- Must visit
Pinacoteca di Brera
One of Italy’s top art museums, featuring masterpieces by Mantegna, Bellini, Raphael, Caravaggio, and Piero della Francesca.
The best way to find a cheap bus ticket from Syracuse to Milan is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Syracuse to Milan will cost around €140 if you buy it on the day, but the cheapest tickets can be found for only €109.
It's difficult to get from Syracuse to Milan without transferring at least once.
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Buses from Syracuse to Milan run on average 4 times per day, taking around 20h 27m. Cheap bus tickets for this journey start at €54 but you can travel from only €30 by train.
The earliest bus runs at 04:38, the last at 22:18. The fastest bus covers the 659 miles (1061 km) distance in 19h 0m.
Distance 659 miles (1061 km) |
Average bus duration 20h 27m |
Cheapest ticket price €54 |
Buses per day 4 |
Fastest bus 19h 0m |
First bus 4:38 AM |
Last bus 10:18 PM |
Cheapest Month Feb |
Cheapest Day Wed |
High Season Jul - Sep |
Low Season Apr - Jun |
Busiest Day Sat |
Least Busy Day Sun |
Best time to book 1 day |
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Syracuse to Milan.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 05:15AM | Arrival Time 09:49AM | Duration 28h34 | Departure days Wed | Cheapest price €71 |
Operator FlixBus | Departure Time 07:15AM | Arrival Time 05:15AM | Duration 22h00 | Departure days Mon, Tue, Thu, Sat, Sun | Cheapest price €98 |
Operator FlixBus | Departure Time 03:05PM | Arrival Time 04:30PM | Duration 25h25 | Departure days Wed | Cheapest price €72 |
Operator FlixBus | Departure Time 03:20PM | Arrival Time 11:45AM | Duration 20h25 | Departure days Wed, Fri | Cheapest price €77 |
Operator FlixBus | Departure Time 04:05PM | Arrival Time 12:45PM | Duration 20h40 | Departure days Wed, Fri | Cheapest price €53 |
Operator FlixBus | Departure Time 04:20PM | Arrival Time 12:45PM | Duration 20h25 | Departure days Wed, Fri | Cheapest price €75 |
Operator FlixBus | Departure Time 05:20PM | Arrival Time 02:35PM | Duration 21h15 | Departure days Mon, Tue, Thu, Sat, Sun | Cheapest price €79 |
The table below shows live departures for Syracuse to Milan buses for tomorrow, Tuesday, November 3. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 7:15 AM Syracuse, Corso Umberto I | 22h00 | 5:15 AM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 1 transfer | |
FlixBus · FlixBus | 7:15 AM Syracuse, Corso Umberto I | 22h40 | 5:55 AM Milano, Autostazione Lampugnano | 1 transfer | |
FlixBus · FlixBus | 5:20 PM Syracuse, Corso Umberto I | 20h25 | 1:45 PM Milano, Autostazione Lampugnano | 1 transfer | |
FlixBus · FlixBus · FlixBus | 5:20 PM Syracuse, Corso Umberto I | 21h15 | 2:35 PM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 5:20 PM Syracuse, Corso Umberto I | 21h55 | 3:15 PM Milano, Autostazione Lampugnano | 2 transfers |
Find all the dates and times for this journey
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Milan — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Milan trip today.
One of Italy’s top art museums, featuring masterpieces by Mantegna, Bellini, Raphael, Caravaggio, and Piero della Francesca.
This contemporary art museum near Porta Romana presents rotating exhibitions in a striking former industrial distillery complex.
Italy’s leading science museum is set in a former monastery and features Leonardo galleries, trains, aircraft, and a submarine.
Milan’s central square frames the cathedral and major civic buildings, making it the city’s essential meeting point and photo stop.
This artistic district offers charming lanes, Brera atmosphere, boutiques, and easy access to galleries and evening strolls.
A large landscaped park behind the castle, perfect for walks, skyline views, and reaching landmarks like the Arch of Peace.
Saffron risotto cooked with butter, stock and cheese. It is Milan's signature dish, linked to the city's love of rich northern Italian rice cookery.
Breaded veal cutlet fried in butter until golden. A classic Milanese main, prized for its simple preparation and long-standing local tradition.
Slow-braised veal shanks with vegetables, wine and broth, often finished with gremolata. A hearty Lombard specialty commonly paired with risotto.
Three-Michelin-star fine dining by Enrico Bartolini in MUDEC. Expect refined Italian tasting menus in a polished contemporary setting.
Historic Milanese restaurant near the Duomo, famous for risotto and cotoletta. Traditional, elegant rooms and a strong local culinary identity.
Long-running local favorite for classic Milanese cuisine, especially risotto and ossobuco. Warm, old-school atmosphere in the Brera area.
Moderate for Western Europe. Hotels and central dining can be pricey, but transit is affordable and budget meals, aperitivo deals, and local cafes help keep daily costs reasonable.
Tipping is modest. Service may be included. Round up or leave €1-2 at cafes, 5-10% for good restaurant service, and round up taxi fares.
Official public transport app
Orio al Serio, Milan Bergamo Airport (Bus station) -> Milano Centrale, Milan
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Milan.
Find answers to the most common questions about traveling from Syracuse to Milan by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Milan, this guide helps you travel smarter and with confidence.

Most Syracuse to Milan buses use the to Milano, Autostazione Lampugnano station pair, with some services arriving at Milano, San Donato - Settore B (Viale Giuseppe Impastato). Use this guide to compare Syracuse and Milan bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Milano, Autostazione Lampugnano is 5 km from Milan city centre. Public transport options include:
Milano, Autostazione Lampugnano has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Lampugnano (in the station), Trattoria Milano (0.5 km), Pizza Express (0.7 km).
Free Wi-Fi. ATMs are located near the main entrance.
Ticket office support is available at Milano, Autostazione Lampugnano.
Available at Milano, Autostazione Lampugnano: Parking, Taxis, WC.
Accessibility facilities are available at Milano, Autostazione Lampugnano: Elevators, ramps.
Milano, San Donato - Settore B (Viale Giuseppe Impastato) is 6 km from Milan city centre. Public transport options include:
Milano, San Donato - Settore B (Viale Giuseppe Impastato) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Italiana (in the station), Fast Food Express (in the station), Trattoria Milano (0.5 km).
Free Wi-Fi. ATMs are located near the main entrance for cash withdrawals.
Ticket office support is available at Milano, San Donato - Settore B (Viale Giuseppe Impastato).
Available at Milano, San Donato - Settore B (Viale Giuseppe Impastato): Parking, Taxis, WC.
Accessibility facilities are available at Milano, San Donato - Settore B (Viale Giuseppe Impastato): Elevators, ramps.
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