- Must visit
Vatican Museums
One of the world's great museum complexes, home to vast papal collections and the Sistine Chapel. A priority visit for art, history, and Renaissance masterpieces.








Cheapest price
$241
Average price
$280
Fastest journey
30h 5m
Average duration
34h 57m
Buses per day
8
Distance
1184 km
Omio recommends booking the flight as it is the most popular option from Madrid to Rome among Omio's users. If you are prioritising price take the flight with prices starting from $54. For those with little time consider booking a flight which can get you there in 5h 39m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 1.4 - 3.4kg. The ticket price range depends on the travel mode: a flight costs an average of $54, and a train costs an average of $330.
Distance: 846 miles (1363 km)
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$240 Average price | $183 Average price Cheapest | $330 Average price | $385 Average price (fuel + tolls) |
21h 20m Average total duration 20h 50m Onboard + 30m Additional time* | 8h 39m Average total duration Fastest 5h 39m Onboard + 3h 0m Additional time* | 50h 22m Average total duration 49h 52m Onboard + 30m Additional time* | 19h 39m Average total duration (door-to-door) |
1.4 - 3.4kg CO2 emissions Lowest | 4.1 - 8.2kg CO2 emissions | - CO2 emissions | - CO2 emissions |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Madrid to Rome:
A flight is $57 (€47) less than a bus for this route with tickets for a bus from Madrid to Rome costing on average $240 (€198).
A flight is $146 (€120) less than a train for this route with tickets for a train from Madrid to Rome costing on average $330 (€271).
Other travel options to Rome take longer:
Bus takes on average 20h 50m.
Train takes on average 49h 52m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator BlaBlaCar Bus | Departure Time 08:35AM | Arrival Time 08:15PM | Duration 35h40 | Departure days Wed, Fri, Sun | Cheapest price $135 |
Operator FlixBus | Departure Time 07:05PM | Arrival Time 06:05AM | Duration 35h00 | Departure days Everyday | Cheapest price $166 |
Operator FlixBus | Departure Time 08:50PM | Arrival Time 09:15AM | Duration 36h25 | Departure days Everyday | Cheapest price $162 |
Operator FlixBus | Departure Time 09:55PM | Arrival Time 07:00AM | Duration 33h05 | Departure days Everyday | Cheapest price $169 |
Operator FlixBus | Departure Time 11:35PM | Arrival Time 11:50AM | Duration 36h15 | Departure days Everyday | Cheapest price $180 |
Operator FlixBus | Departure Time 11:59PM | Arrival Time 11:50AM | Duration 35h51 | Departure days Everyday | Cheapest price $176 |
The table below shows live departures for Madrid to Rome buses for today, Saturday, July 11. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 7:05 PM Madrid, Estación Sur de Autobuses | 35h00 | 6:05 AM Roma, Autostazione (Metro Anagnina) | 1 transfer | |
FlixBus · FlixBus · FlixBus | 7:05 PM Madrid, Estación Sur de Autobuses | 30h05 | 1:10 AM Roma, Autostazione Tiburtina | 2 transfers | |
FlixBus · FlixBus · FlixBus | 8:50 PM Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) | 36h25 | 9:15 AM Roma, Autostazione Tiburtina | 2 transfers | |
FlixBus · FlixBus · FlixBus | 9:55 PM Madrid, Estación Sur de Autobuses | 33h05 | 7:00 AM Roma, Autostazione Tiburtina | 2 transfers | |
FlixBus · FlixBus | 11:35 PM Madrid, Estación Sur de Autobuses | 36h15 | 11:50 AM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus | 11:35 PM Madrid, Estación Sur de Autobuses | 36h40 | 12:15 PM Roma, Autostazione (Metro Anagnina) | 1 transfer | |
FlixBus · FlixBus | 11:59 PM Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) | 35h51 | 11:50 AM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus | 11:59 PM Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) | 36h16 | 12:15 PM Roma, Autostazione (Metro Anagnina) | 1 transfer | |
| Sunday, July 12 | |||||
54152 · 4787 | 8:35 AM Madrid, Estación Sur de Autobuses | 35h40 | 8:15 PM Roma, Autostazione Tiburtina | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Madrid to Rome run on average 7 times per day, taking around 20h 50m. Cheap bus tickets for this journey start at $148 (€122) but you can travel from only $54 (€44) by flight.
The earliest bus runs at 00:10, the last at 23:55. The fastest bus covers the 846 miles (1363 km) distance in 34h 0m.
Distance 846 miles (1363 km) |
Average bus duration 20h 50m |
Cheapest ticket price $148 (€122) |
Buses per day 7 |
Fastest bus 34h 0m |
First bus 12:10 AM |
Last bus 11:55 PM |
Cheapest Month Dec |
Cheapest Day Mon |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Tue |
Least Busy Day Sat |
Best time to book 84 days |
Discover the best of Rome — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Rome trip today.
One of the world's great museum complexes, home to vast papal collections and the Sistine Chapel. A priority visit for art, history, and Renaissance masterpieces.
A superb villa museum with Bernini sculptures and major paintings by Caravaggio, Raphael, and Titian. Timed entry is essential due to limited capacity.
The city's historic civic museums on Capitoline Hill, known for classical sculpture, ancient Roman art, and excellent views over the Forum.
A lively Baroque square with monumental fountains, elegant facades, and one of the most recognizable urban spaces in Rome.
A famous stairway and gathering point linking Piazza di Spagna with Trinita dei Monti, especially popular for photos and central city strolls.
A beloved neighborhood of narrow lanes, ivy-covered buildings, and lively Roman atmosphere, ideal for wandering day or night.
A classic Roman pasta with pecorino Romano, black pepper, and pasta water. It is one of the city’s most iconic dishes for its simplicity and bold flavor.
Traditional Roman pasta made with guanciale, egg yolk, pecorino Romano, and black pepper. It is a defining dish of Rome and is famously made without cream.
A beloved pasta sauce of tomato, guanciale, pecorino Romano, and chili. Though linked to Amatrice, it is deeply rooted in Roman trattoria cooking.
Rome’s best-known luxury fine-dining restaurant, famous for panoramic views, elegant service, and sophisticated Italian cuisine.
A historic restaurant near the Pantheon serving refined Roman classics with strong local identity. Well known for seasonal specialties and pasta.
A celebrated central Rome dining room known for Roman pasta, cured meats, and an exceptional wine list. Lively, polished, and very popular.
Moderate for Western Europe. Sights and central hotels cost more, but food, coffee, and transit can be good value.
Service is often included or modest. Locals may round up or leave EUR 1-2 at cafes; 5-10% is appreciated at restaurants for good service, not obligatory. Round up taxis.
Official public transport app
Rome, Via Marsala / Viale Enrico De Nicola, Rome -> Rome Termini
Find answers to the most common questions about traveling from Madrid to Rome by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

Most Madrid to Rome buses use the Madrid, Estación Sur de Autobuses to Roma, Autostazione Tiburtina station pair, with some services arriving at Roma, Autostazione (Metro Anagnina). Use this guide to compare Madrid and Rome bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Madrid, Estación Sur de Autobuses is 3 km from Madrid city centre. Public transport options include:
Madrid, Estación Sur de Autobuses has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafetería de la estación (in the station), Restaurante El Brillante (0.5 km), La Taberna de Domínguez (0.7 km).
Free Wi-Fi. ATMs are located near the main entrance and in the waiting area.
Ticket office support is available at Madrid, Estación Sur de Autobuses.
Available at Madrid, Estación Sur de Autobuses: Parking, Taxis, WC.
Accessibility facilities are available at Madrid, Estación Sur de Autobuses: Elevators, ramps.
Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) is 12 km from Madrid city centre. Public transport options include:
Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) has practical services for this route, including Dining, ATM, Accessibility, WC, Shower, and Ticket Office.
Food options include: Rodilla, Mahoudrid
ATMs are aTMs located throughout T4, major cards accepted .
Ticket office support is available at Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid).
Available at Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid): WC.
Accessibility facilities are available at Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid): Step-free access, elevators, accessible toilets.
Here are some other resources that might have the information you need