The cheapest and fastest buses from Syracuse to Palermo
Cheapest price
$26
Average price
$36
Fastest journey
6 h 40 m
Average duration
7 h 55 m
Buses per day
2
Distance
204 km
The best way to find a cheap bus ticket from Syracuse to Palermo is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Syracuse to Palermo will cost around $36 if you buy it on the day, but the cheapest tickets can be found for only $26.
It's difficult to get from Syracuse to Palermo without transferring at least once.
FlixBus · FlixBus
BUS LP724+
Regionale Veloce 5363
FlixBus · FlixBus
BUS LP724+
Regionale Veloce 5363Travel Information
Compare bus and train for Syracuse to Palermo
Omio recommends booking the bus as it is the most popular option from Syracuse to Palermo among Omio's users. If you are prioritising price take the train with prices starting from $25. For those with little time consider booking a bus which can get you there in 3h 34m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.2kg. The ticket price range depends on the travel mode: a train costs an average of $25, and a bus costs an average of $20.
Distance: 126 miles (204 km)
Compare bus with
Most popular Bus | Train |
|---|---|
$34 Average price | $26 Average price Cheapest |
4h 4m Average total duration Fastest 3h 34m Onboard + 30m Additional time* | 5h 38m Average total duration 5h 8m Onboard + 30m Additional time* |
0.2 - 0.5kg CO2 emissions | 0.1 - 0.2kg CO2 emissions Lowest |
![]() Most popular bus company | ![]() Most popular train company |
Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Syracuse to Palermo Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 07:15AM | Arrival Time 01:55PM | Duration 6h40 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price $21 |
Operator Trenitalia | Departure Time 08:22AM | Arrival Time 05:32PM | Duration 9h10 | Departure days Wed, Sat | Cheapest price $41 |
Live departures
Syracuse to Palermo bus times
The table below shows live departures for Syracuse to Palermo buses for tomorrow, Saturday, February 28. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 6:15 AM Syracuse, Corso Umberto I | 6h40 | 12:55 PM Palermo, Via Tommaso Fazello (Terminal Bus) | 1 transfer | |
BUS LP724+ Regionale Veloce 5363 | 7:22 AM Syracuse station | 9h10 | 4:32 PM Palermo Centrale | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Syracuse to Palermo by bus or train
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Syracuse to Palermo buses with Omio?
Why book with Omio vs Interbus S.p.A.?
- Compare with other providers: On Omio, you can not only buy tickets for Interbus S.p.A., but also compare tickets for the likes of European Sleeper, Infobus or FlixBus to find the best option for your trip from Syracuse to Palermo.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Interbus S.p.A. with all available travel options, which are bus and train to ensure you get the best deal for traveling from Syracuse to Palermo.
Why book with Omio over Checkmybus, Busbud or Wanderu?
- Compare with other providers: On Omio, you can also compare tickets for the likes of European Sleeper, Infobus or FlixBus to find the best option for your trip from Syracuse to Palermo.
- Multiple modes of transport: Omio allows you to compare travel options including bus and train to find the ideal travel option from Syracuse to Palermo.
Journey information
Overview: Bus from Syracuse to Palermo
Buses from Syracuse to Palermo run on average 6 times per day, taking around 3h 34m. Cheap bus tickets for this journey start at $20 (€16) if you book in advance.
There are 3 buses per day. The earliest bus runs at 04:20, the last at 20:05. The fastest bus covers the 126 miles (204 km) distance in 6h 40m.
Distance 126 miles (204 km) |
Average bus duration 3h 34m |
Cheapest ticket price $20 (€16) |
Buses per day 6 |
Direct buses 3 |
Fastest bus 6h 40m |
First bus 04:20 |
Last bus 20:05 |
Bus providers: Interbus S.p.A., European Sleeper, Infobus, FlixBus, BlaBlaCar from Syracuse to PalermoYou can travel by bus between Syracuse to Palermo with Interbus S.p.A., European Sleeper, Infobus, FlixBus, BlaBlaCar for as low as $20 (€16). When you search for schedules and tickets, Omio will show you the best journey
Infobus
FlixBus
Interbus S.p.A.
European Sleeper
BlaBlaCar
FAQs: Bus from Syracuse to Palermo
Find answers to the most common questions about traveling from Syracuse to Palermo by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Palermo, this guide helps you travel smarter and with confidence.

- European Sleeper
- Pram/stroller access and dedicated wheelchair accessibility are available.
- Infobus
- Assistance
- Priority seating
- Transport for wheelchairs and mobility aids.
- Interbus S.p.A.
- Assistance
- Priority boarding
- Accessible seating.
- Palermo Cathedral, a stunning architectural blend of Norman, Moorish, and Baroque styles
- Teatro Massimo, Italy's largest opera house known for its grand performances and impressive acoustics
- Palazzo dei Normanni, a historic palace featuring the exquisite Palatine Chapel with its Byzantine mosaics
- Quattro Canti, a Baroque square at the intersection of Palermo's two main streets, known for its symmetrical fountains and statues
- Orto Botanico di Palermo, a lush botanical garden showcasing diverse plant species.
- Capuchin Catacombs, an eerie yet fascinating underground cemetery with mummified remains
- Ballarò Market, a bustling street market offering a taste of local Sicilian produce and culture
- Explore the vibrant street art in the Vucciria district
- Take a cooking class to learn how to make traditional Sicilian dishes
- Enjoy a leisurely stroll along the picturesque Foro Italico promenade.
- European Sleeper
- The cancellation policy depends on the type of ticket chosen.
- Infobus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Cancellations within 24 hours may incur a fee.
- Interbus S.p.A.
- You can cancel your ticket up to 24 hours before departure for a 10% fee. No refunds for cancellations within 24 hours.
- European Sleeper
- One piece of baggage and one piece of hand luggage are allowed.
- Infobus
- One carry-on bag up to 5kg (40x20x25) and one checked bag up to 20kg (50x30x80).
- Interbus S.p.A.
- One carry-on bag up to 10kg (55x35x25) and one checked bag up to 20kg (70x50x30).
- European Sleeper
- For medium-sized dogs, an additional ticket is required.
- Infobus
- 10€ per additional bag.
- Interbus S.p.A.
- 10€ per additional bag up to 20 kg.
- European Sleeper
- Small pets are allowed in carriers, and dogs must be muzzled and leashed
- guide dogs are allowed for free.
- Infobus
- Small pets allowed in carriers
- larger pets may require a separate ticket.
- Interbus S.p.A.
- Small pets allowed in carriers
- larger pets may require a ticket and must be leashed and muzzled.
Most popular bus connections from Syracuse
More options for your journey from Syracuse to Palermo
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