- Recommended
East Tennessee History Center
Engaging museum on regional history with permanent and rotating exhibits covering people, places, and events from East Tennessee's past.
Cheapest price on Oct 02
€127
Average ticket price on Oct 02
€166
Fastest journey on Oct 02
2 d 6 h 20 m
Average journey duration on Oct 02
2 d 8 h 22 m
Buses on Oct 02
7
Distance
3058 km
The best way to find a cheap bus ticket from San Diego, CA to Knoxville, TN is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from San Diego, CA to Knoxville, TN will cost around €166 if you buy it on the day, but the cheapest tickets can be found for only €127.
It's difficult to get from San Diego, CA to Knoxville, TN without transferring at least 3 times.
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· Buses from San Diego, CA to Knoxville, TN run on average 8 times per day, taking around 53h 30m. Cheap bus tickets for this journey start at €232 if you book in advance.
The earliest bus runs at 07:35, the last at 22:50. The fastest bus covers the 1900 miles (3058 km) distance in 49h 15m.
Distance 1900 miles (3058 km) |
Average bus duration 53h 30m |
Cheapest ticket price €232 |
Buses per day 8 |
Fastest bus 49h 15m |
First bus 7:35 AM |
Last bus 10:50 PM |
Cheapest Month Jun |
Cheapest Day Tue |
High Season Jan - Mar |
Low Season Apr - Jun |
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 09:15AM | Arrival Time 09:50PM | Duration 57h35 | Departure days Fri | Cheapest price €192 |
Operator Greyhound | Departure Time 09:25AM | Arrival Time 10:30PM | Duration 58h05 | Departure days Fri | Cheapest price €151 |
Operator Greyhound | Departure Time 09:50AM | Arrival Time 09:50PM | Duration 57h00 | Departure days Fri | Cheapest price €127 |
Operator Greyhound | Departure Time 12:40PM | Arrival Time 10:30PM | Duration 54h50 | Departure days Fri | Cheapest price €215 |
Operator Greyhound | Departure Time 01:10PM | Arrival Time 10:30PM | Duration 54h20 | Departure days Fri | Cheapest price €151 |
Operator Greyhound | Departure Time 07:10PM | Arrival Time 07:50PM | Duration 69h40 | Departure days Fri | Cheapest price €194 |
Operator Greyhound | Departure Time 07:45PM | Arrival Time 07:50PM | Duration 69h05 | Departure days Fri | Cheapest price €127 |
Discover the best of Knoxville, TN — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Knoxville, TN trip today.
Engaging museum on regional history with permanent and rotating exhibits covering people, places, and events from East Tennessee's past.
University museum featuring changing exhibitions of American and international art in a modern gallery setting near campus.
Historic house museum preserving the home of artist Adelia Armstrong Lutz, with decorative arts, local history, and period rooms.
Lively pedestrian-friendly square lined with shops, events, and public seating. It is a central gathering place and a great base for exploring downtown.
Urban park from the 1982 World's Fair with lawns, walking paths, performance spaces, and easy access to the Sunsphere and museums.
Historic warehouse district with brick streets, galleries, murals, and nightlife. It blends railroad-era character with a creative local feel.
Smoky pulled pork barbecue is a regional staple in East Tennessee, usually hickory-smoked and served with slaw and sauce at local cookouts and barbecue joints.
Fried catfish is a longtime Tennessee favorite, coated in cornmeal and served with hush puppies or sides, especially popular in casual Southern eateries.
Biscuits with sausage gravy are a classic Southern breakfast in Knoxville, featuring flaky biscuits topped with rich peppery gravy made with pork drippings and milk.
Long-running neighborhood restaurant known for hearty Southern comfort food, pies, and a warm, traditional dining room.
Upscale Southern restaurant in Market Square known for shrimp and grits, steaks, and a polished downtown atmosphere.
Casual old-school barbecue spot serving hickory-smoked pork, ribs, and classic East Tennessee sides in a relaxed setting.
Moderate for U.S. city breaks: hotels and dining are reasonable, while car travel is common and public transit is limited for tourists.
Tip 18-20% at restaurants, 10-15% for taxis, and $1-2 per drink or coffee is appreciated at cafes.
Find answers to the most common questions about traveling from San Diego, CA to Knoxville, TN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Knoxville, TN, this guide helps you travel smarter and with confidence.

Most San Diego, CA to Knoxville, TN buses use the San Diego, Congress Street (Old Town Park) to Knoxville, Kirkwood Street station pair. Use this guide to compare San Diego, CA and Knoxville, TN bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
San Diego, Congress Street (Old Town Park) is 5 km from San Diego city centre. Public transport options include:
San Diego, Congress Street (Old Town Park) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Several dining options nearby.
Wi-Fi is available at San Diego, Congress Street (Old Town Park). ATMs are available at San Diego, Congress Street (Old Town Park).
Ticket office support is available at San Diego, Congress Street (Old Town Park).
Available at San Diego, Congress Street (Old Town Park): Parking, Taxis, WC.
Accessibility facilities are available at San Diego, Congress Street (Old Town Park): Wheelchair accessible routes available.
San Diego, San Ysidro Transit Center is 22 km from San Diego city centre. Public transport options include:
San Diego, San Ysidro Transit Center has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Several fast food eateries located nearby.
Wi-Fi is available at San Diego, San Ysidro Transit Center. ATMs are available near the entrance.
Ticket office support is available at San Diego, San Ysidro Transit Center.
Available at San Diego, San Ysidro Transit Center: Parking, Taxis, WC.
Accessibility facilities are available at San Diego, San Ysidro Transit Center: Wheelchair accessible with ramps.
San Diego, West Harbor Drive (The Headquarters at Seaport District) is 1 km from San Diego city centre. Public transport options include:
San Diego, West Harbor Drive (The Headquarters at Seaport District) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Several dining options are in the area.
Wi-Fi is available at San Diego, West Harbor Drive (The Headquarters at Seaport District). ATMs are available at San Diego, West Harbor Drive (The Headquarters at Seaport District).
Ticket office support is available at San Diego, West Harbor Drive (The Headquarters at Seaport District).
Available at San Diego, West Harbor Drive (The Headquarters at Seaport District): Parking, Taxis, WC.
Accessibility facilities are available at San Diego, West Harbor Drive (The Headquarters at Seaport District): Accessible for persons with disabilities.
Knoxville, Kirkwood Street is 5 km from Knoxville city centre. Public transport options include:
Knoxville, Kirkwood Street has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Knoxville, Kirkwood Street. ATMs are available at Knoxville, Kirkwood Street.
Ticket office support is available at Knoxville, Kirkwood Street.
Available at Knoxville, Kirkwood Street: Parking, Taxis, WC.
Accessibility facilities are available at Knoxville, Kirkwood Street: Wheelchair accessible buses available.
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