Travel Information
Compare bus and flight for Frederick, MD to San Francisco, CA
Omio recommends booking the flight as it is the most popular option from Frederick, MD to San Francisco, CA among Omio's users. If you are prioritising price take the bus with prices starting from $260. For those with little time consider booking a flight which can get you there in 9h 6m. The ticket price range depends on the travel mode: a bus costs an average of $260, and a flight costs an average of $285.
Distance: 2407 miles (3875 km)
Compare bus with
| Bus | Most popular Flight |
|---|---|
$260 Average price Cheapest | $285 Average price |
68h 20m Average total duration 67h 50m Onboard + 30m Additional time* | 12h 6m Average total duration Fastest 9h 6m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options |
Compare prices and tickets Frederick, MD to San Francisco, CA by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Frederick, MD to San Francisco, CA buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Frederick, MD to San Francisco, CA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Frederick, MD to San Francisco, CA.
Journey information
Overview: Bus from Frederick, MD to San Francisco, CA
Buses from Frederick, MD to San Francisco, CA run on average 1 times per day, taking around 67h 50m. Cheap bus tickets for this journey start at $260 (€213) if you book in advance.
The earliest bus runs at 00:35, the last at 00:35. The fastest bus covers the 2407 miles (3875 km) distance in 67h 50m.
Distance 2407 miles (3875 km) |
Average bus duration 67h 50m |
Cheapest ticket price $260 (€213) |
Buses per day 1 |
Fastest bus 67h 50m |
First bus 00:35 |
Last bus 00:35 |
High season Jan - Mar |
Low season Jan - Mar |
Bus providers: Greyhound from Frederick, MD to San Francisco, CAYou can travel by bus between Frederick, MD to San Francisco, CA with Greyhound for as low as $260 (€213). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Frederick, MD to San Francisco, CA
Find answers to the most common questions about traveling from Frederick, MD to San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Francisco, CA, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Golden Gate Bridge, an iconic suspension bridge offering panoramic views of the San Francisco Bay
- Alcatraz Island, a historic site featuring the infamous former prison and informative audio tours
- Fisherman's Wharf, a bustling waterfront area known for seafood, shops, and sea lions
- Golden Gate Park, a large urban park with gardens, museums, and recreational activities
- Chinatown, the oldest and one of the largest Chinatowns in North America, offering vibrant culture and cuisine.
- Ride a cable car through the steep streets of San Francisco for a classic city experience
- Explore the vibrant murals and street art in the Mission District
- Visit the Exploratorium, an interactive science museum perfect for all ages
- Take a scenic walk along the Embarcadero, offering views of the Bay Bridge and access to the Ferry Building Marketplace
- Enjoy a wine tasting tour in nearby Napa Valley, a short drive from the city.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
Most popular bus connections from Frederick, MD
More options for your journey from Frederick, MD to San Francisco, CA
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