- Must visit
Vatican Museums
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
We are not able to find a bus between these two places.
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Omio recommends booking the train as it is the most popular option from Syracuse to Rome among Omio's users. If you are prioritising price take the flight with prices starting from $42. For those with little time consider booking a flight which can get you there in 1h 41m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.5kg. The ticket price range depends on the travel mode: a flight costs an average of $42, and a bus costs an average of $39.
Distance: 364 miles (586 km)
| Bus | Most popular Train | Flight |
|---|---|---|
$94 Average price | $88 Average price | $55 Average price Cheapest |
12h 51m Average total duration 12h 21m Onboard + 30m Additional time* | 10h 29m Average total duration 9h 59m Onboard + 30m Additional time* | 4h 41m Average total duration Fastest 1h 41m Onboard + 3h 0m Additional time* |
0.6 - 1.5kg CO2 emissions | 0.2 - 0.5kg CO2 emissions Lowest | 1.8 - 3.5kg CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Syracuse to Rome:
A flight is $33 (€27) less than a train for this route with tickets for a train from Syracuse to Rome costing on average $88 (€72).
A flight is $39 (€32) less than a bus for this route with tickets for a bus from Syracuse to Rome costing on average $94 (€77).
Other travel options to Rome take longer:
Train takes on average 9h 59m.
Bus takes on average 12h 21m.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 07:15AM | Arrival Time 09:30PM | Duration 14h15 | Departure days Mon, Tue, Thu, Sat, Sun | Cheapest price $82 |
Operator FlixBus | Departure Time 03:20PM | Arrival Time 09:40AM | Duration 18h20 | Departure days Wed, Fri | Cheapest price $79 |
Operator FlixBus | Departure Time 04:05PM | Arrival Time 06:15AM | Duration 14h10 | Departure days Wed, Fri | Cheapest price $68 |
Operator FlixBus | Departure Time 04:20PM | Arrival Time 06:05AM | Duration 13h45 | Departure days Wed, Fri | Cheapest price $62 |
Operator FlixBus | Departure Time 05:20PM | Arrival Time 06:50AM | Duration 13h30 | Departure days Mon, Tue, Thu, Sat, Sun | Cheapest price $81 |
The table below shows live departures for Syracuse to Rome buses for today, Friday, July 17. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 3:20 PM Syracuse | 18h20 | 9:40 AM Rome | 0 transfersDirect | |
![]() | 4:05 PM Syracuse | 14h10 | 6:15 AM Rome | 0 transfersDirect | |
![]() | 4:20 PM Syracuse | 13h45 | 6:05 AM Rome | 0 transfersDirect | |
| Saturday, July 18 | |||||
FlixBus · FlixBus | 7:15 AM Syracuse, Corso Umberto I | 14h15 | 9:30 PM Roma, Autostazione Tiburtina | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Syracuse to Rome run on average 2 times per day, taking around 12h 21m. Cheap bus tickets for this journey start at $39 (€32) but you can travel from only $34 (€28) by train.
The earliest bus runs at 00:45, the last at 23:55. The fastest bus covers the 364 miles (586 km) distance in 13h 30m.
Distance 364 miles (586 km) |
Average bus duration 12h 21m |
Cheapest ticket price $39 (€32) |
Buses per day 2 |
Fastest bus 13h 30m |
First bus 12:45 AM |
Last bus 11:55 PM |
Cheapest Month Mar |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Mon |
Least Busy Day Tue |
Best time to book 70 days |
Discover the best of Rome — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Rome trip today.
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Outstanding ancient sculpture and mosaic museum housed in the Palazzo dei Conservatori and Palazzo Nuovo.
Celebrated villa museum with Bernini sculptures, Caravaggio paintings, and refined garden setting.
Elegant Baroque square with Bernini's fountains, lively atmosphere, and superb people-watching.
Historic square and gathering place at the Spanish Steps, ideal for classic city views and strolls.
Charming cobbled neighborhood filled with ivy-clad lanes, churches, nightlife, and local character.
Classic Roman pasta with guanciale, egg yolk, Pecorino Romano, and black pepper. A city icon known for rich flavor without cream.
Roman pasta with guanciale, tomato, and Pecorino Romano. A traditional Lazio staple tied to shepherd cooking and bold savory flavor.
Pasta with guanciale, Pecorino Romano, and black pepper. Considered one of Rome's oldest pasta dishes and prized for its simplicity.
Three-Michelin-star dining by Niko Romito at Bulgari Hotel Roma, offering refined Italian tasting menus in an elegant setting.
Historic trattoria in Testaccio known for classic Roman pasta and quinto quarto dishes in a lively, traditional setting.
Popular casual spot famed for Roman-style pizzas and fried starters. Bustling atmosphere and a long-standing local reputation.
Moderate for Europe: stays in central Rome are pricey, but transit is cheap and meals range from affordable pizza to costly tourist-area dining.
Service may be included via coperto or servizio. Round up or leave 5-10% at restaurants if service is good; round up in taxis; small change is fine at cafés.
Official public transport app
Via Marsala, Rome -> Piazza Barberini, Rome
Find answers to the most common questions about traveling from Syracuse to Rome by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

Most Syracuse to Rome buses use the Syracuse, Corso Umberto I to Roma, Autostazione Tiburtina station pair, with some services arriving at Roma, Autostazione (Metro Anagnina). Use this guide to compare Syracuse and Rome bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need