- Must visit
Musée des Beaux-Arts de Lyon
Major fine arts museum in a former abbey, with strong collections from antiquity to modern art. A core cultural stop in Lyon.
Cheapest price on Sep 05
$97
Average ticket price on Sep 05
$100
Fastest journey on Sep 05
11 h 45 m
Average journey duration on Sep 05
13 h 21 m
Buses on Sep 05
5
Distance
493 km
The best way to find a cheap bus ticket from Pisa to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Pisa to Lyon will cost around $100 if you buy it on the day, but the cheapest tickets can be found for only $97.
It's difficult to get from Pisa to Lyon without transferring at least once.
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FlixBus · FlixBusOmio recommends booking the bus as it is the most popular option from Pisa to Lyon among Omio's users. If you are prioritising price, take the train, with an average ticket price of $21 For those with little time, consider booking a flight, which has an average total journey time of 5h 40m. Average ticket prices depend on the travel mode: a train costs an average of $21, while a flight costs an average of $691.
Distance: 306 miles (493 km)
Most popular Bus | Train | Flight | Driving |
|---|---|---|---|
$122 Average price | $21 Average price Cheapest | $691 Average price | $293 Average price (fuel + tolls) |
11h 49m Average total duration 11h 19m Onboard + 30m Additional time* | 8h 37m Average total duration 8h 7m Onboard + 30m Additional time* | 5h 40m Average total duration Fastest 3h 40m Onboard + 2h 0m Additional time* | 7h 32m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Pisa to Lyon:
A train is $100 less than a bus for this route with tickets for a bus from Pisa to Lyon costing on average $122.
A train is $670 less than a flight for this route with tickets for a flight from Pisa to Lyon costing on average $691.
Other travel options to Lyon take longer:
Train takes on average 8h 7m.
Bus takes on average 11h 19m.
Tickets start at around $122 compared to roughly $293 in fuel and tolls — a saving of about $172. The journey takes 11h 19m versus 7h 32m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by BlaBlaCar.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 03:45AM | Arrival Time 04:10PM | Duration 12h25 | Departure days Tue | Cheapest price $106 |
Operator FlixBus | Departure Time 04:45AM | Arrival Time 05:10PM | Duration 12h25 | Departure days Tue | Cheapest price $67 |
Operator FlixBus | Departure Time 05:15AM | Arrival Time 09:45PM | Duration 16h30 | Departure days Tue | Cheapest price $77 |
Operator FlixBus | Departure Time 05:45AM | Arrival Time 06:10PM | Duration 12h25 | Departure days Wed | Cheapest price $62 |
Operator FlixBus | Departure Time 06:25AM | Arrival Time 06:10PM | Duration 11h45 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $72 |
Operator FlixBus | Departure Time 07:15AM | Arrival Time 11:45PM | Duration 16h30 | Departure days Mon, Wed | Cheapest price $70 |
Operator FlixBus | Departure Time 09:40AM | Arrival Time 11:45PM | Duration 14h05 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $68 |
Operator FlixBus | Departure Time 01:50PM | Arrival Time 03:55AM | Duration 14h05 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $74 |
Operator FlixBus | Departure Time 05:10PM | Arrival Time 06:30AM | Duration 13h20 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $67 |
Operator FlixBus | Departure Time 06:10PM | Arrival Time 08:45AM | Duration 14h35 | Departure days Wed, Thu, Fri, Sat, Sun | Cheapest price $62 |
The table below shows live departures for Pisa to Lyon buses for today, Friday, September 4. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 5:10 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 13h20 | 6:30 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus | 6:10 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 14h35 | 8:45 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
| Saturday, September 5 | |||||
FlixBus · FlixBus | 6:25 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 11h45 | 6:10 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus | 9:40 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 13h00 | 10:40 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus | 1:50 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 14h05 | 3:55 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Pisa to Lyon run on average 4 times per day, taking around 11h 19m. Cheap bus tickets for this journey start at $45 but you can travel from only $2 by train.
The earliest bus runs at 00:05, the last at 23:00. The fastest bus covers the 306 miles (493 km) distance in 9h 15m.
Distance 306 miles (493 km) |
Average bus duration 11h 19m |
Cheapest ticket price $45 |
Buses per day 4 |
Fastest bus 9h 15m |
First bus 12:05 AM |
Last bus 11:00 PM |
Cheapest Month Oct |
Cheapest Day Wed |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Sun |
Least Busy Day Fri |
Best time to book 1 day |
Discover the best of Lyon — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Lyon trip today.
Major fine arts museum in a former abbey, with strong collections from antiquity to modern art. A core cultural stop in Lyon.
Museum of cinema miniatures and film props in Vieux Lyon. Popular for detailed sets, special-effects history, and family-friendly exhibits.
Excellent free natural history and ethnography museum with fossils, animals, and global cultures. A strong local favorite, especially for families.
Renaissance quarter with cobbled lanes, traboules, courtyards, and major monuments. Essential for atmosphere, history, and walking exploration.
Central peninsula between the Rhône and Saône, packed with elegant streets, squares, shopping, and many of Lyon’s classic city views.
Historic silk-workers’ hill district with stairways, murals, markets, and hidden passageways. Great for local character and city panoramas.
Pike dumplings in a rich crayfish sauce. A Lyon classic from traditional bouchons, prized for its delicate fish texture and luxurious sauce.
Crisp salad of frisée, bacon lardons, croutons, and a poached egg. A staple Lyonnaise bistro dish that reflects the city's hearty cooking style.
Slow-cooked onions with vinegar, often served warm or chilled. This old Lyonnais side dish is traditional in bouchons and pairs well with charcuterie.
Refined dining by Paul Bocuse, known for polished French cuisine and iconic Lyon dishes in an elegant, historic dining room.
Well-known traditional bouchon in Vieux Lyon, praised for generous Lyonnais specialties and a lively old-city atmosphere.
Historic bouchon near Place Bellecour serving quenelles, salade lyonnaise, and classic regional fare in a warm traditional setting.
Moderate for Western Europe: hotels and dining are mid-priced, while public transport is good value for visitors.
Service is usually included. Round up or leave 5-10% for great restaurant service. Round up taxi fares; small change is fine in cafes.
Find answers to the most common questions about traveling from Pisa to Lyon by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

Most Pisa to Lyon buses use the Pisa, Via delle Fiamme Gialle (Park Pietrasantina) to Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) station pair, with some services arriving at Lyon, Gare Routière de Perrache. Use this guide to compare Pisa and Lyon bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Pisa, Via delle Fiamme Gialle (Park Pietrasantina) is 1 km from Pisa city centre. Public transport options include:
Pisa, Via delle Fiamme Gialle (Park Pietrasantina) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, Ticket Office, Bike Parking, and Bike Rental.
Wi-Fi is available at Pisa, Via delle Fiamme Gialle (Park Pietrasantina). ATMs are available at Pisa, Via delle Fiamme Gialle (Park Pietrasantina).
Ticket office support is available at Pisa, Via delle Fiamme Gialle (Park Pietrasantina).
Available at Pisa, Via delle Fiamme Gialle (Park Pietrasantina): Parking, Taxis, WC.
Available at Pisa, Via delle Fiamme Gialle (Park Pietrasantina): Bike Parking, Bike Rental.
Accessibility facilities are available at Pisa, Via delle Fiamme Gialle (Park Pietrasantina): The station is accessible for people with reduced mobility.
Pisa (Pisamover via San Giusto/Aurelia) is 1 km from Pisa city centre. Public transport options include:
Pisa (Pisamover via San Giusto/Aurelia) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Pisa (Pisamover via San Giusto/Aurelia). ATMs are available at Pisa (Pisamover via San Giusto/Aurelia).
Ticket office support is available at Pisa (Pisamover via San Giusto/Aurelia).
Available at Pisa (Pisamover via San Giusto/Aurelia): Parking, Taxis, WC.
Accessibility facilities are available at Pisa (Pisamover via San Giusto/Aurelia): Wheelchair accessible with assistance.
Pisa, Aeroporto is 1 km from Pisa city centre. Public transport options include:
Pisa, Aeroporto has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Pisa, Aeroporto. ATMs are available at Pisa, Aeroporto.
Ticket office support is available at Pisa, Aeroporto.
Available at Pisa, Aeroporto: Parking, Taxis, WC.
Accessibility facilities are available at Pisa, Aeroporto: Wheelchair ramps available.
Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) is 2 km from Lyon city centre. Public transport options include:
Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland). ATMs are available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland).
Ticket office support is available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland).
Available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland): Parking, Taxis, WC.
Accessibility facilities are available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland): Station is accessible for passengers with reduced mobility.
Lyon, Gare Routière de Perrache is 1 km from Lyon city centre. Public transport options include:
Lyon, Gare Routière de Perrache has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Café de la Gare (in the station), Le Bistrot de Lyon (0.5 km), Brasserie Georges (0.6 km).
Free Wi-Fi. ATMs are located near the main entrance.
Ticket office support is available at Lyon, Gare Routière de Perrache.
Available at Lyon, Gare Routière de Perrache: Parking, Taxis, WC.
Accessibility facilities are available at Lyon, Gare Routière de Perrache: Elevators, ramps.
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