The cheapest and fastest buses from Pisa to Lyon
Cheapest price
$63
Average price
$95
Fastest journey
11 h 45 m
Average duration
14 h
Buses per day
4
Distance
493 km
The best way to find a cheap bus ticket from Pisa to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Pisa to Lyon will cost around $95 if you buy it on the day, but the cheapest tickets can be found for only $63.
Of the 4 buses that leave Pisa for Lyon on Tue, Jan 20, 4 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Tue, Jan 20 the direct buses cover the 493 km distance in an average of 14 h but if you time it right, some buses will get you there in just 11 h 45 m .
On Tue, Jan 20 the slowest buses will take 16 h and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.








Travel Information
Compare train, bus, and flight for Pisa to Lyon
Omio recommends booking the bus as it is the most popular option from Pisa to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from €45. For those with little time consider booking a train which can get you there in 7h 47m. The ticket price range depends on the travel mode: a bus costs an average of €45, and a flight costs an average of €159.
Distance: 306 miles (493 km)
Compare bus with
Most popular Bus | Train | Flight |
|---|---|---|
€85 Average price Cheapest | €126 Average price | €703 Average price |
11h 28m Average total duration 10h 58m Onboard + 30m Additional time* | 8h 17m Average total duration Fastest 7h 47m Onboard + 30m Additional time* | 20h 35m Average total duration 17h 35m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Pisa to Lyon Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Intercity Notte | Departure Time 03:26AM | Arrival Time 12:20AM | Duration 20h54 | Departure days Sun | Cheapest price $57 |
Operator Regionale | Departure Time 05:25AM | Arrival Time 12:20AM | Duration 18h55 | Departure days Fri, Sat | Cheapest price $56 |
Operator Intercity | Departure Time 05:42AM | Arrival Time 12:20AM | Duration 18h38 | Departure days Fri, Sat, Sun | Cheapest price $57 |
Operator Intercity Notte | Departure Time 05:54AM | Arrival Time 12:20AM | Duration 18h26 | Departure days Fri, Sat | Cheapest price $54 |
Operator Regionale | Departure Time 06:00AM | Arrival Time 04:05AM | Duration 22h05 | Departure days Sat | Cheapest price $91 |
Operator Intercity Notte | Departure Time 06:09AM | Arrival Time 12:20AM | Duration 18h11 | Departure days Fri, Sat | Cheapest price $52 |
Operator Regionale | Departure Time 06:23AM | Arrival Time 06:45AM | Duration 24h22 | Departure days Fri | Cheapest price $56 |
Operator FlixBus | Departure Time 06:25AM | Arrival Time 06:10PM | Duration 11h45 | Departure days Mon, Fri, Sat, Sun | Cheapest price $61 |
Operator Intercity | Departure Time 06:42AM | Arrival Time 12:20AM | Duration 17h38 | Departure days Fri, Sat, Sun | Cheapest price $59 |
Operator FlixBus | Departure Time 07:15AM | Arrival Time 10:40PM | Duration 15h25 | Departure days Mon, Wed, Fri, Sat, Sun | Cheapest price $61 |
Operator Regionale | Departure Time 07:36AM | Arrival Time 12:20AM | Duration 16h44 | Departure days Sat, Sun | Cheapest price $56 |
Operator Regionale | Departure Time 08:18AM | Arrival Time 06:45AM | Duration 22h27 | Departure days Fri | Cheapest price $56 |
Operator Regionale | Departure Time 08:35AM | Arrival Time 12:20AM | Duration 15h45 | Departure days Sat | Cheapest price $56 |
Operator Frecciargento | Departure Time 08:47AM | Arrival Time 12:20AM | Duration 15h33 | Departure days Fri, Sat | Cheapest price $69 |
Operator Intercity | Departure Time 08:55AM | Arrival Time 06:45AM | Duration 21h50 | Departure days Fri, Sat, Sun | Cheapest price $59 |
Operator Intercity Notte | Departure Time 09:24AM | Arrival Time 12:20AM | Duration 14h56 | Departure days Sun | Cheapest price $54 |
Operator FlixBus | Departure Time 09:40AM | Arrival Time 11:45PM | Duration 14h05 | Departure days Mon, Fri, Sat, Sun | Cheapest price $61 |
Operator Frecciarossa | Departure Time 09:46AM | Arrival Time 06:45AM | Duration 20h59 | Departure days Fri, Sat, Sun | Cheapest price $72 |
Operator Regionale | Departure Time 10:06AM | Arrival Time 06:45AM | Duration 20h39 | Departure days Sun | Cheapest price $59 |
Operator Intercity | Departure Time 11:06AM | Arrival Time 06:45AM | Duration 19h39 | Departure days Fri | Cheapest price $61 |
Operator Regionale | Departure Time 11:06AM | Arrival Time 06:45AM | Duration 19h39 | Departure days Fri | Cheapest price $56 |
Operator Intercity | Departure Time 11:42AM | Arrival Time 06:45AM | Duration 19h03 | Departure days Sat, Sun | Cheapest price $61 |
Operator Regionale | Departure Time 12:06PM | Arrival Time 06:45AM | Duration 18h39 | Departure days Sat, Sun | Cheapest price $58 |
Operator Regionale | Departure Time 12:34PM | Arrival Time 06:45AM | Duration 18h11 | Departure days Fri, Sat, Sun | Cheapest price $56 |
Operator Intercity | Departure Time 01:02PM | Arrival Time 06:45AM | Duration 17h43 | Departure days Sat, Sun | Cheapest price $64 |
Operator Intercity | Departure Time 01:39PM | Arrival Time 06:45AM | Duration 17h06 | Departure days Fri, Sat, Sun | Cheapest price $61 |
Operator FlixBus | Departure Time 01:40PM | Arrival Time 03:50AM | Duration 14h10 | Departure days Mon, Fri, Sat, Sun | Cheapest price $59 |
Operator Intercity | Departure Time 01:47PM | Arrival Time 06:45AM | Duration 16h58 | Departure days Fri | Cheapest price $62 |
Operator Regionale | Departure Time 02:06PM | Arrival Time 11:50AM | Duration 21h44 | Departure days Fri, Sat, Sun | Cheapest price $58 |
Operator Regionale | Departure Time 02:33PM | Arrival Time 11:50AM | Duration 21h17 | Departure days Fri, Sat, Sun | Cheapest price $58 |
Operator Frecciabianca | Departure Time 02:52PM | Arrival Time 06:45AM | Duration 15h53 | Departure days Fri, Sat, Sun | Cheapest price $61 |
Operator Intercity | Departure Time 03:06PM | Arrival Time 11:50AM | Duration 20h44 | Departure days Fri, Sat, Sun | Cheapest price $62 |
Operator Regionale | Departure Time 04:06PM | Arrival Time 11:50AM | Duration 19h44 | Departure days Fri, Sat, Sun | Cheapest price $58 |
Operator Regionale | Departure Time 04:34PM | Arrival Time 11:50AM | Duration 19h16 | Departure days Sat, Sun | Cheapest price $58 |
Operator FlixBus | Departure Time 04:45PM | Arrival Time 06:30AM | Duration 13h45 | Departure days Mon, Fri, Sat, Sun | Cheapest price $59 |
Operator Frecciabianca | Departure Time 04:56PM | Arrival Time 11:50AM | Duration 18h54 | Departure days Fri, Sat, Sun | Cheapest price $62 |
Operator Intercity | Departure Time 05:35PM | Arrival Time 11:50AM | Duration 18h15 | Departure days Sat, Sun | Cheapest price $58 |
Operator Intercity | Departure Time 05:42PM | Arrival Time 11:50AM | Duration 18h08 | Departure days Fri | Cheapest price $61 |
Operator FlixBus | Departure Time 06:10PM | Arrival Time 08:45AM | Duration 14h35 | Departure days Fri, Sat, Sun | Cheapest price $73 |
Operator Regionale | Departure Time 06:34PM | Arrival Time 11:50AM | Duration 17h16 | Departure days Fri, Sat, Sun | Cheapest price $58 |
Operator Frecciargento | Departure Time 06:40PM | Arrival Time 11:50AM | Duration 17h10 | Departure days Fri, Sun | Cheapest price $65 |
Operator Intercity | Departure Time 07:03PM | Arrival Time 11:50AM | Duration 16h47 | Departure days Fri, Sat, Sun | Cheapest price $61 |
Operator Frecciabianca | Departure Time 07:56PM | Arrival Time 11:50AM | Duration 15h54 | Departure days Fri, Sat, Sun | Cheapest price $52 |
Operator BlaBlaCar | Departure Time 09:30PM | Arrival Time 05:10AM | Duration 7h40 | Departure days Fri | Cheapest price $52 |
Live departures
Pisa to Lyon bus times
The table below shows live departures for Pisa to Lyon buses for today, Monday, January 19. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 8:40 AM Pisa, Aeroporto Parcheggio Aurelia | 14h05 | 10:45 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 1 transfer | |
FlixBus · FlixBus | 12:40 PM Pisa, Aeroporto Parcheggio Aurelia | 14h10 | 2:50 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 1 transfer | |
FlixBus · FlixBus | 3:45 PM Pisa, Aeroporto Parcheggio Aurelia | 13h45 | 5:30 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 1 transfer | |
| Tuesday, January 20 | |||||
![]() | 3:45 AM Pisa | 12h25 | 4:10 PM Lyon | 0 transfersDirect | |
![]() | 4:25 AM Pisa | 11h45 | 4:10 PM Lyon | 0 transfersDirect | |
Find all the dates and times for this journey
Compare prices and tickets Pisa to Lyon by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Jan 20
Jan 21
Jan 22
Jan 23
Jan 24
Jan 25
Jan 26
Journey information
Overview: Bus from Pisa to Lyon
Buses from Pisa to Lyon run on average 5 times per day, taking around 10h 58m. Cheap bus tickets for this journey start at $56 (€45) if you book in advance.
The earliest bus runs at 00:05, the last at 23:00. The fastest bus covers the 306 miles (493 km) distance in 11h 45m.
Distance 306 miles (493 km) |
Average bus duration 10h 58m |
Cheapest ticket price $56 (€45) |
Buses per day 5 |
Fastest bus 11h 45m |
First bus 00:05 |
Last bus 23:00 |
Key Takeaways
Train Ticket Prices
- Budget Options: Train tickets from Pisa to Lyon start from as low as $56 (€45) if booked well in advance.
- Standard Fares: Typically, trains cost $105 (€85) depending on the train type and class.
Journey Duration & Frequency
- On average there are 5 daily trains from Pisa to Lyon with 0 direct service.
- The fastest trains can take as little as 11h 45m but the average duration is 10h 58m
Train Operators
- Travel from Pisa to Lyon with FlixBus, BlaBlaCar, and Lirosi Linee
- The most booked train company for this route on Omio is FlixBus.
Stations & Schedule
- Most trains depart from Pisa, Via delle Fiamme Gialle (Park Pietrasantina) and arrive in Lyon, Perrache Bus Station
- First train typically departs at 12:05 AM and the last at 11:00 PM
Bus providers: FlixBus, BlaBlaCar, Lirosi Linee from Pisa to LyonYou can travel by bus between Pisa to Lyon with FlixBus, BlaBlaCar, Lirosi Linee for as low as $56 (€45). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
BlaBlaCar
Lirosi Linee
FAQs: Bus from Pisa to Lyon
Find answers to the most common questions about traveling from Pisa to Lyon by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Basilica of Notre-Dame de Fourvière, a stunning 19th-century basilica offering panoramic views of the city
- Vieux Lyon, a UNESCO World Heritage site known for its Renaissance architecture and narrow cobblestone streets
- Parc de la Tête d'Or, a large urban park featuring a zoo, botanical garden, and lake
- Musée des Confluences, a modern science and anthropology museum with innovative exhibits
- Place Bellecour, one of Europe's largest open squares, ideal for shopping and dining.
- Les Halles de Lyon Paul Bocuse, a renowned indoor market offering gourmet food and local specialties
- Take a river cruise on the Rhône and Saône for a unique view of the city
- Explore the traboules, secret passageways in Vieux Lyon
- Attend a performance at the Opéra de Lyon, known for its diverse program
- Visit the Institut Lumière, dedicated to the history of cinema.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
To find the cheapest bus tickets for your trip from Pisa to Lyon, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- Guide dogs travel for free.
popular bus stations
Popular bus stations from Pisa to Lyon
- 06:00-23:00
- Free Wi-Fi
- Café de la Gare (in the station)
- Le Bistrot de Lyon (0.5 km)
- Brasserie Georges (0.6 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: C19, C20, 31, 46, 49, 55, 60, S1 Metro: A Tram: T1, T2
Most popular bus connections from Pisa
More options for your journey from Pisa to Lyon
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