Taking the bus is the cheapest way to travel from Paris to Brussels. Buses traveling from Paris to Brussels depart from either Paris' Porte Maillot, Gare Routière Galliéni, or Gare Routière Bercy bus station and take at least 3:40 h to arrive at either Brussels' Gare du Midi, Gare du Nord, or Rue de France. Approximately 40 buses travel from Paris to Brussels every day with the first bus departing Paris at 7:30 a.m. Bus companies that travel from Paris to Brussels include Ouibus, Flixbus, and Eurolines.

Taking a train is the fastest way to travel from Paris to Brussels. Traveling from Paris to Brussels by high-speed Thalys train is approximately 2:20 h faster than taking the bus. Trains traveling from Paris to Brussels depart from Paris Gare du Nord and take 1:22 h to arrive at Brussels-Midi train station. Over 20 trains travel from Paris to Brussels every day with the first train departing Paris at 6:00 a.m. All trains traveling from Paris to Brussels are run by Thalys.

Taking the bus is the most popular way to travel from Paris to Brussels. While buses traveling from Paris to Brussels take approximately 2:20 h longer than traveling by train, buses are also €33 cheaper on average. Brussels Airlines also offers one direct flight from Paris to Brussels per day; however, taking a flight is even more expensive than traveling by train and takes longer when traveling to and from Paris and Brussels' airports is taken into consideration.