- Must visit
Vatican Museums
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Cheapest price
$137
Average price
$175
Fastest journey
19 h 35 m
Average duration
20 h 3 m
Buses per day
34
Distance
923 km
The best way to find a cheap bus ticket from Prague to Rome is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Prague to Rome will cost around $175 if you buy it on the day, but the cheapest tickets can be found for only $137.
Of the 34 buses that leave Prague for Rome on Wed, Aug 26, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Aug 26 the direct buses cover the 923 km distance in an average of 20 h 3 m but if you time it right, some buses will get you there in just 19 h 35 m .
On Wed, Aug 26 the slowest buses will take 20 h 25 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus · FlixBus
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus · FlixBus
FlixBus · FlixBusOmio recommends booking the flight as it is the most popular option from Prague to Rome among Omio's users. If you are prioritising price take the bus with prices starting from $50. For those with little time consider booking a flight which can get you there in 3h 41m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.9 - 2.3kg. The ticket price range depends on the travel mode: a bus costs an average of $50, and a flight costs an average of $22.
Distance: 573 miles (923 km)
| Bus | Most popular Flight | Driving |
|---|---|---|
$113 Average price Cheapest | $458 Average price | $362 Average price (fuel + tolls) |
19h 59m Average total duration 19h 29m Onboard + 30m Additional time* | 6h 41m Average total duration Fastest 3h 41m Onboard + 3h 0m Additional time* | 14h 14m Average total duration (door-to-door) |
0.9 - 2.3kg CO2 emissions Lowest | 2.8 - 5.5kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Prague to Rome:
A train is $60 less than a bus for this route with tickets for a bus from Prague to Rome costing on average $113.
A train is $405 less than a flight for this route with tickets for a flight from Prague to Rome costing on average $458.
Other travel options to Rome take longer:
Train takes on average 19h 3m.
Bus takes on average 19h 29m.
Tickets start at around $113 compared to roughly $362 in fuel and tolls — a saving of about $249. The journey takes 19h 29m versus 14h 14m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 02:30AM | Arrival Time 11:00PM | Duration 20h30 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $137 |
Operator FlixBus | Departure Time 05:50AM | Arrival Time 09:30AM | Duration 27h40 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $152 |
Operator FlixBus | Departure Time 06:20AM | Arrival Time 06:10AM | Duration 23h50 | Departure days Mon, Fri, Sat, Sun | Cheapest price $188 |
Operator FlixBus | Departure Time 07:00AM | Arrival Time 06:10AM | Duration 23h10 | Departure days Mon, Fri, Sat, Sun | Cheapest price $188 |
Operator FlixBus | Departure Time 07:55AM | Arrival Time 07:05AM | Duration 23h10 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $139 |
Operator FlixBus | Departure Time 08:20AM | Arrival Time 09:30AM | Duration 25h10 | Departure days Sat, Sun | Cheapest price $160 |
Operator FlixBus | Departure Time 08:30AM | Arrival Time 09:30AM | Duration 25h00 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $143 |
Operator FlixBus | Departure Time 09:00AM | Arrival Time 06:10AM | Duration 21h10 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $148 |
Operator FlixBus | Departure Time 09:40AM | Arrival Time 12:15PM | Duration 26h35 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $140 |
Operator FlixBus | Departure Time 09:50AM | Arrival Time 09:20AM | Duration 23h30 | Departure days Wed | Cheapest price $152 |
Operator FlixBus | Departure Time 10:05AM | Arrival Time 09:20AM | Duration 23h15 | Departure days Wed | Cheapest price $152 |
Operator FlixBus | Departure Time 10:55AM | Arrival Time 09:30AM | Duration 22h35 | Departure days Mon, Wed, Sat, Sun | Cheapest price $152 |
Operator FlixBus | Departure Time 11:00AM | Arrival Time 07:05AM | Duration 20h05 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $137 |
Operator FlixBus | Departure Time 11:15AM | Arrival Time 07:05AM | Duration 19h50 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $137 |
Operator FlixBus | Departure Time 12:50PM | Arrival Time 01:20PM | Duration 24h30 | Departure days Everyday | Cheapest price $140 |
Operator FlixBus | Departure Time 12:55PM | Arrival Time 01:20PM | Duration 24h25 | Departure days Sun | Cheapest price $208 |
Operator FlixBus | Departure Time 01:05PM | Arrival Time 09:30AM | Duration 20h25 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $140 |
Operator FlixBus | Departure Time 02:00PM | Arrival Time 09:30AM | Duration 19h30 | Departure days Sun | Cheapest price $179 |
Operator FlixBus | Departure Time 02:15PM | Arrival Time 09:30AM | Duration 19h15 | Departure days Sun | Cheapest price $179 |
Operator FlixBus | Departure Time 02:30PM | Arrival Time 01:20PM | Duration 22h50 | Departure days Everyday | Cheapest price $146 |
Operator FlixBus | Departure Time 03:00PM | Arrival Time 05:50PM | Duration 26h50 | Departure days Mon, Tue, Fri, Sat, Sun | Cheapest price $158 |
Operator FlixBus | Departure Time 03:05PM | Arrival Time 01:20PM | Duration 22h15 | Departure days Mon, Tue, Wed, Thu, Sat | Cheapest price $144 |
Operator FlixBus | Departure Time 03:30PM | Arrival Time 02:45PM | Duration 23h15 | Departure days Mon, Tue, Fri, Sat, Sun | Cheapest price $160 |
Operator FlixBus | Departure Time 04:00PM | Arrival Time 12:15PM | Duration 20h15 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price $141 |
Operator FlixBus | Departure Time 04:15PM | Arrival Time 12:15PM | Duration 20h00 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price $141 |
Operator FlixBus | Departure Time 05:15PM | Arrival Time 03:05PM | Duration 21h50 | Departure days Everyday | Cheapest price $161 |
Operator FlixBus | Departure Time 05:30PM | Arrival Time 02:45PM | Duration 21h15 | Departure days Everyday | Cheapest price $132 |
Operator FlixBus | Departure Time 05:45PM | Arrival Time 02:45PM | Duration 21h00 | Departure days Everyday | Cheapest price $132 |
Operator RegioJet a.s. | Departure Time 06:30PM | Arrival Time 02:45PM | Duration 20h15 | Departure days Mon, Fri | Cheapest price $89 |
Operator FlixBus | Departure Time 06:45PM | Arrival Time 05:25PM | Duration 22h40 | Departure days Everyday | Cheapest price $144 |
Operator FlixBus | Departure Time 06:55PM | Arrival Time 06:45PM | Duration 23h50 | Departure days Fri | Cheapest price $177 |
Operator FlixBus | Departure Time 07:25PM | Arrival Time 06:45PM | Duration 23h20 | Departure days Mon, Tue, Wed, Thu, Sat | Cheapest price $144 |
Operator FlixBus | Departure Time 08:20PM | Arrival Time 05:50PM | Duration 21h30 | Departure days Sat, Sun | Cheapest price $173 |
Operator FlixBus | Departure Time 08:25PM | Arrival Time 06:45PM | Duration 22h20 | Departure days Sun | Cheapest price $165 |
Operator FlixBus | Departure Time 09:25PM | Arrival Time 05:50PM | Duration 20h25 | Departure days Everyday | Cheapest price $140 |
Operator FlixBus | Departure Time 09:50PM | Arrival Time 11:00PM | Duration 25h10 | Departure days Everyday | Cheapest price $137 |
Operator FlixBus | Departure Time 09:55PM | Arrival Time 08:35PM | Duration 22h40 | Departure days Everyday | Cheapest price $144 |
Operator FlixBus | Departure Time 10:25PM | Arrival Time 11:00PM | Duration 24h35 | Departure days Everyday | Cheapest price $137 |
Operator FlixBus | Departure Time 11:40PM | Arrival Time 11:00PM | Duration 23h20 | Departure days Mon, Tue, Wed, Fri, Sun | Cheapest price $137 |
Operator FlixBus | Departure Time 11:50PM | Arrival Time 09:50PM | Duration 22h00 | Departure days Everyday | Cheapest price $139 |
The table below shows live departures for Prague to Rome buses for today, Tuesday, August 25. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 11:40 PM Praha, ÚAN Florenc | 23h20 | 11:00 PM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus · FlixBus | 11:50 PM Prague, Central Train Station | 22h00 | 9:50 PM Roma, Autostazione Tiburtina | 2 transfers | |
| Wednesday, August 26 | |||||
FlixBus · FlixBus | 2:30 AM Prague, Central Train Station | 20h30 | 11:00 PM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus · FlixBus | 5:50 AM Prague, Central Train Station | 27h40 | 9:30 AM Roma, Autostazione Tiburtina | 2 transfers | |
FlixBus · FlixBus · FlixBus | 8:30 AM Praha, Roztyly | 25h00 | 9:30 AM Roma, Autostazione Tiburtina | 2 transfers | |
FlixBus · FlixBus · FlixBus | 9:00 AM Prague, Central Train Station | 21h10 | 6:10 AM Roma, Autostazione Tiburtina | 2 transfers | |
FlixBus · FlixBus · FlixBus | 9:40 AM Praha, Na Knížecí | 26h35 | 12:15 PM Roma, Autostazione (Metro Anagnina) | 2 transfers | |
FlixBus · FlixBus | 9:50 AM Praha, ÚAN Florenc | 23h30 | 9:20 AM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus | 10:05 AM Prague, Central Train Station | 23h15 | 9:20 AM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus · FlixBus | 10:55 AM Praha, Na Knížecí | 22h35 | 9:30 AM Roma, Autostazione Tiburtina | 2 transfers | |
FlixBus · FlixBus · FlixBus | 11:00 AM Praha, Roztyly | 27h45 | 2:45 PM Roma, Autostazione Tiburtina | 2 transfers | |
FlixBus · FlixBus · FlixBus | 12:50 PM Praha, M. Horákové (Hradčanská) | 26h15 | 3:05 PM Roma, Autostazione (Metro Anagnina) | 2 transfers | |
FlixBus · FlixBus | 12:50 PM Praha, ÚAN Florenc | 20h40 | 9:30 AM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus | 12:50 PM Praha, M. Horákové (Hradčanská) | 24h30 | 1:20 PM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus | 1:05 PM Prague, Central Train Station | 20h25 | 9:30 AM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus | 2:30 PM Praha, Černý Most | 22h50 | 1:20 PM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus · FlixBus | 2:30 PM Praha, Černý Most | 24h35 | 3:05 PM Roma, Autostazione (Metro Anagnina) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 3:05 PM Praha, Zličín | 22h15 | 1:20 PM Roma, Autostazione Tiburtina | 2 transfers | |
FlixBus · FlixBus · FlixBus | 4:00 PM Praha, ÚAN Florenc | 20h15 | 12:15 PM Roma, Autostazione (Metro Anagnina) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 4:15 PM Prague, Central Train Station | 20h00 | 12:15 PM Roma, Autostazione (Metro Anagnina) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 5:15 PM Praha, ÚAN Florenc | 21h50 | 3:05 PM Roma, Autostazione (Metro Anagnina) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 5:30 PM Prague, Central Train Station | 21h35 | 3:05 PM Roma, Autostazione (Metro Anagnina) | 2 transfers | |
FlixBus | 5:30 PM Praha, ÚAN Florenc | 21h15 | 2:45 PM Roma, Autostazione Tiburtina | 0 transfersDirect | |
FlixBus · FlixBus | 5:45 PM Praha, Na Knížecí | 19h35 | 1:20 PM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus | 5:45 PM Prague, Central Train Station | 24h05 | 5:50 PM Roma, Autostazione (Metro Anagnina) | 1 transfer | |
FlixBus · FlixBus · FlixBus | 5:45 PM Praha, Na Knížecí | 21h20 | 3:05 PM Roma, Autostazione (Metro Anagnina) | 2 transfers | |
FlixBus | 5:45 PM Prague, Central Train Station | 21h00 | 2:45 PM Roma, Autostazione Tiburtina | 0 transfersDirect | |
FlixBus · FlixBus | 6:45 PM Praha, Roztyly | 22h40 | 5:25 PM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus · FlixBus | 7:25 PM Praha, Zličín | 23h20 | 6:45 PM Roma, Autostazione Tiburtina | 2 transfers | |
FlixBus · FlixBus | 9:25 PM Praha, ÚAN Florenc | 20h25 | 5:50 PM Roma, Autostazione (Metro Anagnina) | 1 transfer | |
FlixBus · FlixBus | 9:25 PM Praha, ÚAN Florenc | 20h00 | 5:25 PM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus · FlixBus | 9:50 PM Praha, Na Knížecí | 25h10 | 11:00 PM Roma, Autostazione Tiburtina | 2 transfers | |
FlixBus · FlixBus | 9:55 PM Praha, ÚAN Florenc | 22h40 | 8:35 PM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus · FlixBus | 10:25 PM Praha, M. Horákové (Hradčanská) | 24h35 | 11:00 PM Roma, Autostazione Tiburtina | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Prague to Rome run on average 43 times per day, taking around 19h 29m. Cheap bus tickets for this journey start at $50 but you can travel from only $17 by train.
There are 2 buses per day. The earliest bus runs at 00:10, the last at 23:50. The fastest bus covers the 573 miles (923 km) distance in 16h 15m.
Distance 573 miles (923 km) |
Average bus duration 19h 29m |
Cheapest ticket price $50 |
Buses per day 43 |
Direct buses 2 |
Fastest bus 16h 15m |
First bus 12:10 AM |
Last bus 11:50 PM |
Cheapest Month Mar |
Cheapest Day Mon |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Wed |
Least Busy Day Fri |
Best time to book 42 days |
Discover the best of Rome — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Rome trip today.
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Outstanding ancient sculpture and mosaic museum housed in the Palazzo dei Conservatori and Palazzo Nuovo.
Celebrated villa museum with Bernini sculptures, Caravaggio paintings, and refined garden setting.
Elegant Baroque square with Bernini's fountains, lively atmosphere, and superb people-watching.
Historic square and gathering place at the Spanish Steps, ideal for classic city views and strolls.
Charming cobbled neighborhood filled with ivy-clad lanes, churches, nightlife, and local character.
Classic Roman pasta with guanciale, egg yolk, Pecorino Romano, and black pepper. A city icon known for rich flavor without cream.
Roman pasta with guanciale, tomato, and Pecorino Romano. A traditional Lazio staple tied to shepherd cooking and bold savory flavor.
Pasta with guanciale, Pecorino Romano, and black pepper. Considered one of Rome's oldest pasta dishes and prized for its simplicity.
Three-Michelin-star dining by Niko Romito at Bulgari Hotel Roma, offering refined Italian tasting menus in an elegant setting.
Historic trattoria in Testaccio known for classic Roman pasta and quinto quarto dishes in a lively, traditional setting.
Popular casual spot famed for Roman-style pizzas and fried starters. Bustling atmosphere and a long-standing local reputation.
Moderate for Europe: stays in central Rome are pricey, but transit is cheap and meals range from affordable pizza to costly tourist-area dining.
Service may be included via coperto or servizio. Round up or leave 5-10% at restaurants if service is good; round up in taxis; small change is fine at cafés.
Official public transport app
Via Marsala, Rome -> Piazza Barberini, Rome
Find answers to the most common questions about traveling from Prague to Rome by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

Most Prague to Rome buses use the Praha, Hlavní Nádraží to Roma, Autostazione Tiburtina station pair, with some services arriving at Roma, Autostazione (Metro Anagnina). Use this guide to compare Prague and Rome bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Praha, Hlavní Nádraží is 1 km from Prague city centre. Public transport options include:
Praha, Hlavní Nádraží has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Czech Bistro (in the station), Fast Food Express (in the station), Bohemian Café (0.2 km).
Free Wi-Fi. ATMs are located near the main entrance and ticketing area.
Ticket office support is available at Praha, Hlavní Nádraží.
Available at Praha, Hlavní Nádraží: Parking, Taxis, WC.
Accessibility facilities are available at Praha, Hlavní Nádraží: Elevators, ramps.
Praha, ÚAN Florenc is 1 km from Prague city centre. Public transport options include:
Praha, ÚAN Florenc has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Florenc (in the station), Bistro Florenc (0.2 km), Restaurace U Rozvařilů (0.5 km).
Free Wi-Fi. ATMs are located inside the station, offering multiple currency options.
Ticket office support is available at Praha, ÚAN Florenc.
Available at Praha, ÚAN Florenc: Parking, Taxis, WC.
Accessibility facilities are available at Praha, ÚAN Florenc: Elevators, ramps.
Praha, Na Knížecí is 2 km from Prague city centre. Public transport options include:
Praha, Na Knížecí has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, and WC.
Food options include: Café Na Knížecí (in the station), Bistro Praha (0.2 km), Restaurace U Knížete (0.5 km).
Free Wi-Fi. ATMs are located near the entrance.
Available at Praha, Na Knížecí: Parking, Taxis, WC.
Accessibility facilities are available at Praha, Na Knížecí: Elevators, ramps.
Roma, Autostazione Tiburtina is 4 km from Rome city centre. Public transport options include:
Roma, Autostazione Tiburtina has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Cafes and vending machines available.
Wi-Fi is available at Roma, Autostazione Tiburtina. ATMs are aTM available near ticket office.
Ticket office support is available at Roma, Autostazione Tiburtina.
Available at Roma, Autostazione Tiburtina: Parking, Taxis, WC.
Accessibility facilities are available at Roma, Autostazione Tiburtina: Wheelchair accessible entrances and facilities.
Here are some other resources that might have the information you need