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Traveling to Lyon from London is simple and fast, with plenty of options at your disposal. If you need to be in Lyon as quickly as possible, flights can get you there in 1 hour 40 minutes, but when you factor in airport transfers at both ends, the train journey of 5 hours is competitive. Buses are slower, but may well be a cost effective alternative.
Buses to Lyon from the British capital are operated by National Express, Flixbus and Ouibus. There are plenty of possible departure times, ranging from 9:30 a.m. to 10:30 p.m. There is only one direct bus every day, which is operated by Ouibus and takes 15 hours 30 minutes to get to Lyon. However, check the schedules, as Flixbus also offer a faster service, with a change in Paris.
There are two indirect Eurostar services per day to Lyon from London St Pancras, both departing in the morning at 7:00 a.m. and 8:00 a.m. respectively. Both also take around 5 hours to reach Lyon, with a change in either Lille or Paris along the way. If you change in Paris, be aware that you'll need to transfer from Gare du Nord to Gare de Lyon, which takes about 30 minutes.
British Airways and Easyjet provide direct daily flights from London Gatwick and Heathrow to Lyon. The number of flights per day varies, from 2 to 6 (with more in midweek), although there will always be a direct service on your day of travel. The total flight time is 1 hour 40 minutes, and there is always an early morning departure.