- Must visit
Musée des Confluences
A major science and anthropology museum in a striking contemporary building at the confluence of the Rhône and Saône. One of Lyon’s signature cultural sites with strong temporary exhibitions.
Cheapest price
$68
Average price
$106
Fastest journey
14 h 50 m
Average duration
16 h 7 m
Buses per day
16
Distance
860 km
The best way to find a cheap bus ticket from Prague to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Prague to Lyon will cost around $106 if you buy it on the day, but the cheapest tickets can be found for only $68.
Of the 16 buses that leave Prague for Lyon on Fri, Jun 05, 7 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Jun 05 the direct buses cover the 860 km distance in an average of 16 h 7 m but if you time it right, some buses will get you there in just 14 h 50 m .
On Fri, Jun 05 the slowest buses will take 17 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
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FlixBusOmio recommends booking the flight as it is the most popular option from Prague to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $59. For those with little time consider booking a flight which can get you there in 2h 43m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.9 - 2.1kg. The ticket price range depends on the travel mode: a bus costs an average of $59, and a train costs an average of $287.
Distance: 534 miles (860 km)
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$87 Average price Cheapest | $207 Average price | $312 Average price | $267 Average price (fuel + tolls) |
17h 2m Average total duration 16h 32m Onboard + 30m Additional time* | 5h 43m Average total duration Fastest 2h 43m Onboard + 3h 0m Additional time* | 14h 30m Average total duration 14h 0m Onboard + 30m Additional time* | 9h 53m Average total duration (door-to-door) |
0.9 - 2.1kg CO2 emissions Lowest | 2.6 - 5.2kg CO2 emissions | - CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Prague to Lyon:
A bus is $120 (€97) less than a flight for this route with tickets for a flight from Prague to Lyon costing on average $207 (€167).
A bus is $225 (€182) less than a train for this route with tickets for a train from Prague to Lyon costing on average $312 (€252).
Other travel options to Lyon take longer:
Train takes on average 14h 0m.
Bus takes on average 16h 32m.
Tickets start at around $87 (€70) compared to roughly $267 (€216) in fuel and tolls — a saving of about $181 (€146). The journey takes 16h 32m versus 9h 53m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus, BlaBlaCar Bus.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 02:30AM | Arrival Time 09:40PM | Duration 19h10 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $70 |
Operator FlixBus | Departure Time 03:50AM | Arrival Time 11:15PM | Duration 19h25 | Departure days Everyday | Cheapest price $69 |
Operator FlixBus | Departure Time 04:10AM | Arrival Time 11:15PM | Duration 19h05 | Departure days Everyday | Cheapest price $69 |
Operator FlixBus | Departure Time 06:40AM | Arrival Time 11:15PM | Duration 16h35 | Departure days Everyday | Cheapest price $61 |
Operator FlixBus | Departure Time 09:00AM | Arrival Time 04:20AM | Duration 19h20 | Departure days Tue, Sun | Cheapest price $71 |
Operator FlixBus | Departure Time 09:10AM | Arrival Time 05:05AM | Duration 19h55 | Departure days Wed, Thu | Cheapest price $76 |
Operator FlixBus | Departure Time 09:40AM | Arrival Time 04:20AM | Duration 18h40 | Departure days Mon, Tue, Fri, Sat, Sun | Cheapest price $70 |
Operator FlixBus | Departure Time 10:55AM | Arrival Time 08:15AM | Duration 21h20 | Departure days Everyday | Cheapest price $69 |
Operator FlixBus | Departure Time 11:15AM | Arrival Time 04:20AM | Duration 17h05 | Departure days Mon, Fri, Sat | Cheapest price $77 |
Operator FlixBus | Departure Time 12:50PM | Arrival Time 08:15AM | Duration 19h25 | Departure days Sun | Cheapest price $164 |
Operator FlixBus | Departure Time 01:05PM | Arrival Time 08:15AM | Duration 19h10 | Departure days Everyday | Cheapest price $70 |
Operator FlixBus | Departure Time 02:30PM | Arrival Time 08:15AM | Duration 17h45 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $59 |
Operator FlixBus | Departure Time 03:05PM | Arrival Time 08:15AM | Duration 17h10 | Departure days Mon, Tue, Wed, Thu, Sat | Cheapest price $69 |
Operator FlixBus | Departure Time 03:10PM | Arrival Time 08:15AM | Duration 17h05 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $59 |
Operator FlixBus | Departure Time 04:00PM | Arrival Time 09:05AM | Duration 17h05 | Departure days Everyday | Cheapest price $61 |
Operator FlixBus | Departure Time 04:15PM | Arrival Time 09:05AM | Duration 16h50 | Departure days Everyday | Cheapest price $61 |
Operator BlaBlaCar Bus | Departure Time 07:00PM | Arrival Time 06:50PM | Duration 23h50 | Departure days Thu, Sun | Cheapest price $108 |
Operator FlixBus | Departure Time 09:25PM | Arrival Time 12:40PM | Duration 15h15 | Departure days Everyday | Cheapest price $59 |
Operator FlixBus | Departure Time 09:50PM | Arrival Time 12:40PM | Duration 14h50 | Departure days Everyday | Cheapest price $59 |
Operator RegioJet a.s. | Departure Time 11:00PM | Arrival Time 02:50PM | Duration 15h50 | Departure days Thu | Cheapest price $99 |
Operator FlixBus | Departure Time 11:50PM | Arrival Time 08:50PM | Duration 21h00 | Departure days Everyday | Cheapest price $70 |
The table below shows live departures for Prague to Lyon buses for today, Thursday, June 4. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus | 6:40 AM Praha, ÚAN Florenc | 16h35 | 11:15 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
FlixBus · FlixBus | 9:10 AM Praha, Na Knížecí | 19h35 | 4:45 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus | 10:55 AM Praha, Na Knížecí | 21h20 | 8:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus | 1:05 PM Prague, Central Train Station | 19h10 | 8:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus | 2:30 PM Praha, Černý Most | 17h45 | 8:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
FlixBus · FlixBus | 3:05 PM Praha, Zličín | 17h10 | 8:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus | 3:10 PM Praha, ÚAN Florenc | 17h05 | 8:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
FlixBus | 4:00 PM Praha, ÚAN Florenc | 17h05 | 9:05 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
FlixBus | 4:15 PM Prague, Central Train Station | 16h50 | 9:05 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
30513 · 5131 | 7:00 PM Praha, ÚAN Florenc | 23h50 | 6:50 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus | 9:25 PM Praha, ÚAN Florenc | 15h15 | 12:40 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
FlixBus | 9:50 PM Praha, Na Knížecí | 14h50 | 12:40 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
(Prague -> Lyon) | 11:00 PM Praha, ÚAN Florenc | 15h50 | 2:50 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
FlixBus · FlixBus | 11:50 PM Prague, Central Train Station | 21h00 | 8:50 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
| Friday, June 5 | |||||
FlixBus · FlixBus · FlixBus | 2:30 AM Prague, Central Train Station | 19h10 | 9:40 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 2 transfers | |
FlixBus · FlixBus | 3:50 AM Prague, Central Train Station | 19h25 | 11:15 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus | 4:10 AM Praha, Na Knížecí | 19h05 | 11:15 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Prague to Lyon run on average 12 times per day, taking around 16h 32m. Cheap bus tickets for this journey start at $59 (€48) if you book in advance.
There are 6 buses per day. The earliest bus runs at 00:10, the last at 23:55. The fastest bus covers the 534 miles (860 km) distance in 14h 50m.
Distance 534 miles (860 km) |
Average bus duration 16h 32m |
Cheapest ticket price $59 (€48) |
Buses per day 12 |
Direct buses 6 |
Fastest bus 14h 50m |
First bus 12:10 AM |
Last bus 11:55 PM |
Cheapest Month May |
Cheapest Day Wed |
High Season Oct - Dec |
Low Season Jul - Sep |
Busiest Day Wed |
Least Busy Day Fri |
Best time to book 63 days |
Discover the best of Lyon — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Lyon trip today.
A major science and anthropology museum in a striking contemporary building at the confluence of the Rhône and Saône. One of Lyon’s signature cultural sites with strong temporary exhibitions.
Lyon’s premier fine arts museum, housed in a former abbey near Place des Terreaux. Known for strong collections of painting, sculpture, antiquities, and decorative arts.
Museum of Roman Lyon paired with the city’s ancient theaters on Fourvière hill. A key stop for understanding Lugdunum, the Roman origins of Lyon.
Lyon’s atmospheric old quarter with Renaissance lanes, traboules, and riverfront views. It is the city’s classic strolling area and a top priority for first-time visitors.
One of Europe’s largest open squares and a central meeting point in Lyon. It is a practical orientation stop and a key place for city views toward Fourvière.
Lyon’s flagship urban park with broad walking paths, lake, botanical areas, and a zoo. It is one of the best places in the city for relaxation and scenic walks.
Light dumplings made with pike and panade, usually baked in a rich Nantua crayfish sauce. A classic Lyonnais bouchon specialty.
A traditional salad of frisée lettuce with lardons, croutons, and a poached egg. It is one of the city’s most iconic starter dishes.
Lyon’s famous sausage baked inside a soft brioche dough. It is a beloved charcuterie-based specialty found in many bouchons.
A landmark fine dining institution in Lyon, famed for historic prestige and elegant cuisine rooted in the city’s gastronomic heritage.
The city’s celebrated covered food market, ideal for sampling oysters, charcuterie, cheese, pastries, and many iconic Lyonnais products.
A respected traditional restaurant associated with chef Joseph Viola, celebrated for refined Lyonnais classics in a polished but welcoming setting.
Moderate for France: bakeries and bouchons are fair value, while central hotels and fine dining cost more.
Service is included by law. Leaving small change or 5-10% for great service is appreciated, not required. Round up for taxis.
Official public transport app
Lyon Perrache Bus Station, Lyon -> Lyon Part-Dieu Station, Lyon
Find answers to the most common questions about traveling from Prague to Lyon by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

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