- Must visit
Musée des Confluences
A major science and anthropology museum in a striking contemporary building at the confluence of the Rhône and Saône. One of Lyon’s signature cultural sites with strong temporary exhibitions.
Cheapest price
$158
Average price
$180
Fastest journey
6 h 19 m
Average duration
6 h 33 m
Trains per day
12
Distance
498 km
The best way to find a cheap train ticket from Mannheim to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Mannheim to Lyon will cost around $180 if you buy it on the day, but the cheapest tickets can be found for only $158.
It's difficult to get from Mannheim to Lyon without transferring at least once.
ICE 277+
12177+
87424
ICE 277+
5537+
87424
ICE 9590+
12177
ICE 9590+
5537
ICE 103+
5537+
TGV 9574
ICE 9590+
12177
ICE 9590+
5537
ICE 9590+
12177+
96221+
9222
ICE 103+
9879+
TGV 9574
ICE 103+
5537+
TGV 9574Omio recommends booking the train as it is the most popular option from Mannheim to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $33. For those with little time consider booking a train which can get you there in 5h 19m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.4kg. The ticket price range depends on the travel mode: a bus costs an average of $33, and a flight costs an average of $137.
Distance: 309 miles (498 km)
Most popular Train | Bus | Flight | Driving |
|---|---|---|---|
$156 Average price | $51 Average price Cheapest | $308 Average price | $165 Average price (fuel + tolls) |
5h 49m Average total duration Fastest 5h 19m Onboard + 30m Additional time* | 9h 42m Average total duration 9h 12m Onboard + 30m Additional time* | 13h 19m Average total duration 10h 19m Onboard + 3h 0m Additional time* | 6h 33m Average total duration (door-to-door) |
0.1 - 0.4kg CO2 emissions Lowest | 0.5 - 1.2kg CO2 emissions | 1.5 - 3.0kg CO2 emissions | - CO2 emissions |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Mannheim to Lyon:
A bus is $105 (€85) less than a train for this route with tickets for a train from Mannheim to Lyon costing on average $156 (€126).
A bus is $256 (€208) less than a flight for this route with tickets for a flight from Mannheim to Lyon costing on average $308 (€249).
Other travel options to Lyon take longer:
Bus takes on average 9h 12m.
Flight takes on average 10h 19m.
The journey is about 1h 14m faster (5h 19m by train vs 6h 33m by car) and roughly $9 (€8) cheaper once you factor in fuel and tolls ($156 (€126) vs $165 (€134)). You'll also arrive in the city centre rather than hunting for parking, and you can work, read, or watch the landscape go by instead of concentrating on the road.
Direct services run with TGV, SNCF | TGV INOUI.
Driving is still worth considering if you want to stop along the way or need a car once you arrive.
The table below shows live departures for Mannheim to Lyon trains for tomorrow, Thursday, June 4. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
ECE 151+ TGV 9576+ 9879 | 8:46 AM Mannheim Hbf | 8h17 | 5:03 PM Lyon Part Dieu | 2 transfers | |
ECE 151+ TGV 9576+ 5537 | 8:46 AM Mannheim Hbf | 9h13 | 5:59 PM Lyon Part Dieu | 2 transfers | |
ECE 151+ TGV 9576+ 12177 | 8:46 AM Mannheim Hbf | 9h13 | 5:59 PM Lyon Part Dieu | 2 transfers | |
ICE 277+ 5537+ 87424 | 9:37 AM Mannheim Hbf | 8h22 | 5:59 PM Lyon Part Dieu | 2 transfers | |
ICE 277+ 9879+ 87424 | 9:37 AM Mannheim Hbf | 7h26 | 5:03 PM Lyon Part Dieu | 2 transfers | |
ICE 277+ 12177+ 87424 | 9:37 AM Mannheim Hbf | 8h22 | 5:59 PM Lyon Part Dieu | 2 transfers | |
ICE 103+ TGV 9574+ 5537 | 10:37 AM Mannheim Hbf | 7h22 | 5:59 PM Lyon Part Dieu | 2 transfers | |
ICE 103+ TGV 9574+ 12177 | 10:37 AM Mannheim Hbf | 7h22 | 5:59 PM Lyon Part Dieu | 2 transfers | |
ICE 103+ TGV 9574+ 9879 | 10:37 AM Mannheim Hbf | 6h26 | 5:03 PM Lyon Part Dieu | 2 transfers | |
ICE 9590+ 12177 | 11:40 AM Mannheim Hbf | 6h19 | 5:59 PM Lyon Part Dieu | 1 transfer | |
ICE 9590+ 5537 | 11:40 AM Mannheim Hbf | 6h19 | 5:59 PM Lyon Part Dieu | 1 transfer | |
ICE 9590+ 96221+ 12177+ 9222 | 11:40 AM Mannheim Hbf | 6h19 | 5:59 PM Lyon Part Dieu | 3 transfers | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Mannheim to Lyon run on average 3 times per day, taking around 5h 19m. Cheap train tickets for this journey start at $73 (€59) but you can travel from only $33 (€27) by bus.
There are 1 trains per day. The earliest train runs at 03:15, the last at 23:00. The fastest train covers the 309 miles (498 km) distance in 5h 16m.
Distance 309 miles (498 km) |
Average train duration 5h 19m |
Cheapest ticket price $73 (€59) |
Trains per day 3 |
Direct trains 1 |
Fastest train 5h 16m |
First train 3:15 AM |
Last train 11:00 PM |
Cheapest Month Sep |
Cheapest Day Wed |
High Season Apr - Jun |
Low Season Oct - Dec |
Busiest Day Wed |
Least Busy Day Mon |
Best time to book 5 days |
Discover the best of Lyon — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Lyon trip today.
A major science and anthropology museum in a striking contemporary building at the confluence of the Rhône and Saône. One of Lyon’s signature cultural sites with strong temporary exhibitions.
Lyon’s premier fine arts museum, housed in a former abbey near Place des Terreaux. Known for strong collections of painting, sculpture, antiquities, and decorative arts.
Museum of Roman Lyon paired with the city’s ancient theaters on Fourvière hill. A key stop for understanding Lugdunum, the Roman origins of Lyon.
Lyon’s atmospheric old quarter with Renaissance lanes, traboules, and riverfront views. It is the city’s classic strolling area and a top priority for first-time visitors.
One of Europe’s largest open squares and a central meeting point in Lyon. It is a practical orientation stop and a key place for city views toward Fourvière.
Lyon’s flagship urban park with broad walking paths, lake, botanical areas, and a zoo. It is one of the best places in the city for relaxation and scenic walks.
Light dumplings made with pike and panade, usually baked in a rich Nantua crayfish sauce. A classic Lyonnais bouchon specialty.
A traditional salad of frisée lettuce with lardons, croutons, and a poached egg. It is one of the city’s most iconic starter dishes.
Lyon’s famous sausage baked inside a soft brioche dough. It is a beloved charcuterie-based specialty found in many bouchons.
A landmark fine dining institution in Lyon, famed for historic prestige and elegant cuisine rooted in the city’s gastronomic heritage.
The city’s celebrated covered food market, ideal for sampling oysters, charcuterie, cheese, pastries, and many iconic Lyonnais products.
A respected traditional restaurant associated with chef Joseph Viola, celebrated for refined Lyonnais classics in a polished but welcoming setting.
Moderate for France: bakeries and bouchons are fair value, while central hotels and fine dining cost more.
Service is included by law. Leaving small change or 5-10% for great service is appreciated, not required. Round up for taxis.
Official public transport app
Lyon Part-Dieu -> Bellecour, Lyon
Find answers to the most common questions about traveling from Mannheim to Lyon by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

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