- Must visit
Vatican Museums
One of the world’s greatest museum complexes, known for classical sculpture, Renaissance masterpieces, and the Sistine Chapel. Advance booking is strongly recommended due to very high demand.
Cheapest price
$61
Average price
$117
Fastest journey
14 h 20 m
Average duration
14 h 56 m
Buses per day
13
Distance
747 km
The best way to find a cheap bus ticket from Lyon to Rome is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Lyon to Rome will cost around $117 if you buy it on the day, but the cheapest tickets can be found for only $61.
Of the 13 buses that leave Lyon for Rome on Thu, Jul 02, 4 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, Jul 02 the direct buses cover the 747 km distance in an average of 14 h 56 m but if you time it right, some buses will get you there in just 14 h 20 m .
On Thu, Jul 02 the slowest buses will take 15 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
3491
3091 · 3801
3897
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
3491
FlixBus
3897
FlixBusOmio recommends booking the bus as it is the most popular option from Lyon to Rome among Omio's users. If you are prioritising price take the bus with prices starting from $30. For those with little time consider booking a flight which can get you there in 5h 22m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.7 - 1.9kg. The ticket price range depends on the travel mode: a bus costs an average of $30, and a train costs an average of $117.
Distance: 464 miles (747 km)
Most popular Bus | Flight | Train | Driving |
|---|---|---|---|
$64 Average price Cheapest | $211 Average price | $221 Average price | $367 Average price (fuel + tolls) |
12h 34m Average total duration 12h 4m Onboard + 30m Additional time* | 8h 22m Average total duration Fastest 5h 22m Onboard + 3h 0m Additional time* | 10h 11m Average total duration 9h 41m Onboard + 30m Additional time* | 10h 36m Average total duration (door-to-door) |
0.7 - 1.9kg CO2 emissions Lowest | 2.2 - 4.5kg CO2 emissions | - CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Lyon to Rome:
A bus is $147 (€121) less than a flight for this route with tickets for a flight from Lyon to Rome costing on average $211 (€174).
A bus is $157 (€130) less than a train for this route with tickets for a train from Lyon to Rome costing on average $221 (€183).
Other travel options to Rome take longer:
Train takes on average 9h 41m.
Bus takes on average 12h 4m.
Tickets start at around $64 (€53) compared to roughly $367 (€303) in fuel and tolls — a saving of about $303 (€250). The journey takes 12h 4m versus 10h 36m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by Itabus, FlixBus, BlaBlaCar Bus, BlaBlaCar.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 01:15AM | Arrival Time 04:05PM | Duration 14h50 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $127 |
Operator FlixBus | Departure Time 03:15AM | Arrival Time 06:05PM | Duration 14h50 | Departure days Tue, Sat, Sun | Cheapest price $93 |
Operator BlaBlaCar Bus | Departure Time 05:35AM | Arrival Time 08:15PM | Duration 14h40 | Departure days Mon, Tue, Fri, Sat | Cheapest price $85 |
Operator FlixBus | Departure Time 06:15AM | Arrival Time 11:25PM | Duration 17h10 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $92 |
Operator Itabus | Departure Time 09:15AM | Arrival Time 11:45PM | Duration 14h30 | Departure days Everyday | Cheapest price $48 |
Operator FlixBus | Departure Time 09:35AM | Arrival Time 11:45PM | Duration 14h10 | Departure days Mon, Tue, Fri, Sat, Sun | Cheapest price $91 |
Operator FlixBus | Departure Time 10:50AM | Arrival Time 01:10AM | Duration 14h20 | Departure days Wed, Thu | Cheapest price $127 |
Operator FlixBus | Departure Time 12:45PM | Arrival Time 06:05AM | Duration 17h20 | Departure days Mon, Tue, Wed, Sat, Sun | Cheapest price $87 |
Operator FlixBus | Departure Time 02:55PM | Arrival Time 07:00AM | Duration 16h05 | Departure days Everyday | Cheapest price $87 |
Operator Itabus | Departure Time 03:30PM | Arrival Time 07:00AM | Duration 15h30 | Departure days Everyday | Cheapest price $48 |
Operator FlixBus | Departure Time 04:00PM | Arrival Time 07:40AM | Duration 15h40 | Departure days Mon, Tue, Thu | Cheapest price $88 |
Operator FlixBus | Departure Time 06:00PM | Arrival Time 01:50PM | Duration 19h50 | Departure days Tue, Wed, Fri, Sat, Sun | Cheapest price $80 |
Operator FlixBus | Departure Time 06:55PM | Arrival Time 12:10PM | Duration 17h15 | Departure days Mon, Tue, Thu, Sat, Sun | Cheapest price $138 |
Operator FlixBus | Departure Time 08:45PM | Arrival Time 01:20PM | Duration 16h35 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price $74 |
Operator FlixBus | Departure Time 11:00PM | Arrival Time 02:30PM | Duration 15h30 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $112 |
Operator Itabus | Departure Time 11:50PM | Arrival Time 05:30PM | Duration 17h40 | Departure days Everyday | Cheapest price $62 |
The table below shows live departures for Lyon to Rome buses for today, Wednesday, July 1. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 2:55 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 16h05 | 7:00 AM Roma, Autostazione Tiburtina | 1 transfer | |
3897 | 3:30 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 15h30 | 7:00 AM Roma, Autostazione Tiburtina | 0 transfersDirect | |
FlixBus · FlixBus | 6:00 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 16h00 | 10:00 AM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus | 8:45 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 16h35 | 1:20 PM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus | 8:45 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 15h30 | 12:15 PM Roma, Autostazione (Metro Anagnina) | 0 transfersDirect | |
3091 · 3801 | 11:50 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 17h40 | 5:30 PM Roma, Autostazione Tiburtina | 1 transfer | |
| Thursday, July 2 | |||||
FlixBus · FlixBus | 1:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 16h35 | 5:50 PM Roma, Autostazione (Metro Anagnina) | 1 transfer | |
FlixBus | 1:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 14h50 | 4:05 PM Roma, Autostazione Tiburtina | 0 transfersDirect | |
FlixBus · FlixBus | 6:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 17h25 | 11:40 PM Roma, Autostazione Tiburtina | 1 transfer | |
3491 | 9:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 14h30 | 11:45 PM Roma, Autostazione Tiburtina | 0 transfersDirect | |
FlixBus · FlixBus | 10:50 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 14h20 | 1:10 AM Roma, Autostazione Tiburtina | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Lyon to Rome run on average 12 times per day, taking around 12h 4m. Cheap bus tickets for this journey start at $30 (€25) if you book in advance.
There are 5 buses per day. The earliest bus runs at 00:04, the last at 23:50. The fastest bus covers the 464 miles (747 km) distance in 14h 10m.
Distance 464 miles (747 km) |
Average bus duration 12h 4m |
Cheapest ticket price $30 (€25) |
Buses per day 12 |
Direct buses 5 |
Fastest bus 14h 10m |
First bus 12:04 AM |
Last bus 11:50 PM |
Cheapest Month May |
Cheapest Day Sat |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Tue |
Least Busy Day Sat |
Best time to book 42 days |
Discover the best of Rome — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Rome trip today.
One of the world’s greatest museum complexes, known for classical sculpture, Renaissance masterpieces, and the Sistine Chapel. Advance booking is strongly recommended due to very high demand.
A celebrated villa museum with major works by Bernini, Caravaggio, and Canova, set inside Villa Borghese gardens. Timed-entry tickets are required and usually need advance reservation.
The city’s historic civic museums on Capitoline Hill, featuring Roman bronzes, sculpture, paintings, and superb views over the Forum area.
A grand Baroque square lined with fountains, churches, and elegant facades. It remains one of Rome’s classic walking and people-watching spots.
A famous monumental staircase linking Piazza di Spagna with Trinità dei Monti, popular for photos, shopping nearby, and city atmosphere.
A characterful district of narrow lanes, ivy-covered facades, and lively evening atmosphere, widely loved for wandering and street photography.
A classic Roman pasta with Pecorino Romano and black pepper. It is one of the city’s most iconic dishes for its simplicity and bold flavor.
Traditional Roman pasta made with guanciale, egg yolk, Pecorino Romano, and black pepper. It is a defining dish of Rome and should not contain cream.
Pasta with tomato, guanciale, Pecorino Romano, and chili. Though linked with Amatrice, it is a staple on Roman menus and deeply rooted in local cooking.
A historic trattoria near the Pantheon, respected for traditional Roman dishes such as carbonara, amatriciana, and seasonal specialties in an intimate atmosphere.
A celebrated central Rome dining room and delicatessen known for classic Roman pasta, cured meats, and an exceptional wine list in a lively upscale setting.
A famous Trastevere trattoria known for authentic Roman comfort food, including cacio e pepe, meatballs, and artichokes, with a classic casual feel.
Moderate for Western Europe: food and coffee can be reasonable, but hotels and major tourist areas cost more.
Service is often included or modest. Locals may round up or leave EUR 1-2 for coffee, 5-10% for good restaurant service; tips are appreciated, not required.
Official public transport app
Rome, Via Marsala / Viale Enrico De Nicola -> Roma Termini
Find answers to the most common questions about traveling from Lyon to Rome by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

Most Lyon to Rome buses use the Lyon, Gare Routière de Perrache to Roma, Autostazione Tiburtina station pair, with some services arriving at Roma, Autostazione (Metro Anagnina). Use this guide to compare Lyon and Rome bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Lyon, Gare Routière de Perrache is 1 km from Lyon city centre. Public transport options include:
Lyon, Gare Routière de Perrache has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Café de la Gare (in the station), Le Bistrot de Lyon (0.5 km), Brasserie Georges (0.6 km).
Free Wi-Fi. ATMs are located near the main entrance.
Ticket office support is available at Lyon, Gare Routière de Perrache.
Available at Lyon, Gare Routière de Perrache: Parking, Taxis, WC.
Accessibility facilities are available at Lyon, Gare Routière de Perrache: Elevators, ramps.
Lyon, Gare Perrache is 1 km from Lyon city centre. Public transport options include:
Lyon, Gare Perrache has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Café de la Gare (in the station), Bistro Lyonnais (0.2 km), Fast Food Express (0.3 km).
Free Wi-Fi. ATMs are located near the main entrance and in the shopping area.
Ticket office support is available at Lyon, Gare Perrache.
Available at Lyon, Gare Perrache: Parking, Taxis, WC.
Accessibility facilities are available at Lyon, Gare Perrache: Elevators, ramps.
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