Travel Information
Compare bus, train, and flight for Greenville, SC to Jacksonville, FL
Omio recommends booking the bus as it is the most popular option from Greenville, SC to Jacksonville, FL among Omio's users. If you are prioritising price take the bus with prices starting from $89. For those with little time consider booking a flight which can get you there in 5h 16m. The ticket price range depends on the travel mode: a bus costs an average of $89, and a flight costs an average of $151.
Distance: 315 miles (507 km)
Compare bus with
Most popular Bus | Train | Flight | Driving |
|---|---|---|---|
$160 Average price Cheapest | $176 Average price | $277 Average price | $75 Average price (fuel + tolls) |
11h 55m Average total duration 11h 25m Onboard + 30m Additional time* | 23h 59m Average total duration 23h 29m Onboard + 30m Additional time* | 8h 16m Average total duration Fastest 5h 16m Onboard + 3h 0m Additional time* | 5h 33m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Greenville, SC to Jacksonville, FL:
A bus is $16 (€13) less than a train for this route with tickets for a train from Greenville, SC to Jacksonville, FL costing on average $176 (€141).
A bus is $118 (€94) less than a flight for this route with tickets for a flight from Greenville, SC to Jacksonville, FL costing on average $277 (€221).
Other travel options to Jacksonville, FL take longer:
Bus takes on average 11h 25m.
Train takes on average 23h 29m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Compare prices and tickets Greenville, SC to Jacksonville, FL by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Greenville, SC to Jacksonville, FL buses with Omio?
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from Greenville, SC to Jacksonville, FL.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Greenville, SC to Jacksonville, FL.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Greenville, SC to Jacksonville, FL.
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Greenville, SC to Jacksonville, FL.
Journey information
Overview: Bus from Greenville, SC to Jacksonville, FL
Buses from Greenville, SC to Jacksonville, FL run on average 3 times per day, taking around 11h 25m. Cheap bus tickets for this journey start at $89 (€71) if you book in advance.
The earliest bus runs at 07:10, the last at 22:15. The fastest bus covers the 315 miles (507 km) distance in 9h 45m.
Distance 315 miles (507 km) |
Average bus duration 11h 25m |
Cheapest ticket price $89 (€71) |
Buses per day 3 |
Fastest bus 9h 45m |
First bus 7:10 AM |
Last bus 10:15 PM |
Cheapest Month Apr |
Cheapest Day Thu |
High Season Jan - Mar |
Low Season Oct - Dec |
Best time to book 14 days |
Bus providers: Greyhound, FlixBus from Greenville, SC to Jacksonville, FLYou can travel by bus between Greenville, SC to Jacksonville, FL with Greyhound, FlixBus for as low as $89 (€71). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Greyhound
FAQs: Bus from Greenville, SC to Jacksonville, FL
Find answers to the most common questions about traveling from Greenville, SC to Jacksonville, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Jacksonville, FL, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Greenville, SC to Jacksonville, FL
Most popular bus connections from Greenville, SC
More options for your journey from Greenville, SC to Jacksonville, FL
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