San Diego, CA to Knoxville, TN bus with Greyhound

Fri, Oct 02
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The cheapest and fastest buses from San Diego, CA to Knoxville, TN

Showing times, prices and bookable tickets for Oct 02

Cheapest price on Oct 02

€127

Average ticket price on Oct 02

€166

Fastest journey on Oct 02

2 d 6 h 20 m

Average journey duration on Oct 02

2 d 8 h 22 m

Buses on Oct 02

7

Distance

3058 km

Cheap tickets

The best way to find a cheap bus ticket from San Diego, CA to Knoxville, TN is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from San Diego, CA to Knoxville, TN will cost around €166 if you buy it on the day, but the cheapest tickets can be found for only €127.

Fast buses

It's difficult to get from San Diego, CA to Knoxville, TN without transferring at least 3 times.

  • Greyhound · · ·
    7:45 PM69h05
    San Diego, Congress Street (Old Town Park), CA
    7:50 PMKnoxville, Kirkwood Street, TN
    €1271One-way
    4 transfers
  • Greyhound · · ·
    9:50 AM57h00
    San Diego, Congress Street (Old Town Park), CA
    9:50 PMKnoxville, Kirkwood Street, TN
    €1271One-way
    3 transfers
  • FlixBusFlixBus · FlixBus+Greyhound ·
    9:25 AM58h05
    San Diego, Congress Street (Old Town Park), CA
    10:30 PMKnoxville, Kirkwood Street, TN
    €1511One-way
    5 transfers
  • FlixBusFlixBus+Greyhound · ·
    1:10 PM54h20
    San Diego, West Harbor Drive (The Headquarters at Seaport District), CA
    10:30 PMKnoxville, Kirkwood Street, TN
    €1511One-way
    4 transfers
  • Greyhound · · ·
    9:15 AM57h35
    San Diego, San Ysidro Transit Center
    9:50 PMKnoxville, Kirkwood Street, TN
    €1921One-way
    3 transfers

Journey information

Overview: Bus from San Diego, CA to Knoxville, TN

USAUSA
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Icon of bus

Buses from San Diego, CA to Knoxville, TN run on average 8 times per day, taking around 53h 30m. Cheap bus tickets for this journey start at €232 if you book in advance.

The earliest bus runs at 07:35, the last at 22:50. The fastest bus covers the 1900 miles (3058 km) distance in 49h 15m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
1900 miles (3058 km)
Average bus duration
53h 30m
Cheapest ticket price
€232
Buses per day
8
Fastest bus
49h 15m
First bus
7:35 AM
Last bus
10:50 PM
Cheapest Month
Jun
Cheapest Day
Tue
High Season
Jan - Mar
Low Season
Apr - Jun
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

San Diego, CA to Knoxville, TN Bus Timetables

OperatorDeparture TimeArrival TimeDurationDeparture daysCheapest price
Operator
Greyhound
Departure Time
09:15AM
Arrival Time
09:50PM
Duration
57h35
Departure days
Fri
Cheapest price
€192
Operator
Greyhound
Departure Time
09:25AM
Arrival Time
10:30PM
Duration
58h05
Departure days
Fri
Cheapest price
€151
Operator
Greyhound
Departure Time
09:50AM
Arrival Time
09:50PM
Duration
57h00
Departure days
Fri
Cheapest price
€127
Operator
Greyhound
Departure Time
12:40PM
Arrival Time
10:30PM
Duration
54h50
Departure days
Fri
Cheapest price
€215
Operator
Greyhound
Departure Time
01:10PM
Arrival Time
10:30PM
Duration
54h20
Departure days
Fri
Cheapest price
€151
Operator
Greyhound
Departure Time
07:10PM
Arrival Time
07:50PM
Duration
69h40
Departure days
Fri
Cheapest price
€194
Operator
Greyhound
Departure Time
07:45PM
Arrival Time
07:50PM
Duration
69h05
Departure days
Fri
Cheapest price
€127

Why should you book San Diego, CA to Knoxville, TN buses with Omio?

Greyhound operates all buses services from San Diego, CA to Knoxville, TN.
Omio is an official ticket reseller for all your travel options from San Diego, CA to Knoxville, TN.

Why book with Omio vs Greyhound?

  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and flight to ensure you get the best deal for traveling from San Diego, CA to Knoxville, TN.

Why book with Omio over Wanderu?

  • Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from San Diego, CA to Knoxville, TN.

Bus providers: Greyhound from San Diego, CA to Knoxville, TNYou can travel by bus between San Diego, CA to Knoxville, TN with Greyhound for as low as €232. When you search for schedules and tickets, Omio will show you the best journey

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
49h 15m
Cheapest Greyhound Price
€232
Greyhound frequency
8 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.

Complete guide to Knoxville, TN

Things to do in Knoxville, TN

Discover the best of Knoxville, TN — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Knoxville, TN trip today.

  • Recommended

East Tennessee History Center

Engaging museum on regional history with permanent and rotating exhibits covering people, places, and events from East Tennessee's past.

  • Recommended

McClung Museum of Natural History and Culture

University museum featuring changing exhibitions of American and international art in a modern gallery setting near campus.

  • Recommended

Mabry-Hazen House

Historic house museum preserving the home of artist Adelia Armstrong Lutz, with decorative arts, local history, and period rooms.

$ US dollar

Moderate for U.S. city breaks: hotels and dining are reasonable, while car travel is common and public transit is limited for tourists.

Average meal costs

Budget
$10-15 for fast food or a casual lunch.
Mid-range
$18-35 per person for a restaurant meal.
Fine dining
$50+ per person for upscale dining.
Coffee
$3-5 for a coffee or cappuccino.

Tipping culture

Tip 18-20% at restaurants, 10-15% for taxis, and $1-2 per drink or coffee is appreciated at cafes.

FAQs: Bus from San Diego, CA to Knoxville, TN

Find answers to the most common questions about traveling from San Diego, CA to Knoxville, TN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Knoxville, TN, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from San Diego, CA to Knoxville, TN can start from as little as €232 when you book in advance. The average bus ticket price for San Diego, CA to Knoxville, TN is €318 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from San Diego, CA to Knoxville, TN is 49h 15m to travel the 1900 miles (3058 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from San Diego, CA to Knoxville, TN leaves at 7:35 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from San Diego, CA to Knoxville, TN leaves at 10:50 PM.
There are 8 buses a day from San Diego, CA to Knoxville, TN which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from San Diego, CA to Knoxville, TN, you can count on Greyhound for the best way to get you to Knoxville, TN. You can also check all possible bus companies who offer a service between San Diego, CA and Knoxville, TN and compare the amenities they offer before buying a bus ticket.
When departing from San Diego, CA , you have various bus station options to start your journey from including San Diego, Congress Street (Old Town Park), CA, San Diego, San Ysidro Transit Center, San Diego, West Harbor Drive (The Headquarters at Seaport District), CA . When arriving in Knoxville, TN , you can end your journey in bus stations like Knoxville, Kirkwood Street, TN .Passengers board the bus most frequently from San Diego, Congress Street (Old Town Park), CA, which is located around 3 miles (5 km) away from the city centre, and they get off the bus at Knoxville, Kirkwood Street, TN, located 5 away from the city centre.
It's helpful to compare your options as there are 2 ways to travel between San Diego, CA and Knoxville, TN including taking a bus and flight.
Yes, the following accessibility options are available when taking the bus from San Diego, CA to Knoxville, TN:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from San Diego, CA to Knoxville, TN for bus company Greyhound.
Whether you can cancel your bus ticket from San Diego, CA to Knoxville, TN depends on the bus companies:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from San Diego, CA to Knoxville, TN.
Yes, the following luggage options are included when booking a bus ticket from San Diego, CA to Knoxville, TN:
  • Greyhound
    • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from San Diego, CA to Knoxville, TN:
  • Greyhound
    • $15 per additional bag.
Unfortunately, pets are not allowed on the bus from San Diego, CA to Knoxville, TN.
You can reserve your seat on the bus from San Diego, CA to Knoxville, TN with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from San Diego, CA to Knoxville, TN with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from San Diego, CA to Knoxville, TN with the following bus company: Greyhound.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Knoxville, TN, travelers should be cautious of pickpocketing and vehicle break-ins, especially in crowded areas and parking lots. Avoid accepting unsolicited offers for transportation or tours, as unlicensed operators may overcharge or provide unsafe services. It's also advisable to stay in well-lit areas at night and be aware of local traffic patterns when using ride-share or public transportation to ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular bus stations

Popular bus stations from San Diego, CA to Knoxville, TN

Most San Diego, CA to Knoxville, TN buses use the San Diego, Congress Street (Old Town Park) to Knoxville, Kirkwood Street station pair. Use this guide to compare San Diego, CA and Knoxville, TN bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.

Departure bus stations in San Diego
Arrival bus stations in Knoxville

Which San Diego, CA station do buses to Knoxville, TN leave from?

Buses from San Diego, CA to Knoxville, TN leave from San Diego, Congress Street (Old Town Park). The station is 3 miles (6 km) from San Diego, CA city centre at Congress St, San Diego, CA 92110, USA.
San Diego, Congress Street (Old Town Park)Congress St, San Diego, CA 92110, USAWifiParkingDiningATMTaxisAccessibilityWCShowerTicket Office
City-centre transport

Getting to San Diego, Congress Street (Old Town Park) from San Diego city centre

San Diego, Congress Street (Old Town Park) is 5 km from San Diego city centre. Public transport options include:

BusFlixBus 2017 · 20m · €1
83 · 26m · €5
TramGreen, Blue, Event · 16m · every ~18 min
Blue · 21m · every ~9 min

San Diego, Congress Street (Old Town Park) bus station facilities and services

San Diego, Congress Street (Old Town Park) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.

Food and drink

Food options include: Several dining options nearby.

Wi-Fi and ATMs

Wi-Fi is available at San Diego, Congress Street (Old Town Park). ATMs are available at San Diego, Congress Street (Old Town Park).

Tickets and information

Ticket office support is available at San Diego, Congress Street (Old Town Park).

Parking, taxis and toilets

Available at San Diego, Congress Street (Old Town Park): Parking, Taxis, WC.

Accessibility

Accessibility facilities are available at San Diego, Congress Street (Old Town Park): Wheelchair accessible routes available.

San Diego, San Ysidro Transit CenterSan Ysidro Station, San Diego, CA 92173, USAWifiParkingDiningATMTaxisAccessibilityWCShowerTicket Office
City-centre transport

Getting to San Diego, San Ysidro Transit Center from San Diego city centre

San Diego, San Ysidro Transit Center is 22 km from San Diego city centre. Public transport options include:

BusFlixBus 2017 · 25m · €2
910 · 41m · €5
TramBlue · 41m · €14 · every ~14 min
Blue · 43m · €14 · every ~14 min

San Diego, San Ysidro Transit Center bus station facilities and services

San Diego, San Ysidro Transit Center has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.

Food and drink

Food options include: Several fast food eateries located nearby.

Wi-Fi and ATMs

Wi-Fi is available at San Diego, San Ysidro Transit Center. ATMs are available near the entrance.

Tickets and information

Ticket office support is available at San Diego, San Ysidro Transit Center.

Parking, taxis and toilets

Available at San Diego, San Ysidro Transit Center: Parking, Taxis, WC.

Accessibility

Accessibility facilities are available at San Diego, San Ysidro Transit Center: Wheelchair accessible with ramps.

San Diego, West Harbor Drive (The Headquarters at Seaport District)W Harbor Dr, San Diego, CA, USAWifiParkingDiningATMTaxisAccessibilityWCShowerTicket Office
City-centre transport

Getting to San Diego, West Harbor Drive (The Headquarters at Seaport District) from San Diego city centre

San Diego, West Harbor Drive (The Headquarters at Seaport District) is 1 km from San Diego city centre. Public transport options include:

TRUE

San Diego, West Harbor Drive (The Headquarters at Seaport District) bus station facilities and services

San Diego, West Harbor Drive (The Headquarters at Seaport District) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.

Food and drink

Food options include: Several dining options are in the area.

Wi-Fi and ATMs

Wi-Fi is available at San Diego, West Harbor Drive (The Headquarters at Seaport District). ATMs are available at San Diego, West Harbor Drive (The Headquarters at Seaport District).

Tickets and information

Ticket office support is available at San Diego, West Harbor Drive (The Headquarters at Seaport District).

Parking, taxis and toilets

Available at San Diego, West Harbor Drive (The Headquarters at Seaport District): Parking, Taxis, WC.

Accessibility

Accessibility facilities are available at San Diego, West Harbor Drive (The Headquarters at Seaport District): Accessible for persons with disabilities.

More options for your journey from San Diego, CA to Knoxville, TN

Here are some other resources that might have the information you need

HomeBusesBuses in USASan Diego, CA to Knoxville, TN bus

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