The cheapest and fastest buses from Pisa to Frankfurt am Main
Cheapest price
$106
Average price
$120
Fastest journey
16 h 20 m
Average duration
19 h 16 m
Buses per day
5
Distance
723 km
The best way to find a cheap bus ticket from Pisa to Frankfurt am Main is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Pisa to Frankfurt am Main will cost around $120 if you buy it on the day, but the cheapest tickets can be found for only $106.
Of the 5 buses that leave Pisa for Frankfurt am Main on Sat, Dec 06, 5 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Dec 06 the direct buses cover the 723 km distance in an average of 19 h 16 m but if you time it right, some buses will get you there in just 16 h 20 m .
On Sat, Dec 06 the slowest buses will take 23 h 10 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.










Travel Information
Compare train, bus, and flight for Pisa to Frankfurt am Main
Omio recommends booking the flight as it is the most popular option from Pisa to Frankfurt am Main among Omio's users. If you are prioritising price take the bus with prices starting from €56. For those with little time consider booking a flight which can get you there in 2h 26m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.7 - 1.8kg. The ticket price range depends on the travel mode: a bus costs an average of €56, and a flight costs an average of €134.
Distance: 449 miles (723 km)
Compare bus with
| Bus | Most popular Flight | Train |
|---|---|---|
€100 Average price Cheapest | €376 Average price | €250 Average price |
16h 47m Average total duration 16h 17m Onboard + 30m Additional time* | 5h 26m Average total duration Fastest 2h 26m Onboard + 3h 0m Additional time* | 12h 3m Average total duration 11h 33m Onboard + 30m Additional time* |
0.7 - 1.8kg CO2 emissions Lowest | 2.2 - 4.3kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Live departures
Pisa to Frankfurt am Main bus times
The table below shows live departures for Pisa to Frankfurt am Main buses for today, Friday, December 5. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 5:10 AM Pisa | 19h40 | 12:50 AM Frankfurt am Main | 0 transfersDirect | |
![]() | 7:40 AM Pisa | 19h50 | 3:30 AM Frankfurt am Main | 0 transfersDirect | |
![]() | 4:15 PM Pisa | 23h10 | 3:25 PM Frankfurt am Main | 0 transfersDirect | |
![]() | 9:15 PM Pisa | 23h30 | 8:45 PM Frankfurt am Main | 0 transfersDirect | |
![]() | 9:30 PM Pisa | 23h15 | 8:45 PM Frankfurt am Main | 0 transfersDirect |
Find all the dates and times for this journey
Compare prices and tickets Pisa to Frankfurt am Main by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Dec 06
Dec 07
Dec 08
Dec 09
Dec 10
Dec 11
Dec 12
Journey information
Overview: Bus from Pisa to Frankfurt am Main
Buses from Pisa to Frankfurt am Main run on average 9 times per day, taking around 16h 17m. Cheap bus tickets for this journey start at $70 (€56) if you book in advance.
The earliest bus runs at 00:15, the last at 23:30. The fastest bus covers the 449 miles (723 km) distance in 16h 20m.
Distance 449 miles (723 km) |
Average bus duration 16h 17m |
Cheapest ticket price $70 (€56) |
Buses per day 9 |
Fastest bus 16h 20m |
First bus 00:15 |
Last bus 23:30 |
Bus providers: FlixBus, Lirosi Linee from Pisa to Frankfurt am MainYou can travel by bus between Pisa to Frankfurt am Main with FlixBus, Lirosi Linee for as low as $70 (€56). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Lirosi Linee
FAQs: Bus from Pisa to Frankfurt am Main
Find answers to the most common questions about traveling from Pisa to Frankfurt am Main by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Frankfurt am Main, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Römer, a historic city hall with medieval architecture located in the heart of Frankfurt's old town
- Städel Museum, an art museum featuring a vast collection of European artworks from the Middle Ages to the present
- Palmengarten, a large botanical garden showcasing diverse plant species in themed greenhouses and outdoor areas
- Goethe House, the birthplace of the famous writer Johann Wolfgang von Goethe, now a museum dedicated to his life and works
- Frankfurt Cathedral, a Gothic-style church with a rich history and stunning architecture.
- Main Tower, a skyscraper with an observation deck providing panoramic views of the city
- Explore the vibrant Kleinmarkthalle, an indoor market offering a variety of local and international foods
- Visit the Senckenberg Natural History Museum, home to an extensive collection of dinosaur fossils and natural exhibits
- Take a leisurely walk along the River Main and enjoy the scenic views
- Experience the lively atmosphere of the Zeil, Frankfurt's premier shopping street.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
To find the cheapest bus tickets for your trip from Pisa to Frankfurt am Main, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- Guide dogs travel for free.
popular bus stations
Popular bus stations from Pisa to Frankfurt am Main
- 00:00-23:59
- Free Wi-Fi
- McDonald's (in the station)
- Hausmann's (in the station).
- Available outside the terminal at designated taxi stands.
- Elevators, ramps, assistance
- Available in the station.
- Bus: 61, 62, 77 Train: S8, S9
Most popular bus connections from Pisa
More options for your journey from Pisa to Frankfurt am Main
Here are some other resources that might have the information you need


