Travel Information
Compare train, bus, and flight for Pisa to Madrid
Omio recommends booking the flight as it is the most popular option from Pisa to Madrid among Omio's users. If you are prioritising price, take the bus, with an average ticket price of CHF144 For those with little time, consider booking a flight, which has an average total journey time of 6h 54m. If you are seeking to minimise your carbon footprint, the bus is your best option, with estimated CO2 emissions of 1.2 - 3.0kg. Average ticket prices depend on the travel mode: a bus costs an average of CHF144, while a flight costs an average of CHF377.
Distance: 757 miles (1219 km)
Compare flight with
Most popular Flight | Bus |
|---|---|
CHF377 Average price | CHF144 Average price Cheapest |
6h 54m Average total duration Fastest 4h 54m Onboard + 2h 0m Additional time* | 29h 59m Average total duration 29h 29m Onboard + 30m Additional time* |
3.7 - 7.3kg CO2 emissions | 1.2 - 3.0kg CO2 emissions Lowest |
![]() Most popular airline | ![]() Most popular bus company |
Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Pisa to Madrid:
A bus is CHF233 less than a flight for this route with tickets for a flight from Pisa to Madrid costing on average CHF377.
Other travel options to Madrid take longer:
Bus takes on average 29h 59m.
Travel optionsfrom Pisa to Madrid
How to get from Pisa to Madrid by train, bus or flight.
Our recommendation
The best way to travel from Pisa to Madrid is by taking a bus because it’s the best combination of price and speed.
FlixBus · FlixBus · FlixBus10:00 PM36h30Pisa, Via delle Fiamme Gialle (Park Pietrasantina)10:30 AMMadrid, Estación Sur de AutobusesCHF1361One-way2 transfers
Cheapest
FlixBus · FlixBus · FlixBus10:00 PM36h30Pisa, Via delle Fiamme Gialle (Park Pietrasantina)10:30 AMMadrid, Estación Sur de AutobusesCHF1361One-way2 transfers
Fastest
BA613+
BA70654:55 PM5h40Pisa International Airport10:35 PMMadrid Barajas AirportCHF8251One-way1 transfer
Other options
FlixBus · FlixBus6:25 AM28h05Pisa, Via delle Fiamme Gialle (Park Pietrasantina)10:30 AMMadrid, Estación Sur de AutobusesCHF1371One-way1 transfer
FlixBus · FlixBus · FlixBus6:25 AM32h30Pisa, Via delle Fiamme Gialle (Park Pietrasantina)2:55 PMMadrid, Terminal de autobuses T4 (Aeropuerto de Madrid)CHF1481One-way2 transfers
FlixBus · FlixBus · FlixBus11:30 PM40h05Pisa (Pisamover via San Giusto/Aurelia)3:35 PMMadrid, Estación Sur de AutobusesCHF1561One-way2 transfers
Regionale Veloce 4129 · Regionale 20459+
W460137:40 AM12h10Pisa Centrale7:50 PMMadrid Barajas AirportCHF1851One-way2 transfers
Regionale Veloce 4125 · Regionale 20443+
W460135:40 AM14h10Pisa Centrale7:50 PMMadrid Barajas AirportCHF1851One-way2 transfers
InterCityNotte 799+
Regionale 20395+
W460132:56 AM16h54Pisa Centrale7:50 PMMadrid Barajas AirportCHF1941One-way2 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Pisa to Madrid
Travel to Madrid easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Pisa to Madrid.

This is compared to other travel options from Pisa to Madrid:
A bus is CHF233 less than a flight for this route with tickets for a flight from Pisa to Madrid costing on average CHF377.
Other travel options to Madrid take longer:
Bus takes on average 29h 59m.
- Around 15 flights per day.
- Around 5 buses per day.
However, we recommend checking specific travel dates for your route between Pisa and Madrid as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Pisa International Airport and arrive in Madrid Barajas Airport.
- Buses mostly depart from Pisa, Via delle Fiamme Gialle (Park Pietrasantina) and arrive in Madrid, Estación Sur de Autobuses.
- Travel with FlixBus to go to Madrid by bus.
- Travel with Malta Air, Ryanair, KLM, Lufthansa, Vueling, Lufthansa Cityline, Air Europa, Swiss, BA Cityflyer, Brussels Airlines, Air France, Lufthansa City Airlines, Norwegian Air Shuttle, Air Baltic, Helvetic Airways, ITA, British Airways, Edelweiss Air, Iberia to go to Madrid by flight.
- 1 direct flights per day with Malta Air, Ryanair.
Travelling from Pisa to Madrid: related information
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