- Must visit
Art Institute Of Chicago
One of the world’s leading art museums, famous for Impressionist masterpieces, American art, and major special exhibitions.
Cheapest price
$185
Average price
$197
Fastest journey
14 h 25 m
Average duration
16 h 58 m
Buses per day
2
Distance
905 km
The best way to find a cheap bus ticket from Frederick, MD to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Frederick, MD to Chicago, IL will cost around $197 if you buy it on the day, but the cheapest tickets can be found for only $185.
Of the 2 buses that leave Frederick, MD for Chicago, IL on Mon, Jun 15, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Mon, Jun 15 the direct buses cover the 905 km distance in an average of 16 h 58 m but if you time it right, some buses will get you there in just 14 h 25 m .
On Mon, Jun 15 the slowest buses will take 19 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Omio recommends booking the train as it is the most popular option from Frederick, MD to Chicago, IL among Omio's users. If you are prioritising price take the bus with prices starting from $109. For those with little time consider booking a flight which can get you there in 2h 17m. The ticket price range depends on the travel mode: a bus costs an average of $109, and a flight costs an average of $461.
Distance: 562 miles (905 km)
| Bus | Most popular Train | Flight |
|---|---|---|
$109 Average price Cheapest | $205 Average price | $461 Average price |
16h 20m Average total duration 15h 50m Onboard + 30m Additional time* | 16h 53m Average total duration 16h 23m Onboard + 30m Additional time* | 5h 17m Average total duration Fastest 2h 17m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Frederick, MD to Chicago, IL:
A bus is $95 (€78) less than a train for this route with tickets for a train from Frederick, MD to Chicago, IL costing on average $205 (€166).
A bus is $352 (€286) less than a flight for this route with tickets for a flight from Frederick, MD to Chicago, IL costing on average $461 (€374).
Other travel options to Chicago, IL take longer:
Bus takes on average 15h 50m.
Train takes on average 16h 23m.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 12:35AM | Arrival Time 08:05PM | Duration 19h30 | Departure days Mon, Tue, Wed, Thu, Sat | Cheapest price $208 |
Operator Greyhound USA | Departure Time 07:35PM | Arrival Time 10:00AM | Duration 14h25 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price $185 |
Operator Greyhound | Departure Time 11:35PM | Arrival Time 03:00PM | Duration 15h25 | Departure days Fri | Cheapest price $109 |
The table below shows live departures for Frederick, MD to Chicago, IL buses for today, Sunday, June 14. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 7:35 PM Frederick, MD | 14h25 | 10:00 AM Chicago, IL | 0 transfersDirect | |
| Monday, June 15 | |||||
![]() | 12:35 AM Frederick, MD | 19h30 | 8:05 PM Chicago, IL | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Frederick, MD to Chicago, IL run on average 3 times per day, taking around 15h 50m. Cheap bus tickets for this journey start at $109 (€89) if you book in advance.
There are 1 buses per day. The earliest bus runs at 06:55, the last at 23:35. The fastest bus covers the 562 miles (905 km) distance in 15h 25m.
Distance 562 miles (905 km) |
Average bus duration 15h 50m |
Cheapest ticket price $109 (€89) |
Buses per day 3 |
Direct buses 1 |
Fastest bus 15h 25m |
First bus 6:55 AM |
Last bus 11:35 PM |
Cheapest Month Sep |
Cheapest Day Wed |
High Season Apr - Jun |
Low Season Jul - Sep |
Best time to book 4 days |
Discover the best of Chicago — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Chicago trip today.
One of the world’s leading art museums, famous for Impressionist masterpieces, American art, and major special exhibitions.
Major natural history museum known for Sue the T. rex, ancient cultures, and large family-friendly science exhibits.
Large hands-on science museum in Hyde Park with a U-505 submarine, aviation exhibits, and immersive interactive displays.
Chicago’s signature public space, home to Cloud Gate and major events, with strong appeal for first-time visitors and photographers.
Scenic pedestrian route along the Chicago River, popular for architecture views, strolling, and social-media-friendly city scenes.
Famous stretch of North Michigan Avenue known for landmark architecture, flagship stores, and busy big-city energy.
Chicago’s iconic thick-crust pizza baked in a deep pan with layers of cheese, toppings, and chunky tomato sauce.
An all-beef hot dog on a poppy seed bun topped with mustard, onions, relish, tomato, pickle spear, sport peppers, and celery salt.
A classic Chicago sandwich of thin-sliced seasoned beef served on a roll, often dipped in jus and topped with giardiniera or sweet peppers.
A well-known Magnificent Mile restaurant serving Mediterranean-influenced small plates, charcuterie, and strong wine selections.
Chicago’s internationally acclaimed fine-dining restaurant known for inventive tasting menus and a polished, theatrical experience.
A legendary Chicago pizzeria best known for buttery-crust deep-dish pizza in a casual, family-friendly setting.
Moderate by U.S. big-city standards. Hotels can be pricey downtown, but food and transit offer good value.
Tip 18-20% at sit-down restaurants; 20%+ for great service. USD 1-2 per drink at bars, round up or 10-15% for taxis, and USD 1-2 per bag for hotel staff.
Find answers to the most common questions about traveling from Frederick, MD to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

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