The cheapest and fastest buses from Pittsburgh, PA to St. Louis, MO
Cheapest price
$106
Average price
$106
Fastest journey
12 h 55 m
Average duration
12 h 55 m
Buses per day
2
Distance
897 km
The best way to find a cheap bus ticket from Pittsburgh, PA to St. Louis, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Pittsburgh, PA to St. Louis, MO will cost around $106 if you buy it on the day, but the cheapest tickets can be found for only $106.
Of the 2 buses that leave Pittsburgh, PA for St. Louis, MO on Wed, Mar 11, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Mar 11 the direct buses cover the 897 km distance in an average of 12 h 55 m but if you time it right, some buses will get you there in just 12 h 55 m .
On Wed, Mar 11 the slowest buses will take 12 h 55 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Travel Information
Compare train, bus, and flight for Pittsburgh, PA to St. Louis, MO
Omio recommends booking the bus as it is the most popular option from Pittsburgh, PA to St. Louis, MO among Omio's users. If you are prioritising price take the bus with prices starting from $72. For those with little time consider booking a flight which can get you there in 6h 20m. The ticket price range depends on the travel mode: a bus costs an average of $72, and a flight costs an average of $104.
Distance: 557 miles (897 km)
Compare bus with
Most popular Bus | Train | Flight |
|---|---|---|
$95 Average price Cheapest | $190 Average price | $211 Average price |
14h 28m Average total duration 13h 58m Onboard + 30m Additional time* | 15h 29m Average total duration 14h 59m Onboard + 30m Additional time* | 9h 20m Average total duration Fastest 6h 20m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
Pittsburgh, PA to St. Louis, MO bus times
The table below shows live departures for Pittsburgh, PA to St. Louis, MO buses for tomorrow, Wednesday, March 11. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 1:00 AM Pittsburgh, PA | 12h55 | 1:55 PM St. Louis, MO | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Pittsburgh, PA to St. Louis, MO by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 11
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Mar 17
Why should you book Pittsburgh, PA to St. Louis, MO buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Pittsburgh, PA to St. Louis, MO.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Pittsburgh, PA to St. Louis, MO.
Journey information
Overview: Bus from Pittsburgh, PA to St. Louis, MO
Buses from Pittsburgh, PA to St. Louis, MO run on average 3 times per day, taking around 13h 58m. Cheap bus tickets for this journey start at $72 (€58) if you book in advance.
There are 3 buses per day. The earliest bus runs at 01:35, the last at 23:30. The fastest bus covers the 557 miles (897 km) distance in 12h 55m.
Distance 557 miles (897 km) |
Average bus duration 13h 58m |
Cheapest ticket price $72 (€58) |
Buses per day 3 |
Direct buses 3 |
Fastest bus 12h 55m |
First bus 01:35 |
Last bus 23:30 |
Bus providers: Greyhound from Pittsburgh, PA to St. Louis, MOYou can travel by bus between Pittsburgh, PA to St. Louis, MO with Greyhound for as low as $72 (€58). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Pittsburgh, PA to St. Louis, MO
Find answers to the most common questions about traveling from Pittsburgh, PA to St. Louis, MO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Pittsburgh, PA to St. Louis, MO
Most popular bus connections from Pittsburgh, PA
More options for your journey from Pittsburgh, PA to St. Louis, MO
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