- Must visit
Royal Museums of Fine Arts of Belgium
Premier fine arts complex with Old Masters, Magritte, and modern collections, essential for understanding Belgian and European art.



Cheapest price
$104
Average price
$120
Fastest journey
22h 20m
Average duration
23h 30m
Buses per day
3
Distance
262 km
Omio recommends booking the flight as it is the most popular option from Madrid to Brussels among Omio's users. If you are prioritising price take the bus with prices starting from $56. For those with little time consider booking a flight which can get you there in 4h 4m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 1.3 - 3.3kg. The ticket price range depends on the travel mode: a bus costs an average of $56, and a train costs an average of $495.
Distance: 817 miles (1316 km)
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$102 Average price Cheapest | $276 Average price | $501 Average price | $311 Average price (fuel + tolls) |
18h 8m Average total duration 17h 38m Onboard + 30m Additional time* | 7h 4m Average total duration Fastest 4h 4m Onboard + 3h 0m Additional time* | 21h 13m Average total duration 20h 43m Onboard + 30m Additional time* | 16h 17m Average total duration (door-to-door) |
1.3 - 3.3kg CO2 emissions Lowest | 3.9 - 7.9kg CO2 emissions | - CO2 emissions | - CO2 emissions |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Madrid to Brussels:
A bus is $174 (€143) less than a flight for this route with tickets for a flight from Madrid to Brussels costing on average $276 (€226).
A bus is $399 (€327) less than a train for this route with tickets for a train from Madrid to Brussels costing on average $501 (€411).
Other travel options to Brussels take longer:
Bus takes on average 17h 38m.
Train takes on average 20h 43m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 02:50PM | Arrival Time 12:45PM | Duration 21h55 | Departure days Mon, Tue, Wed, Fri, Sat, Sun | Cheapest price $94 |
Operator Internorte | Departure Time 03:30PM | Arrival Time 02:10PM | Duration 22h40 | Departure days Wed, Sun | Cheapest price $79 |
Operator Alsa | Departure Time 03:30PM | Arrival Time 02:10PM | Duration 22h40 | Departure days Wed, Sun | Cheapest price $79 |
Operator FlixBus | Departure Time 03:55PM | Arrival Time 03:50PM | Duration 23h55 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $93 |
Operator FlixBus | Departure Time 04:40PM | Arrival Time 03:50PM | Duration 23h10 | Departure days Everyday | Cheapest price $94 |
Operator BlaBlaCar Bus | Departure Time 06:35PM | Arrival Time 05:30PM | Duration 22h55 | Departure days Everyday | Cheapest price $67 |
Operator FlixBus | Departure Time 08:25PM | Arrival Time 05:55PM | Duration 21h30 | Departure days Everyday | Cheapest price $96 |
Operator FlixBus | Departure Time 08:50PM | Arrival Time 05:55PM | Duration 21h05 | Departure days Everyday | Cheapest price $105 |
Operator BlaBlaCar Bus | Departure Time 10:30PM | Arrival Time 08:50PM | Duration 22h20 | Departure days Everyday | Cheapest price $62 |
Operator FlixBus | Departure Time 10:35PM | Arrival Time 11:30PM | Duration 24h55 | Departure days Everyday | Cheapest price $102 |
Operator FlixBus | Departure Time 10:55PM | Arrival Time 11:30PM | Duration 24h35 | Departure days Everyday | Cheapest price $113 |
The table below shows live departures for Madrid to Brussels buses for today, Thursday, July 16. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
3160 · 50100 | 10:30 PM Madrid, Estación Sur de Autobuses | 22h20 | 8:50 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 10:35 PM Madrid, Estación Sur de Autobuses | 24h15 | 10:50 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 10:55 PM Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) | 23h55 | 10:50 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
| Friday, July 17 | |||||
FlixBus · FlixBus | 2:50 PM Madrid, Estación Sur de Autobuses | 21h55 | 12:45 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus · FlixBus · FlixBus | 3:55 PM Madrid, Estación Sur de Autobuses | 30h15 | 10:10 PM Brussels, Avenue des Magnolias (King Baudouin) | 3 transfers | |
FlixBus · FlixBus · FlixBus | 3:55 PM Madrid, Estación Sur de Autobuses | 23h40 | 3:35 PM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
FlixBus · FlixBus | 3:55 PM Madrid, Estación Sur de Autobuses | 23h55 | 3:50 PM Brussels, Gare Du Midi | 1 transfer | |
FlixBus · FlixBus | 4:40 PM Madrid, Estación Sur de Autobuses | 23h10 | 3:50 PM Brussels, Gare Du Midi | 1 transfer | |
FlixBus · FlixBus · FlixBus | 4:40 PM Madrid, Estación Sur de Autobuses | 29h30 | 10:10 PM Brussels, Avenue des Magnolias (King Baudouin) | 2 transfers | |
FlixBus · FlixBus | 4:40 PM Madrid, Estación Sur de Autobuses | 22h55 | 3:35 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
3162 · 1647 | 6:35 PM Madrid, Estación Sur de Autobuses | 21h05 | 3:40 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 8:25 PM Madrid, Estación Sur de Autobuses | 21h30 | 5:55 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 8:50 PM Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) | 21h05 | 5:55 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Madrid to Brussels run on average 10 times per day, taking around 17h 38m. Cheap bus tickets for this journey start at $56 (€46) if you book in advance.
The earliest bus runs at 00:40, the last at 23:55. The fastest bus covers the 817 miles (1316 km) distance in 20h 30m.
Distance 817 miles (1316 km) |
Average bus duration 17h 38m |
Cheapest ticket price $56 (€46) |
Buses per day 10 |
Fastest bus 20h 30m |
First bus 12:40 AM |
Last bus 11:55 PM |
Cheapest Month Feb |
Cheapest Day Sun |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Tue |
Least Busy Day Sun |
Best time to book 21 days |
Discover the best of Brussels — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Brussels trip today.
Premier fine arts complex with Old Masters, Magritte, and modern collections, essential for understanding Belgian and European art.
Dedicated to surrealist René Magritte, this popular museum presents major works and context for one of Belgium’s most celebrated artists.
Leading comic art museum in a Horta-designed building, highlighting Tintin, the Smurfs, and Belgium’s influential comics culture.
Grand square at Brussels’ heart, lined with ornate guildhalls and lively events, perfect for first-time visitors and evening atmosphere.
Large urban park with the triumphal arch, museums, and wide lawns, excellent for walking, picnics, and classic city photographs.
Popular hilltop viewpoint and garden terrace with one of the best panoramas over central Brussels, especially at sunset.
Mussels steamed with white wine, celery and onion, often served with fries. A Brussels brasserie classic, especially popular in mussel season.
Double-fried potato fries, traditionally served in paper cones with sauces. They are a point of national pride and central to everyday Belgian street food.
A rich beef and onion stew braised with Belgian dark beer. It is a beloved comfort dish found in traditional Brussels restaurants.
Two-Michelin-star restaurant by chef Karen Torosyan, celebrated for pâté en croûte and inventive fine dining in an intimate setting.
Elegant Belle Époque brasserie serving refined Belgian classics, seafood and game in a grand old-world dining room.
Famous casual stop for Brussels waffles with many toppings. Popular, fast-moving and central for a classic sweet local treat.
Moderate for Western Europe: hotels can be pricey, but dining and transit are manageable for most tourists.
Service is usually included. Round up or leave 5-10% for great restaurant service; round up taxi fares; small change is fine in cafes.
Official public transport app
Brussels South (Gare du Midi) -> Brussels Central Station, Brussels
Find answers to the most common questions about traveling from Madrid to Brussels by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brussels, this guide helps you travel smarter and with confidence.

Most Madrid to Brussels buses use the Madrid, Estación Sur de Autobuses to Brussels, Brussels South (Gare du Midi) station pair, with some services arriving at Brussels, Gare Du Midi. Use this guide to compare Madrid and Brussels bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Madrid, Estación Sur de Autobuses is 3 km from Madrid city centre. Public transport options include:
Madrid, Estación Sur de Autobuses has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafetería de la estación (in the station), Restaurante El Brillante (0.5 km), La Taberna de Domínguez (0.7 km).
Free Wi-Fi. ATMs are located near the main entrance and in the waiting area.
Ticket office support is available at Madrid, Estación Sur de Autobuses.
Available at Madrid, Estación Sur de Autobuses: Parking, Taxis, WC.
Accessibility facilities are available at Madrid, Estación Sur de Autobuses: Elevators, ramps.
Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) is 12 km from Madrid city centre. Public transport options include:
Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) has practical services for this route, including Dining, ATM, Accessibility, WC, Shower, and Ticket Office.
Food options include: Rodilla, Mahoudrid
ATMs are aTMs located throughout T4, major cards accepted .
Ticket office support is available at Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid).
Available at Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid): WC.
Accessibility facilities are available at Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid): Step-free access, elevators, accessible toilets.
Brussels, Brussels South (Gare du Midi) is 2 km from Brussels city centre. Public transport options include:
Brussels, Brussels South (Gare du Midi) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Midi (in the station), Belgian Bites (in the station), Fritland Express (0.5 km).
Free Wi-Fi. ATMs are located near the main entrance and throughout the station.
Ticket office support is available at Brussels, Brussels South (Gare du Midi).
Available at Brussels, Brussels South (Gare du Midi): Parking, Taxis, WC.
Accessibility facilities are available at Brussels, Brussels South (Gare du Midi): Elevators, ramps.
Here are some other resources that might have the information you need