- Must visit
Musée des Beaux-Arts de Lyon
Major fine arts museum in a former abbey, with strong collections from antiquity to modern art. A core cultural stop in Lyon.







Cheapest price
$94
Average price
$114
Fastest journey
14h 50m
Average duration
17h 39m
Buses per day
7
Distance
863 km
Omio recommends booking the flight as it is the most popular option from Prague to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $58. For those with little time consider booking a flight which can get you there in 2h 43m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.9 - 2.1kg. The ticket price range depends on the travel mode: a bus costs an average of $58, and a train costs an average of $283.
Distance: 534 miles (860 km)
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$86 Average price Cheapest | $204 Average price | $308 Average price | $264 Average price (fuel + tolls) |
17h 2m Average total duration 16h 32m Onboard + 30m Additional time* | 5h 43m Average total duration Fastest 2h 43m Onboard + 3h 0m Additional time* | 14h 30m Average total duration 14h 0m Onboard + 30m Additional time* | 9h 53m Average total duration (door-to-door) |
0.9 - 2.1kg CO2 emissions Lowest | 2.6 - 5.2kg CO2 emissions | - CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Prague to Lyon:
A bus is $118 (€97) less than a flight for this route with tickets for a flight from Prague to Lyon costing on average $204 (€167).
A bus is $222 (€182) less than a train for this route with tickets for a train from Prague to Lyon costing on average $308 (€252).
Other travel options to Lyon take longer:
Train takes on average 14h 0m.
Bus takes on average 16h 32m.
Tickets start at around $86 (€70) compared to roughly $264 (€216) in fuel and tolls — a saving of about $178 (€146). The journey takes 16h 32m versus 9h 53m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus, BlaBlaCar Bus.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 02:30AM | Arrival Time 09:40PM | Duration 19h10 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $84 |
Operator FlixBus | Departure Time 03:25AM | Arrival Time 11:15PM | Duration 19h50 | Departure days Everyday | Cheapest price $84 |
Operator FlixBus | Departure Time 03:40AM | Arrival Time 11:15PM | Duration 19h35 | Departure days Everyday | Cheapest price $84 |
Operator FlixBus | Departure Time 06:40AM | Arrival Time 11:15PM | Duration 16h35 | Departure days Everyday | Cheapest price $80 |
Operator FlixBus | Departure Time 09:00AM | Arrival Time 04:20AM | Duration 19h20 | Departure days Tue, Wed, Sun | Cheapest price $118 |
Operator FlixBus | Departure Time 09:10AM | Arrival Time 05:05AM | Duration 19h55 | Departure days Fri | Cheapest price $84 |
Operator FlixBus | Departure Time 09:40AM | Arrival Time 04:20AM | Duration 18h40 | Departure days Everyday | Cheapest price $107 |
Operator FlixBus | Departure Time 10:55AM | Arrival Time 08:15AM | Duration 21h20 | Departure days Everyday | Cheapest price $96 |
Operator FlixBus | Departure Time 11:15AM | Arrival Time 04:20AM | Duration 17h05 | Departure days Mon, Thu, Fri, Sat | Cheapest price $87 |
Operator FlixBus | Departure Time 12:55PM | Arrival Time 08:15AM | Duration 19h20 | Departure days Sun | Cheapest price $149 |
Operator FlixBus | Departure Time 01:05PM | Arrival Time 08:15AM | Duration 19h10 | Departure days Everyday | Cheapest price $103 |
Operator FlixBus | Departure Time 02:30PM | Arrival Time 08:15AM | Duration 17h45 | Departure days Everyday | Cheapest price $85 |
Operator FlixBus | Departure Time 03:05PM | Arrival Time 08:15AM | Duration 17h10 | Departure days Mon, Tue, Wed, Thu, Sat | Cheapest price $89 |
Operator FlixBus | Departure Time 03:10PM | Arrival Time 08:15AM | Duration 17h05 | Departure days Everyday | Cheapest price $85 |
Operator FlixBus | Departure Time 04:00PM | Arrival Time 09:05AM | Duration 17h05 | Departure days Everyday | Cheapest price $80 |
Operator FlixBus | Departure Time 04:15PM | Arrival Time 09:05AM | Duration 16h50 | Departure days Everyday | Cheapest price $80 |
Operator BlaBlaCar Bus | Departure Time 07:00PM | Arrival Time 04:25PM | Duration 21h25 | Departure days Thu, Sun | Cheapest price $94 |
Operator FlixBus | Departure Time 09:25PM | Arrival Time 12:40PM | Duration 15h15 | Departure days Everyday | Cheapest price $91 |
Operator FlixBus | Departure Time 09:50PM | Arrival Time 12:40PM | Duration 14h50 | Departure days Everyday | Cheapest price $91 |
Operator RegioJet a.s. | Departure Time 11:00PM | Arrival Time 02:50PM | Duration 15h50 | Departure days Thu | Cheapest price $85 |
Operator FlixBus | Departure Time 11:50PM | Arrival Time 08:50PM | Duration 21h00 | Departure days Everyday | Cheapest price $83 |
The table below shows live departures for Prague to Lyon buses for today, Sunday, July 19. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus | 3:10 PM Praha, ÚAN Florenc | 17h05 | 8:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
FlixBus | 4:00 PM Praha, ÚAN Florenc | 17h05 | 9:05 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
FlixBus | 4:15 PM Prague, Central Train Station | 16h50 | 9:05 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
30513 · 51708 | 7:00 PM Praha, ÚAN Florenc | 21h25 | 4:25 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus | 9:25 PM Praha, ÚAN Florenc | 15h15 | 12:40 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
FlixBus | 9:50 PM Praha, Na Knížecí | 14h50 | 12:40 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
FlixBus · FlixBus | 11:50 PM Prague, Central Train Station | 21h00 | 8:50 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
| Monday, July 20 | |||||
FlixBus · FlixBus · FlixBus | 2:30 AM Prague, Central Train Station | 19h10 | 9:40 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 2 transfers | |
FlixBus · FlixBus | 3:25 AM Prague, Central Train Station | 19h50 | 11:15 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus | 3:40 AM Praha, Na Knížecí | 19h35 | 11:15 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus | 6:40 AM Praha, ÚAN Florenc | 16h35 | 11:15 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
FlixBus · FlixBus | 9:40 AM Praha, Na Knížecí | 18h40 | 4:20 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus | 10:55 AM Praha, Na Knížecí | 21h20 | 8:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus · FlixBus | 11:15 AM Prague, Central Train Station | 17h05 | 4:20 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 2 transfers | |
FlixBus · FlixBus | 1:05 PM Prague, Central Train Station | 19h10 | 8:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus | 2:30 PM Praha, Černý Most | 17h45 | 8:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Prague to Lyon run on average 12 times per day, taking around 16h 32m. Cheap bus tickets for this journey start at $58 (€48) if you book in advance.
There are 6 buses per day. The earliest bus runs at 00:10, the last at 23:55. The fastest bus covers the 534 miles (860 km) distance in 14h 50m.
Distance 534 miles (860 km) |
Average bus duration 16h 32m |
Cheapest ticket price $58 (€48) |
Buses per day 12 |
Direct buses 6 |
Fastest bus 14h 50m |
First bus 12:10 AM |
Last bus 11:55 PM |
Cheapest Month May |
Cheapest Day Wed |
High Season Oct - Dec |
Low Season Jul - Sep |
Busiest Day Wed |
Least Busy Day Fri |
Best time to book 63 days |
Discover the best of Lyon — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Lyon trip today.
Major fine arts museum in a former abbey, with strong collections from antiquity to modern art. A core cultural stop in Lyon.
Museum of cinema miniatures and film props in Vieux Lyon. Popular for detailed sets, special-effects history, and family-friendly exhibits.
Excellent free natural history and ethnography museum with fossils, animals, and global cultures. A strong local favorite, especially for families.
Renaissance quarter with cobbled lanes, traboules, courtyards, and major monuments. Essential for atmosphere, history, and walking exploration.
Central peninsula between the Rhône and Saône, packed with elegant streets, squares, shopping, and many of Lyon’s classic city views.
Historic silk-workers’ hill district with stairways, murals, markets, and hidden passageways. Great for local character and city panoramas.
Pike dumplings in a rich crayfish sauce. A Lyon classic from traditional bouchons, prized for its delicate fish texture and luxurious sauce.
Crisp salad of frisée, bacon lardons, croutons, and a poached egg. A staple Lyonnaise bistro dish that reflects the city's hearty cooking style.
Slow-cooked onions with vinegar, often served warm or chilled. This old Lyonnais side dish is traditional in bouchons and pairs well with charcuterie.
Refined dining by Paul Bocuse, known for polished French cuisine and iconic Lyon dishes in an elegant, historic dining room.
Well-known traditional bouchon in Vieux Lyon, praised for generous Lyonnais specialties and a lively old-city atmosphere.
Historic bouchon near Place Bellecour serving quenelles, salade lyonnaise, and classic regional fare in a warm traditional setting.
Moderate for Western Europe: hotels and dining are mid-priced, while public transport is good value for visitors.
Service is usually included. Round up or leave 5-10% for great restaurant service. Round up taxi fares; small change is fine in cafes.
Find answers to the most common questions about traveling from Prague to Lyon by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

Most Prague to Lyon buses use the Praha, ÚAN Florenc to Lyon, Gare Routière de Perrache station pair, with some services arriving at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan). Use this guide to compare Prague and Lyon bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Praha, ÚAN Florenc is 1 km from Prague city centre. Public transport options include:
Praha, ÚAN Florenc has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Florenc (in the station), Bistro Florenc (0.2 km), Restaurace U Rozvařilů (0.5 km).
Free Wi-Fi. ATMs are located inside the station, offering multiple currency options.
Ticket office support is available at Praha, ÚAN Florenc.
Available at Praha, ÚAN Florenc: Parking, Taxis, WC.
Accessibility facilities are available at Praha, ÚAN Florenc: Elevators, ramps.
Praha, Hlavní Nádraží is 1 km from Prague city centre. Public transport options include:
Praha, Hlavní Nádraží has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Czech Bistro (in the station), Fast Food Express (in the station), Bohemian Café (0.2 km).
Free Wi-Fi. ATMs are located near the main entrance and ticketing area.
Ticket office support is available at Praha, Hlavní Nádraží.
Available at Praha, Hlavní Nádraží: Parking, Taxis, WC.
Accessibility facilities are available at Praha, Hlavní Nádraží: Elevators, ramps.
Praha, Na Knížecí is 2 km from Prague city centre. Public transport options include:
Praha, Na Knížecí has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, and WC.
Food options include: Café Na Knížecí (in the station), Bistro Praha (0.2 km), Restaurace U Knížete (0.5 km).
Free Wi-Fi. ATMs are located near the entrance.
Available at Praha, Na Knížecí: Parking, Taxis, WC.
Accessibility facilities are available at Praha, Na Knížecí: Elevators, ramps.
Lyon, Gare Routière de Perrache is 1 km from Lyon city centre. Public transport options include:
Lyon, Gare Routière de Perrache has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Café de la Gare (in the station), Le Bistrot de Lyon (0.5 km), Brasserie Georges (0.6 km).
Free Wi-Fi. ATMs are located near the main entrance.
Ticket office support is available at Lyon, Gare Routière de Perrache.
Available at Lyon, Gare Routière de Perrache: Parking, Taxis, WC.
Accessibility facilities are available at Lyon, Gare Routière de Perrache: Elevators, ramps.
Here are some other resources that might have the information you need