Travel optionsfrom Pisa to Madrid
How to get from Pisa to Madrid by train, bus or flight.
Our recommendation
The best way to travel from Pisa to Madrid is by taking a flight because it’s the best combination of price and speed.
FR 9494Cheapest
FlixBus · FlixBusFastest
FR 9494Other options
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus · FlixBus · FlixBus
ETRUSCHI LINE 4131 · Regionale 20495+
IB656
Intercity 505+
Regionale 20485+
IB656
ETRUSCHI LINE 4016+
Intercity 583+
Regionale 20483+
IB656Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Travel from Pisa to Madrid
Travel to Madrid easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Pisa to Madrid.

There are 3 options to travel between Pisa and Madrid including taking a train, bus or flight.
The cheapest way to go to Madrid from Pisa is by taking a flight, which costs on average $35 (€32).
This is compared to other ways of getting from Pisa to Madrid:
A flight is $44 (€40) less than a bus with an average ticket price of $80 (€72) from Pisa to Madrid.
A flight is $309 (€279) less than a train with an average ticket price of $345 (€311) from Pisa to Madrid.
The fastest way to get to Madrid from Pisa is by flight with an average travel time of 2 h 20 min.
Other travel options to Madrid take longer:
Bus takes 25 h 50 min on average.
Taking a train requires on average 28 h 36 min of travel time.
The distance from Pisa to Madrid is approximately 755 miles (1218 km).
The average frequency per day from Pisa to Madrid is:
- 1 bus a day.
- 1 train a day.
However, we recommend checking specific travel dates for your route from Pisa to Madrid as scheduled services by train, bus or flight can vary by season or day of the week.
These are the most popular departure and arrival points when traveling from Pisa to Madrid:
- Most travelers catch their flight from Pisa International Airport and arrive in Madrid Barajas Airport.
Omio works with many trusted partners that can help you travel the best way from Pisa to Madrid:
- You can travel between Pisa and Madrid by bus with FlixBus or Lirosi Linee. You can find cheap tickets on Omio for $80 (€72) with FlixBus from Pisa to Madrid.
- You can take a flight from Pisa to Madrid with Ryanair or Vueling Airlines. Cheap tickets can be found for $35 (€32) with Ryanair from Pisa to Madrid.
- You can travel by train between Pisa and Madrid with Regionale, and you can find Regionale Pisa to Madrid tickets for $345 (€311) on Omio.
Yes, there are direct services available from Pisa to Madrid with the following travel companies:
- Direct services by bus with.
- Direct flight with Ryanair.
- Take a direct train with.
Direct services tend to save you time and add more convenience in getting you to Madrid as you won't need to transfer at another stop in between, so it's worth paying attention to before booking your tickets between Pisa and Madrid.
Travelling from Pisa to Madrid: related information
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