Travel optionsfrom Pisa to Lyon
How to get from Pisa to Lyon by train, bus or flight.
Our recommendation
The best way to travel from Pisa to Lyon is by taking a bus because it’s the best combination of price and speed.
FlixBus · FlixBus9:40 AM13h00Pisa, Via delle Fiamme Gialle (Park Pietrasantina)10:40 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$1051One-way1 transfer
Cheapest
FlixBus · FlixBus9:40 AM13h00Pisa, Via delle Fiamme Gialle (Park Pietrasantina)10:40 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$1051One-way1 transfer
Fastest
LH7401+
LH108 · LH225010:40 AM6h25Pisa International Airport5:05 PMLyon Saint Exupery Airport$7501One-way2 transfers
Other options
Regionale 18260+
9920+
FRECCIAROSSA 1000 9296+
Intercity 5806:29 AM14h03Pisa Centrale8:32 PMLyon Part Dieu$2321One-way3 transfers
Regionale 18260+
9924+
FRECCIAROSSA 1000 9296+
Intercity 5806:29 AM14h03Pisa Centrale8:32 PMLyon Part Dieu$2321One-way3 transfers
Regionale 18391+
9924+
FRECCIAROSSA 1000 9296+
Intercity 5805:53 AM14h39Pisa Centrale8:32 PMLyon Part Dieu$2321One-way3 transfers
FlixBus · FlixBus6:25 AM11h45Pisa, Via delle Fiamme Gialle (Park Pietrasantina)6:10 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$1061One-way1 transfer
FlixBus · FlixBus6:10 PM14h35Pisa, Via delle Fiamme Gialle (Park Pietrasantina)8:45 AMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$1121One-way1 transfer
FlixBus · FlixBus5:10 PM13h20Pisa, Via delle Fiamme Gialle (Park Pietrasantina)6:30 AMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$1271One-way1 transfer
LH7401+
LH107810:40 AM7h10Pisa International Airport5:50 PMLyon Saint Exupery Airport$4961One-way1 transfer
BA617 · BA3569:20 PM13h00Pisa International Airport10:20 AMLyon Saint Exupery Airport$5431One-way1 transfer
EN8871+
LH108 · LH225010:40 AM6h25Pisa International Airport5:05 PMLyon Saint Exupery Airport$8041One-way2 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Travel Information
Compare train, bus, and flight for Pisa to Lyon
Omio recommends booking the bus as it is the most popular option from Pisa to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $54. For those with little time consider booking a train which can get you there in 7h 51m. The ticket price range depends on the travel mode: a bus costs an average of $54, and a train costs an average of $130.
Distance: 306 miles (493 km)
Compare bus with
Most popular Bus | Train | Driving |
|---|---|---|
$89 Average price Cheapest | $130 Average price | $289 Average price (fuel + tolls) |
11h 26m Average total duration 10h 56m Onboard + 30m Additional time* | 8h 21m Average total duration Fastest 7h 51m Onboard + 30m Additional time* | 7h 32m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Pisa to Lyon:
A bus is $42 less than a train for this route with tickets for a train from Pisa to Lyon costing on average $130.
A bus is $421 less than a flight for this route with tickets for a flight from Pisa to Lyon costing on average $509.
Other travel options to Lyon take longer:
Bus takes on average 10h 56m.
Flight takes on average 15h 27m.
Compare prices and tickets Prices for trains, buses and flights
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Travel from Pisa to Lyon
Travel to Lyon easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Pisa to Lyon.

This is compared to other travel options from Pisa to Lyon:
A bus is $42 less than a train for this route with tickets for a train from Pisa to Lyon costing on average $130.
A bus is $421 less than a flight for this route with tickets for a flight from Pisa to Lyon costing on average $509.
Other travel options to Lyon take longer:
Bus takes on average 10h 56m.
Flight takes on average 15h 27m.
- Around 5 buses per day.
- Around 5 flights per day.
- Around 1 trains per day.
However, we recommend checking specific travel dates for your route between Pisa and Lyon as scheduled services by train, bus, and flight can vary by season or day of the week.
- Buses mostly depart from Pisa, Via delle Fiamme Gialle (Park Pietrasantina) and arrive in Lyon, Perrache Bus Station.
- Flights mostly depart from Pisa International Airport and arrive in Lyon Saint Exupery Airport.
- Trains mostly depart from Pisa Centrale and arrive in Lyon Part Dieu.
- Travel with FlixBus, BlaBlaCar, Consorzio Pisano Trasporti to go to Lyon by bus.
- Travel with Trenitalia, Regionale to go to Lyon by train.
- 0 direct buses per day with BlaBlaCar.
Travelling from Pisa to Lyon: related information
Here are some other resources that might have the information you need
