Travel Information
Compare train, bus, and flight for Lyon to Brussels
Omio recommends booking the train as it is the most popular option from Lyon to Brussels among Omio's users. If you are prioritising price take the bus with prices starting from $24. For those with little time consider booking a flight which can get you there in 1h 54m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.5kg. The ticket price range depends on the travel mode: a bus costs an average of $24, and a flight costs an average of $121.
Distance: 353 miles (569 km)
Compare train with
Most popular Train | Bus | Flight |
|---|---|---|
$136 Average price | $52 Average price Cheapest | $282 Average price |
6h 8m Average total duration 5h 38m Onboard + 30m Additional time* | 8h 28m Average total duration 7h 58m Onboard + 30m Additional time* | 4h 54m Average total duration Fastest 1h 54m Onboard + 3h 0m Additional time* |
0.2 - 0.5kg CO2 emissions Lowest | 0.6 - 1.4kg CO2 emissions | 1.7 - 3.4kg CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Lyon to Brussels
How to get from Lyon to Brussels by train, bus or flight.
Our recommendation
The best way to travel from Lyon to Brussels is by taking a bus because it’s the best combination of price and speed.
83134 · 503318:30 AM11h15Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)7:45 PMBrussels, Brussels South (Gare du Midi)$361One-way1 transfer
Cheapest
83134 · 503318:30 AM11h15Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)7:45 PMBrussels, Brussels South (Gare du Midi)$361One-way1 transfer
Fastest
SN35881:10 PM1h25Lyon Saint Exupery Airport2:35 PMBrussels Airport$3101One-way0 transfers
Other options
6906+
94297:54 AM4h23Lyon Saint-Exupéry TGV12:17 PMBrussels-Midi$2011One-way1 transfer
6908+
935110:53 AM4h55Lyon Saint-Exupéry TGV3:48 PMBrussels-Midi$2151One-way1 transfer
6906+
93297:54 AM4h23Lyon Saint-Exupéry TGV12:17 PMBrussels-Midi$2201One-way1 transfer
51470 · 16133:50 PM10h23Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)2:13 AMBrussels, Brussels South (Gare du Midi)$381One-way1 transfer
58074 · 5033712:00 PM11h35Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)11:35 PMBrussels, Brussels South (Gare du Midi)$481One-way1 transfer
50618 · 16571:20 AM10h40Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)12:00 PMBrussels, Brussels South (Gare du Midi)$581One-way1 transfer
AF7371+
AF8382+
93646:00 AM11h06Lyon Saint Exupery Airport5:06 PMBrussels-Midi$3631One-way2 transfers
AF7371+
AF8382+
93706:00 AM12h06Lyon Saint Exupery Airport6:06 PMBrussels-Midi$3631One-way2 transfers
AF7371+
AF8382+
93826:00 AM14h06Lyon Saint Exupery Airport8:06 PMBrussels-Midi$3631One-way2 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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How to get from Lyon to Brussels
The Best Way According to our Users
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FAQs: Travel from Lyon to Brussels
Travel to Brussels easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Lyon to Brussels.

This is compared to other travel options from Lyon to Brussels:
A bus is $34 (€27) less than a train for this route with tickets for a train from Lyon to Brussels costing on average $58 (€46).
A bus is $97 (€77) less than a flight for this route with tickets for a flight from Lyon to Brussels costing on average $121 (€96).
Other travel options to Brussels take longer:
Train takes on average 3h 43m.
Bus takes on average 9h 40m.
- Around 16 buses per day.
- Around 11 flights per day.
- Around 4 trains per day.
However, we recommend checking specific travel dates for your route between Lyon and Brussels as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Lyon Saint Exupery Airport and arrive in Brussels Airport.
- Trains mostly depart from Lyon Part Dieu and arrive in Brussels-Midi.
- Buses mostly depart from Lyon, Perrache Bus Station and arrive in Brussels, Brussels South (Gare du Midi).
- Travel with Brussels Airlines, Air Baltic, Lufthansa, Vueling Airlines, KLM, Cityjet, Swiss, easyJet to go to Brussels by flight.
- Travel with BlaBlaCar Bus, FlixBus, BlaBlaCar to go to Brussels by bus.
- Travel with TGV, TGV INOUI to go to Brussels by train.
- 2 direct flights per day with Brussels Airlines, Air Baltic, Swiss, easyJet.
- 3 direct buses per day with BlaBlaCar Bus, FlixBus, BlaBlaCar.
- 4 direct trains per day with TGV, TGV INOUI.
Travelling from Lyon to Brussels: related information
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