Travel Information
Compare train, bus, and flight for Frankfurt am Main to Lyon
Omio recommends booking the train as it is the most popular option from Frankfurt am Main to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $38. For those with little time consider booking a flight which can get you there in 1h 51m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.5kg. The ticket price range depends on the travel mode: a bus costs an average of $38, and a flight costs an average of $190.
Distance: 349 miles (563 km)
Compare train with
Most popular Train | Bus | Flight |
|---|---|---|
$180 Average price | $61 Average price Cheapest | $339 Average price |
6h 29m Average total duration 5h 59m Onboard + 30m Additional time* | 10h 40m Average total duration 10h 10m Onboard + 30m Additional time* | 4h 51m Average total duration Fastest 1h 51m Onboard + 3h 0m Additional time* |
0.2 - 0.5kg CO2 emissions Lowest | 0.6 - 1.4kg CO2 emissions | 1.7 - 3.4kg CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Frankfurt am Main to Lyon
How to get from Frankfurt am Main to Lyon by train, bus or flight.
Our recommendation
The best way to travel from Frankfurt am Main to Lyon is by taking a bus because it’s the best combination of price and speed.
515106:30 PM10h40Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof)5:10 AMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$411One-way0 transfers
Cheapest
515106:30 PM10h40Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof)5:10 AMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$411One-way0 transfers
Fastest
EN89108:35 AM1h20Frankfurt am Main Airport9:55 AMLyon Saint Exupery Airport$8291One-way0 transfers
Other options
9590+
1217711:01 AM6h58Frankfurt (Main) Hbf5:59 PMLyon Part Dieu$2431One-way1 transfer
DB S3+
ICE 593 · ICE 103+
962829:28 AM8h16Frankfurt South station5:44 PMLyon Part Dieu$2541One-way5 transfers
RE5+
ICE 277+
96282+
98798:28 AM9h16Frankfurt South station5:44 PMLyon Part Dieu$2541One-way4 transfers
FlixBus8:15 AM12h35Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof)8:50 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$671One-way0 transfers
FlixBus · FlixBus11:20 AM11h55Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof)11:15 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$601One-way1 transfer
FlixBus10:45 PM11h45Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof)10:30 AMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$671One-way0 transfers
DE4293+
98442:30 PM7h30Frankfurt am Main Airport10:00 PMLyon Part Dieu$4681One-way1 transfer
DE4293+
5240 · 53382:30 PM7h00Frankfurt am Main Airport9:30 PMLyon Part Dieu$4981One-way2 transfers
DE4265+
125268:55 AM5h05Frankfurt am Main Airport2:00 PMLyon Part Dieu$6581One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Travel from Frankfurt am Main to Lyon
Travel to Lyon easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Frankfurt am Main to Lyon.

This is compared to other travel options from Frankfurt am Main to Lyon:
A bus is $41 (€33) less than a train for this route with tickets for a train from Frankfurt am Main to Lyon costing on average $79 (€63).
A bus is $152 (€121) less than a flight for this route with tickets for a flight from Frankfurt am Main to Lyon costing on average $190 (€151).
Other travel options to Lyon take longer:
Train takes on average 5h 56m.
Bus takes on average 9h 35m.
- Around 12 buses per day.
- Around 11 flights per day.
- Around 4 trains per day.
However, we recommend checking specific travel dates for your route between Frankfurt am Main and Lyon as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Frankfurt am Main Airport and arrive in Lyon Saint Exupery Airport.
- Trains mostly depart from Frankfurt (Main) Hbf and arrive in Lyon Part Dieu.
- Buses mostly depart from Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) and arrive in Lyon, Perrache Bus Station.
- Travel with FlixBus, BlaBlaCar Bus, Infobus, Sindbad, BlaBlaCar to go to Lyon by bus.
- Travel with Lufthansa, Air Dolomiti, KLM Cityhopper, KLM, Lufthansa Cityline, Eurowings, Brussels Airlines to go to Lyon by flight.
- Travel with TGV, TGV INOUI, Deutsche Bahn to go to Lyon by train.
- 5 direct buses per day with FlixBus, BlaBlaCar Bus, Infobus, Sindbad, BlaBlaCar.
- 4 direct flights per day with Lufthansa, Air Dolomiti.
- 1 direct trains per day with TGV INOUI, Deutsche Bahn.
Travelling from Frankfurt am Main to Lyon: related information
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