park Pietrasantina)7:25 AMMadrid, Terminal de autobuses T4 (Aeropuerto de Madrid)$1981One-way2 transfers
- FlixBus · FlixBus · FlixBus4:45 PM39h10Pisa, Via delle Fiamme Gialle (Park Pietrasantina)7:55 AMMadrid, Estación Sur de Autobuses$1371One-way2 transfers
Travel Information
Compare train, bus, and flight for Pisa to Madrid
Omio recommends booking the flight as it is the most popular option from Pisa to Madrid among Omio's users. If you are prioritising price take the bus with prices starting from $69. For those with little time consider booking a flight which can get you there in 3h 38m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 1.2 - 3.0kg. The ticket price range depends on the travel mode: a bus costs an average of $69, and a train costs an average of $261.
Distance: 757 miles (1219 km)
Compare bus with
| Bus | Most popular Flight | Train |
|---|---|---|
$145 Average price Cheapest | $240 Average price | $261 Average price |
23h 19m Average total duration 22h 49m Onboard + 30m Additional time* | 6h 38m Average total duration Fastest 3h 38m Onboard + 3h 0m Additional time* | 45h 53m Average total duration 45h 23m Onboard + 30m Additional time* |
1.2 - 3.0kg CO2 emissions Lowest | 3.7 - 7.3kg CO2 emissions | - CO2 emissions |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
The cheapest way to travel from Pisa to Madrid is a bus with an average price of $145 (€117).
This is compared to other travel options from Pisa to Madrid:
A bus is $95 (€77) less than a flight for this route with tickets for a flight from Pisa to Madrid costing on average $240 (€194).
A bus is $116 (€94) less than a train for this route with tickets for a train from Pisa to Madrid costing on average $261 (€211).
The fastest way to travel from Pisa to Madrid is by flight with an average journey time of 3h 38m.
Other travel options to Madrid take longer:
Bus takes on average 22h 49m.
Train takes on average 45h 23m.
It's helpful to compare your options as there are 3 ways to travel between Pisa and Madrid including taking a train, bus, and flight.
We recommend using the flight as it is the most popular way to get from Pisa to Madrid among Omio's users.
Pisa to Madrid Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 05:45AM | Arrival Time 10:30AM | Duration 28h45 | Departure days Tue | Cheapest price $151 |
Operator FlixBus | Departure Time 06:25AM | Arrival Time 10:30AM | Duration 28h05 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $113 |
Operator FlixBus | Departure Time 01:50PM | Arrival Time 07:25AM | Duration 41h35 | Departure days Fri | Cheapest price $199 |
Operator FlixBus | Departure Time 04:45PM | Arrival Time 07:55AM | Duration 39h10 | Departure days Mon, Thu, Sat | Cheapest price $102 |
Operator FlixBus | Departure Time 06:10PM | Arrival Time 02:55PM | Duration 44h45 | Departure days Wed | Cheapest price $197 |
Operator FlixBus | Departure Time 10:00PM | Arrival Time 02:55PM | Duration 40h55 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $118 |
Operator FlixBus | Departure Time 11:30PM | Arrival Time 02:55PM | Duration 39h25 | Departure days Tue, Wed, Thu, Fri, Sat, Sun | Cheapest price $117 |
Live departures
Pisa to Madrid bus times
The table below shows live departures for Pisa to Madrid buses for today, Sunday, May 17. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| FlixBus · FlixBus · FlixBus | 10:00 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 40h55 | 2:55 PM Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) | 2 transfers | |
| FlixBus · FlixBus · FlixBus | 10:00 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 36h30 | 10:30 AM Madrid, Estación Sur de Autobuses | 2 transfers | |
| FlixBus · FlixBus · FlixBus | 11:30 PM Pisa, Aeroporto Parcheggio Aurelia | 40h05 | 3:35 PM Madrid, Estación Sur de Autobuses | 2 transfers | |
| FlixBus · FlixBus · FlixBus | 11:30 PM Pisa, Aeroporto Parcheggio Aurelia | 39h25 | 2:55 PM Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) | 2 transfers | |
| Monday, May 18 | |||||
| FlixBus · FlixBus · FlixBus | 6:25 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 32h30 | 2:55 PM Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) | 2 transfers | |
| FlixBus · FlixBus | 6:25 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 28h05 | 10:30 AM Madrid, Estación Sur de Autobuses | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Pisa to Madrid by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Sun
May 17
May 17
Mon
May 18
May 18
Tue
May 19
May 19
Wed
May 20
May 20
Thu
May 21
May 21
Fri
May 22
May 22
Sat
May 23
May 23
Sun
May 24
May 24
Mon
May 25
May 25
Tue
May 26
May 26
Wed
May 27
May 27
Thu
May 28
May 28
Fri
May 29
May 29
Sat
May 30
May 30
Sun
May 31
May 31
Mon
Jun 01
Jun 01
Tue
Jun 02
Jun 02
Wed
Jun 03
Jun 03
Thu
Jun 04
Jun 04
Fri
Jun 05
Jun 05
Sat
Jun 06
Jun 06
Why should you book Pisa to Madrid buses with Omio?
FlixBus operates all buses services from Pisa to Madrid.
Omio is an official ticket reseller for all your travel options from Pisa to Madrid.
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Pisa to Madrid.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Pisa to Madrid.
Journey information
Overview: Bus from Pisa to Madrid
Italy
Spain
Buses from Pisa to Madrid run on average 5 times per day, taking around 22h 49m. Cheap bus tickets for this journey start at $69 (€56) but you can travel from only $31 (€25) by flight.
The earliest bus runs at 00:25, the last at 23:50. The fastest bus covers the 757 miles (1219 km) distance in 28h 5m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $31 (€25)
Distance 757 miles (1219 km) |
Average bus duration 22h 49m |
Cheapest ticket price $69 (€56) |
Buses per day 5 |
Fastest bus 28h 5m |
First bus 12:25 AM |
Last bus 11:50 PM |
Cheapest Month Oct |
Cheapest Day Wed |
High Season Oct - Dec |
Low Season Apr - Jun |
Busiest Day Wed |
Least Busy Day Fri |
Best time to book 63 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $31 (€25)
Bus providers: FlixBus from Pisa to MadridYou can travel by bus between Pisa to Madrid with FlixBus for as low as $31 (€25). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
28h 5m
Cheapest Price
$69 (€56)
FlixBus frequency
5 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Complete guide to Madrid
Things to do in Madrid
Discover the best of Madrid — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Madrid trip today.
- Must visit
Museo Nacional Centro de Arte Reina Sofía
Spain’s leading museum of modern and contemporary art, best known for Picasso’s Guernica alongside works by Dalí and Miró.
- Must visit
Museo Nacional Thyssen-Bornemisza
Major collection spanning medieval to modern art, with celebrated works by Caravaggio, Monet, Van Gogh, Hopper, and Kandinsky.
- Must visit
Parque de El Retiro
Madrid’s most famous park, ideal for strolling, rowing, people-watching, and seeing monuments such as the Crystal Palace.
- Must visit
Puerta del Sol
The symbolic center of Madrid and Spain’s radial road network, always busy and central to city life and celebrations.
- Must visit
Gran Vía
Madrid’s best-known boulevard, lined with landmark architecture, theaters, shops, and rooftop viewpoints popular with visitors.
- Gluten-free
Cocido Madrileño
Madrid’s classic chickpea stew, traditionally served in stages with broth, vegetables, chickpeas, and assorted meats. It is one of the city’s signature comfort dishes.
Bocadillo de Calamares
A famous Madrid sandwich of fried squid rings in crusty bread, especially associated with bars around Plaza Mayor. It is a simple local staple and iconic snack.
- Gluten-free
Callos a la Madrileña
A rich Madrid-style tripe stew cooked with chorizo, morcilla, and paprika. It is a traditional cold-weather dish with deep roots in local tavern cuisine.
Sobrino de Botín
Historic restaurant founded in the 18th century, famous for roast suckling pig and other classic Castilian dishes in an old-world setting.
Casa Lucio
Well-known traditional restaurant celebrated for huevos rotos and classic Madrid dining. The atmosphere is polished but rooted in old tavern tradition.
Taberna La Bola
Historic tavern especially known for cocido madrileño cooked in individual clay pots. A strong choice for an authentic, traditional meal.
Euro
Moderate for Western Europe: tapas and transit are reasonable, while central hotels and fine dining cost more.
Average meal costs
- Budget
- EUR 10-15 for a simple meal.
- Mid-range
- EUR 20-35 per person.
- Fine dining
- EUR 60+ per person.
- Coffee
- EUR 1.80-3 for coffee.
Tipping culture
Service is usually included. Locals often round up or leave EUR 1-2 at cafes; about 5-10% in restaurants for great service. Taxis are usually rounded up.
Tarjeta Transporte
Get the appOfficial public transport app
Prices
- Single ticket
- 1.50 EUR
- Day pass
- 8.40 EUR
To the city center
Madrid, Estación Sur de Autobuses -> Puerta del Sol, Madrid
- Distance
- 4 km
- Travel time
- 20 min
- You can pay by bank card directly on EMT Madrid city buses, but Metro tickets usually require a transport card or ticket purchase before travel.
- The Tourist Travel Pass covers Metro, EMT buses, and Cercanías in the selected zones, and is often the best choice for unlimited travel.
FAQs: Bus from Pisa to Madrid
Find answers to the most common questions about traveling from Pisa to Madrid by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Madrid, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Pisa to Madrid can start from as little as $69 (€56) when you book in advance. The average bus ticket price for Pisa to Madrid is $145 (€117) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Pisa to Madrid is 28h 5m to travel the 757 miles (1219 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Pisa to Madrid leaves at 12:25 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Pisa to Madrid leaves at 11:50 PM.
There are 5 buses a day from Pisa to Madrid which require at least one change with FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Pisa to Madrid, you can count on FlixBus for the best way to get you to Madrid. You can also check all possible bus companies who offer a service between Pisa and Madrid and compare the amenities they offer before buying a bus ticket.
When departing from Pisa , you have various bus station options to start your journey from including Pisa, Via delle Fiamme Gialle (Park Pietrasantina), Pisa, Aeroporto Parcheggio Aurelia, Lucca, Viale Regina Margherita / Via Montanara . When arriving in Madrid , you can end your journey in bus stations like Madrid, Estación Sur de Autobuses, Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) .Passengers board the bus most frequently from Pisa, Via delle Fiamme Gialle (Park Pietrasantina), which is located around 0 away from the city centre, and they get off the bus at Madrid, Estación Sur de Autobuses, located 3 away from the city centre.
A trip to Madrid from Pisa is worth doing but not as a day trip with a journey time of 28h 5m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Pisa to Madrid is October.
It's helpful to compare your options as there are 3 ways to travel between Pisa and Madrid including taking a train, bus, and flight.
Yes, the following accessibility options are available when taking the bus from Pisa to Madrid:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Pisa to Madrid for bus company FlixBus.
Some of the most interesting sights to explore in Madrid are:
- Prado Museum, a renowned art museum housing European masterpieces from the 12th to the early 20th century
- Royal Palace of Madrid, the official residence of the Spanish royal family with opulent architecture and historical artifacts
- Retiro Park, a large and popular park in the city center featuring sculptures, a lake, and the Crystal Palace
- Plaza Mayor, a grand square surrounded by historic buildings and a hub for cultural events and markets
- Gran Vía, a bustling street known for its shopping, theaters, and vibrant nightlife.
The best things to do in Madrid include:
- Puerta del Sol, a bustling public square known for its iconic clock and vibrant atmosphere
- Mercado de San Miguel, a historic market offering a variety of gourmet foods and traditional Spanish delicacies
- Explore the vibrant nightlife in the Malasaña district, known for its eclectic bars and live music venues
- Attend a flamenco show to experience traditional Spanish dance and music
- Visit the Santiago Bernabéu Stadium, home to Real Madrid, for a tour or to catch a football match.
Whether you can cancel your bus ticket from Pisa to Madrid depends on the bus companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Pisa to Madrid.
Yes, the following luggage options are included when booking a bus ticket from Pisa to Madrid:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Pisa to Madrid:
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Pisa to Madrid. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Pisa to Madrid with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from Pisa to Madrid with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from Pisa to Madrid with the following bus company: FlixBus.
Since both Pisa and Madrid are in the Schengen Area, a passport is not required for European Union (EU) or Schengen-associated country citizens. A national ID card is sufficient.
We recommend using the flight as it is the most popular way to get from Pisa to Madrid among Omio's users.
Spain uses the euro (€) as its currency. Travelers can use both cash and cards, but cards are widely accepted in cities and tourist areas, while cash may be preferred for small purchases, markets, and rural locations.
In Madrid, the main safety concerns for travelers include pickpocketing, especially in crowded areas like Puerta del Sol, Gran Vía, and on public transportation. Common scams involve distraction techniques, such as someone asking for signatures on petitions or offering friendship bracelets, to steal valuables. Travelers should also be cautious of unlicensed taxi drivers and always use official transport services. Staying vigilant in busy tourist spots and keeping belongings secure helps minimize risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Pisa to Madrid
Pisa
Madrid
The major bus station for departures in Pisa is Pisa, Via delle Fiamme Gialle (Park Pietrasantina). Find all the information you need to know about services, amenities and connections at Pisa, Via delle Fiamme Gialle (Park Pietrasantina) for your trip from Pisa to Madrid.
Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
information
Pisa, Aeroporto Parcheggio Aurelia
information
The major bus station for arrivals in Madrid is Madrid, Estación Sur de Autobuses. Find all the information you need to know about services, amenities and connections at Madrid, Estación Sur de Autobuses for your trip to Madrid from Pisa.
Madrid, Estación Sur de Autobuses
Amenities at bus station
WifiParkingDiningATMTaxisAccessibilityWCTicket Officeinformation
Ticket Office Hours
- 06:00-23:00
Distance to city center
3 km
Car connection
Calle de Méndez ÁlvaroWifi
- Free Wi-Fi
Dining
- Cafetería de la estación (in the station)
- Restaurante El Brillante (0.5 km)
- La Taberna de Domínguez (0.7 km).
Taxis
- Available outside the main entrance.
Accessibility
- Elevators, ramps
WC
- Available in the station.
Public transit options for Madrid, Estación Sur de Autobuses
- Bus: 8, 102, 148 Metro: L6 Train: C1, C5
Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid)
Amenities at bus station
DiningATMAccessibilityWCShowerTicket Officeinformation
Ticket Office Hours
- 06:00-23:00
Distance to city center
12 kmCar connection
M-40, M-14Dining
- Rodilla, Mahoudrid
Accessibility
- Step-free access, elevators, accessible toilets
WC
- Located inside the terminal, well-signposted, accessible, and generally clean
Shower
- No public showers in the bus station area; showers available in airport lounges (approx. €15-€30 for lounge access)
Public transit options for Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid)
- Metro Line 8, Aeropuerto T4, 12 km
Most popular bus connections from Pisa
More options for your journey from Pisa to Madrid
Here are some other resources that might have the information you need
Most popular buses to and from Madrid and Pisa
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
