The cheapest and fastest buses from Frederick, MD to San Francisco, CA
Cheapest price
€939
Average price
€939
Fastest journey
3 d 6 h 35 m
Average duration
3 d 6 h 35 m
Buses per day
1
Distance
3875 km
The best way to find a cheap bus ticket from Frederick, MD to San Francisco, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Frederick, MD to San Francisco, CA will cost around €939 if you buy it on the day, but the cheapest tickets can be found for only €939.
It's difficult to get from Frederick, MD to San Francisco, CA without transferring at least 3 times.


Live departures
Frederick, MD to San Francisco, CA bus times
The table below shows live departures for Frederick, MD to San Francisco, CA buses for today, Monday, December 8. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 8:50 AM Frederick, MD | 78h35 | 3:25 PM San Francisco, CA | 3 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Frederick, MD to San Francisco, CA by bus
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Frederick, MD to San Francisco, CA
Buses from Frederick, MD to San Francisco, CA run on average 1 times per day, taking around 78h 35m. Cheap bus tickets for this journey start at $1173 (€945) if you book in advance.
The earliest bus runs at 08:50, the last at 08:50. The fastest bus covers the 2407 miles (3875 km) distance in 78h 35m.
Distance 2407 miles (3875 km) |
Average bus duration 78h 35m |
Cheapest ticket price $1173 (€945) |
Buses per day 1 |
Fastest bus 78h 35m |
First bus 08:50 |
Last bus 08:50 |
Bus providers: Greyhound from Frederick, MD to San Francisco, CAYou can travel by bus between Frederick, MD to San Francisco, CA with Greyhound for as low as $1173 (€945). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Frederick, MD to San Francisco, CA
Find answers to the most common questions about traveling from Frederick, MD to San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Francisco, CA, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Golden Gate Bridge, an iconic suspension bridge offering panoramic views of the San Francisco Bay
- Alcatraz Island, a historic site featuring the infamous former prison and informative audio tours
- Fisherman's Wharf, a bustling waterfront area known for seafood, shops, and sea lions
- Golden Gate Park, a large urban park with gardens, museums, and recreational activities
- Chinatown, the oldest and one of the largest Chinatowns in North America, offering vibrant culture and cuisine.
- Ride a cable car through the steep streets of San Francisco for a classic city experience
- Explore the vibrant murals and street art in the Mission District
- Visit the Exploratorium, an interactive science museum perfect for all ages
- Take a scenic walk along the Embarcadero, offering views of the Bay Bridge and access to the Ferry Building Marketplace
- Enjoy a wine tasting tour in nearby Napa Valley, a short drive from the city.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
To find the cheapest bus tickets for your trip from Frederick, MD to San Francisco, CA, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
Most popular bus connections from Frederick, MD
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