Travel Information
Compare bus for Charleston, SC to Chicago, IL
Omio recommends booking the flight as it is the most popular option from Charleston, SC to Chicago, IL among Omio's users. If you are prioritising price take the bus with prices starting from €167. For those with little time consider booking a flight which can get you there in 3h 39m. The ticket price range depends on the travel mode: a bus costs an average of €167, and a flight costs an average of €358.
Distance: 756 miles (1217 km)
Compare bus with
| Bus | Most popular Flight |
|---|---|
€167 Average price Cheapest | €358 Average price |
24h 43m Average total duration 24h 13m Onboard + 30m Additional time* | 6h 39m Average total duration Fastest 3h 39m Onboard + 3h 0m Additional time* |
![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options |
Compare prices and tickets Charleston, SC to Chicago, IL by bus
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Charleston, SC to Chicago, IL
Buses from Charleston, SC to Chicago, IL run on average 2 times per day, taking around 24h 13m. Cheap bus tickets for this journey start at $206 (€167) if you book in advance.
The earliest bus runs at 10:00, the last at 22:00. The fastest bus covers the 756 miles (1217 km) distance in 41h 35m.
Distance 756 miles (1217 km) |
Average bus duration 24h 13m |
Cheapest ticket price $206 (€167) |
Buses per day 2 |
Fastest bus 41h 35m |
First bus 10:00 |
Last bus 22:00 |
Bus providers: Greyhound from Charleston, SC to Chicago, ILYou can travel by bus between Charleston, SC to Chicago, IL with Greyhound for as low as $206 (€167). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Charleston, SC to Chicago, IL
Find answers to the most common questions about traveling from Charleston, SC to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Millennium Park, a public park known for its modern art installations and the iconic Cloud Gate sculpture
- Art Institute of Chicago, a renowned museum housing an extensive collection of art from around the world
- Navy Pier, a popular entertainment destination featuring rides, restaurants, and lakefront views
- Willis Tower Skydeck, an observation deck offering panoramic views of the city from one of the tallest buildings in the Western Hemisphere
- Field Museum, a natural history museum with vast exhibits including the famous T. Rex skeleton, Sue.
- Museum of Science and Industry, an interactive museum featuring exhibits on science, technology, and industry
- Explore the vibrant neighborhoods of Chicago, such as Wicker Park and Lincoln Park, known for their unique shops and eateries
- Take a river cruise to see the city's iconic architecture from a different perspective
- Attend a live performance at the historic Chicago Theatre
- Enjoy a day at Lincoln Park Zoo, one of the oldest zoos in the U. S. Offering free admission.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
To find the cheapest bus tickets for your trip from Charleston, SC to Chicago, IL, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Charleston, SC to Chicago, IL
Most popular bus connections from Charleston, SC
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