- Must visit
Musée des Beaux-Arts de Lyon
Major fine arts museum in a former abbey, with strong collections from antiquity to modern art. A core cultural stop in Lyon.

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Cheapest price
$55
Average price
$79
Fastest journey
7h 0m
Average duration
11h 3m
Buses per day
6
Distance
85 km
Omio recommends booking the train as it is the most popular option from Mannheim to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $33. For those with little time consider booking a train which can get you there in 5h 19m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.4kg. The ticket price range depends on the travel mode: a bus costs an average of $33, and a flight costs an average of $135.
Distance: 309 miles (498 km)
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$51 Average price Cheapest | $154 Average price | $304 Average price | $163 Average price (fuel + tolls) |
9h 42m Average total duration 9h 12m Onboard + 30m Additional time* | 5h 49m Average total duration Fastest 5h 19m Onboard + 30m Additional time* | 13h 19m Average total duration 10h 19m Onboard + 3h 0m Additional time* | 6h 33m Average total duration (door-to-door) |
0.5 - 1.2kg CO2 emissions | 0.1 - 0.4kg CO2 emissions Lowest | 1.5 - 3.0kg CO2 emissions | - CO2 emissions |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Mannheim to Lyon:
A bus is $103 (€85) less than a train for this route with tickets for a train from Mannheim to Lyon costing on average $154 (€126).
A bus is $254 (€208) less than a flight for this route with tickets for a flight from Mannheim to Lyon costing on average $304 (€249).
Other travel options to Lyon take longer:
Bus takes on average 9h 12m.
Flight takes on average 10h 19m.
Tickets start at around $51 (€42) compared to roughly $163 (€134) in fuel and tolls — a saving of about $113 (€92). The journey takes 9h 12m versus 6h 33m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by BlaBlaCar Bus, FlixBus, BlaBlaCar.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 01:10AM | Arrival Time 02:45PM | Duration 13h35 | Departure days Mon, Tue, Wed, Thu, Fri | Cheapest price $60 |
Operator FlixBus | Departure Time 02:00AM | Arrival Time 12:40PM | Duration 10h40 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $60 |
Operator FlixBus | Departure Time 03:05AM | Arrival Time 05:45PM | Duration 14h40 | Departure days Mon, Tue, Fri | Cheapest price $63 |
Operator FlixBus | Departure Time 09:20AM | Arrival Time 08:50PM | Duration 11h30 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $49 |
Operator BlaBlaCar | Departure Time 10:10AM | Arrival Time 04:10PM | Duration 6h00 | Departure days Tue | Cheapest price $44 |
Operator BlaBlaCar | Departure Time 12:40PM | Arrival Time 07:40PM | Duration 7h00 | Departure days Thu | Cheapest price $70 |
Operator FlixBus | Departure Time 02:45PM | Arrival Time 04:20AM | Duration 13h35 | Departure days Thu | Cheapest price $89 |
Operator FlixBus | Departure Time 02:50PM | Arrival Time 04:20AM | Duration 13h30 | Departure days Wed | Cheapest price $93 |
Operator FlixBus | Departure Time 03:05PM | Arrival Time 02:35AM | Duration 11h30 | Departure days Sat | Cheapest price $81 |
Operator FlixBus | Departure Time 04:05PM | Arrival Time 03:35AM | Duration 11h30 | Departure days Sat | Cheapest price $56 |
Operator FlixBus | Departure Time 04:25PM | Arrival Time 07:15AM | Duration 14h50 | Departure days Wed, Sat | Cheapest price $52 |
Operator FlixBus | Departure Time 05:05PM | Arrival Time 04:20AM | Duration 11h15 | Departure days Mon, Tue, Thu, Fri, Sun | Cheapest price $51 |
Operator FlixBus | Departure Time 05:25PM | Arrival Time 08:15AM | Duration 14h50 | Departure days Mon, Tue, Wed, Thu, Fri | Cheapest price $59 |
Operator BlaBlaCar Bus | Departure Time 06:05PM | Arrival Time 03:10AM | Duration 9h05 | Departure days Sat | Cheapest price $39 |
Operator FlixBus | Departure Time 06:43PM | Arrival Time 04:20AM | Duration 9h37 | Departure days Sun | Cheapest price $96 |
Operator BlaBlaCar Bus | Departure Time 07:05PM | Arrival Time 04:10AM | Duration 9h05 | Departure days Sat | Cheapest price $39 |
Operator BlaBlaCar Bus | Departure Time 08:05PM | Arrival Time 05:10AM | Duration 9h05 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $49 |
Operator FlixBus | Departure Time 10:59PM | Arrival Time 09:30AM | Duration 10h31 | Departure days Sat | Cheapest price $60 |
Operator FlixBus | Departure Time 11:59PM | Arrival Time 10:30AM | Duration 10h31 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $52 |
The table below shows live departures for Mannheim to Lyon buses for today, Thursday, July 16. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixTrain+ FlixBus | 2:45 PM Mannheim Hbf | 13h35 | 4:20 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus | 5:05 PM Mannheim, ZOB (Heinrich-Von-Stephan-Straße) | 11h15 | 4:20 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus | 5:25 PM Mannheim, ZOB (Heinrich-Von-Stephan-Straße) | 14h50 | 8:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
51510 | 8:05 PM Mannheim, ZOB (Heinrich-Von-Stephan-Straße) | 9h05 | 5:10 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
FlixBus | 11:59 PM Mannheim, ZOB (Heinrich-Von-Stephan-Straße) | 10h31 | 10:30 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
FlixBus · FlixBus | 1:10 AM Mannheim, ZOB (Heinrich-Von-Stephan-Straße) | 13h35 | 2:45 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus | 2:00 AM Mannheim, ZOB (Heinrich-Von-Stephan-Straße) | 14h25 | 4:25 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus | 3:05 AM Mannheim, ZOB (Heinrich-Von-Stephan-Straße) | 14h40 | 5:45 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus | 9:20 AM Mannheim, ZOB (Heinrich-Von-Stephan-Straße) | 11h30 | 8:50 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Mannheim to Lyon run on average 8 times per day, taking around 9h 12m. Cheap bus tickets for this journey start at $33 (€27) if you book in advance.
There are 2 buses per day. The earliest bus runs at 00:15, the last at 23:55. The fastest bus covers the 309 miles (498 km) distance in 9h 5m.
Distance 309 miles (498 km) |
Average bus duration 9h 12m |
Cheapest ticket price $33 (€27) |
Buses per day 8 |
Direct buses 2 |
Fastest bus 9h 5m |
First bus 12:15 AM |
Last bus 11:55 PM |
Cheapest Month Dec |
Cheapest Day Thu |
High Season Apr - Jun |
Low Season Oct - Dec |
Busiest Day Wed |
Least Busy Day Mon |
Best time to book 5 days |
Discover the best of Lyon — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Lyon trip today.
Major fine arts museum in a former abbey, with strong collections from antiquity to modern art. A core cultural stop in Lyon.
Museum of cinema miniatures and film props in Vieux Lyon. Popular for detailed sets, special-effects history, and family-friendly exhibits.
Excellent free natural history and ethnography museum with fossils, animals, and global cultures. A strong local favorite, especially for families.
Renaissance quarter with cobbled lanes, traboules, courtyards, and major monuments. Essential for atmosphere, history, and walking exploration.
Central peninsula between the Rhône and Saône, packed with elegant streets, squares, shopping, and many of Lyon’s classic city views.
Historic silk-workers’ hill district with stairways, murals, markets, and hidden passageways. Great for local character and city panoramas.
Pike dumplings in a rich crayfish sauce. A Lyon classic from traditional bouchons, prized for its delicate fish texture and luxurious sauce.
Crisp salad of frisée, bacon lardons, croutons, and a poached egg. A staple Lyonnaise bistro dish that reflects the city's hearty cooking style.
Slow-cooked onions with vinegar, often served warm or chilled. This old Lyonnais side dish is traditional in bouchons and pairs well with charcuterie.
Refined dining by Paul Bocuse, known for polished French cuisine and iconic Lyon dishes in an elegant, historic dining room.
Well-known traditional bouchon in Vieux Lyon, praised for generous Lyonnais specialties and a lively old-city atmosphere.
Historic bouchon near Place Bellecour serving quenelles, salade lyonnaise, and classic regional fare in a warm traditional setting.
Moderate for Western Europe: hotels and dining are mid-priced, while public transport is good value for visitors.
Service is usually included. Round up or leave 5-10% for great restaurant service. Round up taxi fares; small change is fine in cafes.
Find answers to the most common questions about traveling from Mannheim to Lyon by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

Most Mannheim to Lyon buses use the Mannheim, ZOB (Heinrich-Von-Stephan-Straße) to Lyon, Gare Routière de Perrache station pair, with some services arriving at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan). Use this guide to compare Mannheim and Lyon bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Lyon, Gare Routière de Perrache is 1 km from Lyon city centre. Public transport options include:
Lyon, Gare Routière de Perrache has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Café de la Gare (in the station), Le Bistrot de Lyon (0.5 km), Brasserie Georges (0.6 km).
Free Wi-Fi. ATMs are located near the main entrance.
Ticket office support is available at Lyon, Gare Routière de Perrache.
Available at Lyon, Gare Routière de Perrache: Parking, Taxis, WC.
Accessibility facilities are available at Lyon, Gare Routière de Perrache: Elevators, ramps.
Here are some other resources that might have the information you need