The cheapest and fastest buses from Charleston, SC to Indianapolis, IN
Cheapest price
$170
Average price
$170
Fastest journey
1 d 4 h
Average duration
1 d 4 h
Buses per day
1
Distance
957 km
The best way to find a cheap bus ticket from Charleston, SC to Indianapolis, IN is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Charleston, SC to Indianapolis, IN will cost around $170 if you buy it on the day, but the cheapest tickets can be found for only $170.
Of the 1 buses that leave Charleston, SC for Indianapolis, IN on Sun, Dec 21, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Dec 21 the direct buses cover the 957 km distance in an average of 1 d 4 h but if you time it right, some buses will get you there in just 1 d 4 h .
On Sun, Dec 21 the slowest buses will take 1 d 4 h and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare bus and flight for Charleston, SC to Indianapolis, IN
Omio recommends booking the flight as it is the most popular option from Charleston, SC to Indianapolis, IN among Omio's users. If you are prioritising price take the bus with prices starting from €95. For those with little time consider booking a flight which can get you there in 3h 3m. The ticket price range depends on the travel mode: a bus costs an average of €95, and a flight costs an average of €71.
Distance: 594 miles (957 km)
Compare bus with
| Bus | Most popular Flight |
|---|---|
€139 Average price Cheapest | €245 Average price |
24h 42m Average total duration 24h 12m Onboard + 30m Additional time* | 6h 3m Average total duration Fastest 3h 3m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options |
Live departures
Charleston, SC to Indianapolis, IN bus times
The table below shows live departures for Charleston, SC to Indianapolis, IN buses for tomorrow, Sunday, December 21. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 7:15 PM Charleston, SC | 28h00 | 11:15 PM Indianapolis, IN | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Charleston, SC to Indianapolis, IN by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Dec 21
Dec 22
Dec 23
Dec 24
Dec 25
Dec 26
Dec 27
Journey information
Overview: Bus from Charleston, SC to Indianapolis, IN
Buses from Charleston, SC to Indianapolis, IN run on average 2 times per day, taking around 24h 12m. Cheap bus tickets for this journey start at $118 (€95) but you can travel from only $88 (€71) by flight.
The earliest bus runs at 00:15, the last at 23:55. The fastest bus covers the 594 miles (957 km) distance in 20h 50m.
Distance 594 miles (957 km) |
Average bus duration 24h 12m |
Cheapest ticket price $118 (€95) |
Buses per day 2 |
Fastest bus 20h 50m |
First bus 00:15 |
Last bus 23:55 |
FAQs: Bus from Charleston, SC to Indianapolis, IN
Find answers to the most common questions about traveling from Charleston, SC to Indianapolis, IN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Indianapolis, IN, this guide helps you travel smarter and with confidence.

- Indianapolis Motor Speedway, a historic racing circuit known for hosting the Indianapolis 500
- The Children's Museum of Indianapolis, the world's largest children's museum featuring interactive exhibits
- Indianapolis Zoo, a popular attraction with diverse animal exhibits and a botanical garden
- Indiana State Museum, showcasing the state's history, art, and science through various exhibits
- White River State Park, a sprawling urban park offering trails, gardens, and cultural attractions.
- Indianapolis Museum of Art at Newfields, a vast art museum with extensive collections and beautiful gardens
- Attend a race at the Indianapolis Motor Speedway, home of the iconic Indy 500
- Explore the interactive exhibits and educational programs at The Children's Museum of Indianapolis
- Visit the dolphin pavilion and animal habitats at the Indianapolis Zoo
- Enjoy a walk along the canal and cultural attractions at White River State Park.
To find the cheapest bus tickets for your trip from Charleston, SC to Indianapolis, IN, follow these tips:
Start your search now and compare ticket prices to find the best deal!
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Popular bus stations from Charleston, SC to Indianapolis, IN
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