- Must visit
Cummer Museum of Art & Gardens
Major art museum with a strong permanent collection and historic riverfront gardens; one of Jacksonville’s signature cultural attractions.
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The cheapest and fastest buses from Greenville, SC to Jacksonville, FL
Showing times and prices for Jun 21
Cheapest price
$112
Average price
$124
Fastest journey
9 h 45 m
Average duration
11 h 37 m
Buses per day
5
Distance
507 km
Cheap tickets
The best way to find a cheap bus ticket from Greenville, SC to Jacksonville, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Greenville, SC to Jacksonville, FL will cost around $124 if you buy it on the day, but the cheapest tickets can be found for only $112.
Fast buses
It's difficult to get from Greenville, SC to Jacksonville, FL without transferring at least once.
FlixBus+
11:00 AM10h25Greenville, Woodruff Rd ("Raceway" gas station), SC9:25 PMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St$1121One-way1 transfer- FlixBus+7:10 AM11h15Greenville, Woodruff Rd ("Raceway" gas station), SC6:25 PMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St$1131One-way1 transfer
- FlixBus+8:20 PM10h40Greenville, Woodruff Rd ("Raceway" gas station), SC7:00 AMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St$1141One-way1 transfer
- FlixBus · FlixBus · FlixBus9:35 PM16h00Greenville, Woodruff Rd ("Raceway" gas station), SC1:35 PMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St$1311One-way2 transfers
- FlixBus · FlixBus1:20 PM9h45Greenville, Woodruff Rd ("Raceway" gas station), SC11:05 PMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St$1491One-way1 transfer
- FlixBus · FlixBus1:20 PM9h45Greenville, Woodruff Rd ("Raceway" gas station), SC11:05 PMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St$1491One-way1 transfer
- FlixBus+11:00 AM10h25Greenville, Woodruff Rd ("Raceway" gas station), SC9:25 PMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St$1121One-way1 transfer
- FlixBus+8:20 PM10h40Greenville, Woodruff Rd ("Raceway" gas station), SC7:00 AMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St$1141One-way1 transfer
- FlixBus+7:10 AM11h15Greenville, Woodruff Rd ("Raceway" gas station), SC6:25 PMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St$1131One-way1 transfer
- FlixBus · FlixBus · FlixBus9:35 PM16h00Greenville, Woodruff Rd ("Raceway" gas station), SC1:35 PMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St$1311One-way2 transfers
Travel Information
Compare bus, train, and flight for Greenville, SC to Jacksonville, FL
Omio recommends booking the bus as it is the most popular option from Greenville, SC to Jacksonville, FL among Omio's users. If you are prioritising price take the bus with prices starting from $87. For those with little time consider booking a flight which can get you there in 5h 2m. The ticket price range depends on the travel mode: a bus costs an average of $87, and a flight costs an average of $147.
Distance: 315 miles (507 km)
Compare bus with
Most popular Bus | Train | Flight | Driving |
|---|---|---|---|
$155 Average price Cheapest | $188 Average price | $301 Average price | $73 Average price (fuel + tolls) |
11h 55m Average total duration 11h 25m Onboard + 30m Additional time* | 23h 59m Average total duration 23h 29m Onboard + 30m Additional time* | 8h 2m Average total duration Fastest 5h 2m Onboard + 3h 0m Additional time* | 5h 33m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Greenville, SC to Jacksonville, FL is a bus with an average price of $155 (€127).
This is compared to other travel options from Greenville, SC to Jacksonville, FL:
A bus is $33 (€27) less than a train for this route with tickets for a train from Greenville, SC to Jacksonville, FL costing on average $188 (€154).
A bus is $146 (€119) less than a flight for this route with tickets for a flight from Greenville, SC to Jacksonville, FL costing on average $301 (€246).
The fastest way to travel from Greenville, SC to Jacksonville, FL is by flight with an average journey time of 5h 2m.
Other travel options to Jacksonville, FL take longer:
Bus takes on average 11h 25m.
Train takes on average 23h 29m.
It's helpful to compare your options as there are 3 ways to travel between Greenville, SC and Jacksonville, FL including taking a bus, train, and flight.
We recommend using the bus as it is the most popular way to get from Greenville, SC to Jacksonville, FL among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Greenville, SC to Jacksonville, FL Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:40AM | Arrival Time 12:00PM | Duration 11h20 | Departure days Sat | Cheapest price $181 |
Operator FlixBus | Departure Time 07:10AM | Arrival Time 06:25PM | Duration 11h15 | Departure days Mon, Wed, Sat, Sun | Cheapest price $101 |
Operator FlixBus | Departure Time 11:00AM | Arrival Time 09:25PM | Duration 10h25 | Departure days Wed, Sun | Cheapest price $102 |
Operator FlixBus | Departure Time 11:10AM | Arrival Time 10:25PM | Duration 11h15 | Departure days Fri | Cheapest price $186 |
Operator FlixBus | Departure Time 01:20PM | Arrival Time 11:05PM | Duration 9h45 | Departure days Mon, Sat, Sun | Cheapest price $119 |
Operator FlixBus | Departure Time 06:20PM | Arrival Time 04:05AM | Duration 9h45 | Departure days Thu | Cheapest price $203 |
Operator FlixBus | Departure Time 08:20PM | Arrival Time 07:00AM | Duration 10h40 | Departure days Mon, Wed, Sat, Sun | Cheapest price $103 |
Operator FlixBus | Departure Time 09:35PM | Arrival Time 01:35PM | Duration 16h00 | Departure days Mon, Wed, Sat, Sun | Cheapest price $114 |
Live departures
Greenville, SC to Jacksonville, FL bus times
The table below shows live departures for Greenville, SC to Jacksonville, FL buses for today, Saturday, June 20. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| FlixBus+ | 8:20 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 10h40 | 7:00 AM Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St | 1 transfer | |
| FlixBus · FlixBus · FlixBus | 9:35 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 16h00 | 1:35 PM Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St | 2 transfers | |
| Sunday, June 21 | |||||
| +FlixBus | 7:10 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 11h15 | 6:25 PM Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St | 1 transfer | |
| +FlixBus | 11:00 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 10h25 | 9:25 PM Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St | 1 transfer | |
| FlixBus · FlixBus | 1:20 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 9h45 | 11:05 PM Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St | 1 transfer | |
Find all the dates and times for this journey
Compare prices and tickets Greenville, SC to Jacksonville, FL by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Greenville, SC to Jacksonville, FL buses with Omio?
Greyhound as well as FlixBus offer buses services from Greenville, SC to Jacksonville, FL.
Omio is an official ticket reseller for all your travel options from Greenville, SC to Jacksonville, FL.
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from Greenville, SC to Jacksonville, FL.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Greenville, SC to Jacksonville, FL.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Greenville, SC to Jacksonville, FL.
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Greenville, SC to Jacksonville, FL.
Journey information
Overview: Bus from Greenville, SC to Jacksonville, FL
USAUSA
Buses from Greenville, SC to Jacksonville, FL run on average 4 times per day, taking around 11h 25m. Cheap bus tickets for this journey start at $87 (€71) if you book in advance.
The earliest bus runs at 07:10, the last at 23:15. The fastest bus covers the 315 miles (507 km) distance in 9h 45m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 315 miles (507 km) |
Average bus duration 11h 25m |
Cheapest ticket price $87 (€71) |
Buses per day 4 |
Fastest bus 9h 45m |
First bus 7:10 AM |
Last bus 11:15 PM |
Cheapest Month Aug |
Cheapest Day Mon |
High Season Jan - Mar |
Low Season Oct - Dec |
Best time to book 14 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound, FlixBus from Greenville, SC to Jacksonville, FLYou can travel by bus between Greenville, SC to Jacksonville, FL with Greyhound, FlixBus for as low as $87 (€71). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
9h 45m
Cheapest Price
$87 (€71)
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
20h 25m
Cheapest Price
$156 (€128)
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Jacksonville
Things to do in Jacksonville
Discover the best of Jacksonville — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Jacksonville trip today.
- Recommended
Museum of Science & History (MOSH)
Family-friendly science museum on the Southbank with interactive exhibits, regional history, and a planetarium.
- Recommended
MOCA Jacksonville
Downtown contemporary art museum affiliated with the University of North Florida, known for rotating exhibitions and a central urban location.
- Must visit
Riverside Avondale Historic District
One of Jacksonville’s most beloved areas for walking, historic homes, independent shops, and riverfront parks.
- Must visit
Jacksonville Riverwalk
Scenic pedestrian route along both sides of the St. Johns River, popular for skyline views, photos, and evening walks.
- Must visit
Jacksonville Beach
The city’s best-known beach area, popular for ocean views, the fishing pier area, and a lively coastal atmosphere.
- Gluten-free
Mayport Shrimp
Wild-caught shrimp from nearby Mayport, served boiled, fried, blackened, or in baskets and platters. It is one of Jacksonville’s best-known local seafood specialties.
Minorcan Clam Chowder
A Northeast Florida chowder with tomatoes, clams, and the region’s famous datil pepper for heat. It reflects the area’s old Minorcan and coastal heritage.
- Vegetarian
- Vegan
- Gluten-free
Datil Pepper Hot Sauce
A sweet-hot pepper sauce closely associated with Northeast Florida. Locals use it on seafood, sandwiches, and grilled foods for a distinctive regional kick.
Orsay
Upscale bistro blending French technique with Southern influences. Well known for refined cooking, cocktails, and a lively fine-dining setting.
Safe Harbor Seafood Restaurant
Casual Mayport favorite known for very fresh local seafood, especially shrimp and fried platters, with a laid-back working-waterfront feel.
The Blue Fish Restaurant and Oyster Bar
Established seafood spot in Avondale known for oysters, fresh fish, and a polished but relaxed neighborhood atmosphere.
United States Dollar
Costs are moderate by U.S. standards. Dining and coffee are reasonable, while hotels vary by season and beach area.
Average meal costs
- Budget
- USD 10-15 for fast food or a casual lunch.
- Mid-range
- USD 20-40 per person at a mid-range restaurant.
- Fine dining
- USD 60+ per person before drinks and tip.
- Coffee
- USD 4-6 for a standard café coffee.
Tipping culture
Tip 18-20% in restaurants for table service, 20%+ for great service. Tip bartenders USD 1-2 per drink, taxis about 10-15%, hotel staff USD 1-5, and round up for cafés if desired.
FAQs: Bus from Greenville, SC to Jacksonville, FL
Find answers to the most common questions about traveling from Greenville, SC to Jacksonville, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Jacksonville, FL, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Greenville, SC to Jacksonville, FL can start from as little as $87 (€71) when you book in advance. The average bus ticket price for Greenville, SC to Jacksonville, FL is $155 (€127) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Greenville, SC to Jacksonville, FL is 9h 45m to travel the 315 miles (507 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Greenville, SC to Jacksonville, FL leaves at 7:10 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Greenville, SC to Jacksonville, FL leaves at 11:15 PM.
There are 4 buses a day from Greenville, SC to Jacksonville, FL which require at least one change with Greyhound, FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Greenville, SC to Jacksonville, FL, you can count on Greyhound, FlixBus for the best way to get you to Jacksonville, FL. You can also check all possible bus companies who offer a service between Greenville, SC and Jacksonville, FL and compare the amenities they offer before buying a bus ticket.
A trip to Jacksonville, FL from Greenville, SC is worth doing but not as a day trip with a journey time of 9h 45m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Greenville, SC to Jacksonville, FL is August.
It's helpful to compare your options as there are 3 ways to travel between Greenville, SC and Jacksonville, FL including taking a bus, train, and flight.
Yes, the following accessibility options are available when taking the bus from Greenville, SC to Jacksonville, FL:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Greenville, SC to Jacksonville, FL for bus company Greyhound, FlixBus.
Whether you can cancel your bus ticket from Greenville, SC to Jacksonville, FL depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Greyhound, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Greenville, SC to Jacksonville, FL.
Yes, the following luggage options are included when booking a bus ticket from Greenville, SC to Jacksonville, FL:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Greenville, SC to Jacksonville, FL:
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Greenville, SC to Jacksonville, FL. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Greenville, SC to Jacksonville, FL with the following bus company: Greyhound, FlixBus
Yes, there are USB plugs on board the bus from Greenville, SC to Jacksonville, FL with the following bus company: Greyhound, FlixBus.
Yes, there is Wifi on board the bus from Greenville, SC to Jacksonville, FL with the following bus company: Greyhound, FlixBus.
Since neither Greenville, SC nor Jacksonville, FL are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Greenville, SC to Jacksonville, FL among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Jacksonville, FL, travelers should be cautious of pickpocketing and vehicle break-ins, especially in crowded areas and popular tourist spots. Common scams include overcharging by unlicensed taxi or ride-share drivers and fake ticket sellers near attractions. Staying aware of surroundings, using reputable transportation services, and avoiding isolated areas at night can help ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Greenville, SC to Jacksonville, FL
Most Greenville, SC to Jacksonville, FL buses use the Greenville, Woodruff Rd ("Raceway" gas station) to Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St station pair. Use this guide to compare Greenville, SC and Jacksonville, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Greenville
Arrival bus stations in Jacksonville
Greenville, Woodruff Rd ("Raceway" gas station)
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St
City-centre transport
Getting to Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St from Jacksonville city centre
Bus1, 11, 18, 205, 3, Nassau, St. Johns, Clay · 12m · $4 · every ~18 min
1, 19, 3 · 17m · $4 · every ~17 min
SubwaySky · 10m · every ~4 min
Most popular bus connections from Greenville, SC
More options for your journey from Greenville, SC to Jacksonville, FL
Here are some other resources that might have the information you need
Most popular buses to and from Jacksonville, FL and Greenville, SC
Most popular bus connections to Jacksonville, FL
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