The cheapest and fastest buses from Greenville, SC to Jacksonville, FL
Cheapest price
$154
Average price
$154
Fastest journey
10 h 50 m
Average duration
10 h 50 m
Buses per day
1
Distance
507 km
The best way to find a cheap bus ticket from Greenville, SC to Jacksonville, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Greenville, SC to Jacksonville, FL will cost around $154 if you buy it on the day, but the cheapest tickets can be found for only $154.
Of the 1 buses that leave Greenville, SC for Jacksonville, FL on Mon, Mar 23, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Mon, Mar 23 the direct buses cover the 507 km distance in an average of 10 h 50 m but if you time it right, some buses will get you there in just 10 h 50 m .
On Mon, Mar 23 the slowest buses will take 10 h 50 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare bus, train, and flight for Greenville, SC to Jacksonville, FL
Omio recommends booking the bus as it is the most popular option from Greenville, SC to Jacksonville, FL among Omio's users. If you are prioritising price take the bus with prices starting from $88. For those with little time consider booking a flight which can get you there in 5h 16m. The ticket price range depends on the travel mode: a bus costs an average of $88, and a flight costs an average of $149.
Distance: 315 miles (507 km)
Compare bus with
Most popular Bus | Train | Flight |
|---|---|---|
$157 Average price Cheapest | $174 Average price | $273 Average price |
11h 55m Average total duration 11h 25m Onboard + 30m Additional time* | 23h 59m Average total duration 23h 29m Onboard + 30m Additional time* | 8h 16m Average total duration Fastest 5h 16m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Greenville, SC to Jacksonville, FL Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 07:10AM | Arrival Time 06:25PM | Duration 11h15 | Departure days Wed | Cheapest price $152 |
Operator FlixBus | Departure Time 10:50AM | Arrival Time 09:25PM | Duration 10h35 | Departure days Wed | Cheapest price $150 |
Operator FlixBus | Departure Time 11:15AM | Arrival Time 07:00AM | Duration 19h45 | Departure days Wed | Cheapest price $149 |
Operator FlixBus | Departure Time 04:15PM | Arrival Time 11:30AM | Duration 19h15 | Departure days Wed | Cheapest price $155 |
Operator FlixBus | Departure Time 10:00PM | Arrival Time 01:35PM | Duration 15h35 | Departure days Wed | Cheapest price $149 |
Live departures
Greenville, SC to Jacksonville, FL bus times
The table below shows live departures for Greenville, SC to Jacksonville, FL buses for tomorrow, Sunday, March 22. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:25 PM Greenville, SC | 10h50 | 11:15 PM Jacksonville, FL | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Greenville, SC to Jacksonville, FL by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 23
Mar 24
Mar 25
Mar 26
Mar 27
Mar 28
Mar 29
Why should you book Greenville, SC to Jacksonville, FL buses with Omio?
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from Greenville, SC to Jacksonville, FL.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Greenville, SC to Jacksonville, FL.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Greenville, SC to Jacksonville, FL.
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Greenville, SC to Jacksonville, FL.
Journey information
Overview: Bus from Greenville, SC to Jacksonville, FL
Buses from Greenville, SC to Jacksonville, FL run on average 3 times per day, taking around 11h 25m. Cheap bus tickets for this journey start at $88 (€71) if you book in advance.
The earliest bus runs at 07:10, the last at 22:15. The fastest bus covers the 315 miles (507 km) distance in 9h 45m.
Distance 315 miles (507 km) |
Average bus duration 11h 25m |
Cheapest ticket price $88 (€71) |
Buses per day 3 |
Fastest bus 9h 45m |
First bus 07:10 |
Last bus 22:15 |
Cheapest month Apr |
Cheapest day Thu |
High season Jul - Sep |
Low season Jan - Mar |
Best day to book ahead 14 days |
Bus providers: Greyhound, FlixBus from Greenville, SC to Jacksonville, FLYou can travel by bus between Greenville, SC to Jacksonville, FL with Greyhound, FlixBus for as low as $88 (€71). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Greyhound
FAQs: Bus from Greenville, SC to Jacksonville, FL
Find answers to the most common questions about traveling from Greenville, SC to Jacksonville, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Jacksonville, FL, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Greenville, SC to Jacksonville, FL
Most popular bus connections from Greenville, SC
More options for your journey from Greenville, SC to Jacksonville, FL
Here are some other resources that might have the information you need
