- Must visit
Musée des Confluences
A major science and anthropology museum in a striking contemporary building at the confluence of the Rhône and Saône. One of Lyon’s signature cultural sites with strong temporary exhibitions.
Cheapest price
$36
Average price
$53
Fastest journey
10 h 10 m
Average duration
10 h 55 m
Buses per day
6
Distance
569 km
The best way to find a cheap bus ticket from Brussels to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Brussels to Lyon will cost around $53 if you buy it on the day, but the cheapest tickets can be found for only $36.
Of the 6 buses that leave Brussels for Lyon on Wed, Jun 03, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Jun 03 the direct buses cover the 569 km distance in an average of 10 h 55 m but if you time it right, some buses will get you there in just 10 h 10 m .
On Wed, Jun 03 the slowest buses will take 12 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
1408 · 83133
1646 · 50617
50338 · 5133
FlixBus · FlixBus
FlixBus · FlixBus
1408 · 83133
50338 · 5133
FlixBus
FlixBus · FlixBus
FlixBus · FlixBusOmio recommends booking the train as it is the most popular option from Brussels to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $27. For those with little time consider booking a flight which can get you there in 2h 24m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.5kg. The ticket price range depends on the travel mode: a bus costs an average of $27, and a flight costs an average of $146.
Distance: 353 miles (569 km)
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$53 Average price Cheapest | $184 Average price | $379 Average price | $197 Average price (fuel + tolls) |
10h 2m Average total duration 9h 32m Onboard + 30m Additional time* | 3h 47m Average total duration 3h 17m Onboard + 30m Additional time* | 5h 24m Average total duration Fastest 2h 24m Onboard + 3h 0m Additional time* | 6h 56m Average total duration (door-to-door) |
0.6 - 1.4kg CO2 emissions | 0.2 - 0.5kg CO2 emissions Lowest | 1.7 - 3.4kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Brussels to Lyon:
A bus is $130 (€105) less than a train for this route with tickets for a train from Brussels to Lyon costing on average $184 (€148).
A bus is $326 (€263) less than a flight for this route with tickets for a flight from Brussels to Lyon costing on average $379 (€306).
Other travel options to Lyon take longer:
Train takes on average 3h 17m.
Bus takes on average 9h 32m.
Tickets start at around $53 (€43) compared to roughly $197 (€159) in fuel and tolls — a saving of about $144 (€116). The journey takes 9h 32m versus 6h 56m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by BlaBlaCar Bus, FlixBus, BlaBlaCar.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 01:30AM | Arrival Time 12:35PM | Duration 11h05 | Departure days Sat, Sun | Cheapest price $58 |
Operator BlaBlaCar Bus | Departure Time 03:11AM | Arrival Time 02:40PM | Duration 11h29 | Departure days Mon, Fri, Sat, Sun | Cheapest price $51 |
Operator FlixBus | Departure Time 04:15AM | Arrival Time 06:15PM | Duration 14h00 | Departure days Mon, Fri, Sat, Sun | Cheapest price $55 |
Operator BlaBlaCar Bus | Departure Time 06:40AM | Arrival Time 06:50PM | Duration 12h10 | Departure days Thu | Cheapest price $36 |
Operator BlaBlaCar Bus | Departure Time 07:20AM | Arrival Time 06:50PM | Duration 11h30 | Departure days Mon, Fri, Sat, Sun | Cheapest price $35 |
Operator BlaBlaCar | Departure Time 08:00AM | Arrival Time 06:00PM | Duration 10h00 | Departure days Thu, Sat | Cheapest price $73 |
Operator BlaBlaCar Bus | Departure Time 08:05AM | Arrival Time 09:40PM | Duration 13h35 | Departure days Mon, Sat | Cheapest price $36 |
Operator BlaBlaCar | Departure Time 08:30AM | Arrival Time 04:30PM | Duration 8h00 | Departure days Tue, Sat | Cheapest price $86 |
Operator BlaBlaCar Bus | Departure Time 08:35AM | Arrival Time 09:40PM | Duration 13h05 | Departure days Sun | Cheapest price $48 |
Operator BlaBlaCar | Departure Time 08:40AM | Arrival Time 04:20PM | Duration 7h40 | Departure days Thu | Cheapest price $68 |
Operator FlixBus | Departure Time 10:05AM | Arrival Time 11:50PM | Duration 13h45 | Departure days Tue, Thu, Sat | Cheapest price $54 |
Operator FlixBus | Departure Time 11:05AM | Arrival Time 11:50PM | Duration 12h45 | Departure days Tue, Wed, Thu | Cheapest price $57 |
Operator BlaBlaCar Bus | Departure Time 11:30AM | Arrival Time 11:50PM | Duration 12h20 | Departure days Mon | Cheapest price $36 |
Operator FlixBus | Departure Time 11:40AM | Arrival Time 11:50PM | Duration 12h10 | Departure days Mon, Fri, Sat, Sun | Cheapest price $53 |
Operator BlaBlaCar Bus | Departure Time 12:00PM | Arrival Time 11:50PM | Duration 11h50 | Departure days Fri, Sat, Sun | Cheapest price $36 |
Operator BlaBlaCar Bus | Departure Time 01:30PM | Arrival Time 03:30AM | Duration 14h00 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $32 |
Operator FlixBus | Departure Time 01:40PM | Arrival Time 03:10AM | Duration 13h30 | Departure days Mon, Tue | Cheapest price $53 |
Operator BlaBlaCar Bus | Departure Time 02:20PM | Arrival Time 12:50AM | Duration 10h30 | Departure days Mon, Thu, Fri, Sun | Cheapest price $33 |
Operator FlixBus | Departure Time 03:10PM | Arrival Time 02:00AM | Duration 10h50 | Departure days Wed, Thu, Fri, Sat, Sun | Cheapest price $63 |
Operator BlaBlaCar Bus | Departure Time 03:30PM | Arrival Time 01:40AM | Duration 10h10 | Departure days Mon, Thu, Fri, Sun | Cheapest price $42 |
Operator BlaBlaCar | Departure Time 04:30PM | Arrival Time 12:00AM | Duration 7h30 | Departure days Thu | Cheapest price $76 |
Operator BlaBlaCar Bus | Departure Time 04:35PM | Arrival Time 03:30AM | Duration 10h55 | Departure days Thu | Cheapest price $42 |
Operator FlixBus | Departure Time 04:40PM | Arrival Time 05:20AM | Duration 12h40 | Departure days Mon, Tue, Fri, Sat, Sun | Cheapest price $61 |
Operator BlaBlaCar Bus | Departure Time 04:55PM | Arrival Time 03:30AM | Duration 10h35 | Departure days Fri, Sat, Sun | Cheapest price $33 |
Operator BlaBlaCar | Departure Time 05:00PM | Arrival Time 12:40AM | Duration 7h40 | Departure days Wed | Cheapest price $61 |
Operator BlaBlaCar | Departure Time 05:20PM | Arrival Time 12:50AM | Duration 7h30 | Departure days Thu | Cheapest price $66 |
Operator BlaBlaCar Bus | Departure Time 05:55PM | Arrival Time 04:05AM | Duration 10h10 | Departure days Everyday | Cheapest price $32 |
Operator BlaBlaCar Bus | Departure Time 07:05PM | Arrival Time 05:20AM | Duration 10h15 | Departure days Everyday | Cheapest price $32 |
Operator FlixBus | Departure Time 08:15PM | Arrival Time 06:50AM | Duration 10h35 | Departure days Everyday | Cheapest price $53 |
Operator BlaBlaCar Bus | Departure Time 10:15PM | Arrival Time 09:15AM | Duration 11h00 | Departure days Thu, Fri, Sat, Sun | Cheapest price $62 |
The table below shows live departures for Brussels to Lyon buses for today, Tuesday, June 2. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 10:05 AM Brussels, Gare Du Midi | 13h45 | 11:50 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus | 11:05 AM Brussels, Brussels South (Gare du Midi) | 12h45 | 11:50 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus | 1:40 PM Brussels, Brussels South (Gare du Midi) | 13h30 | 3:10 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus | 4:40 PM Brussels, Brussels South (Gare du Midi) | 12h40 | 5:20 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
1408 · 5807 | 5:55 PM Brussels, Brussels South (Gare du Midi) | 10h35 | 4:30 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
50338 · 5133 | 7:05 PM Brussels, Brussels South (Gare du Midi) | 10h15 | 5:20 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus | 8:15 PM Brussels, Brussels South (Gare du Midi) | 10h35 | 6:50 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Brussels to Lyon run on average 15 times per day, taking around 9h 32m. Cheap bus tickets for this journey start at $27 (€21) if you book in advance.
There are 3 buses per day. The earliest bus runs at 00:10, the last at 23:55. The fastest bus covers the 353 miles (569 km) distance in 9h 50m.
Distance 353 miles (569 km) |
Average bus duration 9h 32m |
Cheapest ticket price $27 (€21) |
Buses per day 15 |
Direct buses 3 |
Fastest bus 9h 50m |
First bus 12:10 AM |
Last bus 11:55 PM |
Cheapest Month Sep |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Jan - Mar |
Busiest Day Mon |
Least Busy Day Sun |
Best time to book 84 days |
Discover the best of Lyon — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Lyon trip today.
A major science and anthropology museum in a striking contemporary building at the confluence of the Rhône and Saône. One of Lyon’s signature cultural sites with strong temporary exhibitions.
Lyon’s premier fine arts museum, housed in a former abbey near Place des Terreaux. Known for strong collections of painting, sculpture, antiquities, and decorative arts.
Museum of Roman Lyon paired with the city’s ancient theaters on Fourvière hill. A key stop for understanding Lugdunum, the Roman origins of Lyon.
Lyon’s atmospheric old quarter with Renaissance lanes, traboules, and riverfront views. It is the city’s classic strolling area and a top priority for first-time visitors.
One of Europe’s largest open squares and a central meeting point in Lyon. It is a practical orientation stop and a key place for city views toward Fourvière.
Lyon’s flagship urban park with broad walking paths, lake, botanical areas, and a zoo. It is one of the best places in the city for relaxation and scenic walks.
Light dumplings made with pike and panade, usually baked in a rich Nantua crayfish sauce. A classic Lyonnais bouchon specialty.
A traditional salad of frisée lettuce with lardons, croutons, and a poached egg. It is one of the city’s most iconic starter dishes.
Lyon’s famous sausage baked inside a soft brioche dough. It is a beloved charcuterie-based specialty found in many bouchons.
A landmark fine dining institution in Lyon, famed for historic prestige and elegant cuisine rooted in the city’s gastronomic heritage.
The city’s celebrated covered food market, ideal for sampling oysters, charcuterie, cheese, pastries, and many iconic Lyonnais products.
A respected traditional restaurant associated with chef Joseph Viola, celebrated for refined Lyonnais classics in a polished but welcoming setting.
Moderate for France: bakeries and bouchons are fair value, while central hotels and fine dining cost more.
Service is included by law. Leaving small change or 5-10% for great service is appreciated, not required. Round up for taxis.
Official public transport app
Lyon Perrache Bus Station, Lyon -> Lyon Part-Dieu Station, Lyon
Find answers to the most common questions about traveling from Brussels to Lyon by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

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