Travel Information
Compare train, bus, and flight for Pisa to Lyon
Omio recommends booking the bus as it is the most popular option from Pisa to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $53. For those with little time consider booking a train which can get you there in 7h 51m. The ticket price range depends on the travel mode: a bus costs an average of $53, and a train costs an average of $130.
Distance: 306 miles (493 km)
Compare bus with
Most popular Bus | Train | Driving |
|---|---|---|
$88 Average price Cheapest | $130 Average price | $288 Average price (fuel + tolls) |
11h 26m Average total duration 10h 56m Onboard + 30m Additional time* | 8h 21m Average total duration Fastest 7h 51m Onboard + 30m Additional time* | 7h 32m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Pisa to Lyon:
A bus is $41 (€34) less than a train for this route with tickets for a train from Pisa to Lyon costing on average $130 (€106).
A bus is $418 (€343) less than a flight for this route with tickets for a flight from Pisa to Lyon costing on average $507 (€415).
Other travel options to Lyon take longer:
Bus takes on average 10h 56m.
Flight takes on average 15h 27m.
Travel optionsfrom Pisa to Lyon
How to get from Pisa to Lyon by train, bus or flight.
Our recommendation
The best way to travel from Pisa to Lyon is by taking a bus because it’s the best combination of price and speed.
FlixBus · FlixBus9:40 AM13h00Pisa, Via delle Fiamme Gialle (Park Pietrasantina)10:40 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$851One-way1 transfer
Cheapest
FlixBus · FlixBus9:40 AM13h00Pisa, Via delle Fiamme Gialle (Park Pietrasantina)10:40 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$851One-way1 transfer
Fastest
Regionale Veloce 4030+
FRECCIAROSSA 9514+
9928+
FRECCIAROSSA 1000 929611:30 AM9h02Pisa Centrale8:32 PMLyon Part Dieu$2531One-way3 transfers
Other options
Regionale 2294 · Regionale TTPER 33956+
FRECCIAROSSA 1000 92966:00 AM14h32Pisa Centrale8:32 PMLyon Part Dieu$1971One-way2 transfers
Regionale 19332 · Regionale TTPER 19238 · Regionale TTPER 33956+
FRECCIAROSSA 1000 92967:02 AM13h30Pisa Centrale8:32 PMLyon Part Dieu$1991One-way3 transfers
Regionale 19388 · Regionale Veloce 3261 · Regionale Veloce 3028+
FRECCIAROSSA 1000 92968:18 AM12h14Pisa Centrale8:32 PMLyon Part Dieu$2011One-way3 transfers
FlixBus · FlixBus5:10 PM13h20Pisa, Via delle Fiamme Gialle (Park Pietrasantina)6:30 AMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$911One-way1 transfer
FlixBus · FlixBus1:50 PM14h05Pisa, Via delle Fiamme Gialle (Park Pietrasantina)3:55 AMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$941One-way1 transfer
FlixBus · FlixBus6:25 AM11h45Pisa, Via delle Fiamme Gialle (Park Pietrasantina)6:10 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$1001One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Pisa to Lyon
Travel to Lyon easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Pisa to Lyon.

This is compared to other travel options from Pisa to Lyon:
A bus is $41 (€34) less than a train for this route with tickets for a train from Pisa to Lyon costing on average $130 (€106).
A bus is $418 (€343) less than a flight for this route with tickets for a flight from Pisa to Lyon costing on average $507 (€415).
Other travel options to Lyon take longer:
Bus takes on average 10h 56m.
Flight takes on average 15h 27m.
- Around 5 buses per day.
- Around 5 flights per day.
- Around 1 trains per day.
However, we recommend checking specific travel dates for your route between Pisa and Lyon as scheduled services by train, bus, and flight can vary by season or day of the week.
- Buses mostly depart from Pisa, Via delle Fiamme Gialle (Park Pietrasantina) and arrive in Lyon, Perrache Bus Station.
- Trains mostly depart from Pisa Centrale and arrive in Lyon Part Dieu.
- Flights mostly depart from Pisa International Airport and arrive in Lyon Saint Exupery Airport.
- Travel with Trenitalia, Regionale to go to Lyon by train.
- Travel with FlixBus, BlaBlaCar, Consorzio Pisano Trasporti to go to Lyon by bus.
- 0 direct buses per day with BlaBlaCar.
Travelling from Pisa to Lyon: related information
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