- Must visit
Städel Museum
One of Germany’s leading art museums, with major European works from the Middle Ages to the present on the Museumsufer.
Cheapest price
$125
Average price
$158
Fastest journey
16 h 10 m
Average duration
17 h 33 m
Buses per day
11
Distance
723 km
The best way to find a cheap bus ticket from Pisa to Frankfurt am Main is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Pisa to Frankfurt am Main will cost around $158 if you buy it on the day, but the cheapest tickets can be found for only $125.
It's difficult to get from Pisa to Frankfurt am Main without transferring at least once.
FlixBus · FlixBus
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FlixTrain
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FlixTrainOmio recommends booking the flight as it is the most popular option from Pisa to Frankfurt am Main among Omio's users. If you are prioritising price take the bus with prices starting from $71. For those with little time consider booking a flight which can get you there in 1h 35m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.7 - 1.8kg. The ticket price range depends on the travel mode: a bus costs an average of $71, and a flight costs an average of $165.
Distance: 449 miles (723 km)
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$101 Average price Cheapest | $375 Average price | $304 Average price | $289 Average price (fuel + tolls) |
16h 24m Average total duration 15h 54m Onboard + 30m Additional time* | 4h 35m Average total duration Fastest 1h 35m Onboard + 3h 0m Additional time* | 12h 6m Average total duration 11h 36m Onboard + 30m Additional time* | 10h 10m Average total duration (door-to-door) |
0.7 - 1.8kg CO2 emissions Lowest | 2.2 - 4.3kg CO2 emissions | - CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Pisa to Frankfurt am Main:
A bus is $203 (€164) less than a train for this route with tickets for a train from Pisa to Frankfurt am Main costing on average $304 (€246).
A bus is $274 (€221) less than a flight for this route with tickets for a flight from Pisa to Frankfurt am Main costing on average $375 (€303).
Other travel options to Frankfurt am Main take longer:
Train takes on average 11h 36m.
Bus takes on average 15h 54m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 07:15AM | Arrival Time 02:50AM | Duration 19h35 | Departure days Tue, Wed, Thu, Fri, Sat, Sun | Cheapest price $91 |
Operator FlixBus | Departure Time 09:40AM | Arrival Time 05:50AM | Duration 20h10 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $99 |
Operator FlixBus | Departure Time 01:50PM | Arrival Time 06:00AM | Duration 16h10 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $92 |
Operator FlixBus | Departure Time 04:45PM | Arrival Time 01:55PM | Duration 21h10 | Departure days Mon, Thu | Cheapest price $95 |
Operator FlixBus | Departure Time 05:10PM | Arrival Time 11:30AM | Duration 18h20 | Departure days Everyday | Cheapest price $82 |
Operator FlixBus | Departure Time 10:00PM | Arrival Time 06:00PM | Duration 20h00 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $92 |
Operator FlixBus | Departure Time 11:30PM | Arrival Time 01:55AM | Duration 26h25 | Departure days Tue, Wed | Cheapest price $82 |
The table below shows live departures for Pisa to Frankfurt am Main buses for today, Friday, June 5. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 1:50 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 16h10 | 6:00 AM Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof) | 1 transfer | |
FlixBus · FlixBus · FlixBus | 1:50 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 17h55 | 7:45 AM Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) | 2 transfers | |
FlixBus · FlixBus | 5:10 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 18h20 | 11:30 AM Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof) | 1 transfer | |
FlixBus · FlixBus+ FlixTrain | 5:10 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 18h45 | 11:55 AM Frankfurt South station | 2 transfers | |
FlixBus · FlixBus | 5:10 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 16h35 | 9:45 AM Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) | 1 transfer | |
FlixBus · FlixBus · FlixBus | 10:00 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 20h00 | 6:00 PM Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 10:00 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 19h35 | 5:35 PM Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) | 2 transfers | |
| Saturday, June 6 | |||||
FlixBus · FlixBus · FlixBus | 7:15 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 20h00 | 3:15 AM Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 7:15 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 19h35 | 2:50 AM Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof) | 2 transfers | |
FlixBus · FlixBus | 9:40 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 19h50 | 5:30 AM Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) | 1 transfer | |
FlixBus · FlixBus | 9:40 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 20h10 | 5:50 AM Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Pisa to Frankfurt am Main run on average 10 times per day, taking around 15h 54m. Cheap bus tickets for this journey start at $71 (€58) if you book in advance.
The earliest bus runs at 00:05, the last at 23:30. The fastest bus covers the 449 miles (723 km) distance in 16h 10m.
Distance 449 miles (723 km) |
Average bus duration 15h 54m |
Cheapest ticket price $71 (€58) |
Buses per day 10 |
Fastest bus 16h 10m |
First bus 12:05 AM |
Last bus 11:30 PM |
Cheapest Month Feb |
Cheapest Day Tue |
High Season Oct - Dec |
Low Season Apr - Jun |
Busiest Day Tue |
Least Busy Day Tue |
Best time to book 14 days |
Discover the best of Frankfurt am Main — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Frankfurt am Main trip today.
One of Germany’s leading art museums, with major European works from the Middle Ages to the present on the Museumsufer.
A favorite for families and science lovers, famous for dinosaur skeletons and extensive natural history displays.
Major contemporary and modern art exhibition hall known for high-profile temporary shows in the historic center.
Frankfurt’s historic central square, lined with traditional-style buildings and closely linked to the city’s medieval past.
The museum embankment along the Main is ideal for scenic walks and easy access to many of the city’s top museums.
Riverside promenade popular for skyline photography, walks, and open views across the Main and central Frankfurt.
Thin smoked pork sausages traditionally served warm with mustard, bread, and potato salad. They are one of Frankfurt’s best-known culinary specialties with protected regional status.
Frankfurt’s famous cold herb sauce made with seven herbs, usually served with boiled eggs and potatoes. It is a classic local spring and summer dish strongly associated with the city.
A sour milk cheese specialty marinated with onions, vinegar, and oil. It is a traditional Hessian tavern dish, especially popular with apple wine.
Two-Michelin-star fine dining restaurant in the Palmengarten, known for elegant modern cuisine and polished service in a refined setting.
Classic apple wine tavern in Sachsenhausen known for Grüne Soße, schnitzel, and traditional Frankfurt atmosphere with communal seating.
Well-known traditional Hessian restaurant and cider house, popular for hearty regional dishes and house apple wine in a historic setting.
Prices are high by German standards, especially hotels and dining near the centre and trade fair areas.
Service is usually included. In restaurants, round up or leave 5-10%; about 10% for very good service. Round up taxi fares. Small tips are optional in cafes and bars.
Official public transport app
Flughafen Frankfurt Terminal 1 Busparkplatz P36, Frankfurt am Main -> Frankfurt (Main) Hauptbahnhof, Frankfurt am Main
Find answers to the most common questions about traveling from Pisa to Frankfurt am Main by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Frankfurt am Main, this guide helps you travel smarter and with confidence.

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