- Must visit
Art Institute of Chicago
World-class art museum with masterpieces from Monet to Hopper and the famous Modern Wing.
Cheapest price on Oct 29
$178
Average ticket price on Oct 29
$189
Fastest journey on Oct 29
14 h 25 m
Average journey duration on Oct 29
16 h 58 m
Buses on Oct 29
2
Distance
905 km
The best way to find a cheap bus ticket from Frederick, MD to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Frederick, MD to Chicago, IL will cost around $189 if you buy it on the day, but the cheapest tickets can be found for only $178.
On Thu, Oct 29, we found 2 buses from Frederick, MD to Chicago, IL, including 1 direct services.
On Thu, Oct 29 the direct buses cover the 905 km distance in an average of 16 h 58 m but if you time it right, some buses will get you there in just 14 h 25 m .
On Thu, Oct 29 the slowest buses will take 19 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Frederick, MD to Chicago, IL run on average 4 times per day, taking around 17h 40m. Cheap bus tickets for this journey start at $85 if you book in advance.
There are 1 buses per day. The earliest bus runs at 06:55, the last at 23:35. The fastest bus covers the 562 miles (905 km) distance in 15h 25m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Frederick, MD to Chicago, IL.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 12:35AM | Arrival Time 08:05PM | Duration 19h30 | Departure days Tue, Wed, Thu, Sat | Cheapest price $201 |
Operator Greyhound | Departure Time 05:05AM | Arrival Time 08:00AM | Duration 27h55 | Departure days Mon | Cheapest price $110 |
Operator FlixBus | Departure Time 05:05AM | Arrival Time 06:10AM | Duration 26h05 | Departure days Mon | Cheapest price $108 |
Operator Greyhound | Departure Time 10:25AM | Arrival Time 01:45PM | Duration 28h20 | Departure days Mon | Cheapest price $143 |
Operator Greyhound USA | Departure Time 07:35PM | Arrival Time 10:00AM | Duration 14h25 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price $83 |
Operator Greyhound | Departure Time 11:35PM | Arrival Time 03:00PM | Duration 15h25 | Departure days Fri | Cheapest price $105 |
Operator Greyhound | Departure Time 11:40PM | Arrival Time 08:05PM | Duration 21h25 | Departure days Mon | Cheapest price $101 |
The table below shows live departures for Frederick, MD to Chicago, IL buses for today, Wednesday, October 28. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 7:35 PM Frederick, MD | 14h25 | 10:00 AM Chicago, IL | 0 transfersDirect | |
| Thursday, October 29 | |||||
![]() | 12:35 AM Frederick, MD | 19h30 | 8:05 PM Chicago, IL | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Buses from Frederick, MD to Chicago, IL with Greyhound and FlixBus. Overnight buses available on this route with Greyhound and FlixBus. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Chicago, IL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Chicago, IL trip today.
World-class art museum with masterpieces from Monet to Hopper and the famous Modern Wing.
Major natural history museum with Sue the T. rex, ancient cultures, and strong family appeal.
Hands-on science museum in a grand former fair building, popular for exhibits and a U-505 submarine.
Lively lakefront park with Cloud Gate, Crown Fountain, gardens, and major public art in central Chicago.
Famous shopping boulevard lined with architecture, hotels, riverfront views, and major city energy.
Scenic pedestrian-friendly riverwalk with boat docks, public art, bridges, and standout skyline perspectives.
Deep-dish pizza is Chicago’s iconic pie with a tall buttery crust, layers of cheese and toppings, and chunky tomato sauce baked on top.
The Chicago-style hot dog is an all-beef frank on a poppy seed bun with mustard, relish, onion, tomato, pickle, peppers, and celery salt.
Italian beef is thin-sliced roast beef piled onto a roll, often dipped in savory juices and topped with sweet peppers or spicy giardiniera.
Classic spot for juicy Italian beef sandwiches, especially dipped and topped with spicy giardiniera, with a casual local feel.
Legendary stand for Chicago-style hot dogs and char-grilled sausages, served fast in a no-frills local landmark.
World-famous fine dining destination offering a highly creative tasting menu and refined service in an elegant setting.
Moderate for a major US city: hotels can be pricey, but transit is affordable and dining ranges from cheap eats to upscale options.
Tip 18-20% at restaurants, $1-2 per drink at bars, 10-15% for taxis, and optional small change at cafes.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Chicago, IL.
Find answers to the most common questions about traveling from Frederick, MD to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

Most Frederick, MD to Chicago, IL buses use the Frederick, East Street (Transit Center) to Chicago, Greyhound Bus Station station pair, with some services arriving at Chicago, Union Station (Amtrak). Use this guide to compare Frederick, MD and Chicago, IL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Frederick, East Street (Transit Center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Frederick, East Street (Transit Center). ATMs are available at Frederick, East Street (Transit Center).
Ticket office support is available at Frederick, East Street (Transit Center).
Available at Frederick, East Street (Transit Center): Parking, Taxis, WC.
Accessibility facilities are available at Frederick, East Street (Transit Center): Wheelchair accessible entry and exit points.
Chicago, Greyhound Bus Station is 2 km from Chicago city centre. Public transport options include:
Chicago, Greyhound Bus Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Snack shop and vending machines available
Free Wi-Fi in waiting area. ATMs are located near entrance.
Ticket office support is available at Chicago, Greyhound Bus Station.
Available at Chicago, Greyhound Bus Station: Parking, Taxis, WC.
Accessibility facilities are available at Chicago, Greyhound Bus Station: Wheelchair accessible entrances and seating.
Chicago, Union Station (Amtrak) is 3 km from Chicago city centre. Public transport options include:
Chicago, Union Station (Amtrak) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Multiple dining options are available inside the station.
Free Wi-Fi is available in waiting areas. ATMs are aTMs are located near the main entrance.
Ticket office support is available at Chicago, Union Station (Amtrak).
Available at Chicago, Union Station (Amtrak): Parking, Taxis, WC.
Accessibility facilities are available at Chicago, Union Station (Amtrak): Station is accessible with elevators and ramps.
Check bus stations information for Frederick, MD and Chicago, IL, including where buses depart and arrive on this route.