- Must visit
Saint Louis Art Museum
Major fine arts museum in Forest Park with a strong encyclopedic collection spanning ancient to contemporary works. A top cultural stop in the city.
Cheapest, Fastest
Indianapolis, Illinois St (Greyhound Bus Station)
St. Louis, S 15th St (Civic center)
$991•One-way
The cheapest and fastest busesfrom Indianapolis, IN to St. Louis, MOShowing times and prices for Jul 10
Cheapest price
$99
Average price
$99
Fastest journey
4h 20m
Average duration
4h 20m
Buses per day
1
Distance
370 km
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Indianapolis, IN to St. Louis, MO train with Amtrak
Travel Information
Compare train, bus, and flight for Indianapolis, IN to St. Louis, MO
Omio recommends booking the bus as it is the most popular option from Indianapolis, IN to St. Louis, MO among Omio's users. If you are prioritising price take the bus with prices starting from $33. For those with little time consider booking a bus which can get you there in 5h 22m. The ticket price range depends on the travel mode: a bus costs an average of $33, and a flight costs an average of $135.
Distance: 229 miles (370 km)
Compare train with
| Train | Most popular Bus | Flight | Driving |
|---|---|---|---|
$123 Average price | $54 Average price Cheapest | $331 Average price | $50 Average price (fuel + tolls) |
8h 58m Average total duration 8h 28m Onboard + 30m Additional time* | 5h 52m Average total duration Fastest 5h 22m Onboard + 30m Additional time* | 11h 43m Average total duration 8h 43m Onboard + 3h 0m Additional time* | 3h 31m Average total duration (door-to-door) |
 Most popular train company |  Most popular bus company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Indianapolis, IN to St. Louis, MO is a bus with an average price of $54 (€44).
This is compared to other travel options from Indianapolis, IN to St. Louis, MO:
A bus is $69 (€57) less than a train for this route with tickets for a train from Indianapolis, IN to St. Louis, MO costing on average $123 (€101).
A bus is $277 (€228) less than a flight for this route with tickets for a flight from Indianapolis, IN to St. Louis, MO costing on average $331 (€272).
The fastest way to travel from Indianapolis, IN to St. Louis, MO is by bus with an average journey time of 5h 22m.
Other travel options to St. Louis, MO take longer:
Train takes on average 8h 28m.
Flight takes on average 8h 43m.
It's helpful to compare your options as there are 3 ways to travel between Indianapolis, IN and St. Louis, MO including taking a train, bus, and flight.
We recommend using the bus as it is the most popular way to get from Indianapolis, IN to St. Louis, MO among Omio's users.
Take the train. It's the cheaper option, and the extra time on board is usually more relaxing than driving it.
Tickets start at around $123 (€101) compared to roughly $50 (€41) in fuel and tolls — a saving of about $-73.72 (€-60.56). The journey takes 8h 28m versus 3h 31m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Live departures
Indianapolis, IN to St. Louis, MO train times
The table below shows live departures for Indianapolis, IN to St. Louis, MO trains for tomorrow, Saturday, July 11. You can also manually refresh the results below to see updated train journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 51 Cardinal · 21 Texas Eagle | 6:25 AM Indianapolis Station, Indianapolis, IN | 14h00 | 7:25 PM St. Louis Station, St. Louis, MO | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Indianapolis, IN to St. Louis, MO by train, bus, or flight
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Journey information
Overview: Train from Indianapolis, IN to St. Louis, MO
USAUSA
Trains from Indianapolis, IN to St. Louis, MO run on average 3 times per day, taking around 8h 28m. Cheap train tickets for this journey start at $67 (€55) but you can travel from only $33 (€27) by bus.
The earliest train runs at 04:30, the last at 15:39. The fastest train covers the 229 miles (370 km) distance in 12h 33m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $33 (€27)
Distance 229 miles (370 km) |
Average train duration 8h 28m |
Cheapest ticket price $67 (€55) |
Trains per day 3 |
Fastest train 12h 33m |
First train 4:30 AM |
Last train 3:39 PM |
Cheapest Month Apr |
Cheapest Day Tue |
High Season Oct - Dec |
Low Season Apr - Jun |
Busiest Day Sun |
Least Busy Day Sat |
Best time to book 1 day |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $33 (€27)
Train companies: Amtrak from Indianapolis, IN to St. Louis, MO trainsAmtrak trains will get you between Indianapolis, IN and St. Louis, MO from $33 (€27). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Amtrak
About
Amtrak is the main passenger train operator in the United States, providing medium- and long-distance intercity services across 46 states and three Canadian provinces. Operating over 300 trains daily and serving more than 500 destinations, Amtrak connects cities and regions nationwide through routes such as the high-speed Acela in the Northeast Corridor, the scenic Coast Starlight along the West Coast, and the Empire Builder linking Chicago to the Midwest and the Pacific Northwest. Other notable services include the Northeast Regional, Keystone Service, and the unique Auto Train, which allows passengers to bring their cars onboard. Amtrak offers a variety of classes to suit different budgets and travel needs, including Coach, Business, First Class, and Sleeper Class with options like Roomettes, Bedrooms, and Bedroom Suites for overnight journeys. Ticket types include Saver, Value, Flexible, Business, and Premium. Onboard amenities vary by service but may include comfortable seating, Wi-Fi, power outlets, dining options, and lounge access on select trains. Popular routes include Washington, D.C.–Boston, San Diego–San Luis Obispo, San Jose–Sacramento, and Chicago–Seattle.
Luggage & cancellation policy
Average Duration
6h 21m
Cheapest Price
$67 (€55)
Amtrak frequency
3 a day
Luggage included
2 personal items and 2 carry-on bags included free
Luggage storage
Overhead racks, under seats, and designated luggage areas at end of cars
Cancellation Policy
Cancellation policies depend on ticket type and timing
Refund
Full refund if train is canceled by Amtrak
Amenities on board the train
Wifi
Food sold onboard
Café car with snacks, beverages, and light meals. Long-distance trains have full-service dining cars
Seat reservation
Included in ticket price for Business and First Class. Optional fee for Coach Class
Toilets
USB plugs
Accessibility
Wheelchair spaces, accessible restrooms, Red Cap assistance service, accessible platforms and stations
Pets
Small pets under 20 pounds allowed for $26 fee. Must be in carrier. Service animals travel free
Quiet zone
Complete guide to St. Louis
Things to do in St. Louis
Discover the best of St. Louis — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect St. Louis trip today.
- Must visit
City Museum
Highly original artist-built museum and playground inside a former warehouse, known for tunnels, slides, rooftop features, and immersive installations.
- Recommended
Missouri History Museum
History museum in Forest Park covering St. Louis, Missouri, and regional stories through accessible permanent and temporary exhibitions.
- Must visit
Forest Park
One of the largest urban parks in the United States, home to major cultural institutions, lakes, trails, and broad green space.
- Recommended
Central West End
Walkable neighborhood known for handsome architecture, lively streets, and a strong mix of shops, culture, and city atmosphere.
- Recommended
Delmar Loop
Popular entertainment corridor with street life, public art, music history, and a strong local identity near Washington University.
- Vegetarian
St. Louis-Style Pizza
A thin, cracker-like crust pizza cut into squares and traditionally topped with Provel cheese. It is one of the city’s most iconic local foods.
Toasted Ravioli
Breaded and fried meat- or cheese-filled ravioli, usually served with marinara. This St. Louis specialty is a classic appetizer across the city.
- Vegetarian
Gooey Butter Cake
A rich, dense cake with a buttery base and sweet, gooey topping. It is a beloved St. Louis dessert found in bakeries throughout the region.
Ted Drewes Frozen Custard
Legendary dessert stand serving frozen custard concretes and sundaes; a must-visit local institution with nostalgic charm.
Pappy's Smokehouse
Popular barbecue spot known for Memphis-style smoked ribs, pulled pork, and brisket in a lively casual setting.
Charlie Gitto's On The Hill
Established Italian restaurant in the historic Hill neighborhood, famous for toasted ravioli, pasta, and classic old-school hospitality.
United States Dollar
Generally moderate for U.S. city travel. Hotels vary, while casual dining, coffee, and local transport are fairly manageable.
Average meal costs
- Budget
- USD 10-15 for fast food or a casual lunch.
- Mid-range
- USD 20-40 per person at a mid-range restaurant.
- Fine dining
- USD 75+ per person at upscale restaurants.
- Coffee
- USD 4-6 for a regular café coffee.
Tipping culture
Tip 18-20% at restaurants; 20%+ for great service. Tip bartenders USD 1-2 per drink, taxis about 10-15%, and round up for casual service.
FAQs: Trains from Indianapolis, IN to St. Louis, MO
Find answers to the most common questions about traveling from Indianapolis, IN to St. Louis, MO by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.
Train ticket prices from Indianapolis, IN to St. Louis, MO can vary. The cheapest ticket starts at $67 (€55), while the average price is around $123 (€101).
The train from Indianapolis, IN to St. Louis, MO takes 12h 33m and runs 3 per day.
The distance by train from Indianapolis, IN to St. Louis, MO is 229 miles (370 km).
The first train from Indianapolis, IN to St. Louis, MO leaves at 4:30 AM.
The last train from Indianapolis, IN to St. Louis, MO leaves at 3:39 PM.
There is no high speed train available from Indianapolis, IN to St. Louis, MO.
There is no direct train service currently available from Indianapolis, IN to St. Louis, MO.
Unfortunately, there is no night train available from Indianapolis, IN to St. Louis, MO.
The train station in Indianapolis, IN that goes to St. Louis, MO is Indianapolis Station, Indianapolis, IN, which connects to St. Louis Station, St. Louis, MO.
The cheapest way to get from Indianapolis, IN to St. Louis, MO is by bus, with a cost of around $33 (€27).
The train journey from Indianapolis, IN to St. Louis, MO offers a mix of urban and rural landscapes, including views of the Indiana countryside, small towns, and glimpses of the Mississippi River as you approach St. Louis, providing some scenic elements along the route.
A day trip from Indianapolis, IN to St. Louis, MO is not feasible as the travel duration is 12h 33m. However, there are 4 trains available per day for this route, covering a distance of 229 miles (370 km).
Three days are typically sufficient to explore key attractions in St. Louis, including the Gateway Arch, Forest Park, and the Missouri Botanical Garden.
Yes, you can take the train from Indianapolis, IN to St. Louis, MO.
Since neither Indianapolis, IN nor St. Louis, MO are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
Popular day trips by train from St. Louis, MO include Springfield, IL, Hermann, MO, Washington, MO, Alton, IL, Carlinville, IL.
We recommend using the bus as it is the most popular way to get from Indianapolis, IN to St. Louis, MO among Omio's users.
Items not allowed on trains typically include hazardous materials such as explosives, flammable liquids, corrosive substances, and illegal drugs. Additionally, large or bulky items that may obstruct aisles or emergency exits, as well as pets without proper carriers, may be restricted. Specific prohibited items can vary by train operator and region, so please check the rules for your particular journey.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In St. Louis, MO, travelers should be cautious in certain neighborhoods with higher crime rates, especially after dark. Common safety concerns include petty theft, pickpocketing, and occasional scams targeting visitors near popular attractions like the Gateway Arch. It’s advisable to stay in well-populated areas, avoid displaying valuables openly, and use reputable transportation services to minimize risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular train stations
Popular train stations from Indianapolis, IN to St. Louis, MO
Most Indianapolis, IN to St. Louis, MO trains use the Indianapolis Station to St. Louis Station station pair. Use this guide to compare Indianapolis, IN and St. Louis, MO train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Departure train stations in Indianapolis
Arrival train stations in St. Louis
Which Indianapolis, IN station do trains to St. Louis, MO leave from?
Trains from Indianapolis, IN to St. Louis, MO leave from Indianapolis Station. The station is 0 miles (1 km) from Indianapolis, IN city centre at 350 S Illinois St, Indianapolis, IN 46225, USA.
Indianapolis Station350 S Illinois St, Indianapolis, IN 46225, USA+1 800-872-7245
City-centre transport
Getting to Indianapolis Station from Indianapolis city centre
BusIndyGo routes available nearby
Indianapolis Station train station facilities and services
Indianapolis Station has practical services for this route, including Wifi, Parking, Dining, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Information Desk, and Luggage Carts.
Food and drink
Food options include: Harry & Izzy's, St. Elmo Steak House
Wi-Fi and ATMs
Free.
Tickets and information
Ticket office support is available at Indianapolis Station. Information desks are located in the main hall.
Parking, taxis and toilets
Available at Indianapolis Station: Parking, Taxis, WC.
Bike and car services
Available at Indianapolis Station: Bike Parking.
Accessibility
Accessibility facilities are available at Indianapolis Station: Ramps.
Shops, hotels and contact
Nearby hotels include Crowne Plaza Indianapolis-Dwtn-Union-Stn, Omni Severin Hotel, The Westin Indianapolis.
Which St. Louis, MO station do trains from Indianapolis, IN arrive at?
Trains from Indianapolis, IN to St. Louis, MO most often arrive at St. Louis Station. Some services arrive at Kirkwood Station, so check your ticket before travel to confirm your St. Louis, MO arrival station.
St. Louis Station430 S 15th St, St. Louis, MO 63103, USA+1 800-872-7245
City-centre transport
Getting to St. Louis Station from St. Louis city centre
TrainMlb, Mlr · 3m · $4 · every ~14 min
St. Louis Station train station facilities and services
St. Louis Station has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Car Rental, Information Desk, and Luggage Carts.
Food and drink
Food options include: Landry's Seafood House, The Station Grille
Wi-Fi and ATMs
Free. ATMs are available in the train station.
Tickets and information
Ticket office support is available at St. Louis Station. Information desks are located in the main hall.
Luggage and lost property
Luggage storage is available at St. Louis Station. Lost and found is available at the station.
Parking, taxis and toilets
Available at St. Louis Station: Parking, Taxis, WC.
Bike and car services
Available at St. Louis Station: Bike Parking, Car Rental.
Accessibility
Accessibility facilities are available at St. Louis Station: Ramps, restrooms.
Shops, hotels and contact
Nearby hotels include St. Louis Union Station Hotel, Curio Collection by Hilton, Courtyard St. Louis Downtown West, Drury Inn St. Louis at Union Station.
Most popular train connections from Indianapolis, IN
More options for your journey from Indianapolis, IN to St. Louis, MO
Here are some other resources that might have the information you need
Most popular trains to and from St. Louis, MO and Indianapolis, IN
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