The cheapest and fastest buses from St. Louis, MO to Pittsburgh, PA
Cheapest price
$112
Average price
$195
Fastest journey
12 h 55 m
Average duration
17 h 8 m
Buses per day
5
Distance
897 km
The best way to find a cheap bus ticket from St. Louis, MO to Pittsburgh, PA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Pittsburgh, PA will cost around $195 if you buy it on the day, but the cheapest tickets can be found for only $112.
Of the 5 buses that leave St. Louis, MO for Pittsburgh, PA on Sun, Mar 22, 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Mar 22 the direct buses cover the 897 km distance in an average of 17 h 8 m but if you time it right, some buses will get you there in just 12 h 55 m .
On Sun, Mar 22 the slowest buses will take 1 d 40 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.



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Compare train, bus, and flight for St. Louis, MO to Pittsburgh, PA
Omio recommends booking the bus as it is the most popular option from St. Louis, MO to Pittsburgh, PA among Omio's users. If you are prioritising price take the bus with prices starting from $67. For those with little time consider booking a flight which can get you there in 5h 42m. The ticket price range depends on the travel mode: a bus costs an average of $67, and a train costs an average of $92.
Distance: 557 miles (897 km)
Compare bus with
Most popular Bus | Train | Flight |
|---|---|---|
$88 Average price Cheapest | $338 Average price | $252 Average price |
14h 52m Average total duration 14h 22m Onboard + 30m Additional time* | 15h 29m Average total duration 14h 59m Onboard + 30m Additional time* | 8h 42m Average total duration Fastest 5h 42m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
St. Louis, MO to Pittsburgh, PA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 02:00AM | Arrival Time 05:40PM | Duration 14h40 | Departure days Sun | Cheapest price $164 |
Operator Greyhound | Departure Time 08:45AM | Arrival Time 12:20AM | Duration 14h35 | Departure days Sun | Cheapest price $169 |
Operator Greyhound | Departure Time 01:55PM | Arrival Time 03:50AM | Duration 12h55 | Departure days Sun | Cheapest price $112 |
Operator Greyhound | Departure Time 04:00PM | Arrival Time 05:40PM | Duration 24h40 | Departure days Sun | Cheapest price $320 |
Operator Greyhound | Departure Time 11:30PM | Arrival Time 07:20PM | Duration 18h50 | Departure days Sun | Cheapest price $210 |
Live departures
St. Louis, MO to Pittsburgh, PA bus times
The table below shows live departures for St. Louis, MO to Pittsburgh, PA buses for tomorrow, Saturday, March 21. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 7:00 AM St. Louis, S 15th St (Civic center) | 14h40 | 9:40 PM Pittsburgh, Greyhound Bus Station, PA | 0 transfersDirect | |
![]() | 1:45 PM St. Louis, S 15th St (Civic center) | 14h35 | 4:20 AM Pittsburgh, Greyhound Bus Station, PA | 0 transfersDirect | |
![]() | 6:55 PM St. Louis, S 15th St (Civic center) | 12h55 | 7:50 AM Pittsburgh, Greyhound Bus Station, PA | 0 transfersDirect | |
FlixBus+ undefined · undefined | 9:00 PM St. Louis, S 15th St (Civic center) | 24h40 | 9:40 PM Pittsburgh, Greyhound Bus Station, PA | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets St. Louis, MO to Pittsburgh, PA by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 22
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Mar 28
Why should you book St. Louis, MO to Pittsburgh, PA buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from St. Louis, MO to Pittsburgh, PA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from St. Louis, MO to Pittsburgh, PA.
Journey information
Overview: Bus from St. Louis, MO to Pittsburgh, PA
Buses from St. Louis, MO to Pittsburgh, PA run on average 4 times per day, taking around 14h 22m. Cheap bus tickets for this journey start at $67 (€54) if you book in advance.
There are 3 buses per day. The earliest bus runs at 01:15, the last at 23:30. The fastest bus covers the 557 miles (897 km) distance in 12h 55m.
Distance 557 miles (897 km) |
Average bus duration 14h 22m |
Cheapest ticket price $67 (€54) |
Buses per day 4 |
Direct buses 3 |
Fastest bus 12h 55m |
First bus 01:15 |
Last bus 23:30 |
Cheapest month Sep |
Cheapest day Mon |
High season Oct - Dec |
Low season Jan - Mar |
Busiest day Mon |
Least busy day Mon |
Best day to book ahead 3 days |
Bus providers: Greyhound from St. Louis, MO to Pittsburgh, PAYou can travel by bus between St. Louis, MO to Pittsburgh, PA with Greyhound for as low as $67 (€54). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from St. Louis, MO to Pittsburgh, PA
Find answers to the most common questions about traveling from St. Louis, MO to Pittsburgh, PA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Pittsburgh, PA, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- The Andy Warhol Museum, a comprehensive collection dedicated to the life and works of the iconic pop artist
- Phipps Conservatory and Botanical Gardens, a historic greenhouse with diverse plant exhibits and sustainable architecture
- Carnegie Museum of Natural History, featuring extensive dinosaur displays and global cultural artifacts
- Point State Park, a scenic urban park at the confluence of three rivers with historical significance
- Mount Washington, offering panoramic views of Pittsburgh's skyline from its renowned overlooks.
- Heinz History Center, an affiliate of the Smithsonian Institution showcasing Western Pennsylvania's history and heritage
- Take a ride on the Duquesne Incline for a historic cable car experience and stunning city views
- Explore the Strip District, known for its vibrant markets, eateries, and unique shops
- Visit the National Aviary, home to a diverse collection of birds from around the world
- Enjoy a Pittsburgh Pirates game at PNC Park, renowned for its beautiful views of the city skyline.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from St. Louis, MO to Pittsburgh, PA
Most popular bus connections from St. Louis, MO
More options for your journey from St. Louis, MO to Pittsburgh, PA
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