The cheapest and fastest buses from Pisa to Lyon
Cheapest price
$65
Average price
$87
Fastest journey
11 h 45 m
Average duration
13 h 57 m
Buses per day
5
Distance
493 km
The best way to find a cheap bus ticket from Pisa to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Pisa to Lyon will cost around $87 if you buy it on the day, but the cheapest tickets can be found for only $65.
Of the 5 buses that leave Pisa for Lyon on Fri, Mar 06, 5 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Mar 06 the direct buses cover the 493 km distance in an average of 13 h 57 m but if you time it right, some buses will get you there in just 11 h 45 m .
On Fri, Mar 06 the slowest buses will take 15 h 25 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.










Travel Information
Compare train, bus, and flight for Pisa to Lyon
Omio recommends booking the bus as it is the most popular option from Pisa to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $50. For those with little time consider booking a train which can get you there in 7h 51m. The ticket price range depends on the travel mode: a bus costs an average of $50, and a flight costs an average of $209.
Distance: 306 miles (493 km)
Compare bus with
Most popular Bus | Train | Flight |
|---|---|---|
$88 Average price Cheapest | $154 Average price | $742 Average price |
11h 25m Average total duration 10h 55m Onboard + 30m Additional time* | 8h 21m Average total duration Fastest 7h 51m Onboard + 30m Additional time* | 22h 4m Average total duration 19h 4m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
Pisa to Lyon bus times
The table below shows live departures for Pisa to Lyon buses for tomorrow, Friday, March 6. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 5:25 AM Pisa | 11h45 | 5:10 PM Lyon | 0 transfersDirect | |
![]() | 6:10 AM Pisa | 15h30 | 9:40 PM Lyon | 0 transfersDirect | |
![]() | 12:40 PM Pisa | 14h15 | 2:55 AM Lyon | 0 transfersDirect | |
![]() | 3:45 PM Pisa | 13h50 | 5:35 AM Lyon | 0 transfersDirect | |
![]() | 5:15 PM Pisa | 14h30 | 7:45 AM Lyon | 0 transfersDirect |
Find all the dates and times for this journey
Compare prices and tickets Pisa to Lyon by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 06
Mar 07
Mar 08
Mar 09
Mar 10
Mar 11
Mar 12
Mar 13
Mar 14
Mar 15
Mar 16
Mar 17
Mar 18
Mar 19
Why should you book Pisa to Lyon buses with Omio?
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Lirosi Linee to find the best option for your trip from Pisa to Lyon.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Pisa to Lyon.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Pisa to Lyon.
Journey information
Overview: Bus from Pisa to Lyon
Buses from Pisa to Lyon run on average 5 times per day, taking around 10h 55m. Cheap bus tickets for this journey start at $50 (€40) if you book in advance.
The earliest bus runs at 00:05, the last at 23:00. The fastest bus covers the 306 miles (493 km) distance in 11h 45m.
Distance 306 miles (493 km) |
Average bus duration 10h 55m |
Cheapest ticket price $50 (€40) |
Buses per day 5 |
Fastest bus 11h 45m |
First bus 00:05 |
Last bus 23:00 |
Bus providers: FlixBus, BlaBlaCar, Lirosi Linee from Pisa to LyonYou can travel by bus between Pisa to Lyon with FlixBus, BlaBlaCar, Lirosi Linee for as low as $50 (€40). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
BlaBlaCar
Lirosi Linee
FAQs: Bus from Pisa to Lyon
Find answers to the most common questions about traveling from Pisa to Lyon by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Basilica of Notre-Dame de Fourvière, a stunning 19th-century basilica offering panoramic views of the city
- Vieux Lyon, a UNESCO World Heritage site known for its Renaissance architecture and narrow cobblestone streets
- Parc de la Tête d'Or, a large urban park featuring a zoo, botanical garden, and lake
- Musée des Confluences, a modern science and anthropology museum with innovative exhibits
- Place Bellecour, one of Europe's largest open squares, ideal for shopping and dining.
- Les Halles de Lyon Paul Bocuse, a renowned indoor market offering gourmet food and local specialties
- Take a river cruise on the Rhône and Saône for a unique view of the city
- Explore the traboules, secret passageways in Vieux Lyon
- Attend a performance at the Opéra de Lyon, known for its diverse program
- Visit the Institut Lumière, dedicated to the history of cinema.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Pisa to Lyon
- 06:00-23:00
- Free Wi-Fi
- Café de la Gare (in the station)
- Le Bistrot de Lyon (0.5 km)
- Brasserie Georges (0.6 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: C19, C20, 31, 46, 49, 55, 60, S1 Metro: A Tram: T1, T2
Most popular bus connections from Pisa
More options for your journey from Pisa to Lyon
Here are some other resources that might have the information you need
