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How to travel from Prague to Brussels

Mon, Jan 19
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Travel by train, bus, flight with
FlixBus
Ryanair
Deutsche Bahn
Brussels Airlines
European Sleeper
1,000+ more
FlixBus
Ryanair
Deutsche Bahn
Brussels Airlines
European Sleeper
1,000+ more
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Travel options
from Prague to Brussels

How to get from Prague to Brussels by train, bus or flight.

Our recommendation

flight

The best way to travel from Prague to Brussels is by taking a flight because it’s the best combination of price and speed.

BuzzFR 69
05:30PM1h30
Prague Vaclav Havel Airport
07:00PMBrussels South Charleroi Airport
$601One-way
0 transfers

Cheapest

České dráhyEC 335 · NJ 468
02:21PM19h34
Prague hlavní nádraží
09:55AMBrussels-Midi
$261One-way
1 transfer

Fastest

BuzzFR 69
05:30PM1h30
Prague Vaclav Havel Airport
07:00PMBrussels South Charleroi Airport
$601One-way
0 transfers

Other options

European Sleeper452
06:00PM16h27
Prague hlavní nádraží
10:27AMBrussels-Midi
$1141One-way
0 transfers
České dráhyrj 178 · ICE 558 · ICE 12
08:31AM11h04
Prague hlavní nádraží
07:35PMBrussels-Midi
$1331One-way
2 transfers
České dráhyrj 382 · ICE 556 · ICE 10
10:31AM11h04
Prague hlavní nádraží
09:35PMBrussels-Midi
$1331One-way
2 transfers
Regiojet(Prague -> London)
06:00PM12h00
Praha, ÚAN Florenc
06:00AMBrussels, Brussels South (Gare du Midi)
$701One-way
0 transfers
FlixBusFlixBus
04:15PM15h05
Praha, ÚAN Florenc
07:20AMBrussels, Brussels South (Gare du Midi)
$691One-way
0 transfers
FlixBusFlixBus · FlixBus
06:00PM18h25
Praha, ÚAN Florenc
12:25PMBrussels, Avenue des Magnolias (King Baudouin)
$801One-way
1 transfer
Brussels AirlinesSN2812
06:45PM1h30
Prague Vaclav Havel Airport
08:15PMBrussels Airport
$2601One-way
0 transfers
Brussels AirlinesSN2810
11:40AM1h30
Prague Vaclav Havel Airport
01:10PMBrussels Airport
$3121One-way
0 transfers
Brussels AirlinesSN2816
06:50AM1h35
Prague Vaclav Havel Airport
08:25AMBrussels Airport
$3121One-way
0 transfers

Find all the dates and times for this journey by train, bus, flight, and ferry .

Compare prices and tickets Prices for trains, buses and flights

Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

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How to get from Prague to Brussels

The Best Way According to our Users

When it comes to choosing a method of transportation from Prague to Brussels, 70,86% of our customers do not hesitate to choose the flight as their preferred way to travel. Nowadays, passengers who want to fly around Europe have more options than ever before. With dozens of budget airlines covering several routes which connect to virtually all European countries, taking a flight to reach your desired destination is easy and inexpensive. The low fares and the short flight time are, among others, some of the reasons why our users choose the airplane as the best way to get from Prague to Brussels, even if they have to face baggage limitations and long lines at check-in and security control. You can book your flights with Omio to make sure you are always taking the fastest route or getting the best deal. You can also add extra luggage and book securely with several methods of payment such as Apple Pay, PayPal and more.

Search on Omio to find cheap tickets from Prague to Brussels. It’s easy to find the most attractive prices and choose your preferred route for your journey. Book on web or app, and travel with your mobile ticket —without the stress of printing your ticket.

More than 1,000 travel companies trust us to sell their tickets all in one place.

Trenitalia
Easyjet
Deutsche Bahn
SNCF

FAQs: Travel from Prague to Brussels

Travel to Brussels easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Prague to Brussels.

FAQs

You can get between Prague and Brussels 3 different ways: train, bus or flight.

The cheapest way to travel from Prague to Brussels is a bus with an average price of $44 (€40).

This is compared to other travel options from Prague to Brussels:

Taking a bus costs $1 (€1) less than taking a flight, which costs on average $45 (€41) for the same trip.

A bus is $21 (€19) less than a train for this trip with tickets for a train from Prague to Brussels costing on average $65 (€59).

The quickest way to travel from Prague to Brussels is by flight, which takes on average 1 h 30 min   compared to other travel options that take longer:

Bus takes 12 h on average.

Train takes 11 h on average.

The distance is approximately 445 miles (717 km) from Prague to Brussels.

The average frequency per day from Prague to Brussels is:

  • Around 37 buses per day.
  • Around 33 flights per day.
  • 5 trains a day.

However, we recommend checking specific travel dates for your trip between Prague and Brussels as scheduled services by train, bus or flight can vary by season or day of the week.

These are the most popular departure and arrival points when traveling from Prague to Brussels:

  • Most travelers take a bus from Prague, Central Train Station to Brussels, Brussels South (Gare du Midi).
  • Most travelers who buy a plane ticket from Prague to Brussels depart from Prague Vaclav Havel Airport to Brussels Airport.

Omio works with many trusted partners that can help you travel the best way from Prague to Brussels:

  • You can travel to Brussels from Prague by bus with FlixBus or BlaBlaCar Bus. You can find cheap tickets on Omio for $45 (€41) with FlixBus from Prague to Brussels.
  • You can travel to Brussels from Prague by flight with Ryanair, Brussels Airlines, KLM, KLM Cityhopper, LOT Polish Airlines, CityJet, SAS, LAER, SWISS, Lufthansa Cityline (2) or Air Dolomiti. You can find cheap tickets on Omio for $45 (€41) with Ryanair from Prague to Brussels.
  • You can go to Brussels from Prague by train with Deutsche Bahn or European Sleeper. You'll see cheap train tickets for $65 (€59) with European Sleeper from Prague to Brussels on Omio.

Yes, there are direct routes from Prague to Brussels with the following travel companies:

  • You can find 4 direct buses per day to take to Brussels with FlixBus.
  • You'll find 2 direct flights a day to Brussels with Brussels Airlines.
  • You can find 1 direct train per day to take to Brussels with European Sleeper.

Direct services to Brussels tend to save you time and add more convenience as you won't need to transfer at another stop in between, so it's worth paying attention to before booking tickets for your journey.

Looking to extend your trip from Prague to Brussels? Many Omio customers who go from Prague to Brussels usually extend their vacation to explore other popular destinations like Paris, Amsterdam, Bruges, London or Berlin. If you're looking to explore Paris, Amsterdam, Bruges, London or Berlin from Brussels, let Omio find you the best connections available at an affordable price.
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