The cheapest and fastest buses from Frederick, MD to Buffalo, NY
Cheapest price
$223
Average price
$294
Fastest journey
14 h 40 m
Average duration
18 h 45 m
Buses per day
3
Distance
405 km
The best way to find a cheap bus ticket from Frederick, MD to Buffalo, NY is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Frederick, MD to Buffalo, NY will cost around $294 if you buy it on the day, but the cheapest tickets can be found for only $223.
It's difficult to get from Frederick, MD to Buffalo, NY without transferring at least once.






Travel Information
Compare bus and flight for Frederick, MD to Buffalo, NY
Omio recommends booking the bus as it is the most popular option from Frederick, MD to Buffalo, NY among Omio's users. If you are prioritising price take the bus with prices starting from €59. For those with little time consider booking a flight which can get you there in 4h 25m. The ticket price range depends on the travel mode: a bus costs an average of €59, and a flight costs an average of €91.
Distance: 251 miles (405 km)
Compare bus with
Most popular Bus | Flight |
|---|---|
€84 Average price Cheapest | €91 Average price |
16h 43m Average total duration 16h 13m Onboard + 30m Additional time* | 7h 25m Average total duration Fastest 4h 25m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options |
Live departures
Frederick, MD to Buffalo, NY bus times
The table below shows live departures for Frederick, MD to Buffalo, NY buses for today, Wednesday, January 28. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:30 AM Frederick, MD | 19h40 | 8:10 PM Buffalo, NY | 2 transfers | |
![]() | 8:50 AM Frederick, MD | 14h40 | 11:30 PM Buffalo, NY | 1 transfer | |
![]() | 7:30 PM Frederick, MD | 21h55 | 5:25 PM Buffalo, NY | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Frederick, MD to Buffalo, NY by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Jan 29
Jan 30
Jan 31
Feb 01
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Feb 03
Feb 04
Why should you book Frederick, MD to Buffalo, NY buses with Omio?
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of BayRunner Shuttle to find the best option for your trip from Frederick, MD to Buffalo, NY.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Frederick, MD to Buffalo, NY.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Frederick, MD to Buffalo, NY.
Journey information
Overview: Bus from Frederick, MD to Buffalo, NY
Buses from Frederick, MD to Buffalo, NY run on average 3 times per day, taking around 16h 13m. Cheap bus tickets for this journey start at $75 (€59) if you book in advance.
The earliest bus runs at 07:12, the last at 17:20. The fastest bus covers the 251 miles (405 km) distance in 15h 25m.
Distance 251 miles (405 km) |
Average bus duration 16h 13m |
Cheapest ticket price $75 (€59) |
Buses per day 3 |
Fastest bus 15h 25m |
First bus 07:12 |
Last bus 17:20 |
Bus providers: Greyhound, BayRunner Shuttle from Frederick, MD to Buffalo, NYYou can travel by bus between Frederick, MD to Buffalo, NY with Greyhound, BayRunner Shuttle for as low as $75 (€59). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
BayRunner Shuttle
FAQs: Bus from Frederick, MD to Buffalo, NY
Find answers to the most common questions about traveling from Frederick, MD to Buffalo, NY by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Buffalo, NY, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
To find the cheapest bus tickets for your trip from Frederick, MD to Buffalo, NY, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Frederick, MD to Buffalo, NY
Most popular bus connections from Frederick, MD
More options for your journey from Frederick, MD to Buffalo, NY
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