Travel Information
Compare bus, train, and flight for Prague to Brussels
Omio recommends booking the flight as it is the most popular option from Prague to Brussels among Omio's users. If you are prioritising price take the bus with prices starting from $50. For those with little time consider booking a flight which can get you there in 3h 21m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.6kg. The ticket price range depends on the travel mode: a bus costs an average of $50, and a flight costs an average of $27.
Distance: 445 miles (717 km)
Compare flight with
Most popular Flight | Train | Bus |
|---|---|---|
$135 Average price | $123 Average price | $84 Average price Cheapest |
6h 21m Average total duration Fastest 3h 21m Onboard + 3h 0m Additional time* | 12h 17m Average total duration 11h 47m Onboard + 30m Additional time* | 15h 10m Average total duration 14h 40m Onboard + 30m Additional time* |
2.2 - 4.3kg CO2 emissions | 0.2 - 0.6kg CO2 emissions Lowest | 0.7 - 1.8kg CO2 emissions |
![]() Most popular airline | ![]() Most popular train company | ![]() Most popular bus company |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Prague to Brussels
How to get from Prague to Brussels by train, bus or flight.
Our recommendation
The best way to travel from Prague to Brussels is by taking a flight because it’s the best combination of price and speed.
FR 21229:00 AM1h30Prague Vaclav Havel Airport10:30 AMBrussels South Charleroi Airport$771One-way0 transfers
Cheapest
FlixBus11:05 PM14h50Praha, ÚAN Florenc1:55 PMBrussels, Brussels South (Gare du Midi)$751One-way0 transfers
Fastest
FR 21229:00 AM1h30Prague Vaclav Havel Airport10:30 AMBrussels South Charleroi Airport$771One-way0 transfers
Other options
rj 382 · IC 2442 · ICE 691 · ICE 1010:31 AM11h04Prague hlavní nádraží9:35 PMBrussels-Midi$1201One-way3 transfers
rj 178 · ICE 548 · ICE 128:31 AM11h04Prague hlavní nádraží7:35 PMBrussels-Midi$1201One-way2 transfers
rj 382 · ICE 1556 · ICE 31810:31 AM13h04Prague hlavní nádraží11:35 PMBrussels-Midi$1201One-way2 transfers
FlixBus4:15 PM15h05Praha, ÚAN Florenc7:20 AMBrussels, Brussels South (Gare du Midi)$751One-way0 transfers
FlixBus · FlixBus6:00 PM18h25Praha, ÚAN Florenc12:25 PMBrussels, Avenue des Magnolias (King Baudouin)$851One-way1 transfer
FlixBus · FlixBus4:15 PM17h45Praha, ÚAN Florenc10:00 AMBrussels, Gare Du Midi$851One-way1 transfer
FR 699:25 PM1h30Prague Vaclav Havel Airport10:55 PMBrussels South Charleroi Airport$1331One-way0 transfers
SN28126:45 PM1h30Prague Vaclav Havel Airport8:15 PMBrussels Airport$3251One-way0 transfers
LO530 · LO2377:10 AM5h20Prague Vaclav Havel Airport12:30 PMBrussels Airport$3271One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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How to get from Prague to Brussels
The Best Way According to our Users
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FAQs: Travel from Prague to Brussels
Travel to Brussels easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Prague to Brussels.

This is compared to other travel options from Prague to Brussels:
A train is $10 (€8) less than a flight for this route with tickets for a flight from Prague to Brussels costing on average $27 (€21).
A train is $33 (€27) less than a bus for this route with tickets for a bus from Prague to Brussels costing on average $50 (€40).
Other travel options to Brussels take longer:
Train takes on average 10h 55m.
Bus takes on average 12h 0m.
- Around 38 flights per day.
- Around 18 buses per day.
- Around 7 trains per day.
However, we recommend checking specific travel dates for your route between Prague and Brussels as scheduled services by bus, train, and flight can vary by season or day of the week.
- Flights mostly depart from Prague Vaclav Havel Airport and arrive in Brussels Airport.
- Buses mostly depart from Praha, ÚAN Florenc and arrive in Brussels, Brussels South (Gare du Midi).
- Trains mostly depart from Prague hlavní nádraží and arrive in Brussels-Midi.
- Travel with Ryanair, Brussels Airlines, Smartwings, Buzz, KLM, KLM Cityhopper, Lot Polish Airlines, Lufthansa, Cityjet, Sas Airways, Helvetic Airways, Swiss, Air Baltic, Lufthansa Cityline, TAP Portugal to go to Brussels by flight.
- Travel with FlixBus, BlaBlaCar Bus to go to Brussels by bus.
- Travel with Deutsche Bahn, České dráhy, Alibus, European Sleeper to go to Brussels by train.
- 4 direct flights per day with Ryanair, Brussels Airlines, Buzz.
- 2 direct buses per day with FlixBus.
- 0 direct trains per day with European Sleeper.
Travelling from Prague to Brussels: related information
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