Travel Information between Prague and Brussels
| 445 miles (717 km) | |
| Train, bus or flight | |
| $44 - $65 | |
| Bus • $44 (€40) • 12 h | |
| Flight • $45 (€41) • 1 h 30 min | |
| FlixBus, Ryanair or Deutsche Bahn |
Travel 445 miles (717 km) by train, bus or flight from Prague to Brussels. The most popular travel companies which serve this route are FlixBus, Ryanair or Deutsche Bahn among others. Travelers can even take a direct bus, flight or train from Prague to Brussels.
Travel optionsfrom Prague to Brussels
How to get from Prague to Brussels by train, bus or flight.
Our recommendation
The best way to travel from Prague to Brussels is by taking a flight because it’s the best combination of price and speed.
QS1002Cheapest
(Prague -> London)Fastest
QS1002Other options
EC 458 · Bus 10458 · IC 2508 · ICE 699
EX 358 · RE 3568 · ICE 624 · ICE 814
EX 352 · ICE 20 · ICE 18
FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
QS1000
FR 69
U27928+
9388Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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How to get from Prague to Brussels
The Best Way According to our Users
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FAQs: Travel from Prague to Brussels
Travel to Brussels easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Prague to Brussels.

You can get between Prague and Brussels 3 different ways: train, bus or flight.
The cheapest way to travel from Prague to Brussels is a bus with an average price of $44 (€40).
This is compared to other travel options from Prague to Brussels:
Taking a bus costs $1 (€1) less than taking a flight, which costs on average $45 (€41) for the same trip.
A bus is $21 (€19) less than a train for this trip with tickets for a train from Prague to Brussels costing on average $65 (€59).
The quickest way to travel from Prague to Brussels is by flight, which takes on average 1 h 30 min compared to other travel options that take longer:
Bus takes 12 h on average.
Train takes 11 h on average.
The distance is approximately 445 miles (717 km) from Prague to Brussels.
The average frequency per day from Prague to Brussels is:
- Around 37 buses per day.
- Around 33 flights per day.
- 5 trains a day.
However, we recommend checking specific travel dates for your trip between Prague and Brussels as scheduled services by train, bus or flight can vary by season or day of the week.
These are the most popular departure and arrival points when traveling from Prague to Brussels:
- Most travelers take a bus from Prague, Central Train Station to Brussels, Brussels South (Gare du Midi).
- Most travelers who buy a plane ticket from Prague to Brussels depart from Prague Vaclav Havel Airport to Brussels Airport.
Omio works with many trusted partners that can help you travel the best way from Prague to Brussels:
- You can travel to Brussels from Prague by bus with FlixBus or BlaBlaCar Bus. You can find cheap tickets on Omio for $45 (€41) with FlixBus from Prague to Brussels.
- You can travel to Brussels from Prague by flight with Ryanair, Brussels Airlines, KLM, KLM Cityhopper, LOT Polish Airlines, CityJet, SAS, LAER, SWISS, Lufthansa Cityline (2) or Air Dolomiti. You can find cheap tickets on Omio for $45 (€41) with Ryanair from Prague to Brussels.
- You can go to Brussels from Prague by train with Deutsche Bahn or European Sleeper. You'll see cheap train tickets for $65 (€59) with European Sleeper from Prague to Brussels on Omio.
Yes, there are direct routes from Prague to Brussels with the following travel companies:
- You can find 4 direct buses per day to take to Brussels with FlixBus.
- You'll find 2 direct flights a day to Brussels with Brussels Airlines.
- You can find 1 direct train per day to take to Brussels with European Sleeper.
Direct services to Brussels tend to save you time and add more convenience as you won't need to transfer at another stop in between, so it's worth paying attention to before booking tickets for your journey.
Travelling from Prague to Brussels: related information
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