- Must visit
Art Institute of Chicago
World-class art museum with masterpieces from Monet to Hopper and the famous Modern Wing.
Cheapest price
$182
Average price
$193
Fastest journey
14 h 25 m
Average duration
16 h 58 m
Buses per day
2
Distance
905 km
The best way to find a cheap bus ticket from Frederick, MD to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Frederick, MD to Chicago, IL will cost around $193 if you buy it on the day, but the cheapest tickets can be found for only $182.
Of the 2 buses that leave Frederick, MD for Chicago, IL on Thu, Jul 30, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, Jul 30 the direct buses cover the 905 km distance in an average of 16 h 58 m but if you time it right, some buses will get you there in just 14 h 25 m .
On Thu, Jul 30 the slowest buses will take 19 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Omio recommends booking the train as it is the most popular option from Frederick, MD to Chicago, IL among Omio's users. If you are prioritising price take the bus with prices starting from $107. For those with little time consider booking a flight which can get you there in 2h 17m. The ticket price range depends on the travel mode: a bus costs an average of $107, and a flight costs an average of $454.
Distance: 562 miles (905 km)
| Bus | Most popular Train | Flight |
|---|---|---|
$107 Average price Cheapest | $201 Average price | $454 Average price |
16h 20m Average total duration 15h 50m Onboard + 30m Additional time* | 16h 53m Average total duration 16h 23m Onboard + 30m Additional time* | 5h 17m Average total duration Fastest 2h 17m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Frederick, MD to Chicago, IL:
A bus is $94 (€78) less than a train for this route with tickets for a train from Frederick, MD to Chicago, IL costing on average $201 (€166).
A bus is $346 (€286) less than a flight for this route with tickets for a flight from Frederick, MD to Chicago, IL costing on average $454 (€374).
Other travel options to Chicago, IL take longer:
Bus takes on average 15h 50m.
Train takes on average 16h 23m.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 12:35AM | Arrival Time 08:05PM | Duration 19h30 | Departure days Mon, Tue, Wed, Thu, Sat | Cheapest price $205 |
Operator Greyhound USA | Departure Time 07:35PM | Arrival Time 10:00AM | Duration 14h25 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price $182 |
Operator Greyhound | Departure Time 11:35PM | Arrival Time 03:00PM | Duration 15h25 | Departure days Fri | Cheapest price $107 |
The table below shows live departures for Frederick, MD to Chicago, IL buses for today, Wednesday, July 29. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 7:35 PM Frederick, MD | 14h25 | 10:00 AM Chicago, IL | 0 transfersDirect | |
| Thursday, July 30 | |||||
![]() | 12:35 AM Frederick, MD | 19h30 | 8:05 PM Chicago, IL | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Frederick, MD to Chicago, IL run on average 3 times per day, taking around 15h 50m. Cheap bus tickets for this journey start at $107 (€89) if you book in advance.
There are 1 buses per day. The earliest bus runs at 06:55, the last at 23:35. The fastest bus covers the 562 miles (905 km) distance in 15h 25m.
Distance 562 miles (905 km) |
Average bus duration 15h 50m |
Cheapest ticket price $107 (€89) |
Buses per day 3 |
Direct buses 1 |
Fastest bus 15h 25m |
First bus 6:55 AM |
Last bus 11:35 PM |
Cheapest Month Sep |
Cheapest Day Wed |
High Season Apr - Jun |
Low Season Jul - Sep |
Best time to book 4 days |
Discover the best of Chicago, IL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Chicago, IL trip today.
World-class art museum with masterpieces from Monet to Hopper and the famous Modern Wing.
Major natural history museum with Sue the T. rex, ancient cultures, and strong family appeal.
Hands-on science museum in a grand former fair building, popular for exhibits and a U-505 submarine.
Lively lakefront park with Cloud Gate, Crown Fountain, gardens, and major public art in central Chicago.
Famous shopping boulevard lined with architecture, hotels, riverfront views, and major city energy.
Scenic pedestrian-friendly riverwalk with boat docks, public art, bridges, and standout skyline perspectives.
Deep-dish pizza is Chicago’s iconic pie with a tall buttery crust, layers of cheese and toppings, and chunky tomato sauce baked on top.
The Chicago-style hot dog is an all-beef frank on a poppy seed bun with mustard, relish, onion, tomato, pickle, peppers, and celery salt.
Italian beef is thin-sliced roast beef piled onto a roll, often dipped in savory juices and topped with sweet peppers or spicy giardiniera.
Classic spot for juicy Italian beef sandwiches, especially dipped and topped with spicy giardiniera, with a casual local feel.
Legendary stand for Chicago-style hot dogs and char-grilled sausages, served fast in a no-frills local landmark.
World-famous fine dining destination offering a highly creative tasting menu and refined service in an elegant setting.
Moderate for a major US city: hotels can be pricey, but transit is affordable and dining ranges from cheap eats to upscale options.
Tip 18-20% at restaurants, $1-2 per drink at bars, 10-15% for taxis, and optional small change at cafes.
Find answers to the most common questions about traveling from Frederick, MD to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

Most Frederick, MD to Chicago, IL buses use the Frederick, East Street (Transit Center) to Chicago, Greyhound Bus Station station pair, with some services arriving at Chicago, Union Station (Amtrak). Use this guide to compare Frederick, MD and Chicago, IL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need