Travel Information
Compare train, bus, and flight for Pisa to Lyon
Omio recommends booking the bus as it is the most popular option from Pisa to Lyon among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $94 For those with little time, consider booking a train, which has an average total journey time of 9h 18m. Average ticket prices depend on the travel mode: a bus costs an average of $94, while a train costs an average of $153.
Distance: 306 miles (493 km)
Compare bus with
Most popular Bus | Train | Driving |
|---|---|---|
$94 Average price Cheapest | $153 Average price | $289 Average price (fuel + tolls) |
11h 10m Average total duration 10h 40m Onboard + 30m Additional time* | 9h 18m Average total duration Fastest 8h 48m Onboard + 30m Additional time* | 7h 32m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Pisa to Lyon:
A train is $99 less than a bus for this route with tickets for a bus from Pisa to Lyon costing on average $120.
A train is $661 less than a flight for this route with tickets for a flight from Pisa to Lyon costing on average $682.
Other travel options to Lyon take longer:
Train takes on average 8h 37m.
Bus takes on average 11h 49m.
You'll arrive about 3h 52m sooner (3h 40m by flight vs 7h 32m by car). Tickets start at around $682 compared to roughly $289 in fuel and tolls — a bit more, but you get time back and avoid a long drive.
Driving makes more sense if you're travelling as a group, want flexibility on timing, or plan to stop en route.
Travel optionsfrom Pisa to Lyon
How to get from Pisa to Lyon by train, bus or flight.
Our recommendation
The best way to travel from Pisa to Lyon is by taking a bus because it’s the best combination of price and speed.
FlixBus · FlixBus6:10 PM14h35Pisa, Via delle Fiamme Gialle (Park Pietrasantina)8:45 AMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$941One-way1 transfer
Cheapest
FlixBus · FlixBus6:10 PM14h35Pisa, Via delle Fiamme Gialle (Park Pietrasantina)8:45 AMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$941One-way1 transfer
Fastest
LH7403+
LH10826:30 PM5h00Pisa International Airport11:30 PMLyon Saint Exupery Airport$3461One-way1 transfer
Other options
FlixBus · FlixBus6:25 AM11h45Pisa, Via delle Fiamme Gialle (Park Pietrasantina)6:10 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$1131One-way1 transfer
FlixBus · FlixBus1:50 PM14h05Pisa, Via delle Fiamme Gialle (Park Pietrasantina)3:55 AMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$1301One-way1 transfer
FlixBus · FlixBus5:10 PM13h20Pisa, Via delle Fiamme Gialle (Park Pietrasantina)6:30 AMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$1451One-way1 transfer
LH7401+
LH107810:45 AM7h25Pisa International Airport6:10 PMLyon Saint Exupery Airport$3461One-way1 transfer
LH7403+
LH10766:30 PM19h15Pisa International Airport1:45 PMLyon Saint Exupery Airport$3851One-way1 transfer
LH7401+
LH112 · LH225210:45 AM8h40Pisa International Airport7:25 PMLyon Saint Exupery Airport$4071One-way2 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Pisa to Lyon
Travel to Lyon easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Pisa to Lyon.

This is compared to other travel options from Pisa to Lyon:
A bus is $33 less than a train for this route with tickets for a train from Pisa to Lyon costing on average $153.
A bus is $562 less than a flight for this route with tickets for a flight from Pisa to Lyon costing on average $682.
Other travel options to Lyon take longer:
Train takes on average 9h 18m.
Bus takes on average 11h 49m.
- Around 9 flights per day.
- Around 4 buses per day.
- Around 1 trains per day.
However, we recommend checking specific travel dates for your route between Pisa and Lyon as scheduled services by train, bus, and flight can vary by season or day of the week.
- Trains mostly depart from Pisa Centrale and arrive in Lyon Part Dieu.
- Flights mostly depart from Pisa International Airport and arrive in Lyon Saint Exupery Airport.
- Buses mostly depart from Pisa, Via delle Fiamme Gialle (Park Pietrasantina) and arrive in Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland).
- Travel with FlixBus, BlaBlaCar, Consorzio Pisano Trasporti to go to Lyon by bus.
- Travel with Trenitalia, Intercity, Regionale to go to Lyon by train.
- 0 direct buses per day with BlaBlaCar.
Travelling from Pisa to Lyon: related information
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