- Must visit
Musée des Beaux-Arts de Lyon
Major fine arts museum in a former abbey, with strong collections from antiquity to modern art. A core cultural stop in Lyon.








Cheapest price
$84
Average price
$116
Fastest journey
15h 10m
Average duration
16h 8m
Buses per day
8
Distance
757 km
Omio recommends booking the bus as it is the most popular option from Rome to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $22. For those with little time consider booking a flight which can get you there in 4h 7m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.7 - 1.9kg. The ticket price range depends on the travel mode: a bus costs an average of $22, and a flight costs an average of $76.
Distance: 464 miles (747 km)
Most popular Bus | Flight | Train | Driving |
|---|---|---|---|
$54 Average price Cheapest | $195 Average price | $161 Average price | $390 Average price (fuel + tolls) |
13h 0m Average total duration 12h 30m Onboard + 30m Additional time* | 7h 7m Average total duration Fastest 4h 7m Onboard + 3h 0m Additional time* | 9h 46m Average total duration 9h 16m Onboard + 30m Additional time* | 9h 55m Average total duration (door-to-door) |
0.7 - 1.9kg CO2 emissions Lowest | 2.2 - 4.5kg CO2 emissions | - CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Rome to Lyon:
A bus is $107 (€88) less than a train for this route with tickets for a train from Rome to Lyon costing on average $161 (€133).
A bus is $142 (€117) less than a flight for this route with tickets for a flight from Rome to Lyon costing on average $195 (€161).
Other travel options to Lyon take longer:
Train takes on average 9h 16m.
Bus takes on average 12h 30m.
Tickets start at around $54 (€44) compared to roughly $390 (€322) in fuel and tolls — a saving of about $337 (€278). The journey takes 12h 30m versus 9h 55m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by Itabus, FlixBus, BlaBlaCar Bus, BlaBlaCar, Infobus.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 01:20AM | Arrival Time 06:10PM | Duration 16h50 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $84 |
Operator FlixBus | Departure Time 01:30AM | Arrival Time 07:35PM | Duration 18h05 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $98 |
Operator Itabus | Departure Time 07:00AM | Arrival Time 09:30PM | Duration 14h30 | Departure days Wed, Thu, Fri, Sat, Sun | Cheapest price $61 |
Operator FlixBus | Departure Time 07:45AM | Arrival Time 10:40PM | Duration 14h55 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $86 |
Operator Itabus | Departure Time 08:00AM | Arrival Time 12:25AM | Duration 16h25 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $54 |
Operator FlixBus | Departure Time 08:50AM | Arrival Time 11:45PM | Duration 14h55 | Departure days Everyday | Cheapest price $93 |
Operator BlaBlaCar | Departure Time 10:40AM | Arrival Time 09:20PM | Duration 10h40 | Departure days Mon | Cheapest price $97 |
Operator FlixBus | Departure Time 11:00AM | Arrival Time 03:55AM | Duration 16h55 | Departure days Fri | Cheapest price $99 |
Operator FlixBus | Departure Time 12:10PM | Arrival Time 04:50AM | Duration 16h40 | Departure days Sat, Sun | Cheapest price $116 |
Operator FlixBus | Departure Time 12:20PM | Arrival Time 06:30AM | Duration 18h10 | Departure days Mon, Wed, Thu, Fri | Cheapest price $107 |
Operator RegioJet a.s. | Departure Time 01:00PM | Arrival Time 02:50PM | Duration 49h50 | Departure days Wed | Cheapest price $182 |
Operator Itabus | Departure Time 01:00PM | Arrival Time 04:55AM | Duration 15h55 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $55 |
Operator FlixBus | Departure Time 01:05PM | Arrival Time 03:55AM | Duration 14h50 | Departure days Everyday | Cheapest price $80 |
Operator FlixBus | Departure Time 02:45PM | Arrival Time 06:30AM | Duration 15h45 | Departure days Sat, Sun | Cheapest price $119 |
Operator BlaBlaCar Bus | Departure Time 03:20PM | Arrival Time 06:05AM | Duration 14h45 | Departure days Everyday | Cheapest price $73 |
Operator FlixBus | Departure Time 05:05PM | Arrival Time 08:45AM | Duration 15h40 | Departure days Everyday | Cheapest price $100 |
Operator FlixBus | Departure Time 05:25PM | Arrival Time 08:45AM | Duration 15h20 | Departure days Everyday | Cheapest price $81 |
Operator FlixBus | Departure Time 08:00PM | Arrival Time 12:00PM | Duration 16h00 | Departure days Everyday | Cheapest price $97 |
Operator Itabus | Departure Time 09:45PM | Arrival Time 12:55PM | Duration 15h10 | Departure days Everyday | Cheapest price $49 |
Operator FlixBus | Departure Time 09:55PM | Arrival Time 02:10PM | Duration 16h15 | Departure days Everyday | Cheapest price $84 |
Operator FlixBus | Departure Time 10:45PM | Arrival Time 03:05PM | Duration 16h20 | Departure days Everyday | Cheapest price $98 |
Operator FlixBus | Departure Time 11:35PM | Arrival Time 03:05PM | Duration 15h30 | Departure days Everyday | Cheapest price $105 |
Operator FlixBus | Departure Time 11:50PM | Arrival Time 06:40PM | Duration 18h50 | Departure days Everyday | Cheapest price $120 |
The table below shows live departures for Rome to Lyon buses for today, Tuesday, July 14. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 5:05 PM Roma, Autostazione Tiburtina | 15h40 | 8:45 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus | 5:25 PM Roma, Autostazione (Metro Anagnina) | 15h20 | 8:45 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
FlixBus · FlixBus | 8:00 PM Roma, Autostazione Tiburtina | 16h00 | 12:00 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
3898 | 9:45 PM Roma, Autostazione Tiburtina | 15h10 | 12:55 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
FlixBus · FlixBus | 9:55 PM Roma, Autostazione Tiburtina | 16h15 | 2:10 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus | 10:45 PM Roma, Autostazione Tiburtina | 16h20 | 3:05 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus · FlixBus | 11:35 PM Roma, Autostazione (Metro Anagnina) | 15h30 | 3:05 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 2 transfers | |
FlixBus · FlixBus | 11:50 PM Roma, Autostazione Tiburtina | 18h50 | 6:40 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
| Wednesday, July 15 | |||||
FlixBus · FlixBus | 1:20 AM Roma, Autostazione Tiburtina | 16h50 | 6:10 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
3492 | 7:00 AM Roma, Autostazione Tiburtina | 14h30 | 9:30 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
2126 · 3092 | 8:00 AM Roma, Autostazione Tiburtina | 16h25 | 12:25 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus | 8:50 AM Roma, Autostazione Tiburtina | 14h55 | 11:45 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
FlixBus · FlixBus | 12:20 PM Roma, Autostazione Tiburtina | 18h10 | 6:30 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
(Rome -> Prague) · (Vienna -> Prague) · (Prague -> Lyon) | 1:00 PM Roma, Autostazione Tiburtina | 49h50 | 2:50 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 2 transfers | |
FlixBus · FlixBus | 1:05 PM Roma, Autostazione (Metro Anagnina) | 14h50 | 3:55 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
4788 | 3:20 PM Roma, Autostazione Tiburtina | 14h45 | 6:05 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus, flight, and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Rome to Lyon run on average 14 times per day, taking around 12h 30m. Cheap bus tickets for this journey start at $22 (€18) if you book in advance.
There are 5 buses per day. The earliest bus runs at 00:04, the last at 23:50. The fastest bus covers the 464 miles (747 km) distance in 14h 30m.
Distance 464 miles (747 km) |
Average bus duration 12h 30m |
Cheapest ticket price $22 (€18) |
Buses per day 14 |
Direct buses 5 |
Fastest bus 14h 30m |
First bus 12:04 AM |
Last bus 11:50 PM |
Cheapest Month Feb |
Cheapest Day Sat |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Tue |
Least Busy Day Sun |
Best time to book 49 days |
Discover the best of Lyon — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Lyon trip today.
Major fine arts museum in a former abbey, with strong collections from antiquity to modern art. A core cultural stop in Lyon.
Museum of cinema miniatures and film props in Vieux Lyon. Popular for detailed sets, special-effects history, and family-friendly exhibits.
Excellent free natural history and ethnography museum with fossils, animals, and global cultures. A strong local favorite, especially for families.
Renaissance quarter with cobbled lanes, traboules, courtyards, and major monuments. Essential for atmosphere, history, and walking exploration.
Central peninsula between the Rhône and Saône, packed with elegant streets, squares, shopping, and many of Lyon’s classic city views.
Historic silk-workers’ hill district with stairways, murals, markets, and hidden passageways. Great for local character and city panoramas.
Pike dumplings in a rich crayfish sauce. A Lyon classic from traditional bouchons, prized for its delicate fish texture and luxurious sauce.
Crisp salad of frisée, bacon lardons, croutons, and a poached egg. A staple Lyonnaise bistro dish that reflects the city's hearty cooking style.
Slow-cooked onions with vinegar, often served warm or chilled. This old Lyonnais side dish is traditional in bouchons and pairs well with charcuterie.
Refined dining by Paul Bocuse, known for polished French cuisine and iconic Lyon dishes in an elegant, historic dining room.
Well-known traditional bouchon in Vieux Lyon, praised for generous Lyonnais specialties and a lively old-city atmosphere.
Historic bouchon near Place Bellecour serving quenelles, salade lyonnaise, and classic regional fare in a warm traditional setting.
Moderate for Western Europe: hotels and dining are mid-priced, while public transport is good value for visitors.
Service is usually included. Round up or leave 5-10% for great restaurant service. Round up taxi fares; small change is fine in cafes.
Find answers to the most common questions about traveling from Rome to Lyon by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

Most Rome to Lyon buses use the Roma, Autostazione Tiburtina to Lyon, Gare Routière de Perrache station pair, with some services arriving at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan). Use this guide to compare Rome and Lyon bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Lyon, Gare Routière de Perrache is 1 km from Lyon city centre. Public transport options include:
Lyon, Gare Routière de Perrache has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Café de la Gare (in the station), Le Bistrot de Lyon (0.5 km), Brasserie Georges (0.6 km).
Free Wi-Fi. ATMs are located near the main entrance.
Ticket office support is available at Lyon, Gare Routière de Perrache.
Available at Lyon, Gare Routière de Perrache: Parking, Taxis, WC.
Accessibility facilities are available at Lyon, Gare Routière de Perrache: Elevators, ramps.
Lyon, Gare Perrache is 1 km from Lyon city centre. Public transport options include:
Lyon, Gare Perrache has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Café de la Gare (in the station), Bistro Lyonnais (0.2 km), Fast Food Express (0.3 km).
Free Wi-Fi. ATMs are located near the main entrance and in the shopping area.
Ticket office support is available at Lyon, Gare Perrache.
Available at Lyon, Gare Perrache: Parking, Taxis, WC.
Accessibility facilities are available at Lyon, Gare Perrache: Elevators, ramps.
Here are some other resources that might have the information you need