The cheapest and fastest buses from Prague to Lyon
Cheapest price
$99
Average price
$119
Fastest journey
14 h 40 m
Average duration
16 h 3 m
Buses per day
14
Distance
860 km
The best way to find a cheap bus ticket from Prague to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Prague to Lyon will cost around $119 if you buy it on the day, but the cheapest tickets can be found for only $99.
Of the 14 buses that leave Prague for Lyon on Fri, Mar 06, 7 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Mar 06 the direct buses cover the 860 km distance in an average of 16 h 3 m but if you time it right, some buses will get you there in just 14 h 40 m .
On Fri, Mar 06 the slowest buses will take 17 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus
FlixBus
FlixBus
FlixBus
FlixBus
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FlixBus
FlixBus
FlixBus
FlixBusTravel Information
Compare train, bus, and flight for Prague to Lyon
Omio recommends booking the flight as it is the most popular option from Prague to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $57. For those with little time consider booking a flight which can get you there in 2h 42m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.9 - 2.1kg. The ticket price range depends on the travel mode: a bus costs an average of $57, and a train costs an average of $274.
Distance: 534 miles (860 km)
Compare bus with
| Bus | Most popular Flight | Train |
|---|---|---|
$85 Average price Cheapest | $187 Average price | $310 Average price |
17h 2m Average total duration 16h 32m Onboard + 30m Additional time* | 5h 42m Average total duration Fastest 2h 42m Onboard + 3h 0m Additional time* | 14h 30m Average total duration 14h 0m Onboard + 30m Additional time* |
0.9 - 2.1kg CO2 emissions Lowest | 2.6 - 5.2kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Prague to Lyon Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 03:50AM | Arrival Time 11:15PM | Duration 19h25 | Departure days Mon, Fri, Sun | Cheapest price $94 |
Operator FlixBus | Departure Time 04:00AM | Arrival Time 04:45AM | Duration 24h45 | Departure days Tue | Cheapest price $88 |
Operator FlixBus | Departure Time 04:10AM | Arrival Time 11:15PM | Duration 19h05 | Departure days Mon, Fri, Sun | Cheapest price $94 |
Operator FlixBus | Departure Time 06:40AM | Arrival Time 11:15PM | Duration 16h35 | Departure days Mon, Fri, Sun | Cheapest price $87 |
Operator FlixBus | Departure Time 07:55AM | Arrival Time 04:45AM | Duration 20h50 | Departure days Tue, Wed | Cheapest price $88 |
Operator FlixBus | Departure Time 08:55AM | Arrival Time 12:00PM | Duration 27h05 | Departure days Tue | Cheapest price $89 |
Operator FlixBus | Departure Time 09:00AM | Arrival Time 04:35AM | Duration 19h35 | Departure days Mon, Fri, Sun | Cheapest price $92 |
Operator FlixBus | Departure Time 09:10AM | Arrival Time 04:45AM | Duration 19h35 | Departure days Mon, Fri, Sun | Cheapest price $96 |
Operator FlixBus | Departure Time 09:40AM | Arrival Time 09:05AM | Duration 23h25 | Departure days Mon | Cheapest price $92 |
Operator FlixBus | Departure Time 10:55AM | Arrival Time 10:30AM | Duration 23h35 | Departure days Mon | Cheapest price $100 |
Operator FlixBus | Departure Time 12:50PM | Arrival Time 10:30AM | Duration 21h40 | Departure days Mon | Cheapest price $94 |
Operator FlixBus | Departure Time 12:55PM | Arrival Time 08:15AM | Duration 19h20 | Departure days Wed, Thu, Sun | Cheapest price $82 |
Operator FlixBus | Departure Time 01:05PM | Arrival Time 08:15AM | Duration 19h10 | Departure days Wed, Thu, Fri, Sun | Cheapest price $84 |
Operator FlixBus | Departure Time 02:30PM | Arrival Time 08:15AM | Duration 17h45 | Departure days Wed, Thu, Fri, Sun | Cheapest price $79 |
Operator FlixBus | Departure Time 03:10PM | Arrival Time 08:15AM | Duration 17h05 | Departure days Wed, Thu, Fri, Sun | Cheapest price $79 |
Operator FlixBus | Departure Time 04:00PM | Arrival Time 09:05AM | Duration 17h05 | Departure days Mon, Thu, Fri, Sun | Cheapest price $87 |
Operator FlixBus | Departure Time 04:15PM | Arrival Time 09:05AM | Duration 16h50 | Departure days Mon, Thu, Fri, Sun | Cheapest price $87 |
Operator FlixBus | Departure Time 05:30PM | Arrival Time 02:00PM | Duration 20h30 | Departure days Wed | Cheapest price $80 |
Operator FlixBus | Departure Time 05:35PM | Arrival Time 04:25PM | Duration 22h50 | Departure days Tue | Cheapest price $88 |
Operator FlixBus | Departure Time 05:45PM | Arrival Time 02:45PM | Duration 21h00 | Departure days Mon | Cheapest price $93 |
Operator BlaBlaCar Bus | Departure Time 07:00PM | Arrival Time 06:50PM | Duration 23h50 | Departure days Thu, Sun | Cheapest price $94 |
Operator FlixBus | Departure Time 07:25PM | Arrival Time 09:10PM | Duration 25h45 | Departure days Tue | Cheapest price $109 |
Operator FlixBus | Departure Time 07:30PM | Arrival Time 02:45PM | Duration 19h15 | Departure days Mon, Tue | Cheapest price $92 |
Operator FlixBus | Departure Time 08:20PM | Arrival Time 09:10PM | Duration 24h50 | Departure days Tue | Cheapest price $107 |
Operator FlixBus | Departure Time 09:25PM | Arrival Time 12:30PM | Duration 15h05 | Departure days Wed, Thu, Fri, Sun | Cheapest price $77 |
Operator FlixBus | Departure Time 09:50PM | Arrival Time 12:30PM | Duration 14h40 | Departure days Wed, Thu, Fri, Sun | Cheapest price $77 |
Operator Regiojet | Departure Time 11:00PM | Arrival Time 02:50PM | Duration 15h50 | Departure days Thu | Cheapest price $85 |
Operator FlixBus | Departure Time 11:50PM | Arrival Time 08:35PM | Duration 20h45 | Departure days Wed, Thu, Fri, Sun | Cheapest price $80 |
Live departures
Prague to Lyon bus times
The table below shows live departures for Prague to Lyon buses for today, Thursday, March 5. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus | 8:50 PM Praha, Na Knížecí | 14h40 | 11:30 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 0 transfersDirect | |
(Prague -> Lyon) | 10:00 PM Praha, ÚAN Florenc | 15h50 | 1:50 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 0 transfersDirect | |
FlixBus · FlixBus | 10:50 PM Prague, Central Train Station | 20h45 | 7:35 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 1 transfer | |
| Friday, March 6 | |||||
FlixBus · FlixBus | 2:50 AM Prague, Central Train Station | 19h25 | 10:15 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 1 transfer | |
FlixBus · FlixBus | 3:10 AM Praha, Na Knížecí | 19h05 | 10:15 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 1 transfer | |
FlixBus | 5:40 AM Praha, ÚAN Florenc | 16h35 | 10:15 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 0 transfersDirect | |
FlixBus · FlixBus | 8:00 AM Prague, Central Train Station | 19h35 | 3:35 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 1 transfer | |
FlixBus · FlixBus | 8:10 AM Praha, Na Knížecí | 19h35 | 3:45 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 1 transfer | |
FlixBus · FlixBus | 12:05 PM Praha, Zličín | 19h10 | 7:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 1 transfer | |
FlixBus · FlixBus | 12:05 PM Prague, Central Train Station | 19h10 | 7:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 1 transfer | |
FlixBus | 1:30 PM Praha, Černý Most | 17h45 | 7:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 0 transfersDirect | |
FlixBus | 2:10 PM Praha, ÚAN Florenc | 17h05 | 7:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 0 transfersDirect | |
FlixBus | 3:00 PM Praha, ÚAN Florenc | 17h05 | 8:05 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 0 transfersDirect | |
FlixBus | 3:15 PM Prague, Central Train Station | 16h50 | 8:05 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 0 transfersDirect | |
FlixBus | 8:25 PM Praha, ÚAN Florenc | 15h05 | 11:30 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan) | 0 transfersDirect | |
Find all the dates and times for this journey
Compare prices and tickets Prague to Lyon by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Prague to Lyon buses with Omio?
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of BlaBlaCar Bus to find the best option for your trip from Prague to Lyon.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Prague to Lyon.
Why book with Omio over Wanderu, Trainline or Checkmybus?
- Compare with other providers: On Omio, you can also compare tickets for the likes of BlaBlaCar Bus to find the best option for your trip from Prague to Lyon.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Prague to Lyon.
Journey information
Overview: Bus from Prague to Lyon
Buses from Prague to Lyon run on average 12 times per day, taking around 16h 32m. Cheap bus tickets for this journey start at $57 (€46) but you can travel from only $52 (€42) by flight.
There are 6 buses per day. The earliest bus runs at 00:10, the last at 23:55. The fastest bus covers the 534 miles (860 km) distance in 14h 35m.
Distance 534 miles (860 km) |
Average bus duration 16h 32m |
Cheapest ticket price $57 (€46) |
Buses per day 12 |
Direct buses 6 |
Fastest bus 14h 35m |
First bus 00:10 |
Last bus 23:55 |
Cheapest month Apr |
Cheapest day Wed |
High season Oct - Dec |
Low season Apr - Jun |
Busiest day Wed |
Least busy day Fri |
Best day to book ahead 63 days |
Bus providers: FlixBus, BlaBlaCar Bus from Prague to LyonYou can travel by bus between Prague to Lyon with FlixBus, BlaBlaCar Bus for as low as $52 (€42). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
BlaBlaCar Bus
FAQs: Bus from Prague to Lyon
Find answers to the most common questions about traveling from Prague to Lyon by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

- BlaBlaCar Bus
- Assistance
- Priority boarding
- Accessible seating options.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Basilica of Notre-Dame de Fourvière, a stunning 19th-century basilica offering panoramic views of the city
- Vieux Lyon, a UNESCO World Heritage site known for its Renaissance architecture and narrow cobblestone streets
- Parc de la Tête d'Or, a large urban park featuring a zoo, botanical garden, and lake
- Musée des Confluences, a modern science and anthropology museum with innovative exhibits
- Place Bellecour, one of Europe's largest open squares, ideal for shopping and dining.
- Les Halles de Lyon Paul Bocuse, a renowned indoor market offering gourmet food and local specialties
- Take a river cruise on the Rhône and Saône for a unique view of the city
- Explore the traboules, secret passageways in Vieux Lyon
- Attend a performance at the Opéra de Lyon, known for its diverse program
- Visit the Institut Lumière, dedicated to the history of cinema.
- BlaBlaCar Bus
- You can cancel your ticket up to 30 minutes before departure for a refund in the form of a voucher.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- BlaBlaCar Bus
- One carry-on bag up to 7kg and one checked bag up to 20kg.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- BlaBlaCar Bus
- Additional luggage can be purchased for a fee.
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Prague to Lyon
- 06:00-23:00
- Free Wi-Fi
- Cafeteria Florenc (in the station)
- Bistro Florenc (0.2 km)
- Restaurace U Rozvařilů (0.5 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 133, 135, 175, 207 Metro: B, C
- 00:00-23:59
- Free Wi-Fi
- Czech Bistro (in the station)
- Fast Food Express (in the station)
- Bohemian Café (0.2 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 135, 175, 207 Metro: C Train: All major s
- Free Wi-Fi
- Café Na Knížecí (in the station)
- Bistro Praha (0.2 km)
- Restaurace U Knížete (0.5 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 137, 176, 191 Metro: B
- 06:00-23:00
- Free Wi-Fi
- Café de la Gare (in the station)
- Le Bistrot de Lyon (0.5 km)
- Brasserie Georges (0.6 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: C19, C20, 31, 46, 49, 55, 60, S1 Metro: A Tram: T1, T2
More options for your journey from Prague to Lyon
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