Pisa to Frankfurt am Main bus with FlixBus

Sat, Jun 06
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The cheapest and fastest buses from Pisa to Frankfurt am Main

Showing times and prices for Jun 06

Cheapest price

$125

Average price

$158

Fastest journey

16 h 10 m

Average duration

17 h 33 m

Buses per day

11

Distance

723 km

Cheap tickets

The best way to find a cheap bus ticket from Pisa to Frankfurt am Main is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from Pisa to Frankfurt am Main will cost around $158 if you buy it on the day, but the cheapest tickets can be found for only $125.

Fast buses

It's difficult to get from Pisa to Frankfurt am Main without transferring at least once.

  • FlixBusFlixBus · FlixBus
    1:50 PM16h10
    Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
    6:00 AMFrankfurt, Stuttgarter Straße (Fermomnibusbahnhof)
    $1251One-way
    1 transfer
  • FlixBusFlixBus · FlixBus · FlixBus
    1:50 PM17h55
    Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
    7:45 AMFrankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)
    $1261One-way
    2 transfers
  • FlixBusFlixBus · FlixBus
    9:40 AM20h10
    Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
    5:50 AMFrankfurt, Stuttgarter Straße (Fermomnibusbahnhof)
    $1381One-way
    1 transfer
  • FlixBusFlixBus · FlixBus+FlixTrainFlixTrain
    5:10 PM18h45
    Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
    11:55 AMFrankfurt South station
    $1401One-way
    2 transfers
  • FlixBusFlixBus · FlixBus
    9:40 AM19h50
    Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
    5:30 AMFrankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)
    $1411One-way
    1 transfer

Travel Information

Compare train, bus, and flight for Pisa to Frankfurt am Main

Omio recommends booking the flight as it is the most popular option from Pisa to Frankfurt am Main among Omio's users. If you are prioritising price take the bus with prices starting from $71. For those with little time consider booking a flight which can get you there in 1h 35m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.7 - 1.8kg. The ticket price range depends on the travel mode: a bus costs an average of $71, and a flight costs an average of $165.

Distance: 449 miles (723 km)

Compare bus with

Bus
Most popular
Flight
Train
Driving

$101

Average price

Cheapest

$375

Average price

$304

Average price

$288

Average price

(fuel + tolls)

16h 24m

Average total duration

15h 54m

Onboard

+

30m

Additional time*

4h 35m

Average total duration

Fastest

1h 35m

Onboard

+

3h 0m

Additional time*

12h 6m

Average total duration

11h 36m

Onboard

+

30m

Additional time*

10h 10m

Average total duration

(door-to-door)

0.7 - 1.8kg

CO2 emissions

Lowest

2.2 - 4.3kg

CO2 emissions

-

CO2 emissions

-

CO2 emissions

FlixBus

Most popular bus company

Air Dolomiti

Most popular airline

Deutsche Bahn

Most popular train company

Your own car or car rental

Direct Options

Direct Options

Direct Options

Direct Options

Additional time: Average total travel duration to departure point, security checks and transfers.

The cheapest way to travel from Pisa to Frankfurt am Main is a bus with an average price of $101 (€82).

This is compared to other travel options from Pisa to Frankfurt am Main:

A bus is $203 (€164) less than a train for this route with tickets for a train from Pisa to Frankfurt am Main costing on average $304 (€246).

A bus is $274 (€221) less than a flight for this route with tickets for a flight from Pisa to Frankfurt am Main costing on average $375 (€303).

The fastest way to travel from Pisa to Frankfurt am Main is by flight with an average journey time of 1h 35m.

Other travel options to Frankfurt am Main take longer:

Train takes on average 11h 36m.

Bus takes on average 15h 54m.

It's helpful to compare your options as there are 3 ways to travel between Pisa and Frankfurt am Main including taking a train, bus, and flight.
We recommend using the flight as it is the most popular way to get from Pisa to Frankfurt am Main among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.

You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.

Direct coaches are operated by {directProviders}.

Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.

Pisa to Frankfurt am Main Bus Timetables

OperatorDeparture TimeArrival TimeDurationDeparture daysCheapest price
Operator
FlixBus
Departure Time
07:15AM
Arrival Time
02:50AM
Duration
19h35
Departure days
Tue, Wed, Thu, Fri, Sat, Sun
Cheapest price
$91
Operator
FlixBus
Departure Time
09:40AM
Arrival Time
05:30AM
Duration
19h50
Departure days
Mon, Thu, Fri, Sat, Sun
Cheapest price
$99
Operator
FlixBus
Departure Time
01:50PM
Arrival Time
06:00AM
Duration
16h10
Departure days
Mon, Thu, Fri, Sat, Sun
Cheapest price
$91
Operator
FlixBus
Departure Time
04:45PM
Arrival Time
01:55PM
Duration
21h10
Departure days
Mon, Thu
Cheapest price
$95
Operator
FlixBus
Departure Time
05:10PM
Arrival Time
11:30AM
Duration
18h20
Departure days
Everyday
Cheapest price
$82
Operator
FlixBus
Departure Time
10:00PM
Arrival Time
06:00PM
Duration
20h00
Departure days
Mon, Thu, Fri, Sat, Sun
Cheapest price
$92
Operator
FlixBus
Departure Time
11:30PM
Arrival Time
01:55AM
Duration
26h25
Departure days
Tue, Wed
Cheapest price
$82

Live departures

Pisa to Frankfurt am Main bus times

The table below shows live departures for Pisa to Frankfurt am Main buses for today, Friday, June 5. You can also manually refresh the results below to see updated bus journeys.

Last updated at
ProviderDepartsDurationArrivesTransfers
Tickets
FlixBusFlixBus · FlixBus9:40 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
20h10
5:50 AM Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof)1 transfer
FlixBusFlixBus · FlixBus9:40 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
19h50
5:30 AM Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)1 transfer
FlixBusFlixBus · FlixBus1:50 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
16h10
6:00 AM Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof)1 transfer
FlixBusFlixBus · FlixBus · FlixBus1:50 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
17h55
7:45 AM Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)2 transfers
FlixBusFlixBus · FlixBus5:10 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
18h20
11:30 AM Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof)1 transfer
FlixBusFlixBus · FlixBus+FlixTrainFlixTrain5:10 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
18h45
11:55 AM Frankfurt South station2 transfers
FlixBusFlixBus · FlixBus5:10 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
16h35
9:45 AM Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)1 transfer
FlixBusFlixBus · FlixBus · FlixBus10:00 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
20h00
6:00 PM Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof)2 transfers
FlixBusFlixBus · FlixBus · FlixBus10:00 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
19h35
5:35 PM Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)2 transfers
Saturday, June 6
FlixBusFlixBus · FlixBus · FlixBus7:15 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
20h00
3:15 AM Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)2 transfers
FlixBusFlixBus · FlixBus · FlixBus7:15 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
19h35
2:50 AM Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof)2 transfers

This is the last bus of the day.

Find all the dates and times for this journey

Compare prices and tickets Pisa to Frankfurt am Main by train, bus, or flight

Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Sat
Jun 06
Sun
Jun 07
Mon
Jun 08
Tue
Jun 09
Wed
Jun 10
Thu
Jun 11
Fri
Jun 12
Sat
Jun 13
Sun
Jun 14
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19

Why should you book Pisa to Frankfurt am Main buses with Omio?

FlixBus operates all buses services from Pisa to Frankfurt am Main.
Omio is an official ticket reseller for all your travel options from Pisa to Frankfurt am Main.

Why book with Omio vs FlixBus?

  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Pisa to Frankfurt am Main.

Why book with Omio over Wanderu or Trainline?

  • Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Pisa to Frankfurt am Main.

Journey information

Overview: Bus from Pisa to Frankfurt am Main

ItalyItaly
GermanyGermany
Icon of bus

Buses from Pisa to Frankfurt am Main run on average 10 times per day, taking around 15h 54m. Cheap bus tickets for this journey start at $71 (€58) if you book in advance.

The earliest bus runs at 00:05, the last at 23:30. The fastest bus covers the 449 miles (723 km) distance in 16h 10m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
449 miles (723 km)
Average bus duration
15h 54m
Cheapest ticket price
$71 (€58)
Buses per day
10
Fastest bus
16h 10m
First bus
12:05 AM
Last bus
11:30 PM
Cheapest Month
Feb
Cheapest Day
Tue
High Season
Oct - Dec
Low Season
Apr - Jun
Busiest Day
Tue
Least Busy Day
Tue
Best time to book
14 days
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: FlixBus from Pisa to Frankfurt am MainYou can travel by bus between Pisa to Frankfurt am Main with FlixBus for as low as $71 (€58). When you search for schedules and tickets, Omio will show you the best journey

FlixBus

About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
16h 10m
Cheapest Price
$71 (€58)
FlixBus frequency
10 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.

Complete guide to Frankfurt am Main

Things to do in Frankfurt am Main

Discover the best of Frankfurt am Main — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Frankfurt am Main trip today.

  • Must visit

Städel Museum

One of Germany’s leading art museums, with major European works from the Middle Ages to the present on the Museumsufer.

  • Must visit

Senckenberg Naturmuseum

A favorite for families and science lovers, famous for dinosaur skeletons and extensive natural history displays.

  • Recommended

Schirn Kunsthalle Frankfurt

Major contemporary and modern art exhibition hall known for high-profile temporary shows in the historic center.

Euro

Prices are high by German standards, especially hotels and dining near the centre and trade fair areas.

Average meal costs

Budget
EUR 8-15 for kebab, bakery, or simple lunch.
Mid-range
EUR 18-35 per person at a casual restaurant.
Fine dining
EUR 70+ per person at upscale restaurants.
Coffee
EUR 3-5 for a cappuccino or latte.

Tipping culture

Service is usually included. In restaurants, round up or leave 5-10%; about 10% for very good service. Round up taxi fares. Small tips are optional in cafes and bars.

FAQs: Bus from Pisa to Frankfurt am Main

Find answers to the most common questions about traveling from Pisa to Frankfurt am Main by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Frankfurt am Main, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from Pisa to Frankfurt am Main can start from as little as $71 (€58) when you book in advance. The average bus ticket price for Pisa to Frankfurt am Main is $101 (€82) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Pisa to Frankfurt am Main is 16h 10m to travel the 449 miles (723 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Pisa to Frankfurt am Main leaves at 12:05 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Pisa to Frankfurt am Main leaves at 11:30 PM.
There are 10 buses a day from Pisa to Frankfurt am Main which require at least one change with FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Pisa to Frankfurt am Main, you can count on FlixBus for the best way to get you to Frankfurt am Main. You can also check all possible bus companies who offer a service between Pisa and Frankfurt am Main and compare the amenities they offer before buying a bus ticket.
When departing from Pisa , you have various bus station options to start your journey from including Pisa, Via delle Fiamme Gialle (Park Pietrasantina), Pisa, Aeroporto Parcheggio Aurelia, Lucca, Viale Regina Margherita / Via Montanara . When arriving in Frankfurt am Main , you can end your journey in bus stations like Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36), Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof), Darmstadt, Busbahnhof Zweifalltorweg, Darmstadt, Lise-Meitner-Str. / Europaplatz .Passengers board the bus most frequently from Pisa, Via delle Fiamme Gialle (Park Pietrasantina), which is located around 0 away from the city centre, and they get off the bus at Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36), located 10 away from the city centre.
A trip to Frankfurt am Main from Pisa is worth doing but not as a day trip with a journey time of 16h 10m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Pisa to Frankfurt am Main is February.
It's helpful to compare your options as there are 3 ways to travel between Pisa and Frankfurt am Main including taking a train, bus, and flight.
Yes, there are bathrooms on board the bus from Pisa to Frankfurt am Main for bus company FlixBus.
Yes, the following accessibility options are available when taking the bus from Pisa to Frankfurt am Main:
  • FlixBus
    • Assistance
    • Priority boarding
    • Wheelchair-accessible buses.
Some of the most interesting sights to explore in Frankfurt am Main are:
  • Römer, a historic city hall with medieval architecture located in the heart of Frankfurt's old town
  • Städel Museum, an art museum featuring a vast collection of European artworks from the Middle Ages to the present
  • Palmengarten, a large botanical garden showcasing diverse plant species in themed greenhouses and outdoor areas
  • Goethe House, the birthplace of the famous writer Johann Wolfgang von Goethe, now a museum dedicated to his life and works
  • Frankfurt Cathedral, a Gothic-style church with a rich history and stunning architecture.
The best things to do in Frankfurt am Main include:
  • Main Tower, a skyscraper with an observation deck providing panoramic views of the city
  • Explore the vibrant Kleinmarkthalle, an indoor market offering a variety of local and international foods
  • Visit the Senckenberg Natural History Museum, home to an extensive collection of dinosaur fossils and natural exhibits
  • Take a leisurely walk along the River Main and enjoy the scenic views
  • Experience the lively atmosphere of the Zeil, Frankfurt's premier shopping street.
Whether you can cancel your bus ticket from Pisa to Frankfurt am Main depends on the bus companies:
  • FlixBus
    • You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Pisa to Frankfurt am Main.
Yes, the following luggage options are included when booking a bus ticket from Pisa to Frankfurt am Main:
  • FlixBus
    • One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Pisa to Frankfurt am Main:
  • FlixBus
    • Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Pisa to Frankfurt am Main. The following conditions apply:
  • FlixBus
    • Small pets in carriers allowed
    • guide dogs travel for free.
You can reserve your seat on the bus from Pisa to Frankfurt am Main with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from Pisa to Frankfurt am Main with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from Pisa to Frankfurt am Main with the following bus company: FlixBus.
Since both Pisa and Frankfurt am Main are in the Schengen Area, a passport is not required for European Union (EU) or Schengen-associated country citizens. A national ID card is sufficient.
We recommend using the flight as it is the most popular way to get from Pisa to Frankfurt am Main among Omio's users.
Germany uses the euro (€) as its currency. Travelers generally find it convenient to use cards, especially contactless payments, in cities and larger establishments. However, cash is still widely accepted and sometimes preferred in smaller shops, markets, and rural areas. Carrying some cash is recommended for flexibility.
In Frankfurt am Main, travelers should be cautious of pickpocketing, especially in crowded areas like train stations, public transport, and popular tourist spots. Common scams include distraction techniques where one person diverts attention while another steals belongings. It's also important to be wary of unofficial taxi drivers overcharging and to use licensed services. Staying alert in nightlife districts and avoiding poorly lit areas at night can help ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular bus stations

Popular bus stations from Pisa to Frankfurt am Main

Pisa
Frankfurt am Main
The major bus station for departures in Pisa is Pisa, Via delle Fiamme Gialle (Park Pietrasantina). Find all the information you need to know about services, amenities and connections at Pisa, Via delle Fiamme Gialle (Park Pietrasantina) for your trip from Pisa to Frankfurt am Main.
Pisa, Via delle Fiamme Gialle (Park Pietrasantina)
Pisa, Aeroporto Parcheggio Aurelia
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