- Must visit
The Charleston Museum
America’s first museum with natural history, decorative arts, and Charleston stories across several historic sites.
Cheapest price on Sep 19
$108
Average ticket price on Sep 19
$117
Fastest journey on Sep 19
1 d 6 h 10 m
Average journey duration on Sep 19
1 d 7 h 13 m
Buses on Sep 19
8
Distance
1128 km
The best way to find a cheap bus ticket from Buffalo, NY to Charleston, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Buffalo, NY to Charleston, SC will cost around $117 if you buy it on the day, but the cheapest tickets can be found for only $108.
It's difficult to get from Buffalo, NY to Charleston, SC without transferring at least 2 times.
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· · Omio recommends booking the bus as it is the most popular option from Buffalo, NY to Charleston, SC among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $179 For those with little time, consider booking a train, which has an average total journey time of 23h 21m. Average ticket prices depend on the travel mode: a bus costs an average of $179, while a train costs an average of $406.
Distance: 700 miles (1128 km)
Most popular Bus | Flight | Train | Driving |
|---|---|---|---|
$179 Average price Cheapest | $406 Average price | $177 Average price (fuel + tolls) | |
27h 35m Average total duration 27h 5m Onboard + 30m Additional time* | 23h 21m Average total duration Fastest 22h 51m Onboard + 30m Additional time* | 13h 11m Average total duration (door-to-door) | |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Buffalo, NY to Charleston, SC:
A bus is $227 (€186) less than a train for this route with tickets for a train from Buffalo, NY to Charleston, SC costing on average $406 (€332).
Other travel options to Charleston, SC take longer:
Bus takes on average 27h 5m.
Tickets start at around $179 (€146) compared to roughly $177 (€144) in fuel and tolls — a saving of about $-2.17 (€-1.77). The journey takes 27h 5m versus 13h 11m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 03:30AM | Arrival Time 12:15PM | Duration 32h45 | Departure days Tue | Cheapest price $125 |
Operator Greyhound | Departure Time 03:50AM | Arrival Time 12:15PM | Duration 32h25 | Departure days Thu | Cheapest price $138 |
Operator FlixBus | Departure Time 05:30AM | Arrival Time 12:45PM | Duration 31h15 | Departure days Fri, Sat, Sun | Cheapest price $98 |
Operator FlixBus | Departure Time 05:45AM | Arrival Time 12:45PM | Duration 31h00 | Departure days Tue, Fri, Sat, Sun | Cheapest price $99 |
Operator Greyhound | Departure Time 10:30AM | Arrival Time 06:30PM | Duration 32h00 | Departure days Tue, Thu, Fri, Sat, Sun | Cheapest price $105 |
Operator Greyhound | Departure Time 10:50AM | Arrival Time 06:30PM | Duration 31h40 | Departure days Tue, Thu, Fri, Sat, Sun | Cheapest price $106 |
Operator FlixBus | Departure Time 01:05PM | Arrival Time 09:50PM | Duration 32h45 | Departure days Tue, Thu, Fri, Sat | Cheapest price $117 |
Operator FlixBus | Departure Time 03:20PM | Arrival Time 09:40PM | Duration 30h20 | Departure days Sun | Cheapest price $97 |
Operator Greyhound | Departure Time 03:40PM | Arrival Time 09:40PM | Duration 30h00 | Departure days Tue, Thu, Fri, Sat, Sun | Cheapest price $98 |
Operator Greyhound | Departure Time 11:00PM | Arrival Time 12:15PM | Duration 37h15 | Departure days Tue | Cheapest price $109 |
Operator Greyhound | Departure Time 11:20PM | Arrival Time 12:45PM | Duration 37h25 | Departure days Tue, Sun | Cheapest price $104 |
Operator FlixBus | Departure Time 11:20PM | Arrival Time 12:45PM | Duration 37h25 | Departure days Thu, Fri, Sat | Cheapest price $123 |
Operator FlixBus | Departure Time 11:59PM | Arrival Time 12:45PM | Duration 36h46 | Departure days Tue, Thu, Fri, Sat, Sun | Cheapest price $97 |
The table below shows live departures for Buffalo, NY to Charleston, SC buses for today, Friday, September 18. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus+ · · | 10:30 AM Buffalo, NFTA Metro Center | 32h00 | 6:30 PM Charleston, Gaynor Avenue (Greyhound Bus Station), SC | 3 transfers | |
FlixBus+ · · | 10:50 AM Cheektowaga, BNIA Drway & BNIA Terminal | 31h40 | 6:30 PM Charleston, Gaynor Avenue (Greyhound Bus Station), SC | 3 transfers | |
FlixBus · FlixBus+ · | 1:05 PM Cheektowaga, BNIA Drway & BNIA Terminal | 32h45 | 9:50 PM Charleston, Gaynor Avenue (Greyhound Bus Station), SC | 3 transfers | |
· · | 3:40 PM Buffalo, NFTA Metro Center | 30h10 | 9:50 PM Charleston, Gaynor Avenue (Greyhound Bus Station), SC | 2 transfers | |
FlixBus · FlixBus+![]() | 11:20 PM Cheektowaga, BNIA Drway & BNIA Terminal | 36h55 | 12:15 PM Charleston, Gaynor Avenue (Greyhound Bus Station), SC | 2 transfers | |
FlixBus · FlixBus · FlixBus · FlixBus | 11:59 PM Buffalo, NFTA Metro Center | 36h16 | 12:15 PM Charleston, Gaynor Avenue (Greyhound Bus Station), SC | 4 transfers | |
| Saturday, September 19 | |||||
FlixBus · FlixBus · FlixBus+![]() | 5:30 AM Buffalo, NFTA Metro Center | 31h15 | 12:45 PM Charleston, Gaynor Avenue (Greyhound Bus Station), SC | 3 transfers | |
FlixBus · FlixBus+![]() | 5:45 AM Cheektowaga, BNIA Drway & BNIA Terminal | 31h00 | 12:45 PM Charleston, Gaynor Avenue (Greyhound Bus Station), SC | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Buses from Buffalo, NY to Charleston, SC run on average 7 times per day, taking around 27h 5m. Cheap bus tickets for this journey start at $114 (€93) if you book in advance.
The earliest bus runs at 08:45, the last at 23:55. The fastest bus covers the 700 miles (1128 km) distance in 24h 15m.
Distance 700 miles (1128 km) |
Average bus duration 27h 5m |
Cheapest ticket price $114 (€93) |
Buses per day 7 |
Fastest bus 24h 15m |
First bus 8:45 AM |
Last bus 11:55 PM |
Cheapest Month Jul |
Cheapest Day Sun |
High Season Jul - Sep |
Low Season Jan - Mar |
Discover the best of Charleston, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Charleston, SC trip today.
America’s first museum with natural history, decorative arts, and Charleston stories across several historic sites.
Leading Southern museum for contemporary art, known for bold exhibitions and strong local creative connections.
Powerful museum on Gadsden’s Wharf interpreting the African American journey and Charleston’s global significance.
Legendary waterfront promenade lined with antebellum homes, harbor breezes, and some of Charleston’s best views.
Historic defensive seawall and walk beside White Point Garden, ideal for sunset, mansions, and harbor panoramas.
Lively pedestrian-friendly market district known for crafts, architecture, and easy access to major downtown sights.
A Lowcountry rice dish with shrimp, sausage, or chicken simmered in rich broth. It reflects Charleston's Gullah Geechee and coastal cooking traditions.
Stone-ground grits cooked creamy and topped with local shrimp, often with bacon or gravy. It is one of Charleston's signature brunch and supper dishes.
A rich soup of blue crab, crab roe, cream, and sherry. This classic Charleston dish is closely tied to the city's historic seafood culture.
Historic fine-dining restaurant focused on seasonal Lowcountry cuisine. Known for polished Southern hospitality and dishes using regional ingredients.
Upscale seafood restaurant celebrated for local oysters and inventive Lowcountry dishes. Stylish, lively, and one of Charleston's best-known dining rooms.
Refined Southern restaurant in the Historic District, known for shrimp and grits, seafood, and polished service in an elegant setting.
Moderate for a US coastal city; hotels and dining in the historic district run higher, while transit is limited and many visitors rely on walking, rideshare, or car hire.
Tip 18-20% in restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip screens; small tips are appreciated but optional.
Find answers to the most common questions about traveling from Buffalo, NY to Charleston, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Charleston, SC, this guide helps you travel smarter and with confidence.

Most Buffalo, NY to Charleston, SC buses use the Cheektowaga, BNIA Drway & BNIA Terminal to Charleston, Gaynor Avenue (Greyhound Bus Station) station pair. Use this guide to compare Buffalo, NY and Charleston, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Buffalo, NFTA Metro Center has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free WiFi is available in the station. ATMs are aTM services are available near the entrance.
Ticket office support is available at Buffalo, NFTA Metro Center.
Available at Buffalo, NFTA Metro Center: Parking, Taxis, WC.
Accessibility facilities are available at Buffalo, NFTA Metro Center: Accessible for passengers with reduced mobility.
Charleston, Gaynor Avenue (Greyhound Bus Station) is 12 km from Charleston city centre. Public transport options include:
Charleston, Gaynor Avenue (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free Wi-Fi available. ATMs are available at Charleston, Gaynor Avenue (Greyhound Bus Station).
Ticket office support is available at Charleston, Gaynor Avenue (Greyhound Bus Station).
Available at Charleston, Gaynor Avenue (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Charleston, Gaynor Avenue (Greyhound Bus Station): Wheelchair accessible.
Here are some other resources that might have the information you need